Front Cell Dev Biol March 2019 PMID 30984757

Avian Primordial Germ Cells Contribute to and Interact With the Extracellular Matrix During Early Migration.

David J Huss, Sasha Saias, Sevag Hamamah, Jennifer M Singh, Jinhui Wang, Mohit Dave, Junhyong Kim, James Eberwine, Rusty Lansford

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Mentions

Peak: 2 in Mar 2019

across 3 sources since Mar 2019

Extended reach

36,769

potential audience

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9,674

Mentions per month

Mar 2019 – Oct 2025

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AI synopsis

What people are saying

Discussions reflect a balanced appreciation for the research, with mentions of ECM components like fibronectin and laminin, and notes on how PGC movement is influenced or independent of integrin 1—words like 'interaction' and 'migration' convey technical engagement, while references to broader implications demonstrate recognition of its significance.

AgreementModerate agreement

Most discussions recognize the importance of the study in understanding germ cell migration and ECM interactions, showing general support for its findings.

InterestModerate interest

Participants seem moderately interested, with mentions of specific cellular interactions and methodological approaches that indicate engagement but not necessarily high enthusiasm.

EngagementModerate engagement

Comments include references to the biological processes and potential implications, suggesting a decent level of thoughtful engagement.

ImpactModerate impact

The discussions highlight the relevance of the research to broader fields such as developmental biology and genetics, implying a moderate perceived impact.

Abstract in brief

This study investigates how primordial germ cells (PGCs) in birds migrate during early development, focusing on their interaction with the extracellular matrix (ECM), including key components like fibronectin and laminin.
Using techniques such as bioinformatics, single-cell RNA sequencing, and live imaging, the researchers found that PGCs express genes related to ECM and are closely associated with a dynamic ECM fibril network during migration.
Blocking integrin 1 receptors affected ECM formation but did not stop PGC movement, indicating that while integrin 1 is crucial for ECM assembly, PGC migration can occur independently of it.]

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Transcriptomes

@transcriptomes · X

Avian Primordial Germ Cells Contribute to and Interact With the Extracellular Matrix During E... https://t.co/cZv39thAfK

Apr 16, 2019 · 1,811 followers View post →

Frontiers - Cell Biology

@FrontCellDevBio · X

Mar 28, 2019 · 1 like · 3,809 followers View post →

BOU

@IBIS_journal · X

Avian primordial germ cells contribute to and interact with the extracellular matrix during early migration https://t.co/7qdkzDdGGp | @FrontEcolEvol | #ornithology

Mar 15, 2019 · 21,476 followers View post →