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Nat Biomed Eng November 2019 PMID 30988472

A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia.

C W Hu, Y Qiu, A Ligeralde, A Y Raybon, S Y Yoo, K R Coombes, A A Qutub, S M Kornblau

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Mentions

27
Peak: 7 in Apr 2019
across 5 sources since Apr 2019

Extended reach

181,082
potential audience

Total likes

8

Video views

285

Mentions per month

Apr 2019 – May 2019

Where it's discussed

  • News11 articles
  • X / Twitter8 posts
  • Blogs4 articles
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

Throughout the discussions, phrases like 'Great new resource for AML researchers!' and references to the article as a 'quantitative analysis' demonstrate enthusiasm and recognition of the study’s importance. The tone emphasizes novelty and usefulness, showing moderate engagement and interest, but without extensive debate or critical analysis that would indicate high impact.

AgreementModerate agreement

Most discussions recognize the article as a valuable resource, indicating general agreement on its significance.

InterestHigh interest

The high interest score reflects enthusiasm and curiosity about the new resource and its implications for AML research.

EngagementModerate engagement

Comments show moderate engagement, with some sharing positive impressions and highlighting the usefulness of the resource.

ImpactModerate impact

While the discussions note the resource's potential, there is limited evidence of deep influence or transformative impact yet, hence a moderate score.

Abstract in brief

  • The study introduces the AML Proteome Atlas, a new database that analyzes the protein profiles of 205 AML patients and 111 leukemia cell lines, revealing 154 functional molecular patterns, 11 groups of related patterns, and 13 signatures that help predict patient outcomes.
  • The research finds that proteomic data in AML shows limited overlap with traditional genetic information like cytogenetics and mutations, and leukemia cell lines do not fully replicate patient cell profiles, highlighting the importance of studying actual patient samples.
  • Overall, the AML Proteome Atlas serves as a valuable resource for understanding the diverse protein behaviors in AML, assisting in better leukemia cell line selection and providing a computational method to explore heterogeneity in protein expression for improved disease insights.
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Top posts

Most liked on X and Bluesky
مركز الأبحاث
@KFSHRC_Research · X

A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia https://t.co/5QJigeFr4X https://t.co/jRKhXBErS1

May 19, 2019 · 3 likes · 1 share · 71,903 followers View post →
Nature Biomedical Engineering
@natBME · X

A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia https://t.co/9oDE80RMNM https://t.co/AmOOUxvlFb

Apr 15, 2019 · 3 likes · 4 shares · 52,510 followers View post →
Paul Humphries
@PaulHumpa · X

Great new resource for AML researchers! A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia https://t.co/xO3MTEwyez

Apr 17, 2019 · 2 likes · 2,604 followers View post →
Nature Biomedical Engineering
@natBME · X

RT @natBME: A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia https://t.co/9oDE80RMNM https://t.co/Am…

May 27, 2019 · 4 shares · 52,510 followers View post →
Eric Brey
@brey_lab · X

RT @natBME: A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia https://t.co/9oDE80RMNM https://t.co/Am…

Apr 17, 2019 · 4 shares · 494 followers View post →
Amina Qutub
@eBionic · X

RT @natBME: A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia https://t.co/9oDE80RMNM https://t.co/Am…

Apr 16, 2019 · 4 shares · 385 followers View post →

All mentions

Nature Biomedical Engineering
@natBME · X

RT @natBME: A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia https://t.co/9oDE80RMNM https://t.co/Am…

May 27, 2019 · 4 shares · 52,510 followers View post →
أضف اسمك
@ilovevoshion · X

RT @KFSHRC_Research: A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia https://t.co/5QJigeFr4X https:…

May 19, 2019 · 1 share · 101 followers View post →
مركز الأبحاث
@KFSHRC_Research · X

A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia https://t.co/5QJigeFr4X https://t.co/jRKhXBErS1

May 19, 2019 · 3 likes · 1 share · 71,903 followers View post →
Paul Humphries
@PaulHumpa · X

Great new resource for AML researchers! A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia https://t.co/xO3MTEwyez

Apr 17, 2019 · 2 likes · 2,604 followers View post →
Eric Brey
@brey_lab · X

RT @natBME: A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia https://t.co/9oDE80RMNM https://t.co/Am…

Apr 17, 2019 · 4 shares · 494 followers View post →
Amina Qutub
@eBionic · X

RT @natBME: A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia https://t.co/9oDE80RMNM https://t.co/Am…

Apr 16, 2019 · 4 shares · 385 followers View post →
Qutub Lab
@QutubLab · X

RT @natBME: A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia https://t.co/9oDE80RMNM https://t.co/Am…

Apr 15, 2019 · 4 shares · 246 followers View post →
Nature Biomedical Engineering
@natBME · X

A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia https://t.co/9oDE80RMNM https://t.co/AmOOUxvlFb

Apr 15, 2019 · 3 likes · 4 shares · 52,510 followers View post →