Nat Biotechnol July 2019 PMID 30988505

Engineered toxin-intein antimicrobials can selectively target and kill antibiotic-resistant bacteria in mixed populations.

Rocío López-Igual, Joaquín Bernal-Bayard, Alfonso Rodríguez-Patón, Jean-Marc Ghigo, Didier Mazel

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Peak: 67 in Apr 2019

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AI synopsis

What people are saying

Numerous discussions underscore the innovative aspect of the research, with phrases like 'Nifty bioengineering' and 'promising way to target drug-resistant bacteria' reflecting a positive reception. The tone, characterized by excitement and optimism, suggests that participants believe this method could significantly alter the landscape of treatment for antibiotic-resistant infections.

AgreementStrong agreement

The majority of discussions express strong support for the findings of the publication, with many participants highlighting its significance.

InterestHigh interest

Posts demonstrate high enthusiasm and a strong curiosity regarding the implications of the research, as indicated by the frequent sharing and commentary.

EngagementModerate engagement

While most comments are affirming, the engagement is somewhat surface-level, primarily focusing on sharing the publication rather than in-depth analysis.

ImpactHigh impact

There is a consensus that this research could lead to groundbreaking changes in how antibiotic resistance is managed, with many users emphasizing its potential effectiveness.

Abstract in brief

Engineered toxins using inteins can target and eliminate antibiotic-resistant bacteria without harming beneficial microbes in mixed populations.
This method aims to cure diseases while preventing disruption of healthy microbiota and the rise of antimicrobial resistance.
In tests on Vibrio cholerae, 100% of antibiotic-resistant bacteria were killed, with very few escape mutants observed, demonstrating the effectiveness of this targeted approach in natural hosts like zebrafish and crustacean larvae.

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Targeted Antibiotics: Combatting Resistance Effectively and Safely

This video discusses engineered toxins using inteins to selectively eliminate antibiotic-resistant bacteria while preserving beneficial microbes. Learn about the effectiveness of this approach, demonstrated through…

Alfonso Rodríguez-Patón · Apr 10, 2019 5,204 views

Targeting Antibiotic-Resistant Bacteria with Engineered Antimicrobials

Ali Doğa Yücel presents research on engineered toxins using inteins that target and eliminate antibiotic-resistant bacteria without affecting beneficial microbes. This approach aims to combat diseases while preserving…

Sentetik Biyoloji Türkiye · Jun 28, 2020 335 views

Adventure Micro Class

@ClassMicro · X

Bacteria may hold the key to their own destruction: manipulating toxin-antitoxin systems is a promising a way to target drug-resistant bacteria in mixed populations. https://t.co/2Wq6rptG1m

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Huiluo Cao 曹慧荦

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Engineered toxin–intein antimicrobials can selectively target and kill antibiotic-resistant bacteria in mixed populations | Nature Biotechnology https://t.co/Kv7XuSxsr5

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» Engineered toxin–intein antimicrobials can selectively target and kill antibiotic-resistant bacteria in mixed populations | Nature Biotechnology https://t.co/PTgj39Gs04

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Engineered toxin–intein antimicrobials can selectively target and kill antibiotic-resistant bacteria in mixed populations, by Rocío López-Igual @InvestigaUS et al. https://t.co/14RdoorrvB cc @bio_sintesis

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Chih-Horng Kuo (郭志鴻)

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Engineered toxin–intein antimicrobials can selectively target and kill antibiotic-resistant bacteria in mixed populations https://t.co/ekuiR726ws

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Engineered toxin-intein antimicrobials can selectively target and kill antibiotic-resistant bacteria in mixed populations.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Targeted Antibiotics: Combatting Resistance Effectively and Safely

Targeting Antibiotic-Resistant Bacteria with Engineered Antimicrobials