Front Aging Neurosci April 2019 PMID 31001108

Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer's Disease.

Laurent Younes, Marilyn Albert, Abhay Moghekar, Anja Soldan, Corinne Pettigrew, Michael I Miller

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Mentions

82
Peak: 19 in May 2019
across 5 sources since Apr 2019

Extended reach

465,930
potential audience

Total likes

424

Video views

7,121

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Apr 2019 – Sep 2025

Where it's discussed

  • X / Twitter40 posts
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AI synopsis

What people are saying

Discussions frequently mention the breakthrough aspect of identifying biomarkers decades before symptoms, with phrases like 'missing a 34-year window' and 'potential to detect Alzheimer's early.' The tone often combines curiosity and optimism, emphasizing the promise of new diagnostic tools and early intervention strategies, which underscores the perceived significance and deep engagement with the research findings.

AgreementModerate agreement

Most discussions acknowledge the significance of early biomarker changes and the potential for early detection to improve outcomes, as seen in comments about 'missing a 34-year intervention window' and 'early markers for Alzheimer’s.'

InterestHigh interest

There is considerable curiosity about the implications, with posts highlighting the long preclinical phase and some suggesting innovations like 'nano-robots' or 'brain imaging' as key tools, showing high interest.

EngagementHigh engagement

Several posts delve into detailed summaries of the study's findings, including specific changepoint years and the importance of different biomarkers, indicating deep engagement with the research.

ImpactHigh impact

Multiple comments emphasize the transformative potential of the research, mentioning how it could lead to early interventions and new diagnostic techniques, reflecting a perception of high impact.

Abstract in brief

  • The study aimed to find the points in time when various biomarkers (like CSF measures, MRI scans, and cognitive tests) change significantly before Alzheimer's symptoms appear, using data from 306 cognitively normal people.
  • All nine biomarkers showed changepoints before clinical symptoms started, with some changing as early as 34 years prior, especially CSF tau, while others changed 10-15 years earlier.
  • These findings suggest that Alzheimer's disease begins developing in the brain many years before symptoms are noticeable, with different markers showing changes at different times, highlighting the long preclinical phase of the disease.

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Frontiers
@FrontiersIn · X

Research in @FrontNeurosci suggests it may be possible to use #brainimaging & spinal fluid analysis to assess risk of #Alzheimer’s disease at least 10 years or more before the most common symptoms occur Read article: https://t.co/0WwJNtOyUd or blog post⬇https://t.co/TYugfs6sA5

Jun 26, 2019 · 258 likes · 137 shares · 90,077 followers View post →
Frontiers
@FrontiersIn · X

Research in @FrontNeurosci suggests it may be possible to use #brainimaging & spinal fluid analysis to assess risk of #Alzheimer’s disease at least 10 years or more before the most common symptoms occur Read paper: https://t.co/0WwJNtOyUd or blog post ⬇ https://t.co/TYugfs6sA5

Jan 2, 2020 · 19 likes · 9 shares · 90,077 followers View post →
Frontiers
@FrontiersIn · X

Research in @FrontNeurosci suggests it may be possible to use #brainimaging & spinal fluid analysis to assess risk of #Alzheimer’s disease at least 10 years or more before the most common symptoms occur Read article: https://t.co/0WwJNtOyUd or blog post⬇https://t.co/TYugfs6sA5

Jul 1, 2019 · 12 likes · 3 shares · 90,077 followers View post →
ProMIS Neurosciences
@ProMISinc · X

Amazing study shows biomarker change 34 years before onset of Alzheimer’s symptoms! New biomarkers could dramatically improve our track record in the race to find a therapy. #Alzheimers #StopAlz #EndAlz #EndAlzheimers @BrainCanada @TheADDF https://t.co/1hdw4AuTzO

May 20, 2019 · 12 likes · 6 shares · 742 followers View post →
Frontiers - Neuroscience
@FrontNeurosci · X

Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer’s Disease: Laurent Younes, Marilyn Albert, Abhay Moghekar, Anja Soldan, Corinne Pettigrew, Michael I. Miller https://t.co/tZvrrWJ8fD

Apr 13, 2019 · 4 likes · 2 shares · 81,088 followers View post →
Kat Fu, M.S., M.S.
@thekatfu · X

@Erichealthcoach Here's the study: Younes L, Albert M, Moghekar A, Soldan A, Pettigrew C, Miller MI. Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer's Disease. Front Aging Neurosci. 2019 Apr 2;11:74. doi: 10.3389/fnagi.2019.00074. PMID: 31001108; PMCID:

Jun 23, 2023 · 1 like · 17,904 followers View post →

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Aubrai
@Aubrai_ · X

@NathanMoor61041 We're missing a 34-year intervention window. CSF tau changes that early before Alzheimer's symptoms (DOI: 10.3389/fnagi.2019.00074). Nano-robots detecting these changepoints could trigger targeted drug release decades before disease manifests. The tech isn't the barrier - it's

Sep 1, 2025 · 10,584 followers View post →
Aubrai
@Aubrai_ · X

@Darusyaaa @BioProtocol

Aug 24, 2025 · 10,584 followers View post →
Kat Fu, M.S., M.S.
@thekatfu · X

@Erichealthcoach Here's the study: Younes L, Albert M, Moghekar A, Soldan A, Pettigrew C, Miller MI. Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer's Disease. Front Aging Neurosci. 2019 Apr 2;11:74. doi: 10.3389/fnagi.2019.00074. PMID: 31001108; PMCID:

Jun 23, 2023 · 1 like · 17,904 followers View post →
815wrldtrvlr
@815wrldtrvlr · X

Frontiers | Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer’s Disease | Frontiers in Aging Neuroscience https://t.co/wgmj3ed8zq

Sep 22, 2020 · 36,628 followers View post →
Researching the Brain
@Brain_Database · X

Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer’s Disease https://t.co/gUsjXVSg87

Jan 10, 2020 · 1,037 followers View post →
huseyinbezirgan
@huseyinbezirgan · X

RT @FrontiersIn: Research in @FrontNeurosci suggests it may be possible to use #brainimaging & spinal fluid analysis to assess risk of #Alz…

Jan 2, 2020 · 9 shares · 571 followers View post →
Frontiers
@FrontiersIn · X

Research in @FrontNeurosci suggests it may be possible to use #brainimaging & spinal fluid analysis to assess risk of #Alzheimer’s disease at least 10 years or more before the most common symptoms occur Read paper: https://t.co/0WwJNtOyUd or blog post ⬇ https://t.co/TYugfs6sA5

Jan 2, 2020 · 19 likes · 9 shares · 90,077 followers View post →
ORiON
@Erdgn_PCCi · X

Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer’s Disease https://t.co/rox3wIKhXd

Nov 24, 2019 · 146 followers View post →
ORiON
@Erdgn_PCCi · X

Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer’s Disease https://t.co/rox3wIKhXd

Nov 14, 2019 · 146 followers View post →
100ans-de-solitude
@140cDeSolitude · X

Identification des points de changement dans les #biomarqueur-s pendant la phase préclinique d'#Alzheimer https://t.co/K8aRyxf2uf anglais via Frontiers #science

Jul 18, 2019 · 496 followers View post →
Dirk Hadrich
@HadrichDirk · X

Can #Alzheimer be predicted 10-30 years prior to symptoms onset? #ageing #biomarkers #HealthyLife #diagnostics #PrecisionMedicine #health #lifescience https://t.co/lGLpqnKihd

Jul 9, 2019 · 100 followers View post →
Lisa Vermunt
@LisaVermunt · X

RT @Brain__News: "Brain imaging and spinal fluid analysis could help to guide the use of future preventive treatments for Alzheimer’s" htt…

Jul 8, 2019 · 1 share · 397 followers View post →
Researching the Brain
@Brain_Database · X

"Brain imaging and spinal fluid analysis could help to guide the use of future preventive treatments for Alzheimer’s" https://t.co/FfnmL6aZld

Jul 5, 2019 · 1 like · 1 share · 1,037 followers View post →
Fabrice Jaine
@FabriceJaine · X

RT @FrontiersIn: Research in @FrontNeurosci suggests it may be possible to use #brainimaging & spinal fluid analysis to assess risk of #Alz…

Jul 1, 2019 · 3 shares · 1,141 followers View post →
Frontiers
@FrontiersIn · X

Research in @FrontNeurosci suggests it may be possible to use #brainimaging & spinal fluid analysis to assess risk of #Alzheimer’s disease at least 10 years or more before the most common symptoms occur Read article: https://t.co/0WwJNtOyUd or blog post⬇https://t.co/TYugfs6sA5

Jul 1, 2019 · 12 likes · 3 shares · 90,077 followers View post →
Eric García-López
@ericgarcialopez · X

RT @FrontiersIn: Research in @FrontNeurosci suggests it may be possible to use #brainimaging & spinal fluid analysis to assess risk of #Alz…

Jun 26, 2019 · 137 shares · 4,539 followers View post →
Frontiers
@FrontiersIn · X

Research in @FrontNeurosci suggests it may be possible to use #brainimaging & spinal fluid analysis to assess risk of #Alzheimer’s disease at least 10 years or more before the most common symptoms occur Read article: https://t.co/0WwJNtOyUd or blog post⬇https://t.co/TYugfs6sA5

Jun 26, 2019 · 258 likes · 137 shares · 90,077 followers View post →
Syrentis Research
@Syrentis1 · X

New study identifies Alzheimer's years before symptoms occur - TomoNews https://t.co/Dw0yobTQ9l via @YouTube

May 29, 2019 · 344 followers View post →
ひかり
@juanastella · X

https://t.co/jyu0ScEsPX

May 22, 2019 · 162 followers View post →
Čongor Nadj / Nagy Csongor
@CongorN · X

it may be possible to use brain imaging and spinal fluid analysis to assess the risk of Alzheimer’s disease at least 10 years. Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer’s Disease https://t.co/0QqtOHjjkX

May 22, 2019 · 246 followers View post →
Jim Mcaleer
@jmcaleer111 · X

"Accumulating evidence indicates that the underlying neuropathological mechanisms associated with Alzheimer’s disease (AD) begin a decade or more before the emergence of mild cognitive impairment" https://t.co/XvydAujWSA

May 22, 2019 · 716 followers View post →
哇係灰熊啦⛽️tw
@icaretw · X

https://t.co/r9QeQZ1lhT

May 21, 2019 · 95 followers View post →
Ars Lazko
@ArsLazko · X

RT @ProMISinc: Amazing study shows biomarker change 34 years before onset of Alzheimer’s symptoms! New biomarkers could dramatically improv…

May 20, 2019 · 6 shares · 1,671 followers View post →
Randy Smith
@Rjsmitty555 · X

RT @ProMISinc: Amazing study shows biomarker change 34 years before onset of Alzheimer’s symptoms! New biomarkers could dramatically improv…

May 20, 2019 · 6 shares · 104 followers View post →
Donald A Buskirk
@dbuzmkt · X

RT @ProMISinc: Amazing study shows biomarker change 34 years before onset of Alzheimer’s symptoms! New biomarkers could dramatically improv…

May 20, 2019 · 6 shares · 49 followers View post →
Gail Zeigler Dawson
@GailJoyZD · X

RT @ProMISinc: Amazing study shows biomarker change 34 years before onset of Alzheimer’s symptoms! New biomarkers could dramatically improv…

May 20, 2019 · 6 shares · 247 followers View post →
Jaryd Knutsen
@JarydKnutsen · X

RT @ProMISinc: Amazing study shows biomarker change 34 years before onset of Alzheimer’s symptoms! New biomarkers could dramatically improv…

May 20, 2019 · 6 shares · 502 followers View post →
ProMIS Neurosciences
@ProMISinc · X

Amazing study shows biomarker change 34 years before onset of Alzheimer’s symptoms! New biomarkers could dramatically improve our track record in the race to find a therapy. #Alzheimers #StopAlz #EndAlz #EndAlzheimers @BrainCanada @TheADDF https://t.co/1hdw4AuTzO

May 20, 2019 · 12 likes · 6 shares · 742 followers View post →
Creepypasta Slenderverse Fan
@Masky_Jay_Hoody · X

https://t.co/WcZRqDgjGp

May 19, 2019 · 2,015 followers View post →
KnightMadDragon
@Jason_Chi7 · X

New study identifies Alzheimer's years before symptoms occur - TomoNews https://t.co/2EGdaF8hqh via @YouTube

May 19, 2019 · 166 followers View post →
EDIMO PEREIRA
@EDIMOSIP · X

RT @EDIMOSIP: https://t.co/wgGHFPQNop

May 18, 2019 · 1 share · 1,684 followers View post →
EDIMO PEREIRA
@EDIMOSIP · X

https://t.co/wgGHFPQNop

May 18, 2019 · 1 share · 1,684 followers View post →
PsicoForensia
@psicoforensia · X

RT @deustoNeuroLab: Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer’s Disease https://t.co/YxFBNddzYy

May 17, 2019 · 1 share · 188 followers View post →
Deusto NeuroLab
@deustoNeuroLab · X

Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer’s Disease https://t.co/YxFBNddzYy

May 17, 2019 · 1 like · 1 share · 1,176 followers View post →
Sinan Yuruker
@sinanyuruker · X

Early markers for Alzheimer's disease https://t.co/N25gJ1aOFN

May 16, 2019 · 20 followers View post →
Brian Wang, Ph.D.
@brianzwang · X

RT @FrontNeurosci: Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer’s Disease: Laurent Younes, Marilyn Albe…

Apr 13, 2019 · 2 shares · 116 followers View post →
Sergio Alarcón
@astructio · X

RT @FrontNeurosci: Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer’s Disease: Laurent Younes, Marilyn Albe…

Apr 13, 2019 · 2 shares · 154 followers View post →
Frontiers - Neuroscience
@FrontNeurosci · X

Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer’s Disease: Laurent Younes, Marilyn Albert, Abhay Moghekar, Anja Soldan, Corinne Pettigrew, Michael I. Miller https://t.co/tZvrrWJ8fD

Apr 13, 2019 · 4 likes · 2 shares · 81,088 followers View post →
12Alice Lee
@PepperPell · X

RT @PharmacyOnline8: Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer’s Disease https://t.co/ZubcfckcCg htt…

Apr 6, 2019 · 1 share · 3,160 followers View post →
Online Pharmacy
@PharmacyOnline8 · X

Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer’s Disease https://t.co/ZubcfckcCg https://t.co/6bvlRMHh6Q

Apr 5, 2019 · 1 like · 1 share · 6,244 followers View post →