The discussions highlight a high level of interest and impact, often framing the study as a breakthrough capable of advancing personalized medicine, with examples like calls to 'see our new paper' and descriptions of genetics as a 'potential risk factor.' The tone ranges from enthusiastic endorsements to cautious examination of the methods, showing active engagement but also critical reflection on its implications.
AgreementModerate agreement
Most discussions acknowledge the significance of the research, with many referencing the predictability of obesity based on genetics, indicating general agreement with the findings.
InterestHigh interest
The topic draws high interest from the community, with numerous posts encouraging further reading, sharing insights, or suggesting implications for personalized medicine.
EngagementModerate engagement
Engagement varies from sharing links and summaries to participants debating methodological concerns, reflecting moderate but thoughtful involvement.
ImpactHigh impact
The collective tone suggests the research is viewed as influential, potentially transforming approaches to obesity prediction and prevention, as seen in references to clinical applications and future research directions.
Abstract in brief
The study develops a new polygenic predictor using 21 million DNA variants to estimate genetic susceptibility to weight gain and obesity, showing it is highly heritable and polygenic.
In middle-aged adults, the predictor reveals significant differences in weight and obesity risk across genetic score groups, with a 1.3 kg weight difference and 25-fold increase in severe obesity risk.
In a birth cohort, genetic risk showed little impact on birthweight but became more pronounced by early childhood and adolescence, highlighting the influence of genetics on weight trajectories over time.]
New journal club discussion started on recent polygenic score and BMI article - I hope that @skathire adds his responses there and so do others: https://t.co/2XbWpp4iGB @cecilejanssens @CellCellPress
How can we use genetics to predict obesity? See our new paper in Cell to find out! https://t.co/yGiHqHUIK3 And the @statnews summary of the work https://t.co/waQcfwgKlg https://t.co/KMjUWRzreR
I shared my thoughts on: Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood
@f2harrell, thx for starting this conversation!
https://t.co/nK5OW6Pc1t
PREDICCIÓN POLIGENICA EN SOBREPESO Y OBESIDAD
En algunos casos la obesidad no es sólo mala alimentación
En este caso es una enfermedad @EstebanDL ?
https://t.co/mXuAhQCerQ https://t.co/Jw5heVzmNI
This video discusses how a new polygenic predictor incorporating 21 million DNA variants estimates genetic susceptibility to weight gain and obesity, highlighting the heritable and polygenic nature of these traits and…
Sekar Kathiresan discusses how recent research using polygenic predictors with 21 million DNA variants aids in understanding the genetic basis of obesity and weight trajectories from birth to adulthood.
Nov 14, 2021 · 1 like · 7,578 followersView post →
БS
Бывший Data Scientist
@dsunderhood · X
Я поспорю на одной статье, недавней нашумевшей https://t.co/oCkxlu1KDm, где сделали полигенный скор ИМТ (индекса массы тела) из 2.1 миллиона вариантов (фичей). Просто потому, что, как мне кажется, она позволяет опровергнуть / продемонстрировать все три аргумента.
Sep 12, 2021 · 1 like · 2,957 followersView post →
FQ
Fiona Quigley
@FionaQuigs · X
Much new research being done in this area 8/10
Example:
Polygenic Prediction of Weight and Obesity
Trajectories from Birth to Adulthood
https://t.co/ouedS4jaFB
Aug 15, 2020 · 2 likes · 4,335 followersView post →
JM
Jacek Mokrosiński
@jmokrosinski · X
@cecilejanssens @ullasovio How about these papers assessing GPS in obesity: https://t.co/nkC2DAHsjO and https://t.co/c4hEBhcneq ?
Human Genome Project: Obesity
Eric S. Lander: His novel approach to quantity inherited susceptibility to obesity affords fresh opportunities for clinical prevention and mechanistic assessment. #NUT6679S20 https://t.co/jb7JJRpD7J https://t.co/IoZnXn6W2o
Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.
https://t.co/MN2dLxEu12
Single gene mutations that impact weight rare, but polygenic mutations that combine into a single risk score is a strong indicator of increased weight trajectory from birth.
En el siguiente estudio realizado por el Instituto Broad de Medicina Genómica, se habla sobre el uso de un puntaje poligénico para predicción de trayectorias de peso y #obesidad de la infancia a la edad adulta. Te invitamos a conocerlo:
https://t.co/ogPmXuXapv https://t.co/XZxXfF6JoC
PREDICCIÓN POLIGENICA EN SOBREPESO Y OBESIDAD
En algunos casos la obesidad no es sólo mala alimentación
En este caso es una enfermedad @EstebanDL ?
https://t.co/mXuAhQCerQ https://t.co/Jw5heVzmNI
@skathire Well ... there was a lot to dislike again ... We're just too worried that people think it was a very good paper. ;-)
For those who are interested to learn about some concerns: https://t.co/nK5OW6xACT
The most read paper on Researcher this week was 'Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood'. @amitvkhera @CellPressNews
Read the paper on Researcher: https://t.co/XILnGxis7u https://t.co/i6EhaFGmOW
@dataandme I wish! It's probably because of the ongoing debate about polygenic risk scores or other areas of medical research I've taken aim at (propensity scores, #Machinelearning, etc.). https://t.co/2XbWpp4iGB
I shared my thoughts on: Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood
@f2harrell, thx for starting this conversation!
https://t.co/nK5OW6Pc1t
New journal club discussion started on recent polygenic score and BMI article - I hope that @skathire adds his responses there and so do others: https://t.co/2XbWpp4iGB @cecilejanssens @CellCellPress
Great Graphic, Interesting #precisionmedicine article - Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood https://t.co/aKRExnOgqE
Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood https://t.co/AJeJJkKkAO People with MC4R mutations tend to be obese .. https://t.co/TXnvt5fmPg Scientists have devised a genetic test that scores your lifetime risk for obesity https://t.co/h8RTVBWAQR
Apr 20, 2019 · 1 like · 3 shares · 7,861 followersView post →
SH
Society for Social Medicine & Population Health
@SocSocMed · X
RT @Caketin_Wade: How can we use genetics to predict obesity? See our new paper in Cell to find out! https://t.co/yGiHqHUIK3 And the @statn…
I remember that there are many sessions about polygenic score in ASHG2018. It will be applying to non-medical traits in near future.
Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood @CellCellPress
https://t.co/Zo5NkcYaPE
How can we use genetics to predict obesity? See our new paper in Cell to find out! https://t.co/yGiHqHUIK3 And the @statnews summary of the work https://t.co/waQcfwgKlg https://t.co/KMjUWRzreR
Localization of the Gene Encoding the Human Interleukin-2 ...
News
... CELLS, JOURNAL OF IMMUNOLOGY 133: 1691 (1984). PubMed · Web of Science · Google ... https://doi.org/10.1016/j.immuni.2019.03.028 · Crossref. Warren J. Leonard ...
A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing. Mol Cell. 2019;73(4):714-26 e4. Epub 2018/12/26. doi: 10.1016/j.molcel.2018.12 ...