Drug Test Anal August 2019 PMID 31009168

Variability in content and dissolution profiles of MDMA tablets collected in the UK between 2001 and 2018 - A potential risk to users?

Lewis Couchman, Anca Frinculescu, Catarina Sobreira, Trevor Shine, John Ramsey, Max Hecht, Karin Kipper, David Holt, Atholl Johnston

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Mentions

29
Peak: 10 in May 2019
across 5 sources since Apr 2019

Extended reach

275,120
potential audience

Total likes

2,886

Video views

188,871

Mentions per month

Apr 2019 – Jul 2025

Where it's discussed

  • X / Twitter18 posts
  • News5 articles
  • YouTube2 videos
  • Facebook2 posts
  • TikTok2 posts

AI synopsis

What people are saying

The social discussions reflect a strong interest and concern about the variability in MDMA content and dissolution rates, with phrases like 'worrying MDMA facts' and mentions of the unpredictability of effects, which underscores the potential health risks and need for regulation. The tone and choice of words convey a sense of urgency and importance, aligning with the higher scores in interest and impact.

AgreementModerate agreement

Most discussions acknowledge the study’s findings about MDMA variability and agree on the potential health risks posed to users, indicated by phrases like 'worrying MDMA facts' and discussions of public health concerns.

InterestHigh interest

The social discussions demonstrate high interest, with reactions highlighting the significance of the findings and raising questions about regulation and safety, reflecting curiosity and concern.

EngagementHigh engagement

Multiple posts delve into details such as variability within batches, effects on users, and implications for regulation, showing deep engagement with the research and its implications.

ImpactHigh impact

The discussions emphasize the practical health and safety impacts, suggesting that the findings could influence drug regulation policies and harm reduction strategies, indicating high perceived impact.

Abstract in brief

  • The study analyzed MDMA tablets collected in the UK between 2001 and 2018 and found that recent samples, especially from 2016-2018, tend to have higher MDMA content, with some exceeding 100mg per tablet, and showed significant variability both between and within batches.
  • Dissolution tests revealed no clear link between tablet characteristics and how quickly the drug is released, meaning users cannot predict if a tablet will be fast or slow-releasing based on appearance or other factors.
  • The variability in both MDMA content and dissolution rates poses health risks, as high or delayed release tablets can lead to toxic effects or prolonged intoxication, increasing the danger of redosing and negative health consequences.]

Top posts

Most liked on X and Bluesky
Larissa J. Maier, PhD
@LarissaJMaier · X

The high demand for ecstasy tablets, professional drug checking services, & other quality control measures have resulted in high-content tablets produced/sold in EU countries. Varying content & dissolution profiles put PWUD at risk, regulation could help! https://t.co/NBGyfTGuOC

May 2, 2019 · 10 likes · 5 shares · 2,755 followers View post →
Claudio Vidal
@claudiovidalg · X

This study addresses an important question I have thinking of a lot. Ecstasy tablets from a same batch could not contain the same amount of MDMA because the illicit nature of their production (lack of quality control). https://t.co/LoNp55mMGv https://t.co/1oBTnPWigQ

Apr 23, 2019 · 7 likes · 3 shares · 3,554 followers View post →
Joseph Palamar
@JosephPalamar · X

New drug-testing paper: a lot of variability in dosage and release time within single batches of MDMA/ecstasy. Therefore, doses from the same batch may have different effects https://t.co/rzPvu0Ba9I https://t.co/ktZ3og2HgV

May 3, 2019 · 5 likes · 1,260 followers View post →
Prison_Health
@Prison_Health · X

Variability in content and dissolution profiles of #MDMA tablets collected in the UK between 2001 and 2018 - A potential risk to users? [a] https://t.co/3NfxI9DFJa HT Pharmaceutical Sciences Clinical Academic Group @kingscollegelon #SUD #PWUD #Ecstasy https://t.co/Un6Hesi4np

Jun 16, 2019 · 19,158 followers View post →
Prison_Health
@Prison_Health · X

Variability in content and dissolution profiles of #MDMA tablets collected in the UK between 2001 and 2018 - A potential risk to users? [a] https://t.co/3NfxI9DFJa HT Pharmaceutical Sciences Clinical Academic Group @kingscollegelon #SUD #PWUD #Ecstasy https://t.co/P82KpvIrtQ

May 29, 2019 · 19,158 followers View post →
Leo Beletsky
@LeoBeletsky · X

RT @maier_larissa: The high demand for ecstasy tablets, professional drug checking services, & other quality control measures have resulted…

May 3, 2019 · 5 shares · 17,385 followers View post →

All mentions

Analytical Services International
@ASI_lab · X

This study compares UK data with other countries to address public health authorities' concerns over the prevalence of 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) tablets.

Nov 1, 2023 · 137 followers View post →
Prison_Health
@Prison_Health · X

Variability in content and dissolution profiles of #MDMA tablets collected in the UK between 2001 and 2018 - A potential risk to users? [a] https://t.co/3NfxI9DFJa HT Pharmaceutical Sciences Clinical Academic Group @kingscollegelon #SUD #PWUD #Ecstasy https://t.co/Un6Hesi4np

Jun 16, 2019 · 19,158 followers View post →
Prison_Health
@Prison_Health · X

Variability in content and dissolution profiles of #MDMA tablets collected in the UK between 2001 and 2018 - A potential risk to users? [a] https://t.co/3NfxI9DFJa HT Pharmaceutical Sciences Clinical Academic Group @kingscollegelon #SUD #PWUD #Ecstasy https://t.co/P82KpvIrtQ

May 29, 2019 · 19,158 followers View post →
Analytical Services International
@ASI_lab · X

ASI's pioneering research flags worrying MDMA facts:- 1 Concentration of MDMA in tablets is going up. 2 Tablets from the same batch can vary in MDMA content by up to 250%. 3 Tablets from the same batch can release MDMA at significantly varying rates. See https://t.co/xGyGlLD30i

May 7, 2019 · 137 followers View post →
Ayana “Get out & Vote” Jordan
@DrAyanaJordan · X

RT @maier_larissa: The high demand for ecstasy tablets, professional drug checking services, & other quality control measures have resulted…

May 3, 2019 · 5 shares · 13,486 followers View post →
Joseph Palamar
@JosephPalamar · X

New drug-testing paper: a lot of variability in dosage and release time within single batches of MDMA/ecstasy. Therefore, doses from the same batch may have different effects https://t.co/rzPvu0Ba9I https://t.co/ktZ3og2HgV

May 3, 2019 · 5 likes · 1,260 followers View post →
Leo Beletsky
@LeoBeletsky · X

RT @maier_larissa: The high demand for ecstasy tablets, professional drug checking services, & other quality control measures have resulted…

May 3, 2019 · 5 shares · 17,385 followers View post →
Spellyr
@Sp3llyr · X

RT @maier_larissa: The high demand for ecstasy tablets, professional drug checking services, & other quality control measures have resulted…

May 2, 2019 · 5 shares · 706 followers View post →
Chief Executive Alcohol & Drugs Action
@CEO_ADA · X

Variability in content and dissolution profiles of MDMA tablets collected in the UK between 2001 and 2018 – a potential risk to users? - Couchman - - Drug Testing and Analysis - Wiley Online Library https://t.co/qWXlHhyaNo

May 2, 2019 · 1,198 followers View post →
Emma Crawshaw (she, her)
@EmmaCrawshaw · X

RT @maier_larissa: The high demand for ecstasy tablets, professional drug checking services, & other quality control measures have resulted…

May 2, 2019 · 5 shares · 669 followers View post →
Nicki Killeen
@nickikilleen · X

RT @maier_larissa: The high demand for ecstasy tablets, professional drug checking services, & other quality control measures have resulted…

May 2, 2019 · 5 shares · 2,717 followers View post →
Larissa J. Maier, PhD
@LarissaJMaier · X

The high demand for ecstasy tablets, professional drug checking services, & other quality control measures have resulted in high-content tablets produced/sold in EU countries. Varying content & dissolution profiles put PWUD at risk, regulation could help! https://t.co/NBGyfTGuOC

May 2, 2019 · 10 likes · 5 shares · 2,755 followers View post →
Jeff Hackett
@Jeff04091958 · X

New MDMA paper from LTG members: https://t.co/KGA21pD3Rd

Apr 24, 2019 · 61 followers View post →
HNT
@HealthyNiteLife · X

RT @claudiovidalg: This study addresses an important question I have thinking of a lot. Ecstasy tablets from a same batch could not contain…

Apr 24, 2019 · 3 shares · 329 followers View post →
Jose López Guerrero
@joselopguerre · X

RT @claudiovidalg: This study addresses an important question I have thinking of a lot. Ecstasy tablets from a same batch could not contain…

Apr 23, 2019 · 3 shares · 295 followers View post →
alejoalberdi
@alejoalberdi · X

RT @claudiovidalg: This study addresses an important question I have thinking of a lot. Ecstasy tablets from a same batch could not contain…

Apr 23, 2019 · 3 shares · 2,810 followers View post →
Claudio Vidal
@claudiovidalg · X

This study addresses an important question I have thinking of a lot. Ecstasy tablets from a same batch could not contain the same amount of MDMA because the illicit nature of their production (lack of quality control). https://t.co/LoNp55mMGv https://t.co/1oBTnPWigQ

Apr 23, 2019 · 7 likes · 3 shares · 3,554 followers View post →
Sam Shirley-Beavan
@samshirlb · X

From the paper: "For MDMA users, our data suggest that analysis of a single tablet from a batch cannot guarantee that all others in the same batch are of the same content." https://t.co/htFvGr7vVt

Apr 23, 2019 · 260 followers View post →
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