Immunology June 2019 PMID 31013364

A C-terminal CXCL8 peptide based on chemokine-glycosaminoglycan interactions reduces neutrophil adhesion and migration during inflammation.

Beatriz Martínez-Burgo, Steven L Cobb, Ehmke Pohl, Dmitry Kashanin, Toby Paul, John A Kirby, Neil S Sheerin, Simi Ali

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Mentions

Peak: 12 in May 2019

across 2 sources since Apr 2019

Extended reach

17,576

potential audience

Total likes

Video views

441

Mentions per month

Apr 2019 – May 2019

Where it's discussed

X / Twitter13 posts
YouTube1 videos

AI synopsis

What people are saying

The discussions reflect strong enthusiasm, with posts like 'Great paper' and mentions of the research being 'in print' suggest appreciation and excitement. The use of words like 'pleased to share' and hashtags indicating chemistry and inflammation demonstrate genuine interest, while references to the study's technical aspects indicate deep engagement and consideration of its scientific impact.

AgreementModerate agreement

Most discussions express positive support and recognition of the paper’s significance in inflammation research, indicating agreement with its findings.

InterestHigh interest

The posts demonstrate high interest, with many sharing their excitement and emphasizing the novelty of the chemokine-GAG interaction research.

EngagementHigh engagement

Several comments delve into the specifics of the study, including mentions of methodology, signaling, and potential applications, showing deep engagement.

ImpactModerate impact

While some posts highlight the importance for inflammation treatment development, most focus on recognition rather than transformative potential, resulting in a moderate impact score.

Abstract in brief

The study investigates a C-terminal peptide of CXCL8, a chemokine involved in attracting neutrophils during inflammation, to see if it can modulate how CXCL8 interacts with glycosaminoglycans (GAGs) and influence neutrophil recruitment.
Researchers synthesized different peptides, including a wild-type and variants with modifications like increased positive charge, and found that one peptide (with a lysine substitution) could bind GAGs and inhibit neutrophil adhesion and migration without affecting the receptor signaling.
These findings suggest that the modified CXCL8 peptide might be used as a basis for developing new anti-inflammatory treatments that specifically target chemokine-GAG interactions to control neutrophil-driven inflammation.]

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All mentions

CXCL8 Peptide Reduces Neutrophil Recruitment in Inflammation

The study explores a C-terminal CXCL8 peptide that modulates chemokine interactions with glycosaminoglycans to reduce neutrophil adhesion and migration during inflammation. This potential anti-inflammatory approach…

Beatriz Martínez Burgo · May 1, 2019 441 views

Matthew Kitching

@MattOKitch · X