JAMA Cardiol June 2019 PMID 31017618

Estimation of the Required Lipoprotein(a)-Lowering Therapeutic Effect Size for Reduction in Coronary Heart Disease Outcomes: A Mendelian Randomization Analysis.

Claudia Lamina, Florian Kronenberg

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Mentions

21
Peak: 3 in Feb 2022
across 5 sources since Apr 2019

Extended reach

60,528
potential audience

Total likes

218

Video views

10,725

Mentions per month

Apr 2019 – Nov 2023

Where it's discussed

  • News8 articles
  • X / Twitter6 posts
  • Facebook3 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

The discussions revolve around the potential clinical impact of the study, as evidenced by posts like 'what's your opinion about these estimations?' and references to the article's focus on therapeutic effect sizes. The tone is analytical yet optimistic, emphasizing the importance of the findings for advancing CHD treatments and interpreting genetic data for practical use.

AgreementModerate agreement

Most discussions acknowledge the importance of the study and its findings, with some opinions supporting the idea that understanding Lp(a) lowering is crucial for CHD risk reduction.

InterestModerate interest

Posts show moderate curiosity, focusing on the significance of the estimates for future therapies and clinical implications.

EngagementModerate engagement

Comments demonstrate some active participation, including questions and references to methodological approaches, indicating a reasonable level of engagement.

ImpactModerate impact

The discussions suggest potential influence on research and clinical practices, with mentions of guiding therapeutic targets and future treatments.

Abstract in brief

  • The study investigates how much Lp(a) levels need to be lowered to significantly reduce coronary heart disease (CHD) risk, using genetic data and Mendelian randomization analysis.
  • Researchers analyzed genetic variants related to Lp(a) and their association with CHD across multiple populations, estimating that a reduction of about 6.57 mg/dL in Lp(a) could lead to meaningful CHD risk reduction.
  • The findings aim to guide future therapies aimed at lowering Lp(a), by providing a target effect size necessary for clinical benefits comparable to those achieved by LDL cholesterol-lowering treatments.]

Top posts

Most liked on X and Bluesky
Pablo Corral MD
@drpablocorral · X

@Lpa_Doc Thx Sam. What’s your opinion about these estimations? https://t.co/5h3mj5Bbxs https://t.co/E1DpkRVZ4V https://t.co/RKXQLJREu5

Feb 6, 2022 · 4 likes · 2 shares · 11,239 followers View post →
Joel "Heart Prevention" Kahn MD, FACC
@drjkahn · X

Estimation of the required lipoprotein(a)-lowering therapeutic effect size for reduction in coronary heart disease outcomes: a mendelian randomization analysis ⁦@lipoproteinaFDN⁩ ⁦@lipiddoc⁩ ⁦@Lpa_Doc⁩ https://t.co/vPsD5SR9gm

Jun 25, 2019 · 3 likes · 32,282 followers View post →
MR_lit
@Mendelian_lit · X

Estimation of the Required Lipoprotein(a)-Lowering Therapeutic Effect Size for Reduction in Coronary Heart Disease Outcomes: A Mendelian Randomization Analysis. https://t.co/I4EYLWcAHL

Apr 25, 2019 · 1 like · 1 share · 1,839 followers View post →
Marilyn Mann
@MarilynMann · X

RT @Mendelian_lit: Estimation of the Required Lipoprotein(a)-Lowering Therapeutic Effect Size for Reduction in Coronary Heart Disease Outco…

Apr 25, 2019 · 1 share · 2,773 followers View post →
CarlosAguilarSalinas
@caguilarsalinas · X

RT @drpablocorral: @Lpa_Doc Thx Sam. What’s your opinion about these estimations? https://t.co/5h3mj5Bbxs https://t.co/E1DpkRVZ4V https:/…

Feb 6, 2022 · 2 shares · 1,639 followers View post →
xuejingemily
@Jingxue64154654 · X

RT @drpablocorral: @Lpa_Doc Thx Sam. What’s your opinion about these estimations? https://t.co/5h3mj5Bbxs https://t.co/E1DpkRVZ4V https:/…

Feb 7, 2022 · 2 shares · 15 followers View post →

All mentions

xuejingemily
@Jingxue64154654 · X

RT @drpablocorral: @Lpa_Doc Thx Sam. What’s your opinion about these estimations? https://t.co/5h3mj5Bbxs https://t.co/E1DpkRVZ4V https:/…

Feb 7, 2022 · 2 shares · 15 followers View post →
CarlosAguilarSalinas
@caguilarsalinas · X

RT @drpablocorral: @Lpa_Doc Thx Sam. What’s your opinion about these estimations? https://t.co/5h3mj5Bbxs https://t.co/E1DpkRVZ4V https:/…

Feb 6, 2022 · 2 shares · 1,639 followers View post →
Pablo Corral MD
@drpablocorral · X

@Lpa_Doc Thx Sam. What’s your opinion about these estimations? https://t.co/5h3mj5Bbxs https://t.co/E1DpkRVZ4V https://t.co/RKXQLJREu5

Feb 6, 2022 · 4 likes · 2 shares · 11,239 followers View post →
Joel "Heart Prevention" Kahn MD, FACC
@drjkahn · X

Estimation of the required lipoprotein(a)-lowering therapeutic effect size for reduction in coronary heart disease outcomes: a mendelian randomization analysis ⁦@lipoproteinaFDN⁩ ⁦@lipiddoc⁩ ⁦@Lpa_Doc⁩ https://t.co/vPsD5SR9gm

Jun 25, 2019 · 3 likes · 32,282 followers View post →
Marilyn Mann
@MarilynMann · X

RT @Mendelian_lit: Estimation of the Required Lipoprotein(a)-Lowering Therapeutic Effect Size for Reduction in Coronary Heart Disease Outco…

Apr 25, 2019 · 1 share · 2,773 followers View post →
MR_lit
@Mendelian_lit · X

Estimation of the Required Lipoprotein(a)-Lowering Therapeutic Effect Size for Reduction in Coronary Heart Disease Outcomes: A Mendelian Randomization Analysis. https://t.co/I4EYLWcAHL

Apr 25, 2019 · 1 like · 1 share · 1,839 followers View post →