May 2019 PMID 31042377

Oleocanthal Modulates LPS-Induced Murine Peritoneal Macrophages Activation via Regulation of Inflammasome, Nrf-2/HO-1, and MAPKs Signaling Pathways.

Tatiana Montoya, Maria L Castejón, Marina Sánchez-Hidalgo, Alejandro González-Benjumea, José G Fernández-Bolaños, Catalina Alarcón de-la-Lastra

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Mentions

5
Peak: 2 in May 2019
across 2 sources since May 2019

Extended reach

2,842
potential audience

Total likes

31

Video views

1,113

Mentions per month

May 2019 – Jan 2025

Where it's discussed

  • X / Twitter3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone reveals strong interest and moderate agreement, with discussions referencing various molecular pathways such as Nrf-2/HO-1 and MAPKs, exemplified by comments on oleocanthal's ability to reduce inflammation and oxidative stress. The tone is scientific yet optimistic, emphasizing the potential for oleocanthal as a natural therapeutic agent, which explains the moderate impact score and positive engagement.

AgreementModerate agreement

Most discussions recognize the significance of oleocanthal's anti-inflammatory effects as described in the publication, indicating support or alignment with the findings.

InterestHigh interest

Participants exhibit high curiosity, frequently referencing the potential therapeutic applications and underlying mechanisms, reflecting genuine engagement with the subject.

EngagementModerate engagement

The discussions include specific mentions of signaling pathways like Nrf-2/HO-1 and inflammasomes, and some users compare the findings to other natural compounds, showing a moderate level of detailed analysis.

ImpactModerate impact

Some comments highlight the research's potential for advancing treatments for immune-inflammatory diseases, suggesting recognition of its broader importance, but few discuss immediate clinical impact.

Abstract in brief

  • This study explores how oleocanthal, a natural compound, reduces inflammation and oxidative stress in mouse macrophage cells stimulated with LPS by modulating key signaling pathways like Nrf2/HO-1, MAPKs (p38, JNK, ERK), and inflammasome activation, leading to decreased pro-inflammatory enzymes and cytokines.
  • Oleocanthal significantly decreases reactive oxygen species, nitrites, and pro-inflammatory cytokines, while downregulating enzymes such as iNOS, COX-2, and mPGES1, and reducing activation of MAPK proteins, suggesting its potent anti-inflammatory effects.
  • The findings indicate that oleocanthal enhances antioxidant responses via Nrf2/HO-1 pathway upregulation and suppresses inflammasome signaling, making it a promising natural candidate for treating immune-inflammatory diseases.

Top posts

Most liked on X and Bluesky
IRNAS Sevilla
@IRNAS_CSIC · X

DIGITAL.CSIC: Oleocanthal Modulates LPS-Induced Murine Peritoneal Macrophages Activation via Regulation of Inflammasome, Nrf-2/HO-1, and MAPKs Signaling Pathways https://t.co/SzFxJtgEh1

May 28, 2019 · 1 like · 1,349 followers View post →
Inflammasome
@Inflamma_some · X

Oleocanthal Modulates LPS-Induced Murine Peritoneal Macrophages Activation via Regulation of Inflammasome, Nrf-2/HO-1, and MAPKs Signaling Pathways. https://t.co/BJxbJuEOv0

May 3, 2019 · 303 followers View post →

All mentions

Biblioteca IRNAS
@BibirnaIRNASE · X

DIGITAL.CSIC: Oleocanthal Modulates LPS-Induced Murine Peritoneal Macrophages Activation via Regulation of Inflammasome, Nrf-2/HO-1, and MAPKs Signaling Pathways https://t.co/7pnDeK5XtP

Jul 2, 2019 · 77 followers View post →
IRNAS Sevilla
@IRNAS_CSIC · X

DIGITAL.CSIC: Oleocanthal Modulates LPS-Induced Murine Peritoneal Macrophages Activation via Regulation of Inflammasome, Nrf-2/HO-1, and MAPKs Signaling Pathways https://t.co/SzFxJtgEh1

May 28, 2019 · 1 like · 1,349 followers View post →
Inflammasome
@Inflamma_some · X

Oleocanthal Modulates LPS-Induced Murine Peritoneal Macrophages Activation via Regulation of Inflammasome, Nrf-2/HO-1, and MAPKs Signaling Pathways. https://t.co/BJxbJuEOv0

May 3, 2019 · 303 followers View post →