April 2019 PMID 31057483

The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids.

Joris H J van Sadelhoff, Paula Perez Pardo, Jiangbo Wu, Johan Garssen, Jeroen van Bergenhenegouwen, Astrid Hogenkamp, Anita Hartog, Aletta D Kraneveld

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Mentions

18
Peak: 2 in May 2019
across 4 sources since May 2019

Extended reach

1,933,295
potential audience

Total likes

51,806

Video views

1,879,533

Mentions per month

May 2019 – Sep 2024

Where it's discussed

  • X / Twitter10 posts
  • YouTube3 videos
  • Facebook3 posts
  • Reddit2 posts

AI synopsis

What people are saying

The collective discussions show interest in the gut-immune-brain connection in autism, with examples like mentions of mast cell activation influencing behavior, and dietary management strategies such as probiotics and amino acids, reflecting a nuanced engagement with the research. The tone combines scientific references with personal and practical insights, emphasizing the potential for immune and gut-focused interventions to improve ASD symptoms.

AgreementModerate agreement

Most discussions acknowledge the connection between gut health, immune responses, and autism, showing general support for the publication's focus on these links.

InterestModerate interest

Participants demonstrate moderate curiosity, sharing ideas about managing autism through diet and immune modulation and referencing related biological mechanisms.

EngagementModerate engagement

Several comments delve into specific biological processes like mast cell activation, the role of amino acids, and the gut-brain axis, indicating active engagement in understanding the topic.

ImpactModerate impact

The discussions highlight that the publication has a meaningful influence on how individuals think about managing autism, especially through dietary and immune-centered approaches.

Abstract in brief

  • Autism Spectrum Disorder (ASD) involves social, gastrointestinal, and immune system issues, with a strong link to changes in gut microbiota, immune response, and brain function.
  • Mutations that activate the mTOR pathway are common in ASD and contribute to neuronal communication problems and immune deficits; inhibiting mTOR can improve ASD symptoms but has side effects.
  • Amino acids can regulate mTOR activity, reduce inflammation, strengthen gut barriers, and alter microbiota, making them a promising nutritional approach for managing ASD through the gut-brain-immune connection.

Top posts

Most liked on X and Bluesky
David Diamond
@LDLSkeptic · X

@Grimhood @GeorgiaEdeMD Thanks GA - link of autoimmunity to autism Doi 10.1177/039463200902200103 DOI: 10.3389/fendo.2019.00247 "mast cell activation ... ⬆️in ASD patients, resulting in elevated release of inflammatory and neurotoxic mediators, which in turn could contribute to (ASD)" @nicknorwitz

Jun 9, 2020 · 3 likes · 44,997 followers View post →
Szyzygy
@Szyzygy2 · X

@exceedhergrasp1 @laurenancona Mast cell activation is increased in ASD patients. The influence of mast cells on behavior is not limited to the effects of mediator-release, as mast cells can also influence behavior via direct mast cell-neuron interactions in the brain and gut. https://t.co/WNFJVeILlh

Jan 9, 2023 · 2 likes · 1,175 followers View post →
Peripheral Minds
@PeripheralMinds · X

@MEllisPhotograp @AskingAutistics Yes. My go-to are probiotics, sometimes slippery elm or quercetin. Autism & Atopic Derm https://t.co/p4phegYHNB Stress and the HPA Axis in the Atopic Dermatitis https://t.co/EgF5z5lvJ6 Microbiome & Derm https://t.co/3xR1KjVsSH Autism, HPA & Microbiome https://t.co/Q5j02dmj94

Mar 5, 2020 · 1 like · 1 share · 1,570 followers View post →
(((Deb Hochhauser, JD, MLS)))
@DebHochhauser · X

The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids https://t.co/GXNGvoGaZK

May 31, 2019 · 1 like · 692 followers View post →
M.Ellis
@MEllisPhotograp · X

RT @PeripheralMinds: @MEllisPhotograp @AskingAutistics Yes. My go-to are probiotics, sometimes slippery elm or quercetin. Autism & Atopic…

Mar 5, 2020 · 1 share · 1,603 followers View post →
Peripheral Minds
@PeripheralMinds · X

The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids https://t.co/m7yhCICU0X

Mar 16, 2021 · 1,570 followers View post →

All mentions

Szyzygy
@Szyzygy2 · X

@exceedhergrasp1 @laurenancona Mast cell activation is increased in ASD patients. The influence of mast cells on behavior is not limited to the effects of mediator-release, as mast cells can also influence behavior via direct mast cell-neuron interactions in the brain and gut. https://t.co/WNFJVeILlh

Jan 9, 2023 · 2 likes · 1,175 followers View post →
Richard Oddy
@richoddy · X

@AlisonM202 @ItsEmilyKaty https://t.co/u5YtHZdpIH Look here as a start, but there’s plenty out there. Like I say, this isn’t cure, its helping to manage. There’s a few specialist clinicians in the Uk, have a look at Dr Strigner. I’m not preaching, I’ve just seen amazing results from managing diet

May 23, 2021 · 251 followers View post →
Peripheral Minds
@PeripheralMinds · X

The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids https://t.co/m7yhCICU0X

Mar 16, 2021 · 1,570 followers View post →
deman760
@deman760 · X

@EpigeneticWhisp @meeshryderdie The gut brain axis is also affected by GMO foods. It’s also affected by hormone disruptions from other organs. All of which cause inflammation https://t.co/mkf4gPgnWG

Aug 22, 2020 · 300 followers View post →
David Diamond
@LDLSkeptic · X

@Grimhood @GeorgiaEdeMD Thanks GA - link of autoimmunity to autism Doi 10.1177/039463200902200103 DOI: 10.3389/fendo.2019.00247 "mast cell activation ... ⬆️in ASD patients, resulting in elevated release of inflammatory and neurotoxic mediators, which in turn could contribute to (ASD)" @nicknorwitz

Jun 9, 2020 · 3 likes · 44,997 followers View post →
M.Ellis
@MEllisPhotograp · X

RT @PeripheralMinds: @MEllisPhotograp @AskingAutistics Yes. My go-to are probiotics, sometimes slippery elm or quercetin. Autism & Atopic…

Mar 5, 2020 · 1 share · 1,603 followers View post →
Peripheral Minds
@PeripheralMinds · X

@MEllisPhotograp @AskingAutistics Yes. My go-to are probiotics, sometimes slippery elm or quercetin. Autism & Atopic Derm https://t.co/p4phegYHNB Stress and the HPA Axis in the Atopic Dermatitis https://t.co/EgF5z5lvJ6 Microbiome & Derm https://t.co/3xR1KjVsSH Autism, HPA & Microbiome https://t.co/Q5j02dmj94

Mar 5, 2020 · 1 like · 1 share · 1,570 followers View post →
AwokenTheLBC
@AwokenLbc · X

The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids https://t.co/NXFzPEROiR

Oct 20, 2019 · 492 followers View post →
(((Deb Hochhauser, JD, MLS)))
@DebHochhauser · X

The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids https://t.co/GXNGvoGaZK

May 31, 2019 · 1 like · 692 followers View post →
Symbiosis papers
@Symbiosispapers · X

The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids. https://t.co/txdYM4PfiG

May 7, 2019 · 1,109 followers View post →