Psychopharmacology (Berl) September 2019 PMID 31065731

MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials.

Michael C Mithoefer, Allison A Feduccia, Lisa Jerome, Anne Mithoefer, Mark Wagner, Zach Walsh, Scott Hamilton, Berra Yazar-Klosinski, Amy Emerson, Rick Doblin

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Mentions

69
Peak: 28 in May 2019
across 5 sources since May 2019

Extended reach

414,099
potential audience

Total likes

242

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7,965

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May 2019 – Nov 2025

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AI synopsis

What people are saying

Participants broadly agree that the article presents promising evidence supporting MDMA-assisted psychotherapy as an effective treatment for PTSD, with phrases like 'groundbreaking' and 'hope for the future' indicating strong positive sentiment. The tone is optimistic and analytical, often referencing FDA approval and large-scale trial results, which demonstrate a high degree of interest and engagement.

AgreementModerate agreement

Most discussions support the positive findings and potential of MDMA-assisted psychotherapy, emphasizing its efficacy and progress toward phase 3 trials.

InterestHigh interest

Participants display high curiosity and enthusiasm, often highlighting the breakthrough nature and clinical significance of the research.

EngagementHigh engagement

Several discussions reference the methodology, regulatory progress, and potential implications, showing deep involvement in understanding the study’s impact.

ImpactHigh impact

The conversations recognize the research’s high potential to transform PTSD treatment, with mentions of FDA approvals and promising results.

Abstract in brief

  • The pooled analysis of six phase 2 trials shows that MDMA-assisted psychotherapy significantly reduces PTSD symptoms, with the active group experiencing greater improvements than the placebo group.
  • The studies involved administering MDMA (75-125 mg) during therapy sessions spaced out a month apart, with additional preparatory and follow-up sessions, and found MDMA to be well tolerated.
  • These findings support designing phase 3 trials to further evaluate MDMA-assisted psychotherapy as an effective treatment for PTSD, given its large effect size and safety profile.]

Top posts

Most liked on X and Bluesky
sharonlevinson
@Sharonlevinson2 · X

17)באזור 2007-8 התחיל המחקר הקליני בטיפול משולב MDMA, ולפני ארבע שנים, כשהסתיים שלב 2 אחרון (בוצעו 6 ניסויים של שלב 2 בטיפול), הוא עלה לתודעה הציבורית, כי התוצאות הסטטיסטיות היו די חזקות ליעילות של הטיפול. https://t.co/QXypx5ry3p

May 20, 2021 · 40 likes · 1,766 followers View post →
Brian D. Earp, Ph.D.
@briandavidearp · X

MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials | SpringerLink https://t.co/PFQMN7aZuj

Jun 1, 2019 · 16 likes · 4 shares · 26,108 followers View post →
Todd Harrison
@todd_harrison · X

A study found that "MDMA-assisted psychotherapy was efficacious and well tolerated in a large sample of adults with PTSD." h/t @tomangell https://t.co/aIoJBt3nIG

May 8, 2019 · 13 likes · 2 shares · 69,417 followers View post →
scott cunningham
@causalinf · X

MDMA + psychotherapy assisted treatment for PTSD RCTs just out. Large reductions in PTSD symptoms in treatment group. https://t.co/vY7ZZMCuBN https://t.co/LZOCSONmV4

May 7, 2019 · 10 likes · 1 share · 52,395 followers View post →
Psychedelics Today
@PsydelicsToday · X

MDMA-assisted psychotherapy for treatment of PTSD : study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials https://t.co/uFcn4jPLWi

May 8, 2019 · 9 likes · 3 shares · 41,622 followers View post →
BryanRoth
@zenbrainest · X

MDMA treats PTSD https://t.co/jtzUy9lnLF

May 30, 2019 · 9 likes · 2 shares · 17,146 followers View post →

All mentions

Michael Haichin
@MichaelHaichin · X

@JacobSAday @MayoOnTheBrain Something more recent than this? https://t.co/UzmCvYTmjQ

Oct 19, 2023 · 2 likes · 3,715 followers View post →
Jonny Miller
@jonnym1ller · X

@wolftivy the phase II results from @MAPS trials would beg to differ https://t.co/FxYNtBWOxP

Oct 28, 2022 · 17,357 followers View post →
☿ Footnotes2Plato ☼☽
@ThouArtThat · X

@D__Nickles @RickDoblin I understand your criticisms, but apparently the FDA thought this pooled analysis was sufficient to move to phase 3? https://t.co/l3xpX2vaQV

Mar 22, 2022 · 9,230 followers View post →
TheTamarDick
@TheTamarDick · X

RT @Psychedelic_Med: #MDMA assisted psychotherapy for treating #PTSD has begun FDA-approved phase 3 trials. Check out the full article disc…

Sep 9, 2021 · 5 shares · 20,747 followers View post →
The Conscious Fund
@ConsciousFundHQ · X

RT @Psychedelic_Med: #MDMA assisted psychotherapy for treating #PTSD has begun FDA-approved phase 3 trials. Check out the full article disc…

Sep 7, 2021 · 5 shares · 2,762 followers View post →
Mind Escape Podcast
@MikeEscape · X

RT @Psychedelic_Med: #MDMA assisted psychotherapy for treating #PTSD has begun FDA-approved phase 3 trials. Check out the full article disc…

Sep 7, 2021 · 5 shares · 4,078 followers View post →
Mike Philip
@mike_stauder · X

RT @Psychedelic_Med: #MDMA assisted psychotherapy for treating #PTSD has begun FDA-approved phase 3 trials. Check out the full article disc…

Sep 7, 2021 · 5 shares · 710 followers View post →
Psychedelic Medicine Association
@Psychedelic_Med · X

#MDMA assisted psychotherapy for treating #PTSD has begun FDA-approved phase 3 trials. Check out the full article discussing the six phase 2 randomized controlled trials which showed how effective this #psychedelictherapy can be: https://t.co/QRzbJ9DIxB

Sep 7, 2021 · 6 likes · 5 shares · 10,606 followers View post →
socknug
@socknug · X

https://t.co/YtXR7PwfnO

Jun 18, 2021 · 2,159 followers View post →
sharonlevinson
@Sharonlevinson2 · X

17)באזור 2007-8 התחיל המחקר הקליני בטיפול משולב MDMA, ולפני ארבע שנים, כשהסתיים שלב 2 אחרון (בוצעו 6 ניסויים של שלב 2 בטיפול), הוא עלה לתודעה הציבורית, כי התוצאות הסטטיסטיות היו די חזקות ליעילות של הטיפול. https://t.co/QXypx5ry3p

May 20, 2021 · 40 likes · 1,766 followers View post →
Kristleifur Daðason
@kristleifur · X

@sveinbjornp Þetta mun vera ritrýnda fræðigreinin sem tekur saman Phase 2 rannsóknirnar. Þær eru mjög svipaðar og Phase 3. 3. stig er betur fjármagnað. Hægt að fylgja þáttakendum betur eftir og herða upp í rannsóknaraðferðum sem gerir niðurstöður enn skýrari. https://t.co/fQAkHmGgwN

May 10, 2021 · 1 like · 906 followers View post →
Paul Denver
@PaulDenver84 · X

@Gorman_JG @RichardJGrant They’re already doing this work MDMA-assisted psychotherapy for PTSD: https://t.co/4H5eJDxOaz Ketamine for depression: https://t.co/mg7G3Mm5aa Psilocybin for depression and anxiety: https://t.co/biiPy4Ajr0 Etc Johns Hopkins leads a lot of this kind of work

Aug 3, 2020 · 1 like · 558 followers View post →
David Van Doren
@DavidVanDoren · X

https://t.co/7orhQAg6xU https://t.co/7orhQAg6xU

Oct 16, 2019 · 12 followers View post →
National Academy of Inventors
@AcadofInventors · X

Read about the FIRST GROUNDBREAKING TREATMENT for PTSD in 17 YEARS! NAI Member Institute Medical University of South Carolina and its partners published the results of a study with a CURE RATE of 68%! https://t.co/iGvKhkBjXo #ptsd #ScientistsHealingTheWorld

Sep 19, 2019 · 5,813 followers View post →
ChiMaBa
@ChiMaBa1 · X

MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials | SpringerLink https://t.co/Sg81KpmTyT

Sep 3, 2019 · 1 like · 40 followers View post →
Dr. Sherry Walling
@drsherrywalling · X

Posttraumatic stress disorder is a prevalent mental health condition with substantial impact on daily functioning that lacks sufficient treatment options. https://t.co/eiUwnC7aoq

Jul 13, 2019 · 3,517 followers View post →
Greenthumb_one
@Greenthumb_one · X

@PsyPost Source: https://t.co/adutZ2jhYv

Jul 3, 2019 · 4,509 followers View post →
The Matilda Centre
@TheMatilda_USyd · X

MDMA + psychotherapy found to be effective and well-received as a treatment for adults suffering from PTSD. Recent paper evaluates multiple phase 2 clinical trials https://t.co/EL8RtetvK4

Jun 28, 2019 · 3 likes · 4,798 followers View post →
Sean Wilkes, M.D.
@DrSeanWilkes · X

“#MDMA-assisted #psychotherapy was efficacious and well tolerated in a large sample of adults with #PTSD. These studies supported expansion into phase 3 trials and led to #FDA granting Breakthrough Therapy designation for this promising treatment.” https://t.co/QZmfnxu7nC

Jun 21, 2019 · 1,320 followers View post →
Sheila Early
@SDEBC · X

Canadian study on effects of Ecstasy on PTSD patients https://t.co/gCaUjQnDC3

Jun 8, 2019 · 1 like · 439 followers View post →
Sebastian Hendricks (he/him)
@Hearing4Kids · X

RT briandavidearp: RT briandavidearp: MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials | SpringerLink https://t.co/KcjQKIQsrg

Jun 2, 2019 · 656 followers View post →
Dr Robin Hadley
@RobinHadley1 · X

RT @briandavidearp: MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analys…

Jun 1, 2019 · 4 shares · 6,353 followers View post →
Sebastian Hendricks (he/him)
@Hearing4Kids · X

RT briandavidearp: MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials | SpringerLink https://t.co/KcjQKIQsrg

Jun 1, 2019 · 656 followers View post →
Brian D. Earp, Ph.D.
@briandavidearp · X

MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials | SpringerLink https://t.co/PFQMN7aZuj

Jun 1, 2019 · 16 likes · 4 shares · 26,108 followers View post →
Giuseppe Giannotti
@GiusGiannotti · X

RT @zenbrainest: MDMA treats PTSD https://t.co/jtzUy9lnLF

May 30, 2019 · 2 shares · 755 followers View post →
Thomas J Graham
@ThomasJAGraham · X

RT @zenbrainest: MDMA treats PTSD https://t.co/jtzUy9lnLF

May 30, 2019 · 2 shares · 173 followers View post →
BryanRoth
@zenbrainest · X

MDMA treats PTSD https://t.co/jtzUy9lnLF

May 30, 2019 · 9 likes · 2 shares · 17,146 followers View post →
scott cunningham
@causalinf · X

As I wait for IPUMS to put my data together, I thought I'd post a new publication in PSYCHOPHARMACOLOGY. It's a study pooling six RCTs evaluating the causal effect of MDMA on PTSD symptoms. At the moment, you can download it freely. https://t.co/vY7ZZMCuBN

May 21, 2019 · 1 like · 52,395 followers View post →
Mark Fallu
@brisvegas1 · X

If you are feeling like I am this morning - MDMA shows promise in treatment of PTSD... just saying https://t.co/JrJSoOWDUg

May 18, 2019 · 2 likes · 1,149 followers View post →
Roni
@RainerFake · X

Video // Hashem Al-Ghaili: Ecstasy shows promising results in treating PTSD https://t.co/aWlXxxWmk2

May 18, 2019 · 13 followers View post →
Dr. Elden Wayne Whalen III, ShD
@wayne_effect · X

MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials https://t.co/c1jqP20Zub

May 17, 2019 · 1,303 followers View post →
Dreamgbutterfly
@dreamgbutterfly · X

MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials https://t.co/wkvcmfGcHg https://t.co/3iOqEiNclD

May 16, 2019 · 80 followers View post →
Sebastian Hendricks (he/him)
@Hearing4Kids · X

RT briandavidearp: RT briandavidearp: MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials | SpringerLink https://t.co/KcjQKIQsrg

May 9, 2019 · 656 followers View post →
vulpes inculta
@Vulpes_Inculta_ · X

RT @PsydelicsToday: MDMA-assisted psychotherapy for treatment of PTSD : study design and rationale for phase 3 trials based on pooled analy…

May 8, 2019 · 3 shares · 39 followers View post →
Gigi
@GIGIP0831 · X

RT @PsydelicsToday: MDMA-assisted psychotherapy for treatment of PTSD : study design and rationale for phase 3 trials based on pooled analy…

May 8, 2019 · 3 shares · 154 followers View post →
Fergz_Kamasakii
@Fergz_kamasakii · X

RT @AlanaArmstrong: Interested in MDMA-assisted psychotherapy for PTSD? This just in. https://t.co/DmjIpbAf1v

May 8, 2019 · 2 shares · 608 followers View post →
Psychedelics Today
@PsydelicsToday · X

MDMA-assisted psychotherapy for treatment of PTSD : study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials https://t.co/uFcn4jPLWi

May 8, 2019 · 9 likes · 3 shares · 41,622 followers View post →
Dr Seb Henagulph
@drhenagulph · X

Promising results for MDMA in PTSD treatment. If Phase 3 goes as well @MAPS expects FDA approval by 2021...watch this space. https://t.co/Xb6CMFh3UQ

May 8, 2019 · 114 followers View post →
Mike Samways
@mikesamways55 · X

RT @AlanaArmstrong: Interested in MDMA-assisted psychotherapy for PTSD? This just in. https://t.co/DmjIpbAf1v

May 8, 2019 · 2 shares · 199 followers View post →
Jeff Siegel
@jeffsiegel · X

A study found that "MDMA-assisted psychotherapy was efficacious and well tolerated in a large sample of adults with PTSD." https://t.co/pFAljENVxt

May 8, 2019 · 1 like · 5,457 followers View post →
Alana Armstrong
@AlanaArmstrong · X

Interested in MDMA-assisted psychotherapy for PTSD? This just in. https://t.co/DmjIpbAf1v

May 8, 2019 · 2 likes · 2 shares · 2,168 followers View post →
lucy u
@lucyuprichard · X

here's the recently published study: https://t.co/LABbPlJF8k and the article i wrote last year for context https://t.co/CaVQrgnsZY

May 8, 2019 · 1,145 followers View post →
TAZ Media
@tazziez25 · X

RT @todd_harrison: A study found that "MDMA-assisted psychotherapy was efficacious and well tolerated in a large sample of adults with PTSD…

May 8, 2019 · 2 shares · 269 followers View post →
Nateib ☮️
@chartjunkie271 · X

RT @todd_harrison: A study found that "MDMA-assisted psychotherapy was efficacious and well tolerated in a large sample of adults with PTSD…

May 8, 2019 · 2 shares · 329 followers View post →
Todd Harrison
@todd_harrison · X

A study found that "MDMA-assisted psychotherapy was efficacious and well tolerated in a large sample of adults with PTSD." h/t @tomangell https://t.co/aIoJBt3nIG

May 8, 2019 · 13 likes · 2 shares · 69,417 followers View post →
Matina Liosi
@MatinaLiosi · X

RT @briandavidearp: MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analys…

May 8, 2019 · 4 shares · 1,123 followers View post →
The Exponential Growth Understander
@intensivemargin · X

RT @causalinf: MDMA + psychotherapy assisted treatment for PTSD RCTs just out. Large reductions in PTSD symptoms in treatment group. https:…

May 7, 2019 · 1 share · 151 followers View post →
Sebastian Hendricks (he/him)
@Hearing4Kids · X

RT briandavidearp: MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials | SpringerLink https://t.co/KcjQKIQsrg

May 7, 2019 · 656 followers View post →
Brian D. Earp, Ph.D.
@briandavidearp · X

MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials | SpringerLink https://t.co/PFQMN7aZuj

May 7, 2019 · 7 likes · 4 shares · 26,108 followers View post →
Arnþór
@arnthorjon · X

#MDMA-assisted #psychotherapy for treatment of #PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials https://t.co/JCCquKI2Ti

May 7, 2019 · 4 likes · 1,396 followers View post →
scott cunningham
@causalinf · X

MDMA + psychotherapy assisted treatment for PTSD RCTs just out. Large reductions in PTSD symptoms in treatment group. https://t.co/vY7ZZMCuBN https://t.co/LZOCSONmV4

May 7, 2019 · 10 likes · 1 share · 52,395 followers View post →
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