Psychopharmacology (Berl) May 2019 PMID 31119329

Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties.

David G Smith, Roberta Martinelli, Gurdyal S Besra, Petr A Illarionov, Istvan Szatmari, Peter Brazda, Mary A Allen, Wenqing Xu, Xiang Wang, László Nagy, Robin D Dowell, Graham A W Rook, Laura Rosa Brunet, Christopher A Lowry

Mentions

107
Peak: 32 in May 2019
across 7 sources since May 2019

Extended reach

196,938
potential audience

Total likes

115

Video views

2,258

Mentions per month

May 2019 – Dec 2025

Where it's discussed

  • Facebook50 posts
  • X / Twitter42 posts
  • Instagram7 posts
  • News3 articles
  • YouTube2 videos
  • Blogs2 articles
  • Reddit1 posts

AI synopsis

What people are saying

Discussions frequently highlight the discovery of anti-inflammatory molecules from soil bacteria, emphasizing their potential to influence stress and inflammation treatments, with phrases like 'stress vaccine' and 'fend off anxiety disorders,' reflecting excitement and belief in its importance. The tone suggests keen interest and recognition of possible medical breakthroughs, though some posts remain speculative about direct impacts.

AgreementModerate agreement

Most discussions recognize the significance of discovering anti-inflammatory lipids from soil bacteria, aligning with the article's findings.

InterestHigh interest

Posts demonstrate high curiosity about the implications, such as stress reduction and potential treatments, showing strong interest.

EngagementModerate engagement

Many participants reference mechanisms and broader concepts like the hygiene hypothesis, indicating moderate engagement.

ImpactModerate impact

The emphasis on novel molecules and their potential for stress and inflammation management suggests a perceived moderate impact.

Abstract in brief

  • Researchers identified a new anti-inflammatory triglyceride called 123tri Z10hexadecenoyl glycerol from Mycobacterium vaccae, a bacterium known for its immune-regulating properties.
  • The fatty acid form of this molecule, 10Z-hexadecenoic acid, was shown to reduce inflammatory responses in mouse immune cells by decreasing the secretion of pro-inflammatory cytokines and activating genes related to anti-inflammatory pathways like PPAR-alpha.
  • This discovery helps to better understand how M. vaccae exerts its anti-inflammatory effects and could lead to potential new treatments for inflammatory diseases.

Top posts

Most liked on X and Bluesky
Christopher A Lowry
@CALowryPhD · X

Soil-derived bacterium, Mycobacterium vaccae, plays a game of molecular mimicry/semiochemical signaling, producing a novel fatty acid that binds host PPARalpha receptors in immune cells and shuts off the inflammatory cascade. https://t.co/MR7Wn8oRWS

May 28, 2019 · 20 likes · 12 shares · 404 followers View post →
manasataramgini
@blog_supplement · X

@emswam nAsAdhvani vA karNadhvani vA

Dec 6, 2019 · 5 likes · 2 shares · 18,856 followers View post →
VVB_LJ
@VVB_LJ · X

@Nereide @ExeterMed I don't think this was the link I posted, but, like I said, there are various. Here are three (the second one quoting directly Lowry; the third one leads to s study): https://t.co/y7Axei6PgD https://t.co/Oy4Vxx0sY4 https://t.co/W763eqdtSk

Jan 20, 2020 · 5 likes · 2 shares · 728 followers View post →
Scott Anderson
@Psychobiotic · X

Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties. Another good result from killed bacteria. https://t.co/5QHrL5elrO

Jun 17, 2019 · 4 likes · 1 share · 18,511 followers View post →
Sergio Solari
@SergioSolari6 · X

Museomics of tree squirrels https://t.co/XJcETlgeBl

Jun 27, 2020 · 4 likes · 471 followers View post →
GutMicrobiota Health
@GMFHx · X

The mechanisms behind the protective functions of M. vaccae living in the soil are poorly understood. @CALowryPhD & colleagues have identified and characterized novel anti-inflammatory molecules from this bacterium on immunoregulation in mice https://t.co/XviyZxZwGY

May 30, 2019 · 3 likes · 2 shares · 35,567 followers View post →

All mentions

Richard Jonathan O Taduran
@rjotaduran · X

https://t.co/9QS9LHwNfA

Jun 19, 2023 · 345 followers View post →
石井秀治
@syujiishii · X

@withpain_mio @take0504 https://t.co/48jdjXkKX0 ←炎症には土!  土触って食ってみましょう。    イベルメクチンの原料も静岡の土の微生物

Aug 17, 2021 · 7 followers View post →
François Booream
@BooraemFrancois · X

https://t.co/el3RZAUpMe

Apr 10, 2021 · 719 followers View post →
Sergio Solari
@SergioSolari6 · X

Museomics of tree squirrels https://t.co/XJcETlgeBl

Jun 27, 2020 · 4 likes · 471 followers View post →
後藤健太
@Kenta_Goto · X

ア、アースしたい♥(←畑欠乏症)土いじりすると心身の健康に良いんですよ。マイコバクテリウム・バッカエという細菌が好影響を及ぼすそう。みんな今すぐ畑はじめよう♥ https://t.co/XBvqYVZIpB

Jun 23, 2020 · 2 likes · 4,312 followers View post →
Rosy's Science Project
@meryrosyu · X

RT @VVB_LJ: @Nereide @ExeterMed I don't think this was the link I posted, but, like I said, there are various. Here are three (the second o…

Jan 21, 2020 · 2 shares · 287 followers View post →
Joey Avenger Jr.
@joyfulmath3 · X

RT @VVB_LJ: @Nereide @ExeterMed I don't think this was the link I posted, but, like I said, there are various. Here are three (the second o…

Jan 20, 2020 · 2 shares · 204 followers View post →
VVB_LJ
@VVB_LJ · X

@Nereide @ExeterMed I don't think this was the link I posted, but, like I said, there are various. Here are three (the second one quoting directly Lowry; the third one leads to s study): https://t.co/y7Axei6PgD https://t.co/Oy4Vxx0sY4 https://t.co/W763eqdtSk

Jan 20, 2020 · 5 likes · 2 shares · 728 followers View post →
manasataramgini
@blog_supplement · X

@emswam nAsAdhvani vA karNadhvani vA

Dec 6, 2019 · 5 likes · 2 shares · 18,856 followers View post →
Aimee Bloom
@Aimee_Bloom1 · X

Scientists one step closer to creating a theoretical “stress vaccine” after identifying a fatty acid in the bacteria Mycobacterium vaccae that appears to dial down the fight-or-flight response in mice https://t.co/WdunCusPkK https://t.co/guobReu2sI #stress #wellbeing #research

Oct 22, 2019 · 109 followers View post →
Strickland Nutrition (ANutr)
@NutritionMSc · X

https://t.co/HKG6dTSobU

Oct 14, 2019 · 88 followers View post →
ママDr
@AGMjQZwFqQg4F0e · X

https://t.co/Cb4yjzivKL 学術誌「Psychopharmacology」に掲載された論文。土壌に生息する腐生性細菌マイコバクテリウム・ヴァッカエには、抗炎症、免疫調節、およびストレス耐性の性質がある。これらの保護効果は、この細菌が持つ特殊な「脂質」が要因のひとつであることが今回の研究で明らかに!

Oct 8, 2019 · 1 like · 7 followers View post →
サイエンスラジオ
@Science_RadioJP · X

泥んこ遊びがストレス耐性を高める話☝️ アップロードしました! https://t.co/bFAa65cQrN

Sep 18, 2019 · 16 followers View post →
Core
@HelloCore · X

An anti-stress pill may be coming

Jun 24, 2019 · 2 likes · 924 followers View post →
@Pelissolo Psy
@A_Pelissolo · X

Mycobacterium vaccae : un futur vaccin contre le #stress ? https://t.co/K1AEhS2NuW

Jun 24, 2019 · 1 like · 4,085 followers View post →
Coumarin
@B_treefrog · X

微生物脂質!子供の泥遊びもまんざらではない https://t.co/WY5FLYUHVL

Jun 21, 2019 · 150 followers View post →
Edgar Ortega
@EdgarOr39956032 · X

RT @Psychobiotic: Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived…

Jun 17, 2019 · 1 share · 100 followers View post →
Scott Anderson
@Psychobiotic · X

Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties. Another good result from killed bacteria. https://t.co/5QHrL5elrO

Jun 17, 2019 · 4 likes · 1 share · 18,511 followers View post →
内田
@uchida_kawasaki · X

土に触れる生活が心身の健康につながる。抗ストレスの妙薬は「土壌」にあった:研究結果 @wired_jp https://t.co/5BzRB9nhYI https://t.co/WF8rI42XOi

Jun 10, 2019 · 1,920 followers View post →
H.M. Pettersen
@HMPettersen2 · X

RT @CALowryPhD: Soil-derived bacterium, Mycobacterium vaccae, plays a game of molecular mimicry/semiochemical signaling, producing a novel…

Jun 8, 2019 · 12 shares · 177 followers View post →
Salesianos Argentina
@salesianoarg1 · X

RT @GMFHx: The mechanisms behind the protective functions of M. vaccae living in the soil are poorly understood. @CALowryPhD & colleagues h…

May 30, 2019 · 2 shares · 604 followers View post →
Hello Phyta
@hellophyta · X

RT @GMFHx: The mechanisms behind the protective functions of M. vaccae living in the soil are poorly understood. @CALowryPhD & colleagues h…

May 30, 2019 · 2 shares · 16 followers View post →
GutMicrobiota Health
@GMFHx · X

The mechanisms behind the protective functions of M. vaccae living in the soil are poorly understood. @CALowryPhD & colleagues have identified and characterized novel anti-inflammatory molecules from this bacterium on immunoregulation in mice https://t.co/XviyZxZwGY

May 30, 2019 · 3 likes · 2 shares · 35,567 followers View post →
bgroat
@groatb · X

https://t.co/ef9vvs7iRu

May 29, 2019 · 124 followers View post →
Dr. Harriet Schellekens
@harschellekens · X

Anti-inflammatory fat in a soil-dwelling as #stress vaccine: hygiene hypothesis revisited? #microbiome #anxiety https://t.co/bQ5Vl9G34c

May 29, 2019 · 2,151 followers View post →
Robert West, PhD ✝️
@westr · X

Healthy fat hidden in dirt may fend off #anxiety disorders https://t.co/3CowIu3gIh via @cubouldernews @EurekAlert #stress #hygeine #FattyAcid #PPAR Lipid discovered in soil-dwelling bacteria helps explain 'hygiene hypothesis' - Stress vaccine? https://t.co/ddAsND4Maw

May 29, 2019 · 19,276 followers View post →
wolodya
@wolodya · X

RT @jfcryan: New data from @CALowryPhD in Psychopharmacology on the mechanisms underpining the behavioural effects of M. Vaccae https://t.c…

May 29, 2019 · 1 share · 1,069 followers View post →
John F. Cryan
@jfcryan · X

New data from @CALowryPhD in Psychopharmacology on the mechanisms underpining the behavioural effects of M. Vaccae https://t.co/RgMURBsYM4 https://t.co/rHu9JrdTmk

May 29, 2019 · 3 likes · 1 share · 22,434 followers View post →
Pawel (Paul) Matusz @paul.matusz.b*ky.social
@paulmatusz · X

Why Millenials Buy Plants Instead Of Houses? - - that’s why: “As humans have moved away from farms (..) into cities, we have lost contact with organisms that served to regulate our immune system and suppress inappropriate inflammation” https://t.co/VWzRQOZfnF

May 29, 2019 · 1 like · 1,256 followers View post →
Ana Maranha
@ana__maranha · X

identification of an anti-inflammatory triglyceride from Mycobacterium vaccae. https://t.co/uMtUBdPFJT

May 29, 2019 · 126 followers View post →
Jack A Gilbert (he/him/his)
@gilbertjacka · X

RT @CALowryPhD: Soil-derived bacterium, Mycobacterium vaccae, plays a game of molecular mimicry/semiochemical signaling, producing a novel…

May 28, 2019 · 12 shares · 13,012 followers View post →
Andrew Hoisington
@andyhois · X

RT @CALowryPhD: Soil-derived bacterium, Mycobacterium vaccae, plays a game of molecular mimicry/semiochemical signaling, producing a novel…

May 28, 2019 · 12 shares · 204 followers View post →
Brian Fan
@bfan · X

RT @CALowryPhD: Soil-derived bacterium, Mycobacterium vaccae, plays a game of molecular mimicry/semiochemical signaling, producing a novel…

May 28, 2019 · 12 shares · 211 followers View post →
Marcus Böhme
@BoehmeMarcus · X

RT @CALowryPhD: Soil-derived bacterium, Mycobacterium vaccae, plays a game of molecular mimicry/semiochemical signaling, producing a novel…

May 28, 2019 · 12 shares · 4,313 followers View post →
Emad El-Omar
@emadelomar · X

RT @CALowryPhD: Soil-derived bacterium, Mycobacterium vaccae, plays a game of molecular mimicry/semiochemical signaling, producing a novel…

May 28, 2019 · 12 shares · 3,859 followers View post →
wolodya
@wolodya · X

RT @CALowryPhD: Soil-derived bacterium, Mycobacterium vaccae, plays a game of molecular mimicry/semiochemical signaling, producing a novel…

May 28, 2019 · 12 shares · 1,069 followers View post →
John F. Cryan
@jfcryan · X

RT @CALowryPhD: Soil-derived bacterium, Mycobacterium vaccae, plays a game of molecular mimicry/semiochemical signaling, producing a novel…

May 28, 2019 · 12 shares · 22,434 followers View post →
MVM-CoRE
@MVM_CoRE · X

RT @CALowryPhD: Soil-derived bacterium, Mycobacterium vaccae, plays a game of molecular mimicry/semiochemical signaling, producing a novel…

May 28, 2019 · 12 shares · 302 followers View post →
CU Anschutz Physical Medicine
@CUPhysMed · X

RT @CALowryPhD: Soil-derived bacterium, Mycobacterium vaccae, plays a game of molecular mimicry/semiochemical signaling, producing a novel…

May 28, 2019 · 12 shares · 2,083 followers View post →
UCCpsychiatry
@UCCpsychiatry · X

RT @CALowryPhD: Soil-derived bacterium, Mycobacterium vaccae, plays a game of molecular mimicry/semiochemical signaling, producing a novel…

May 28, 2019 · 12 shares · 3,527 followers View post →
Natalya Murakhver
@AppletoZucchini · X

RT @CALowryPhD: Soil-derived bacterium, Mycobacterium vaccae, plays a game of molecular mimicry/semiochemical signaling, producing a novel…

May 28, 2019 · 12 shares · 7,646 followers View post →
Christopher A Lowry
@CALowryPhD · X

Soil-derived bacterium, Mycobacterium vaccae, plays a game of molecular mimicry/semiochemical signaling, producing a novel fatty acid that binds host PPARalpha receptors in immune cells and shuts off the inflammatory cascade. https://t.co/MR7Wn8oRWS

May 28, 2019 · 20 likes · 12 shares · 404 followers View post →
Christopher Lowry, University of Colorado at Boulder [IMAGE ...
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Research paper: https://www.ncbi.nlm.nih.gov/pubmed/31119329 ...
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Anti-inflammatory fat in soil-dwelling bacterium
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Lowry. Psychopharmacology. doi:10.1007/s00213-019-05253-9. Sorry guys, it's paywalled. If anyone has access to the open, can you please share.

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Researchers discover healthy, stress-busting fat in soil-dwelling ...
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doi.org/10.1007/s00213-019-05253-9. Be the first to rate this article. Posted in: Medical Science News | Medical Research News. Comments (0).

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Healthy fat hidden in dirt may fend off anxiety disorders | EurekAlert!
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10.1007/s00213-019-05253-9. Keywords. /Health and medicine/Diseases and disorders/Psychiatric disorders/Neuroses/Anxiety disorders/Post ...

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Healthy, stress-busting fat found hidden in dirt | ScienceDaily
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Psychopharmacology, 2019; DOI: 10.1007/s00213-019-05253-9; Stefan O. Reber, Philip H. Siebler, Nina C. Donner, James T. Morton, David G ...

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Soil-based bacteria may reduce anxiety disorders
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... 10.1007/s00213-019-05253-9 Mycobacterium vaccae (NCTC 11659) is an environmental saprophytic bacterium with anti- inflammatory ...

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From the article: "For the new study, Lowry and his team identified ...
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19 juillet 2018: " A group of researchers has discovered that neural ...
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doi: 10.1007/s00213-019-05253-9 #neuroscience #microbiology #psychology #inflammation #anxiety #stress #health #science. Healthy fat hidden ...

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Cordysobin, a novel alkaline serine protease with HIV-1 reverse ...
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Feb 22, 2019 View →
https://www.ncbi.nlm.nih.gov/pubmed/22771318 https://www.ncbi ...
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doi: 10.1007/s00213-019-05253-9 #neuroscience #microbiology #psychology #inflammation #anxiety #stress #health #science. Healthy fat hidden ...

Nov 19, 2018 View →
Ke Li et al, Fatty-acid derivative acts as a sea lamprey migratory ...
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A new antibiotic was discovered which strongly inhibited mRNA ...
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May 28, 2018 View →
Anti microbial resistance by who | Facebook
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doi: 10.1007/s00213-019-05253-9 #neuroscience #microbiology ... 10.1007/978-1-4939-1625-2_3 ·

Jan 21, 2018 View →
Neat! "So-called "gram-negative" bacteria, such as E. coli (and the ...
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doi: 10.1007/s00213-019-05253-9 #neuroscience #microbiology #psychology #inflammation #anxiety #stress #health #science. Healthy fat hidden ...

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Bacterial adhesion not inhibited by ion-releasing bioactive glass ...
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May 8, 2017 View →
Of all the people to pick to try to say we're wrong and "blindly ...
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Sep 12, 2016 View →
Practical advice for inhibited types.
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