Genome Med May 2019 PMID 31126321

Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data.

Francesca Finotello, Clemens Mayer, Christina Plattner, Gerhard Laschober, Dietmar Rieder, Hubert Hackl, Anne Krogsdam, Zuzana Loncova, Wilfried Posch, Doris Wilflingseder, Sieghart Sopper, Marieke Ijsselsteijn, Thomas P Brouwer, Douglas Johnson, Yaomin Xu

Mentions

49
Peak: 10 in May 2019
across 3 sources since May 2019

Extended reach

167,303
potential audience

Total likes

63

Video views

81

Mentions per month

May 2019 – Oct 2024

Where it's discussed

  • X / Twitter42 posts
  • YouTube5 videos
  • Blogs2 articles

AI synopsis

What people are saying

The collective discussions emphasize the importance of quanTIseq in understanding tumor immune contexture, with posts describing it as a 'game changer' and a 'highlight' of 2019, and citing its robustness for identifying CD8+ T cells. Words like 'highest cited,' 'technique,' and 'highlight' demonstrate high regard and perceived influence among the community, reflecting both enthusiasm and recognition of its broad implications.

AgreementStrong agreement

Most discussions praise the significance and validity of the quanTIseq methodology, highlighting it as a highly cited and influential paper in the field.

InterestHigh interest

Posts show high interest, with many sharing enthusiasm, highlights, and practical applications of the research.

EngagementHigh engagement

There is deep engagement, evident through references to the method’s robustness, usage in reviews, and comparisons with other techniques.

ImpactHigh impact

The discussions suggest the article has substantial impact, being recognized as a breakthrough and a popular resource in the community.

Abstract in brief

  • quanTIseq is a new method for measuring the presence of ten different immune cell types in bulk RNA-sequencing data.
  • It was validated using blood and tumor samples, showing that cytotoxic T cell levels relate more to CXCR3/CXCL9 activation than to mutation rates in tumors.
  • This tool also helps understand how kinase inhibitors affect immune cells and identifies which immune types influence patient responses to checkpoint blockade therapy.

Top posts

Most liked on X and Bluesky
Genome Medicine
@GenomeMedicine · X

This method is currently our most cited article of 2019: Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data #openaccess

Apr 1, 2020 · 22 likes · 7 shares · 24,736 followers View post →
Genome Medicine
@GenomeMedicine · X

Read one of our most popular articles of 2019: Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data #openaccess

Feb 14, 2020 · 20 likes · 5 shares · 24,736 followers View post →
Francesca Finotello
@Francesca_Fin_ · X

Happy to share that our #quanTIseq paper was one of the Springer Nature 2019 highlights in genetics! #2019HighlightsAuthor You can read about RNA-seq data #deconvolution with quanTIseq here: https://t.co/JIA1tqt3tq https://t.co/G9ynubHQLD

Feb 27, 2020 · 9 likes · 1 share · 1,163 followers View post →
Federico Marini
@FedeBioinfo · X

@KVittingSeerup @CSoneson @markrobinsonca @Francesca_Fin_ Review: https://t.co/ZAkay6Kzc1 QuanTIseq: https://t.co/BCUoRey7Qf The comparison: https://t.co/kL3GR0KEmv, lead by Gregor Sturm

Jun 24, 2019 · 5 likes · 968 followers View post →
SeqComplete
@SeqComplete · X

Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data https://t.co/yIrvWeMkVM

Jun 2, 2019 · 2 likes · 1 share · 4,412 followers View post →
Daniel Gautheret
@DGautheret · X

Cibersort: https://t.co/Yvs4KpjzC1 xCell: https://t.co/K80VH3sDwA MCP-counter: https://t.co/Ev6Ua8oUbI quanTIseq: https://t.co/KFBVpiftgy Bisque: https://t.co/MGMEqvZtLc DWLS: https://t.co/YbQ8xPOvN1 2/2

Aug 7, 2019 · 2 likes · 339 followers View post →

All mentions

ラーどん
@La_donjiba · X

RT @GenomeMedicine: This method is currently our most cited article of 2019: Molecular and pharmacological modulators of the tumor immune c…

Jun 27, 2020 · 7 shares · 1,708 followers View post →
Francesca Finotello
@Francesca_Fin_ · X

RT @GenomeMedicine: This method is currently our most cited article of 2019: Molecular and pharmacological modulators of the tumor immune c…

Jun 26, 2020 · 7 shares · 1,163 followers View post →
ali lütfü yüğnük
@yugnuk · X

RT @GenomeMedicine: This method is currently our most cited article of 2019: Molecular and pharmacological modulators of the tumor immune c…

Jun 26, 2020 · 7 shares · 1,883 followers View post →
うろ
@uro9000 · X

RT @GenomeMedicine: This method is currently our most cited article of 2019: Molecular and pharmacological modulators of the tumor immune c…

Jun 17, 2020 · 7 shares · 1,105 followers View post →
Martin Correa
@martinrafco · X

RT @GenomeMedicine: This method is currently our most cited article of 2019: Molecular and pharmacological modulators of the tumor immune c…

Jun 14, 2020 · 7 shares · 231 followers View post →
Niyi Olarewaju, PhD, MBA
@Olaniyi_OP · X

RT @GenomeMedicine: This method is currently our most cited article of 2019: Molecular and pharmacological modulators of the tumor immune c…

May 22, 2020 · 7 shares · 5,121 followers View post →
Inky Mark
@inky_mark · X

RT @GenomeMedicine: This method is currently our most cited article of 2019: Molecular and pharmacological modulators of the tumor immune c…

May 15, 2020 · 7 shares · 20,335 followers View post →
Genome Medicine
@GenomeMedicine · X

This method is currently our most cited article of 2019: Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data #openaccess

Apr 1, 2020 · 22 likes · 7 shares · 24,736 followers View post →
ACAFARMUR
@acafarmur · X

Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data https://t.co/QIPuD8SRG9

Mar 4, 2020 · 1 like · 692 followers View post →
ACAFARMUR
@acafarmur · X

Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data https://t.co/QIPuD8SRG9

Mar 2, 2020 · 1 like · 692 followers View post →
Springer Nature Authors
@SN_Authors · X

RT @Francesca_Fin_: Happy to share that our #quanTIseq paper was one of the Springer Nature 2019 highlights in genetics! #2019HighlightsAut…

Feb 27, 2020 · 1 share · 8,127 followers View post →
Francesca Finotello
@Francesca_Fin_ · X

Happy to share that our #quanTIseq paper was one of the Springer Nature 2019 highlights in genetics! #2019HighlightsAuthor You can read about RNA-seq data #deconvolution with quanTIseq here: https://t.co/JIA1tqt3tq https://t.co/G9ynubHQLD

Feb 27, 2020 · 9 likes · 1 share · 1,163 followers View post →
ACAFARMUR
@acafarmur · X

Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data https://t.co/QIPuD8SRG9

Feb 22, 2020 · 692 followers View post →
Alberto
@MBAlberto · X

RT @GenomeMedicine: Read one of our most popular articles of 2019: Molecular and pharmacological modulators of the tumor immune contexture…

Feb 21, 2020 · 5 shares · 281 followers View post →
Ganjasmoker
@GanjasmokerCb · X

RT @GenomeMedicine: Read one of our most popular articles of 2019: Molecular and pharmacological modulators of the tumor immune contexture…

Feb 16, 2020 · 5 shares · 2,312 followers View post →
francine braun
@chaweeh · X

RT @GenomeMedicine: Read one of our most popular articles of 2019: Molecular and pharmacological modulators of the tumor immune contexture…

Feb 15, 2020 · 5 shares · 196 followers View post →
Rosa Fasching
@rosinafasching · X

RT @GenomeMedicine: Read one of our most popular articles of 2019: Molecular and pharmacological modulators of the tumor immune contexture…

Feb 15, 2020 · 5 shares · 1,287 followers View post →
Genome Medicine
@GenomeMedicine · X

Read one of our most popular articles of 2019: Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data #openaccess

Feb 14, 2020 · 20 likes · 5 shares · 24,736 followers View post →
Science Alerts
@Science_Alerts · X

RT @EurekaMag: Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data https://t.…

Oct 13, 2019 · 2 shares · 1,240 followers View post →
POPLINE
@POPLINE_org · X

RT @EurekaMag: Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data https://t.…

Oct 13, 2019 · 2 shares · 5,271 followers View post →
EurekaMag
@EurekaMag · X

Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data https://t.co/l05vBP0lsS

Oct 13, 2019 · 2 shares · 6,447 followers View post →
Francesca Finotello
@Francesca_Fin_ · X

RT @Francesca_Fin_: After a long journey, #quanTIseq is finally published on @GenomeMedicine: https://t.co/n2UcD38TA4 quanTIseq is #comput…

Sep 17, 2019 · 13 shares · 1,163 followers View post →
David Gfeller
@GfellerD · X

RT @Francesca_Fin_: After a long journey, #quanTIseq is finally published on @GenomeMedicine: https://t.co/n2UcD38TA4 quanTIseq is #comput…

Aug 22, 2019 · 13 shares · 909 followers View post →
Daniel Gautheret
@DGautheret · X

Cibersort: https://t.co/Yvs4KpjzC1 xCell: https://t.co/K80VH3sDwA MCP-counter: https://t.co/Ev6Ua8oUbI quanTIseq: https://t.co/KFBVpiftgy Bisque: https://t.co/MGMEqvZtLc DWLS: https://t.co/YbQ8xPOvN1 2/2

Aug 7, 2019 · 2 likes · 339 followers View post →
Fabrice Leclerc
@rnomics · X

https://t.co/NrNtbb2Ueg Correction to: Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data. - PubMed - NCBI https://t.co/aosUPEmgX7 PubMed comprises more than 29 million citations for biomedical literature from ME…

Jul 31, 2019 · 2,762 followers View post →
CompBiolPapers
@CompBiolPapers · X

Correction to: Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data. https://t.co/lz9gc17tL1

Jul 31, 2019 · 1,781 followers View post →
Marco Donia
@DoniaMarco · X

RT @Francesca_Fin_: After a long journey, #quanTIseq is finally published on @GenomeMedicine: https://t.co/n2UcD38TA4 quanTIseq is #comput…

Jul 2, 2019 · 13 shares · 632 followers View post →
Francesca Finotello
@Francesca_Fin_ · X

@ee_reh_neh I'd suggest quanTIseq (of course!): https://t.co/aVqFJQLy7y. And it's very robust for CD8+ T cells. Our review might be also useful to have an overview of deconvolution methods: https://t.co/5A0nchnV8S

Jul 1, 2019 · 1,163 followers View post →
Federico Marini
@FedeBioinfo · X

@KVittingSeerup @CSoneson @markrobinsonca @Francesca_Fin_ Review: https://t.co/ZAkay6Kzc1 QuanTIseq: https://t.co/BCUoRey7Qf The comparison: https://t.co/kL3GR0KEmv, lead by Gregor Sturm

Jun 24, 2019 · 5 likes · 968 followers View post →
Europe PMC articles
@EuropePMC · X

New from #ERC_Research https://t.co/HhJFb3r0SS Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data

Jun 2, 2019 · 1 share · 1,552 followers View post →
Francesca Finotello
@Francesca_Fin_ · X

RT @SeqComplete: Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data https://…

Jun 2, 2019 · 1 share · 1,163 followers View post →
SeqComplete
@SeqComplete · X

Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data https://t.co/yIrvWeMkVM

Jun 2, 2019 · 2 likes · 1 share · 4,412 followers View post →
Robert Castelo
@robertclab · X

RT @Francesca_Fin_: After a long journey, #quanTIseq is finally published on @GenomeMedicine: https://t.co/n2UcD38TA4 quanTIseq is #comput…

May 28, 2019 · 13 shares · 919 followers View post →
Sigve Nakken
@sigven · X

RT @Francesca_Fin_: After a long journey, #quanTIseq is finally published on @GenomeMedicine: https://t.co/n2UcD38TA4 quanTIseq is #comput…

May 28, 2019 · 13 shares · 240 followers View post →
Andrés López-Cortés
@Andres_Lopez_C · X

RT @Francesca_Fin_: After a long journey, #quanTIseq is finally published on @GenomeMedicine: https://t.co/n2UcD38TA4 quanTIseq is #comput…

May 28, 2019 · 13 shares · 5,787 followers View post →
Genome Medicine
@GenomeMedicine · X

RT @Francesca_Fin_: After a long journey, #quanTIseq is finally published on @GenomeMedicine: https://t.co/n2UcD38TA4 quanTIseq is #comput…

May 28, 2019 · 13 shares · 24,736 followers View post →
Aurélie Gabriel
@gabriel_aurelie · X

RT @Francesca_Fin_: After a long journey, #quanTIseq is finally published on @GenomeMedicine: https://t.co/n2UcD38TA4 quanTIseq is #comput…

May 28, 2019 · 13 shares · 154 followers View post →
Marcel Schulz - @marcelschulz@genomic.social
@TheMarcelSchulz · X

RT @Francesca_Fin_: After a long journey, #quanTIseq is finally published on @GenomeMedicine: https://t.co/n2UcD38TA4 quanTIseq is #comput…

May 28, 2019 · 13 shares · 942 followers View post →
Dvir Aran
@dvir_a · X

RT @Francesca_Fin_: After a long journey, #quanTIseq is finally published on @GenomeMedicine: https://t.co/n2UcD38TA4 quanTIseq is #comput…

May 27, 2019 · 13 shares · 6,229 followers View post →
Noel F. de Miranda
@NFdeMiranda · X

RT @Francesca_Fin_: After a long journey, #quanTIseq is finally published on @GenomeMedicine: https://t.co/n2UcD38TA4 quanTIseq is #comput…

May 27, 2019 · 13 shares · 687 followers View post →
de Miranda Lab
@deMirandaLab · X

RT @Francesca_Fin_: After a long journey, #quanTIseq is finally published on @GenomeMedicine: https://t.co/n2UcD38TA4 quanTIseq is #comput…

May 27, 2019 · 13 shares · 485 followers View post →
RomualdiLab
@LabRomualdi · X

RT @Francesca_Fin_: After a long journey, #quanTIseq is finally published on @GenomeMedicine: https://t.co/n2UcD38TA4 quanTIseq is #comput…

May 27, 2019 · 13 shares · 260 followers View post →