October 2020 PMID 31134054

Molecular Pathways Mediating Immunosuppression in Response to Prolonged Intensive Physical Training, Low-Energy Availability, and Intensive Weight Loss.

Heikki V Sarin, Ivan Gudelj, Jarno Honkanen, Johanna K Ihalainen, Arja Vuorela, Joseph H Lee, Zhenzhen Jin, Joseph D Terwilliger, Ville Isola, Juha P Ahtiainen, Keijo Häkkinen, Julija Jurić, Gordan Lauc, Kati Kristiansson, Juha J Hulmi

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Mentions

Peak: 28 in Dec 2020

across 4 sources since Apr 2019

Extended reach

344,230

potential audience

Total likes

323

Video views

3,198

Mentions per month

Apr 2019 – Nov 2024

Where it's discussed

X / Twitter57 posts
Facebook3 posts
News3 articles
YouTube2 videos

AI synopsis

What people are saying

Many posts endorse the idea that combined effects of low-energy availability and intense training harm immune health, with phrases like 'damage your long term health' and 'immunosuppression,' illustrating concern and awareness. The tone reflects a mixture of agreement and curiosity, with some discussing molecular pathways and broader health implications, indicating meaningful engagement and perceived importance of the study.

AgreementModerate agreement

Most discussions agree that prolonged intense training combined with low energy intake can negatively impact immune function, reflecting support for the publication's findings.

InterestHigh interest

The participants show high interest, with many references to the molecular pathways and implications for health, indicating engagement with the topic.

EngagementModerate engagement

There is moderate to deep engagement, as some posts cite specific molecular mechanisms or studies, such as IgG glycome changes and cytokine effects, demonstrating they are processing detailed information.

ImpactModerate impact

The discussions highlight potential health risks and practical concerns related to athletic training and dieting, suggesting they perceive the research as impactful.

Abstract in brief

The study investigates how prolonged intensive weight loss and energy deprivation impact the immune system in healthy women, showing that such practices can lead to immune suppression through alterations in multiple molecular pathways.
Using advanced systems biology techniques, researchers observed significant changes in immune parameters, including white blood cells, immunoglobulins, and cytokines, particularly during the weight loss phase, with some effects persisting during recovery.
Overall, the findings suggest that extreme weight loss practices in athletes may impair immune function by affecting processes like blood cell production, inflammation, and immune cell activity, highlighting potential health risks associated with severe dieting and training.

Read the full abstract

All mentions

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Selene Yeager

@FitChick3 · X

@cyu888 There is some on the combination of LEA and intensive training https://t.co/Cv9WGrdjkl

Oct 20, 2022 · 1 like · 5,774 followers View post →

Nikolina Lauc

@entreprylexia · X

@__JosephWilk Very true https://t.co/BfzZkZLqx9

Feb 27, 2022 · 1,421 followers View post →

Nikolina Lauc

@entreprylexia · X

@LauraMinquini Not necessarily, as if you are eating less and exercising intensity, the two together over-stress the body and damage your long term health https://t.co/BfzZkZLqx9

Nov 5, 2021 · 3 likes · 1,421 followers View post →

Ferfitness-coach

@ferchoandradez · X