Front Nutr May 2019 PMID 31139630

The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of Parkinson's Disease.

Nicholas G Norwitz, Michele T Hu, Kieran Clarke

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Mentions

46
Peak: 9 in Dec 2019
across 4 sources since May 2019

Extended reach

1,151,231
potential audience

Total likes

8,505

Video views

303,668

Mentions per month

May 2019 – Jan 2025

Where it's discussed

  • X / Twitter39 posts
  • YouTube3 videos
  • Facebook2 posts
  • News2 articles

AI synopsis

What people are saying

The discussions frequently affirm the significance of the article by referencing related research from 2019 and noting how ketone bodies influence cellular pathways like antioxidant defenses. Words like 'excellent review,' 'game changer,' and mentions of molecular mechanisms such as SOD activity and NADPH regeneration reflect a tone of respect and curiosity, indicating high engagement and interest, but with a cautious view on immediate impact.

AgreementModerate agreement

Most discussions support the potential benefits of ketone bodies, referencing prior research and expressing optimism about the mechanism described in the publication.

InterestHigh interest

Posts show high interest by sharing detailed insights, relevant reviews, and personal accounts about ketosis and Parkinson's disease.

EngagementHigh engagement

Many posts delve into the molecular pathways, cite previous studies, and discuss implications, indicating deep engagement.

ImpactModerate impact

While some highlight the importance of this research for future therapies, others emphasize personal experiences, suggesting moderate perceived impact.

Abstract in brief

  • Parkinson's disease involves the progressive loss of dopamine-producing neurons, and current treatments mainly manage symptoms rather than stopping the disease's progression.
  • The ketone body D-hydroxybutyrate, produced during fasting or ketogenic diets, might offer neuroprotective benefits by supporting neuron energy production and reducing oxidative damage, potentially slowing or preventing disease development.
  • D-hydroxybutyrate works both as a metabolic fuel and as a signaling molecule, influencing cellular pathways that could help protect neurons, making it a promising candidate for future therapies targeting the underlying causes of Parkinson's disease.]

Top posts

Most liked on X and Bluesky
Isabella Cooper
@I_mitochondria · X

Hyperinsulinemia inhibits ketogenesis = little to no ketones (BHB) for the brain. BHB = fuel, anti-oxidant & signalling molecule. Endogenously produced BHB means physiologically healthy insulin and glucose levels for the individual. https://t.co/FUk3LjY90U https://t.co/zhnrLwBikl

Dec 16, 2019 · 24 likes · 9 shares · 10,363 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

@janellison https://t.co/PimzAW26Wn https://t.co/suv3QKtK3j https://t.co/Khi2oH4l7B I may have written a 350 page thesis on that topic

Apr 12, 2023 · 11 likes · 1 share · 109,430 followers View post →
IberianCitizen
@IberianCitizen · X

Mecanismos por los que el D-β-hidroxibutirato puede mejorar las múltiples patologías celulares de la enfermedad de Parkinson by @nicknorwitz https://t.co/7bJk4E41hY https://t.co/zyyprJUvwY

Aug 19, 2020 · 11 likes · 12,932 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

Absolutely! #Parkinson https://t.co/Mdp2aHiYBf https://t.co/euVtnL0Pvg This last only share because BP had PD was in the trials, loved way she felt and has been #keto ever since. Sometimes patient voice means more than any research. FWIW https://t.co/MUars6DRr8 https://t.co/8RYXhccreR

Sep 24, 2021 · 10 likes · 109,430 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

For those who think all chronic disease, including #Alzheimer's come down to metabolic dysfunction & poor lifestyle https://t.co/JgrkTJzLS7 https://t.co/kEWUt63Z3b https://t.co/KUGUwj6evi

Apr 24, 2020 · 10 likes · 3 shares · 109,430 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

#Ketones / BHB bolster the body’s natural #antioxidant defenses by supporting regeneration of NADPH https://t.co/euVtnL0Pvg https://t.co/AW936l646H

Aug 11, 2020 · 8 likes · 2 shares · 109,430 followers View post →

All mentions

Myths and Facts about the Carnivore Diet

The carnivore diet has faced criticism and myths, but recent studies show real health benefits. Research from Harvard with over 2,000 participants indicates significant metabolic health improvements, challenging myths…

Henrique Autran · Jan 24, 2025 2,432 views
Ashwin Subbaraj
@AshPT2018 · X

RT @nicknorwitz: @janellison https://t.co/PimzAW26Wn https://t.co/suv3QKtK3j https://t.co/Khi2oH4l7B I may have written a 350 page thesi…

Apr 12, 2023 · 1 share · 590 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

@janellison https://t.co/PimzAW26Wn https://t.co/suv3QKtK3j https://t.co/Khi2oH4l7B I may have written a 350 page thesis on that topic

Apr 12, 2023 · 11 likes · 1 share · 109,430 followers View post →
David Bezpalec
@BezpalecDavid · X

https://t.co/KkZdfoQvL2

Mar 27, 2023 · 1,424 followers View post →
Nicole Laurent, LMHC
@KetoCounselor · X

Then you should check in with these researchers who literally wrote a paper all about it in 2019. I keep telling you all. I am not making this stuff up

Jan 31, 2023 · 9,032 followers View post →
KOJI@プライマルコーチ
@kojija · X

【βHBはHCAR2を介して抗酸化作用】 FOXO3Aを活性することで、抗酸化酵素であるSODが生まれて抗酸化酵素活性 βHB/HCAR2/AMPK/SIRT1/FOXO3A/MnSOD(抗酸化酵素)⇧ https://t.co/GH7bXvb7NT https://t.co/43oHnuZ8Eh

Oct 30, 2022 · 1 like · 2,310 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

Absolutely! #Parkinson https://t.co/Mdp2aHiYBf https://t.co/euVtnL0Pvg This last only share because BP had PD was in the trials, loved way she felt and has been #keto ever since. Sometimes patient voice means more than any research. FWIW https://t.co/MUars6DRr8 https://t.co/8RYXhccreR

Sep 24, 2021 · 10 likes · 109,430 followers View post →
The Troy
@WichanonTroy · X

Thesis Challange: The Mechanisms by Which the Ketone Body May Improve the Multiple Cellular Pathologies of Parkinson's Disease https://t.co/h51BNQctvj

Jul 28, 2021 · 74 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

@TerriEdmonston @lochossian Answer: yes. Here are 3 papers on the topic. https://t.co/euVtnL0Pvg https://t.co/OyZ8pWH4Lb https://t.co/iBwNTFLdb3

Aug 24, 2020 · 109,430 followers View post →
IberianCitizen
@IberianCitizen · X

Mecanismos por los que el D-β-hidroxibutirato puede mejorar las múltiples patologías celulares de la enfermedad de Parkinson by @nicknorwitz https://t.co/7bJk4E41hY https://t.co/zyyprJUvwY

Aug 19, 2020 · 11 likes · 12,932 followers View post →
Trevor Quinton
@TrevorKQuinton · X

RT @nicknorwitz: #Ketones / BHB bolster the body’s natural #antioxidant defenses by supporting regeneration of NADPH https://t.co/euVtnL0P…

Aug 11, 2020 · 2 shares · 1,092 followers View post →
Adam Isherwood
@AdamIsherwood5 · X

RT @nicknorwitz: #Ketones / BHB bolster the body’s natural #antioxidant defenses by supporting regeneration of NADPH https://t.co/euVtnL0P…

Aug 11, 2020 · 2 shares · 306 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

#Ketones / BHB bolster the body’s natural #antioxidant defenses by supporting regeneration of NADPH https://t.co/euVtnL0Pvg https://t.co/AW936l646H

Aug 11, 2020 · 8 likes · 2 shares · 109,430 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

@AbAnand9 And NADPH (not to be confused with NADH) is itself supported by ketosis. https://t.co/kEWUt63Z3b https://t.co/0ibJsbtqkq

Jul 20, 2020 · 109,430 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

@GeorgiaEdeMD @lochossian Very well put. Def all about metabolic dysfunction. Couldn't agree more. Below two reviews on the topic. Open access. https://t.co/P8ks97LpAq https://t.co/euVtnL0Pvg https://t.co/d03TiDeyIR

Jun 12, 2020 · 1 like · 109,430 followers View post →
Ginger Sladky⌛☮️
@dragin97 · X

RT @nicknorwitz: For those who think all chronic disease, including #Alzheimer's come down to metabolic dysfunction & poor lifestyle https:…

Apr 25, 2020 · 3 shares · 1,077 followers View post →
Shaun Scott
@upyrbike · X

RT @nicknorwitz: For those who think all chronic disease, including #Alzheimer's come down to metabolic dysfunction & poor lifestyle https:…

Apr 24, 2020 · 3 shares · 1,439 followers View post →
kLee
@AndrokLee · X

RT @nicknorwitz: For those who think all chronic disease, including #Alzheimer's come down to metabolic dysfunction & poor lifestyle https:…

Apr 24, 2020 · 3 shares · 1,532 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

For those who think all chronic disease, including #Alzheimer's come down to metabolic dysfunction & poor lifestyle https://t.co/JgrkTJzLS7 https://t.co/kEWUt63Z3b https://t.co/KUGUwj6evi

Apr 24, 2020 · 10 likes · 3 shares · 109,430 followers View post →
Pattibe
@pattiber1 · X

RT @upyrbike: @michaelwoodhci @AnnChildersMD @GeorgiaEdeMD 2019 Hu et al: “ The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May…

Feb 21, 2020 · 1 share · 778 followers View post →
Shaun Scott
@upyrbike · X

@michaelwoodhci @AnnChildersMD @GeorgiaEdeMD 2019 Hu et al: “ The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of Parkinson's Disease” https://t.co/IRWpgJ6oMN

Feb 20, 2020 · 2 likes · 1 share · 1,439 followers View post →
Frontiers - Nutrition
@FrontNutrition · X

The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of #Parkinsons Disease Read the full #openaccess review here: https://t.co/sY2M3A1Zmx #health #disease #nutrition https://t.co/0aZUb0lDYw

Dec 29, 2019 · 2 likes · 3,898 followers View post →
Simon Gonzalez
@simonkill909 · X

RT @I_mitochondria: Hyperinsulinemia inhibits ketogenesis = little to no ketones (BHB) for the brain. BHB = fuel, anti-oxidant & signalling…

Dec 17, 2019 · 9 shares · 134 followers View post →
Jorge Riquelme
@RiquelmeJorge · X

RT @I_mitochondria: Hyperinsulinemia inhibits ketogenesis = little to no ketones (BHB) for the brain. BHB = fuel, anti-oxidant & signalling…

Dec 17, 2019 · 9 shares · 846 followers View post →
Marco Reyes, RChE
@hancole1 · X

RT @I_mitochondria: Hyperinsulinemia inhibits ketogenesis = little to no ketones (BHB) for the brain. BHB = fuel, anti-oxidant & signalling…

Dec 17, 2019 · 9 shares · 114 followers View post →
HENRI PINEDA
@Endocrino_TV · X

RT @I_mitochondria: Hyperinsulinemia inhibits ketogenesis = little to no ketones (BHB) for the brain. BHB = fuel, anti-oxidant & signalling…

Dec 17, 2019 · 9 shares · 560 followers View post →
AnaMuñiz
@megustastarbien · X

RT @I_mitochondria: Hyperinsulinemia inhibits ketogenesis = little to no ketones (BHB) for the brain. BHB = fuel, anti-oxidant & signalling…

Dec 17, 2019 · 9 shares · 4,748 followers View post →
Andrew Miles
@MilesHighLife · X

RT @I_mitochondria: Hyperinsulinemia inhibits ketogenesis = little to no ketones (BHB) for the brain. BHB = fuel, anti-oxidant & signalling…

Dec 17, 2019 · 9 shares · 1,448 followers View post →
Jordi Garcia Alberch
@JGA_bdn · X

RT @I_mitochondria: Hyperinsulinemia inhibits ketogenesis = little to no ketones (BHB) for the brain. BHB = fuel, anti-oxidant & signalling…

Dec 17, 2019 · 9 shares · 120 followers View post →
Isabella Cooper
@I_mitochondria · X

Hyperinsulinemia inhibits ketogenesis = little to no ketones (BHB) for the brain. BHB = fuel, anti-oxidant & signalling molecule. Endogenously produced BHB means physiologically healthy insulin and glucose levels for the individual. https://t.co/FUk3LjY90U https://t.co/zhnrLwBikl

Dec 16, 2019 · 24 likes · 9 shares · 10,363 followers View post →
Natural Law Enforcer
@BChinatti · X

RT @upyrbike: @FructoseNo @GeorgiaEdeMD @MigraineBook @BenBikmanPhD @BelindaFettke @KenDBerryMD @ProfTimNoakes @bschermd @drjoesDIYhealth @…

Nov 30, 2019 · 1 share · 1,210 followers View post →
Shaun Scott
@upyrbike · X

@FructoseNo @GeorgiaEdeMD @MigraineBook @BenBikmanPhD @BelindaFettke @KenDBerryMD @ProfTimNoakes @bschermd @drjoesDIYhealth @DrAseemMalhotra From the Oxford ‘Ketone Lab’ (Clarke, DPAG) 2019: PD: https://t.co/IRWpgJ6oMN AD: https://t.co/XTfYvst1ok

Nov 29, 2019 · 5 likes · 1 share · 1,439 followers View post →
Jake Mey, PhD, RD
@CakeNutrition · X

@PrimaryCarePAC Humans too

Oct 18, 2019 · 1 like · 8,645 followers View post →
Steven M. Weil
@smweilhermes · X

RT @CoberlyRobert: K Clarke& Oxford Neuroscience. Review focused on DBHB energetic,redox,epigenetic,HCA receptor actions. https://t.co/6oTg…

Jun 7, 2019 · 1 share · 305 followers View post →
Robert Coberly
@CoberlyRobert · X

K Clarke& Oxford Neuroscience. Review focused on DBHB energetic,redox,epigenetic,HCA receptor actions. https://t.co/6oTgNgwdUo &there is more to consider.For neuropharm effects, also read Rho JM,Cunnane SC,Masino SA,Kossoff EH,Hartman AL...&others https://t.co/8CxpfLVMto

Jun 6, 2019 · 1 like · 1 share · 150 followers View post →
Tracey Kilgour
@tkilgour11 · X

The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of Parkinson's Disease https://t.co/nVrtwulQ8n

Jun 6, 2019 · 1 like · 167 followers View post →
DesignedByNature
@DesignedNature · X

I just posted "The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of Parkinson's Disease - May 2019" on Reddit https://t.co/1322Uj5cbC

Jun 4, 2019 · 441 followers View post →
Dianne Bramble
@diannejgb · X

RT @ScienceofPD: An excellent review of the mechanisms by which the ketone body D-β-Hydroxybutyrate may improve various pathologies of #Par…

May 31, 2019 · 1 share · 273 followers View post →
GirlyGirl
@PookySoupy · X

RT @ScienceofPD: An excellent review of the mechanisms by which the ketone body D-β-Hydroxybutyrate may improve various pathologies of #Par…

May 31, 2019 · 1 share · 1,579 followers View post →
The Science of Parkinson's
@ScienceofPD · X

An excellent review of the mechanisms by which the ketone body D-β-Hydroxybutyrate may improve various pathologies of #Parkinsons (this will be my reading on route to WPC) https://t.co/IR1qFXDaez https://t.co/Io1IVbtBC8

May 30, 2019 · 5 likes · 1 share · 10,888 followers View post →