Hyperinsulinemia inhibits ketogenesis = little to no ketones (BHB) for the brain. BHB = fuel, anti-oxidant & signalling molecule. Endogenously produced BHB means physiologically healthy insulin and glucose levels for the individual. https://t.co/FUk3LjY90U https://t.co/zhnrLwBikl
The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of Parkinson's Disease.
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May 2019 – Jan 2025Where it's discussed
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X / Twitter39 posts
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YouTube3 videos
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Facebook2 posts
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News2 articles
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What people are saying
The discussions frequently affirm the significance of the article by referencing related research from 2019 and noting how ketone bodies influence cellular pathways like antioxidant defenses. Words like 'excellent review,' 'game changer,' and mentions of molecular mechanisms such as SOD activity and NADPH regeneration reflect a tone of respect and curiosity, indicating high engagement and interest, but with a cautious view on immediate impact.
Most discussions support the potential benefits of ketone bodies, referencing prior research and expressing optimism about the mechanism described in the publication.
Posts show high interest by sharing detailed insights, relevant reviews, and personal accounts about ketosis and Parkinson's disease.
Many posts delve into the molecular pathways, cite previous studies, and discuss implications, indicating deep engagement.
While some highlight the importance of this research for future therapies, others emphasize personal experiences, suggesting moderate perceived impact.
Abstract in brief
- Parkinson's disease involves the progressive loss of dopamine-producing neurons, and current treatments mainly manage symptoms rather than stopping the disease's progression.
- The ketone body D-hydroxybutyrate, produced during fasting or ketogenic diets, might offer neuroprotective benefits by supporting neuron energy production and reducing oxidative damage, potentially slowing or preventing disease development.
- D-hydroxybutyrate works both as a metabolic fuel and as a signaling molecule, influencing cellular pathways that could help protect neurons, making it a promising candidate for future therapies targeting the underlying causes of Parkinson's disease.]
Top posts
Most liked on X and Bluesky@janellison https://t.co/PimzAW26Wn https://t.co/suv3QKtK3j https://t.co/Khi2oH4l7B I may have written a 350 page thesis on that topic
Mecanismos por los que el D-β-hidroxibutirato puede mejorar las múltiples patologías celulares de la enfermedad de Parkinson by @nicknorwitz https://t.co/7bJk4E41hY https://t.co/zyyprJUvwY
Absolutely! #Parkinson https://t.co/Mdp2aHiYBf https://t.co/euVtnL0Pvg This last only share because BP had PD was in the trials, loved way she felt and has been #keto ever since. Sometimes patient voice means more than any research. FWIW https://t.co/MUars6DRr8 https://t.co/8RYXhccreR
For those who think all chronic disease, including #Alzheimer's come down to metabolic dysfunction & poor lifestyle https://t.co/JgrkTJzLS7 https://t.co/kEWUt63Z3b https://t.co/KUGUwj6evi
#Ketones / BHB bolster the body’s natural #antioxidant defenses by supporting regeneration of NADPH https://t.co/euVtnL0Pvg https://t.co/AW936l646H
All mentions
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RT @nicknorwitz: @janellison https://t.co/PimzAW26Wn https://t.co/suv3QKtK3j https://t.co/Khi2oH4l7B I may have written a 350 page thesi…
@janellison https://t.co/PimzAW26Wn https://t.co/suv3QKtK3j https://t.co/Khi2oH4l7B I may have written a 350 page thesis on that topic
https://t.co/KkZdfoQvL2
Then you should check in with these researchers who literally wrote a paper all about it in 2019. I keep telling you all. I am not making this stuff up
【βHBはHCAR2を介して抗酸化作用】 FOXO3Aを活性することで、抗酸化酵素であるSODが生まれて抗酸化酵素活性 βHB/HCAR2/AMPK/SIRT1/FOXO3A/MnSOD(抗酸化酵素)⇧ https://t.co/GH7bXvb7NT https://t.co/43oHnuZ8Eh
Absolutely! #Parkinson https://t.co/Mdp2aHiYBf https://t.co/euVtnL0Pvg This last only share because BP had PD was in the trials, loved way she felt and has been #keto ever since. Sometimes patient voice means more than any research. FWIW https://t.co/MUars6DRr8 https://t.co/8RYXhccreR
Thesis Challange: The Mechanisms by Which the Ketone Body May Improve the Multiple Cellular Pathologies of Parkinson's Disease https://t.co/h51BNQctvj
@TerriEdmonston @lochossian Answer: yes. Here are 3 papers on the topic. https://t.co/euVtnL0Pvg https://t.co/OyZ8pWH4Lb https://t.co/iBwNTFLdb3
Mecanismos por los que el D-β-hidroxibutirato puede mejorar las múltiples patologías celulares de la enfermedad de Parkinson by @nicknorwitz https://t.co/7bJk4E41hY https://t.co/zyyprJUvwY
RT @nicknorwitz: #Ketones / BHB bolster the body’s natural #antioxidant defenses by supporting regeneration of NADPH https://t.co/euVtnL0P…
RT @nicknorwitz: #Ketones / BHB bolster the body’s natural #antioxidant defenses by supporting regeneration of NADPH https://t.co/euVtnL0P…
#Ketones / BHB bolster the body’s natural #antioxidant defenses by supporting regeneration of NADPH https://t.co/euVtnL0Pvg https://t.co/AW936l646H
@AbAnand9 And NADPH (not to be confused with NADH) is itself supported by ketosis. https://t.co/kEWUt63Z3b https://t.co/0ibJsbtqkq
@GeorgiaEdeMD @lochossian Very well put. Def all about metabolic dysfunction. Couldn't agree more. Below two reviews on the topic. Open access. https://t.co/P8ks97LpAq https://t.co/euVtnL0Pvg https://t.co/d03TiDeyIR
RT @nicknorwitz: For those who think all chronic disease, including #Alzheimer's come down to metabolic dysfunction & poor lifestyle https:…
RT @nicknorwitz: For those who think all chronic disease, including #Alzheimer's come down to metabolic dysfunction & poor lifestyle https:…
RT @nicknorwitz: For those who think all chronic disease, including #Alzheimer's come down to metabolic dysfunction & poor lifestyle https:…
For those who think all chronic disease, including #Alzheimer's come down to metabolic dysfunction & poor lifestyle https://t.co/JgrkTJzLS7 https://t.co/kEWUt63Z3b https://t.co/KUGUwj6evi
RT @upyrbike: @michaelwoodhci @AnnChildersMD @GeorgiaEdeMD 2019 Hu et al: “ The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May…
@michaelwoodhci @AnnChildersMD @GeorgiaEdeMD 2019 Hu et al: “ The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of Parkinson's Disease” https://t.co/IRWpgJ6oMN
The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of #Parkinsons Disease Read the full #openaccess review here: https://t.co/sY2M3A1Zmx #health #disease #nutrition https://t.co/0aZUb0lDYw
RT @I_mitochondria: Hyperinsulinemia inhibits ketogenesis = little to no ketones (BHB) for the brain. BHB = fuel, anti-oxidant & signalling…
RT @I_mitochondria: Hyperinsulinemia inhibits ketogenesis = little to no ketones (BHB) for the brain. BHB = fuel, anti-oxidant & signalling…
RT @I_mitochondria: Hyperinsulinemia inhibits ketogenesis = little to no ketones (BHB) for the brain. BHB = fuel, anti-oxidant & signalling…
RT @I_mitochondria: Hyperinsulinemia inhibits ketogenesis = little to no ketones (BHB) for the brain. BHB = fuel, anti-oxidant & signalling…
RT @I_mitochondria: Hyperinsulinemia inhibits ketogenesis = little to no ketones (BHB) for the brain. BHB = fuel, anti-oxidant & signalling…
RT @I_mitochondria: Hyperinsulinemia inhibits ketogenesis = little to no ketones (BHB) for the brain. BHB = fuel, anti-oxidant & signalling…
RT @I_mitochondria: Hyperinsulinemia inhibits ketogenesis = little to no ketones (BHB) for the brain. BHB = fuel, anti-oxidant & signalling…
Hyperinsulinemia inhibits ketogenesis = little to no ketones (BHB) for the brain. BHB = fuel, anti-oxidant & signalling molecule. Endogenously produced BHB means physiologically healthy insulin and glucose levels for the individual. https://t.co/FUk3LjY90U https://t.co/zhnrLwBikl
RT @upyrbike: @FructoseNo @GeorgiaEdeMD @MigraineBook @BenBikmanPhD @BelindaFettke @KenDBerryMD @ProfTimNoakes @bschermd @drjoesDIYhealth @…
@FructoseNo @GeorgiaEdeMD @MigraineBook @BenBikmanPhD @BelindaFettke @KenDBerryMD @ProfTimNoakes @bschermd @drjoesDIYhealth @DrAseemMalhotra From the Oxford ‘Ketone Lab’ (Clarke, DPAG) 2019: PD: https://t.co/IRWpgJ6oMN AD: https://t.co/XTfYvst1ok
@PrimaryCarePAC Humans too
RT @CoberlyRobert: K Clarke& Oxford Neuroscience. Review focused on DBHB energetic,redox,epigenetic,HCA receptor actions. https://t.co/6oTg…
K Clarke& Oxford Neuroscience. Review focused on DBHB energetic,redox,epigenetic,HCA receptor actions. https://t.co/6oTgNgwdUo &there is more to consider.For neuropharm effects, also read Rho JM,Cunnane SC,Masino SA,Kossoff EH,Hartman AL...&others https://t.co/8CxpfLVMto
The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of Parkinson's Disease https://t.co/nVrtwulQ8n
I just posted "The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of Parkinson's Disease - May 2019" on Reddit https://t.co/1322Uj5cbC
RT @ScienceofPD: An excellent review of the mechanisms by which the ketone body D-β-Hydroxybutyrate may improve various pathologies of #Par…
RT @ScienceofPD: An excellent review of the mechanisms by which the ketone body D-β-Hydroxybutyrate may improve various pathologies of #Par…
An excellent review of the mechanisms by which the ketone body D-β-Hydroxybutyrate may improve various pathologies of #Parkinsons (this will be my reading on route to WPC) https://t.co/IR1qFXDaez https://t.co/Io1IVbtBC8