The discussions show a nuanced perspective, with users referencing experimental findings, such as null results from research, to question traditional views that dehydration causes blood sugar dysregulation, and they use lively examples like ecstasy's effects to challenge or expand current understanding. The tone combines scientific critique with curiosity, reflecting active engagement and an interest in advancing the field.
AgreementModerate agreement
Most discussions acknowledge the complexity of hydration and AVP's role in blood sugar regulation, with some highlighting that manipulating hydration may not improve glucoregulatory health, thus showing partial agreement with the article's cautious stance
InterestHigh interest
The tweets demonstrate high interest, evidenced by references to new research, personal studies, and innovative ideas such as using ecstasy as a model to understand AVP's effects.
EngagementModerate engagement
Participants actively critique previous assumptions, share their research experiences, and discuss the implications, indicating moderate engagement.
ImpactModerate impact
Debates surrounding the validity of existing theories and the potential for new models suggest a modest but meaningful impact in challenging prevailing ideas in hydration research.
Abstract in brief
The article reviews the role of water intake and arginine vasopressin (AVP) in regulating blood sugar levels, highlighting that current dietary guidelines promoting water consumption are not based on direct causal evidence but rather on mechanistic data and observational studies.
Historically, research in the 1970s and 1980s linked elevated AVP levels to blood sugar regulation, but interest in this area waned until recent decades, when new types of studies, including human hydration manipulations, revived the investigation into AVP’s role in glucoregulation.
The authors suggest that while AVP may influence blood sugar control, evidence from more realistic human studies indicates this effect could be independent of hydration status itself, implying that simply increasing water intake to lower AVP might not necessarily improve glucoregulatory health.]
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
First theory paper now published! Very excited to get this out as its a culmination of lots of theories ive had brewing over the last few years about the influence of AVP, #hydration status, & #glucose regulation... 1/9
#Health #diabetes #metabolism #water
https://t.co/N7LkJvOgW5 https://t.co/jBkvKoEbC2
May 28, 2019 · 23 likes · 4 shares · 8,810 followersView post →
HC
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
Fun fact: ecstasy (the party drug) gives all the *symptoms* of DEhydration, when on a cellular level it cause OVERhydration. as such, it can be useful to understand the independent effects of certain systems:
https://t.co/N7LkJvOgW5
easy to read summary: https://t.co/b9BzORFY8z
Dec 2, 2020 · 14 likes · 8 shares · 8,810 followersView post →
HC
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
Here is an example: my PhD found null findings in one of my studies. This offered the opportunity to explore the validity of the prior research and its underpinning ideas on the topic. If we try to ignore these results, we fail to progress
https://t.co/QYKwvHA7gi
Feb 16, 2023 · 10 likes · 8,810 followersView post →
HC
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
@Saltykid41 @Mae522018 Yes it does. Heres an example: the way me and my colleague read the literature came to a vastly different conclusion to most others. Both perspectives are data driven expert opinion
https://t.co/QYKwvHA7gi
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
And it also adds weight to me and Lewis' hypothesis that "manipulating hydration status to reduce circulating AVP concentrations may not be an effective method to improve glucoregulatory health"
https://t.co/N7LkJvOOLD
Mar 21, 2025 · 2 likes · 8,810 followersView post →
HC
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
2. Our opinion on current theories relating to AVP, hydration and glucoregulation. Including how we can use #ecstacy as a model to uncouple AVP and hydration
https://t.co/N7LkJvOgW5
#H4H2019 #hydration #Health #mdma 2/2
Jun 26, 2019 · 1 like · 8,810 followersView post →
Diabetes type 2 is a chronic disease that can be prevented. This video explores overlooked causes and misconceptions about diabetes, including diagnostic criteria and risk factors, emphasizing the importance of…
This video explores the role of water intake and arginine vasopressin in blood sugar regulation, emphasizing that current guidelines are based on mechanistic data. Recent studies suggest AVP's impact on glucoregulation…
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
RT @angryhacademic: Fun fact: ecstasy (the party drug) gives all the *symptoms* of DEhydration, when on a cellular level it cause OVERhydra…
Dec 2, 2025 · 8 shares · 8,810 followersView post →
YG
YO PEEP GAME!
@YDWYPG · X
RT @angryhacademic: Fun fact: ecstasy (the party drug) gives all the *symptoms* of DEhydration, when on a cellular level it cause OVERhydra…
May 28, 2025 · 8 shares · 2,383 followersView post →
HC
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
And it also adds weight to me and Lewis' hypothesis that "manipulating hydration status to reduce circulating AVP concentrations may not be an effective method to improve glucoregulatory health"
https://t.co/N7LkJvOOLD
Mar 21, 2025 · 2 likes · 8,810 followersView post →
R
rachel
@shadowboxer73 · X
RT @angryhacademic: Fun fact: ecstasy (the party drug) gives all the *symptoms* of DEhydration, when on a cellular level it cause OVERhydra…
Dec 2, 2024 · 8 shares · 1,997 followersView post →
HC
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
RT @angryhacademic: Fun fact: ecstasy (the party drug) gives all the *symptoms* of DEhydration, when on a cellular level it cause OVERhydra…
Dec 2, 2024 · 8 shares · 8,810 followersView post →
A
Alex
@softminus · X
RT @angryhacademic: Fun fact: ecstasy (the party drug) gives all the *symptoms* of DEhydration, when on a cellular level it cause OVERhydra…
Dec 1, 2023 · 8 shares · 10,096 followersView post →
HC
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
RT @angryhacademic: Fun fact: ecstasy (the party drug) gives all the *symptoms* of DEhydration, when on a cellular level it cause OVERhydra…
Dec 1, 2023 · 8 shares · 8,810 followersView post →
HC
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
Here is an example: my PhD found null findings in one of my studies. This offered the opportunity to explore the validity of the prior research and its underpinning ideas on the topic. If we try to ignore these results, we fail to progress
https://t.co/QYKwvHA7gi
Feb 16, 2023 · 10 likes · 8,810 followersView post →
HC
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
RT @angryhacademic: Fun fact: ecstasy (the party drug) gives all the *symptoms* of DEhydration, when on a cellular level it cause OVERhydra…
Dec 2, 2022 · 8 shares · 8,810 followersView post →
HC
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
@Saltykid41 @Mae522018 Yes it does. Heres an example: the way me and my colleague read the literature came to a vastly different conclusion to most others. Both perspectives are data driven expert opinion
https://t.co/QYKwvHA7gi
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
3. academically in my field (hydration), the current party line to tow is that dehydration causes blood sugar dysregulation. i based 2 masters degrees & a PhD on this idea. here i am disagreeing with that as new data suggested to me that the idea was wrong
https://t.co/QYKwvHA7gi
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
Fun fact: ecstasy (the party drug) gives all the *symptoms* of DEhydration, when on a cellular level it cause OVERhydration. as such, it can be useful to understand the independent effects of certain systems:
https://t.co/N7LkJvOgW5
easy to read summary: https://t.co/b9BzORFY8z
Dec 2, 2020 · 14 likes · 8 shares · 8,810 followersView post →
CR
CREEB Roehampton
@CREEBroehampton · X
RT @angryhacademic: First theory paper now published! Very excited to get this out as its a culmination of lots of theories ive had brewing…
Mar 25, 2020 · 4 shares · 708 followersView post →
HC
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
@JonDavidAdams @USARIEM Cant access the full text on my phone. Sounds v interesting though
We also touched on the pitfalls on AVP as a hydration biomarker in our perspective piece. Imo we need to distinguish total body water (hydration status) & hydration physiology a bit better
https://t.co/N7LkJvwFxv
RT @angryhacademic: First theory paper now published! Very excited to get this out as its a culmination of lots of theories ive had brewing…
Jan 16, 2020 · 4 shares · 1,653 followersView post →
H
HEATStressLab
@HEATStressLab · X
RT @angryhacademic: First theory paper now published! Very excited to get this out as its a culmination of lots of theories ive had brewing…
Jan 16, 2020 · 4 shares · 384 followersView post →
HC
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
Question from the audience about #diabetes insipidus - something we discuss in our persepctive piece:
https://t.co/N7LkJvOgW5
#H4H2019 #hydration #Health
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
2. Our opinion on current theories relating to AVP, hydration and glucoregulation. Including how we can use #ecstacy as a model to uncouple AVP and hydration
https://t.co/N7LkJvOgW5
#H4H2019 #hydration #Health #mdma 2/2
Jun 26, 2019 · 1 like · 8,810 followersView post →
HC
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
@MatthewJDalby Yeah sorry that got hidden a bit in the first tweet!
https://t.co/N7LkJvOgW5
May 28, 2019 · 1 like · 8,810 followersView post →
HC
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X
First theory paper now published! Very excited to get this out as its a culmination of lots of theories ive had brewing over the last few years about the influence of AVP, #hydration status, & #glucose regulation... 1/9
#Health #diabetes #metabolism #water
https://t.co/N7LkJvOgW5 https://t.co/jBkvKoEbC2
May 28, 2019 · 23 likes · 4 shares · 8,810 followersView post →
I
Blood sugar highs can be influenced by hydration. Low fluid intake ...
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... 10.3390/nu11061201. PMID: 31141915; PMCID: PMC6627358.) I personally wonder if the "dawn effect" seen in Type II diabetes where the glucose ...