Findings also support the REBUS hypothesis (https://t.co/Qfw5XE03Z4). While the precision of priors (TOP-related) goes down, increased connectivity in limbic areas may act as the ‘source’ of novel content emerging during psychedelics. More work is needed to test this directly 9/n
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics.
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Jun 2019 – Sep 2025Where it's discussed
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News82 articles
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X / Twitter59 posts
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Blogs15 articles
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YouTube6 videos
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AI synopsis
What people are saying
The discussions reflect a strong collective interest in how the REBUS model explains the relaxation of rigid beliefs through psychedelics, with users referencing specific mechanisms like limbic connectivity and predictive processing. The tone is enthusiastic and inquisitive, emphasizing the model's relevance to mental health and neuroscience, which contribute to the overall high agreement and impact scores.
Most discussions concur that the REBUS model offers a compelling framework for understanding psychedelics' effects on the brain, emphasizing its informative value for neuroscience and mental health.
Many posts display high curiosity, with multiple references to reading, exploring related papers, and discussing the model’s implications, indicating strong engagement and interest.
Frequent mentions of the paper's details, debates about the mechanisms, and calls to read or understand more demonstrate deep engagement with the concepts and research.
The discussions highlight the model’s potential to influence our understanding of belief formation, mental health treatments, and the neuroscience of psychedelics, suggesting a high impact in scientific and clinical fields.
Abstract in brief
- This paper introduces the REBUS model, which explains how psychedelics relax high-level beliefs in the brain by increasing brain entropy, allowing more bottom-up information to flow, especially from the limbic system.
- It suggests that this process can help revise overly rigid or pathological beliefs, providing a potential mechanism for therapeutic benefits in mental health conditions.
- The model also implies that psychedelics could potentially help alter deeply held beliefs outside of mental health, like political or religious views, by updating or softening heavily weighted prior beliefs.
Top posts
Most liked on X and Bluesky@painaulaitt good question — @JakeOrthwein mentioned a paper co-authored by Friston and Carhart-Harris on Predictive Processing and psychedelics — I think here: https://t.co/Ko62uzykYe @sunofdopamine also mentioned a paper on PP and EMDR, which I can't find because Twitter search is trash
@spirit_raccoon REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics R L Carhart-Harris, K J Friston This paper formulates the action of psychedelics by integrating the free-energy principle and entropic brain hypothesis. We call this formulation relaxed
@visakanv Low neural annealing When temp is low, you get stuck in local maxima A lot of psychedelic and ai science seems to be pointing toward a brain model like this. Have you read REBUS ? https://t.co/NjgAsQtWko https://t.co/gqyvvY9vwj
Strengthened beliefs under psychedelics (SEBUS)? A Commentary on "REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics" https://t.co/N6M5cOYcFV
@PaulAustin3w Not a really a 'discovery' but this is the best as attempt so far a explaining how psychedelics work. "REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics" https://t.co/CGXioPyy1w https://t.co/noCqj6J3CQ
All mentions
Exploring Consciousness: REBUS and Psychedelic Brain Actions
This video delves into consciousness and its relation to psychedelics via the REBUS model. It summarizes key research including Carhart-Harris's theories on brain states influenced by psychedelics, aiming for a unified…
Psychedelics, Entropy, and the Anarchic Brain Explained
This webinar, led by Dr. Samuli Kangaslampi, explores how psychedelics influence the brain and mind by examining mechanisms of action through the lens of entropy and anarchic models. The presentation discusses credible…
The Role of Psychedelics in Inducing Mystical Experiences and Personal Growth
Psilocybin can trigger mystical-like experiences with lasting personal and spiritual significance. When administered in supportive settings, high doses induce perceptual and emotional changes, leading to enduring…
Understanding the Neuroscience of Psychedelics
This video explores the neuroscience behind psychedelics, referencing comprehensive studies on brain function and consciousness. Notable works include insights from Carhart-Harris and Friston on unifying brain action…
Integrating Your Psychedelic Experience: A 3-Step Approach
Had a huge ceremony and now everything feels overwhelming. This video covers the science behind the psychedelic aftermath and offers a simple 3-step plan for stabilizing and integrating your experience safely, based on…
Understanding GABA and DMT's Role in Brain Function
This video explores the roles of GABA and DMT within brain functions. It reviews research from various studies, including recent work by Parnia et al. and Carhart-Harris et al., to illustrate how these compounds…
@Nayberryk Relevant to all these cfsers we’re talking to: https://t.co/iuMK0v8L7a
カリフォルニア大学サンフランシスコ校のRobin Carhart‑Harris(ロビン・カート・ハリス)「REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics (幻覚下での信念の弛緩およびアナーキーな脳)」(2019)を調べた。 自由エネルギー原理とエントロピー脳仮説 を統合し、幻覚薬が高レベルの信念を弛緩させ、ボトムアップの信号伝達を解放(アナーキーな状態)にするという理論。薬物による現実感覚変容を説明するモデル。いかに私たちが信念によって現実を枠組みづけているか。
@spirit_raccoon REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics R L Carhart-Harris, K J Friston This paper formulates the action of psychedelics by integrating the free-energy principle and entropic brain hypothesis. We call this formulation relaxed
RT @K_Dong96: #CNS2025 | Just happened Poster session F @michaelangyus presented a study exploring “Does prediction error in the auditoty s…
RT @K_Dong96: #CNS2025 | Just happened Poster session F @michaelangyus presented a study exploring “Does prediction error in the auditoty s…
#CNS2025 | Just happened Poster session F Michael Angyus presented a study exploring “Does prediction error in the auditoty system have associated changes in entropy” using an auditory odd ball task. They find a correlation with entropy and MMN amplitude. pubmed.ncbi.nlm.nih.gov/31221820/
#CNS2025 | Just happened Poster session F @michaelangyus presented a study exploring “Does prediction error in the auditoty system have associated changes in entropy” using an auditory odd ball task. They find a correlation with entropy and MMN amplitude. https://t.co/zCXwGX2G9U https://t.co/khV5R01eQB
@_coenen Absolutely. Have you read REBUS by Carhart Harris? If not, you need to: https://t.co/NjgAsQtWko
“REBUS” suggests psychedelics relax a rigid brain, enabling new connections. This model offers insights into reducing rumination and fostering adaptation in conditions like #PTSD, #chronicpain, or #depression. Read more: doi.org/10.1124/pr.118.017160 #Psychedelics #Neuroscience #MentalHealth #REBUS
@georgejwdeane @introspection @NeuroConsc @EricElmoznino @ConstantAxel @g_lajoie_ And the associated papers here: https://t.co/uKzoLouUfu https://t.co/Epckz51vt4 https://t.co/5w63kyS3vn
@visakanv Low neural annealing When temp is low, you get stuck in local maxima A lot of psychedelic and ai science seems to be pointing toward a brain model like this. Have you read REBUS ? https://t.co/NjgAsQtWko https://t.co/gqyvvY9vwj
@QualiaRI @InferenceActive 59↑ REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics https://t.co/AwPF8usiBj
RT @neurodelia: Findings also support the REBUS hypothesis (https://t.co/Qfw5XE03Z4). While the precision of priors (TOP-related) goes down…
RT @neurodelia: Findings also support the REBUS hypothesis (https://t.co/Qfw5XE03Z4). While the precision of priors (TOP-related) goes down…
Findings also support the REBUS hypothesis (https://t.co/Qfw5XE03Z4). While the precision of priors (TOP-related) goes down, increased connectivity in limbic areas may act as the ‘source’ of novel content emerging during psychedelics. More work is needed to test this directly 9/n
@painaulaitt good question — @JakeOrthwein mentioned a paper co-authored by Friston and Carhart-Harris on Predictive Processing and psychedelics — I think here: https://t.co/Ko62uzykYe @sunofdopamine also mentioned a paper on PP and EMDR, which I can't find because Twitter search is trash
Are you familiar with the REBUS model of psychodelics? Relaxed Beliefs Under Psychodelics. REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of #Psychedelics https://t.co/a6pDRh3GYx
https://t.co/VHrkA4SdQT
@jillnephew [4/n] Arguably the highest-level model is the REBUS/EBH from Carhart-Harris and Friston. You could argue that it satisfies some criteria of "mechanism" (if you're okay with higher-order causal relationships). https://t.co/krVmIMhxdq
@HundredthIdiot https://t.co/KtyF0623FX
@tangled_zans This is a pretty comprehensive proposal that I'm generally sympathetic to (although it makes a *lot* of simplifying assumptions about the serotonin system). https://t.co/bywBwSF4Qu
In his view, "the REBUS model" (https://t.co/mgtGXds43n) does not emphasize the potential contributions of Cortico-Striato-ThalamoCortical feedback mechanisms enough." Non-pharmacological methods (https://t.co/8XhAgaeZts) indicate that subcortical regions are important as well.
@keithfrankish https://t.co/MvxgYyYxpL
RT @ViewsOnDrugsBot: REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of #Psychedelics 1/5 https://t.co/V8GYjk5Xje
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of #Psychedelics 1/5 https://t.co/V8GYjk5Xje
RT @Astro_Erik: @clemoscatarina @cerebral_haze @sierra_photon @Clubhouse Thanks for the reference* @creon *relaxed beliefs under psyched…
@clemoscatarina @cerebral_haze @sierra_photon @Clubhouse Thanks for the reference* @creon *relaxed beliefs under psychedelics https://t.co/sgddPvkxxg
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics https://t.co/4voUJK6Dtw
RT @KlinkBart: Fascinating review of the neuroscience of psychedelics by @RCarhartHarris and Karl Friston. Naturalistic explanations of the…
Fascinating review of the neuroscience of psychedelics by @RCarhartHarris and Karl Friston. Naturalistic explanations of these wonderful experiences are getting better and better. The supernatural is not needed to explain it. https://t.co/W2HXXN4xgn
Have you read this paper, REBUS? Groundbreaking ideas about psychedelics and belief formation REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics: https://t.co/HX92N67Hii
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics https://t.co/BFZjrO8Ljd
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics https://t.co/mxip6V9HCL https://t.co/pZVkCcjC8D
Strengthened Beliefs Under Psychedelics (SEBUS)? A Commentary on "REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics" https://t.co/9dG2njjt7f
Commenting on the seminal REBUS paper by Carhart-Harris and Friston (2019). https://t.co/ErXDzWqebz
RT @PsyArXivBot: Strengthened beliefs under psychedelics (SEBUS)? A Commentary on "REBUS and the Anarchic Brain: Toward a Unified Model of…
Strengthened beliefs under psychedelics (SEBUS)? A Commentary on "REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics" https://t.co/N6M5cOYcFV
#REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics - 2019 paper by R. L. Carhart-Harris and K. J. Friston https://t.co/EcqL3tSUpq #science
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics - 2019 paper by R. L. Carhart-Harris and K. J. Friston https://t.co/QIa4MmT7xS
RT @Neur0naut: @PaulAustin3w Not a really a 'discovery' but this is the best as attempt so far a explaining how psychedelics work. "REBUS a…
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics https://t.co/GRU63oabcg
@PaulAustin3w Not a really a 'discovery' but this is the best as attempt so far a explaining how psychedelics work. "REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics" https://t.co/CGXioPyy1w https://t.co/noCqj6J3CQ
@bayesianboy @casper_hesp @neuropoetic @fluffycyborg @MdKirchhoff @hohwy If you're interested in this stuff,..., check this out,..., REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics, This paper formulates the action of psychedelics by integrating the free-energy principle and entropic brain hypothesis
Both papers were a good primer before we dive into #REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics https://t.co/knaFoXtlla
RT @APRA_bot: REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics. https://t.co/4Hwgh4sZHT
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics. https://t.co/4Hwgh4sZHT
Pharmacological Reviews REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics https://t.co/3S7ZfCDVnL
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics https://t.co/2PKp92pTse
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics https://t.co/YtdWGW4Lxt MIND SWIRL: https://t.co/Umyh0vrF1e
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics @johnrkelly https://t.co/ekkZd7sfFM
Open Access, and a popular read - REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics: https://t.co/m1Pev7wMmd https://t.co/zyzLixIEoK
RT @ottpsychlist: Spending my day home sick re-reading "REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psyched…
Spending my day home sick re-reading "REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics" https://t.co/zCDFt0Mqb8 #psychedelics @RCarhartHarris #REBUS
A digest of Karl Friston and Robin Carhart-Harris's recent paper REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics. https://t.co/Wn8yEjfiZe
RElaxed Beliefs Under pSychedelics (REBUS) and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics | Pharmacological Reviews https://t.co/tuZZu0Icmo
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics | Pharmacological Reviews https://t.co/tuZZu0Icmo
@qorprate You mean "REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics"? I'll read it
Open Access UCL Research: REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics https://t.co/9525jMj7JT
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics. https://t.co/ST3Su9AP1Y
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics. https://t.co/pQoAvm1ctp
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics. https://t.co/kpeZcQgZYd