Overall, the social discussions reflect strong agreement with the study's conclusions, with many posts emphasizing the potential harm from long-term use of anticholinergic medications. Words such as 'significant', 'increased risk', and phrases like 'should be reconsidered' convey a tone of urgency and concern, illustrating that participants view this research as a pivotal call for reevaluating medication use in older populations.
AgreementModerate agreement
Most discussions support the connection between anticholinergic drugs and increased dementia risk, showing consensus on the study's findings.
InterestHigh interest
Many posts highlight the significance of the research, suggesting high curiosity and concern about the implications.
EngagementHigh engagement
Several participants reference specific studies, mention risk percentages, and debate the ethical and medical impacts, indicating deep engagement.
ImpactHigh impact
The widespread referencing of risk estimates and calls for cautious prescribing demonstrate that discussions see this research as highly impactful for public health and medical practice.
Abstract in brief
The study examined the long-term effects of anticholinergic drugs, which are medications known to cause short-term cognitive issues but with uncertain links to dementia, by analyzing data from older adults (55+) in England and finding that higher cumulative use was associated with an increased risk of developing dementia.
Researchers looked at the prescribed doses of 56 drugs with strong anticholinergic properties over 1 to 11 years before diagnosis and found that as the total dose increased, so did the likelihood of dementia, particularly for antidepressants and antiparkinson drugs.
Overall, the findings suggest that long-term use of anticholinergic medications may raise dementia risk, emphasizing the need for cautious prescribing, especially for older adults at risk for cognitive decline.]
@quantian1 nows a good time to remind everyone that chronic use of anticholinergics like benadryl will cause cognitive impairment and may increase your odds of contracting dementia later on by >60% https://t.co/kx9EzZUSRG
Aug 26, 2024 · 49 likes · 171 followersView post →
RM
Rachel S. Rubin, MD
@drrachelrubin · X
But the new libido drug causing mild nausea is too dangerous?
Jun 25, 2019 · 18 likes · 2 shares · 23,931 followersView post →
JM
JAMA Internal Medicine
@JAMAInternalMed · X
Anticholinergic Drug Exposure and the Risk of Dementia https://t.co/Ybj5EwX17z #MostCited
4/
Now we have increasing evidence from longitudinal studies that anticholinergic exposure increases dementia risk:
"The population-attributable fraction associated w/ anticholinergic drug exposure during the 1-11 years before diagnosis was 10.3%."
https://t.co/8MNHYJTUF4 https://t.co/YhIztctcBm
Jun 4, 2021 · 12 likes · 2 shares · 8,923 followersView post →
AM
Amy Park, MD
@dramypark · X
Maybe we can get better insurance coverage for mirabegron!
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | Dementia and Cognitive Impairment | JAMA Internal Medicine | JAMA Network https://t.co/RZSSGbQ8Bn
Jun 25, 2019 · 12 likes · 2 shares · 5,642 followersView post →
GS
Graham Stretch
@GrahamStretch · X
‘Anticholinergic Drug Exposure and the Risk of Dementia, A Nested Case-Control Study’ Coupland et al. Further evidence of anti-cholinergics risks and dementia https://t.co/8V2gxGeOZf https://t.co/DwpMtusDXo
Jun 24, 2019 · 11 likes · 2 shares · 9,234 followersView post →
This video explores strategies to enhance well-being during pregnancy, focusing on sleep, nutrition, movement, grooming, and nesting. It offers practical tips for expecting mothers to feel great throughout pregnancy.
This video shares personal experiences with the American mental healthcare system and the lasting damage caused by systemic failures. It emphasizes the need for reform and highlights the importance of informed consent…
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | Dementia and Cognitive Impairment | JAMA Internal Medicine | JAMA Network https://t.co/ielelrA9hG
Jun 11, 2025 · 19 shares · 1,017 followersView post →
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AndreaDona
@AndreaDona60 · X
@NeherBirgitta @Yash25571056 You are ignorant and insolent.
'Long-term use of anticholinergic drugs is associated with an increased risk of dementia. Anticholinergics block acetylcholine receptors in the brain, which can impair cognitive function.'
https://t.co/IMsQsfZm4y
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study
https://t.co/8g3bWhmOsO
Sep 22, 2024 · 1 like · 1,073 followersView post →
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adrian
@0fab1e · X
@quantian1 nows a good time to remind everyone that chronic use of anticholinergics like benadryl will cause cognitive impairment and may increase your odds of contracting dementia later on by >60% https://t.co/kx9EzZUSRG
Aug 26, 2024 · 49 likes · 171 followersView post →
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vixenfury
@IA7755 · X
@CTCaveman @eliotmuir Some studies have linked blocking histamine to an increased risk of dementia due to anticholinergic properties (reduced acetylcholine) so it may be a bigger deal than you think.
https://t.co/hbTbq0mbKm
A 2019 study found anticholinergic drugs were associated with a ↑ risk of #dementia. Overall, anticholinergic antidepressants, antipsychotic, anti-Parkinson’s, bladder, & epilepsy drugs were associated with the highest dementia risks #Gibraltar https://t.co/jDu3HCM9IG
@jimbovelure @atomicaceso @ChrisPalmerMD In UK research, those prescribed anticholinergic drugs, including ADs, are at a 50% ⬆️ risk of dementia. The researchers suggested that adverse effects may result in about 20,000 cases of dementia per year in the UK alone.
Clearly, more research needed?
https://t.co/myzEPFmFYZ
Anticholinergic Drug Exposure and the Risk of Dementiaというのはだいぶ有名な話となりつつありますが、ある程度パワーのある論文というとこれとかになりますでしょうか。少し古いですが、孫引きもふくめて、今一度読み解いてみてくださいませ。
https://t.co/KoG7xgCwWF
@angryhacademic It may be worthwhile to mention that 1st gen antihistamines are suspected to cause and/or contribute to onset of dementia.
E.g. https://t.co/jd8Z52v7dN
Been wondering what 2nd and 3rd gen might do to the brain, seeing as our BBB seems to have trouble filtering even small pebbles
@SiobhanAbrahams Three years of daily amitriptyline use associated with 50% increased odds of dementia. Should we be exposing our patients to this risk without evidence of benefit. Note cochrane review did find some benefit from duloxetine without anticholinergic risk
https://t.co/ntBiO9klRK
May 11, 2023 · 3 likes · 1 share · 68 followersView post →
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Krzysztof Potempa
@BRAINCURES · X
Is the risk of dementia among persons 55 years or older associated with the use of different types of anticholinergic medication?
https://t.co/YIHBc025vo
3/ Which OTC drugs did the studies mention?
Research has found a statistically significant link between dementia and common OTC drugs like antihistamine medications, sleep aids, motion sickness medication, & various cold medicines.
Source: https://t.co/MdkqMc7rUZ
READ BELOW: https://t.co/jquZ4riuyw
RT @organichemusic: @TMaritanoAquino @donutdisaster It's not safe in older populations due to the sedation increasing risk of falls.
It's g…
Feb 15, 2023 · 1 share · 3,793 followersView post →
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LongCovidPharmD
@organichemusic · X
@TMaritanoAquino @donutdisaster It's not safe in older populations due to the sedation increasing risk of falls.
It's generally not something I would want to take long-term due to increased risk of dementia with certain anticholinergics.
https://t.co/E9j10p9rcn
Jan 5, 2023 · 2 likes · 1 share · 35,454 followersView post →
BH
Boris D Heifets
@TheBorisLab · X
@anandabits IMO it’s a risk/benefit decision, and there needs to be informed consent about risks of anticholinergic drugs and the risk of dementia. Risk of dementia goes up with cumulative exposure to anticholinergics - and not just scop https://t.co/1TQ4ALsrWU
RT @PanDanTag: @arikouts @ImmortelleXIII @MikiLaMalice Tiens là c'est avéré, +49% de cas de démence 1 à 11 ans après la prise du médicament…
Dec 20, 2022 · 2 shares · 3,184 followersView post →
I
ImmortelleXIII
@ImmortelleXIII · X
RT @PanDanTag: @arikouts @ImmortelleXIII @MikiLaMalice Tiens là c'est avéré, +49% de cas de démence 1 à 11 ans après la prise du médicament…
Dec 20, 2022 · 2 shares · 1,904 followersView post →
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PanDanTag
@PanDanTag · X
@arikouts @ImmortelleXIII @MikiLaMalice Tiens là c'est avéré, +49% de cas de démence 1 à 11 ans après la prise du médicament
https://t.co/jN9ucroaQf
Dec 20, 2022 · 3 likes · 2 shares · 30,916 followersView post →
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Constantine
@Epikratw · X
RT @haidut: @healthygutgirl @Mangan150 @Epikratw These absird claims are based on a one OBSERVATIONAL study, so the link was never proven t…
Nov 18, 2022 · 1 share · 1,497 followersView post →
GD
Georgi D.
@haidut · X
@healthygutgirl @Mangan150 @Epikratw These absird claims are based on a one OBSERVATIONAL study, so the link was never proven to be causal.
https://t.co/mC7Ey81Tgt
Btw, the claim that anticholinergic drugs may cause AD is based on the already-discredited theory that acetylcholine is low in AD and raising it is good.
Nov 18, 2022 · 8 likes · 1 share · 31,909 followersView post →
LS
Lee Stevenson
@bashuser · X
Anticholinergic Drug Exposure and the Risk of Dementia https://t.co/WY9VTMtBEU via @JAMAInternalMed part of @JAMANetwork
Anticholinergic Drug Exposure and the Risk of Dementia A Nested Case-Control Study
https://t.co/cS9ncda5DT
This large, nested case-control study found an increased risk of dementia associated with anticholinergic medication use.
1/
RT @DrSaripanidis: @ProfRobHoward Antidepressant administration to the elderly is unethical because it increases dementia!
https://t.co/PU5…
Nov 15, 2021 · 3 shares · 1,092 followersView post →
AH
Angela Howard
@AngelaH04520715 · X
RT @DrSaripanidis: @ProfRobHoward Antidepressant administration to the elderly is unethical because it increases dementia!
https://t.co/PU5…
Nov 15, 2021 · 3 shares · 177 followersView post →
RR
recovery&renewal
@recover2renew · X
RT @DrSaripanidis: @ProfRobHoward Antidepressant administration to the elderly is unethical because it increases dementia!
https://t.co/PU5…
Nov 15, 2021 · 3 shares · 4,168 followersView post →
SM
Stavros Saripanidis, MD
@DrSaripanidis · X
@ProfRobHoward Antidepressant administration to the elderly is unethical because it increases dementia!
https://t.co/PU53stU9AP
https://t.co/qw3TkRfCp9
https://t.co/rEOI7xWi76
https://t.co/6fIuGos99S
https://t.co/ugx1W5ruyJ
Nov 14, 2021 · 4 likes · 3 shares · 694 followersView post →
RT @HengartnerMP: @CVolkmannMD @PloederlM There are some analyses on anticholinergic burden, if that fits into your concept of causal mecha…
Oct 1, 2021 · 1 share · 2,143 followersView post →
MP
Michael P. Hengartner, PhD
@HengartnerMP · X
@CVolkmannMD @PloederlM There are some analyses on anticholinergic burden, if that fits into your concept of causal mechanism. For example:
https://t.co/49tf1NWngO
@joannamoncrieff @CEP_UK Anticholinergic effects of antipsychtics (and various other drugs frequently prescribed in schizophrenia) most likely contribute to cognitive impairments and dementia. Repeatedly demonstrated in well-controlled studies:
https://t.co/IR7LJrRyWB
https://t.co/49tf1NWngO
RT @psychunseen: 4/
Now we have increasing evidence from longitudinal studies that anticholinergic exposure increases dementia risk:
"Th…
Jun 4, 2021 · 2 shares · 2,278 followersView post →
JM
Joe Pierre, MD
@psychunseen · X
4/
Now we have increasing evidence from longitudinal studies that anticholinergic exposure increases dementia risk:
"The population-attributable fraction associated w/ anticholinergic drug exposure during the 1-11 years before diagnosis was 10.3%."
https://t.co/8MNHYJTUF4 https://t.co/YhIztctcBm
Jun 4, 2021 · 12 likes · 2 shares · 8,923 followersView post →
MG
Maria Queralt Gorgas
@qgorgas · X
Anticholinergic Drug Exposure and the Risk of Dementia https://t.co/58KUALRZaP via @JAMAInternalMed part of @JAMANetwork
May 29, 2021 · 1 like · 1,468 followersView post →
CR
Clinical Rehab
@ClinicalRehab · X
DW. Anticholinergic drugs are widely used in rehabilitation. This paper supports critical review all drug intake. Though the risk of dementia may be small compared with all else, the risk of dementia from anticholinergics should still be considered. https://t.co/1NDBRn0N5a
https://t.co/AqK7IKZgUO So #antidepressants, #antipsychotic drugs, bladder #antimuscarinics, and #antiepileptic drugs. So #gabapentin for #pain management is one.
There is an increased need for #PFMT #biofeedback like @HealthJogo for #incontinence given #dementia risk from #anticholinergic drugs #medtwitter #urology
https://t.co/cYydAC10oy
Recent studies suggest that long term use of #anticholinergics ( antiparkinson drugs, #antipsychotic drugs, bladder antimuscarinics, #antidepressants and #antiepileptic )drugs were associated with COGNITIVE decline and DEMENTIA
#drugs #pharma
https://t.co/0Y2lk5NcH2
@psychunseen Recent studies suggest that long term use of anticholinergics ( antiparkinson drugs, antipsychotic drugs, bladder antimuscarinics, and antiepileptic )drugs were associated with cognitive decline and dementia.
https://t.co/0Y2lk5NcH2
Interesting study shows that anti-cholinergic drugs cause cognitive decline. This makes sense, because it stops you from firing one of the most common "do this/concentrate" signals in the brain. Like reverse adderall. https://t.co/Kq2Zzq1edm
@ProfRobHoward @CoyneoftheRealm There is legitimate cause for concern, unless the University of Nottingham has gone antipsychiatry as well.
https://t.co/9lXK58YJNp
Bordel, je m’attendais pas à un tel chiffre. C’est archi-bourrin quand même…
#Anticholinergique #Démence #Risque
Source : Univadis au sujet de Anticholinergic Drug Exposure and the Risk of Dementia. A Nested Case-Control Study
https://t.co/ufR2U5Ss0Z https://t.co/ZscT6HWOZj
Jan 17, 2020 · 1 like · 2,053 followersView post →
ET
Empower Together
@sandycamillo · X
Your medicine have an unwanted Side effect #ageism Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | Dementia and Cognitive Impairment | JAMA Internal Medicine | JAMA Network https://t.co/AX70ifQMoD
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | Dementia and Cognitive Impairment | JAMA Internal Medicine | JAMA Network @JAMAInternalMed @JAMANetwork https://t.co/QacHfdseiq
Nov 1, 2019 · 1 share · 2,289 followersView post →
U
UltimApe
@ultimape · X
@TedDinan Without looking at the article, I guessed it was about choline. Fun effects found on vagus nerve/inflammation in mouse models:
https://t.co/QJ8pexxRyD
It fits associations between anticholinergenic drugs and dimentia risk
https://t.co/APMlzqprXP
https://t.co/hh6qhAN1vg
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | Dementia and Cognitive Impairment | JAMA Internal Medicine | JAMA Network https://t.co/SEIFBszFA5
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | Dementia and Cognitive Impairment | JAMA Internal Medicine | JAMA Network https://t.co/KABXc04zLq
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | Dementia and Cognitive Impairment | JAMA Internal Medicine | JAMA Network https://t.co/RFgNzqQN9U
RT @UnravelMedicine: We critically analyzed a study published in @JAMAInternalMed investigating the risk of dementia with anticholinergic d…
Jun 30, 2019 · 4 shares · 984 followersView post →
FH
Frank Harrell
@f2harrell · X
@UBC researchers @MohitsodhiUBC @etminanm @farzinkhosrow have critically evaluated the recent @JAMAInternalMed paper on anticholinergics and dementia: https://t.co/hPk4pMNUzo
Jun 29, 2019 · 1 like · 29,835 followersView post →
JH
James Hawkins
@DrJamesHawkins · X
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study. https://t.co/uVQu6H3JLJ
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | Dementia and Cognitive Impairment | JAMA Internal Medicine | JAMA Network https://t.co/Gix5nGgQtg
Jun 29, 2019 · 1 like · 14,894 followersView post →
GC
Gary Collins
@GSCollins · X
RT @UnravelMedicine: We critically analyzed a study published in @JAMAInternalMed investigating the risk of dementia with anticholinergic d…
Jun 29, 2019 · 4 shares · 10,391 followersView post →
MS
Mohit Sodhi
@MohitSodhiMD · X
RT @UnravelMedicine: We critically analyzed a study published in @JAMAInternalMed investigating the risk of dementia with anticholinergic d…
We critically analyzed a study published in @JAMAInternalMed investigating the risk of dementia with anticholinergic drug use https://t.co/aC1zaQT1gX #JAMA #InternalMedicine #Medicine #neurology #dementia #epidemiology #pharmacology #science https://t.co/DAyLgPpDKA
Jun 28, 2019 · 3 likes · 4 shares · 49 followersView post →
VS
Verna Smith
@VernaPolitics · X
RT @NeilFlochMD: Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | Dementia and Cognitive Impairment |…
Jun 28, 2019 · 3 shares · 6,371 followersView post →
NM
Neil Floch MD
@NeilFlochMD · X
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | Dementia and Cognitive Impairment | JAMA Internal Medicine | JAMA Network https://t.co/5yyEOl0T6l
Jun 28, 2019 · 1 like · 3 shares · 130,165 followersView post →
DM
Dr. Stacy Lenger, MD
@StacyLengerMD · X
RT @dramypark: Maybe we can get better insurance coverage for mirabegron!
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested…
Jun 27, 2019 · 2 shares · 399 followersView post →
AS
Aoife Sweeney
@aoifemsweeney · X
"These findings highlight the importance of reducing exposure to anticholinergic drugs in middle-aged and older people."
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study. https://t.co/utD0RPsRZU
RT @CRPV_Limoges: Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | Dementia and Cognitive Impairment |…
Jun 26, 2019 · 5 shares · 1,193 followersView post →
SM
Syndicat Jeunes MG
@SNJMG · X
RT @CRPV_Limoges: Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | Dementia and Cognitive Impairment |…
Jun 26, 2019 · 5 shares · 9,969 followersView post →
CC
Compte officiel du Réseau FR des CRPV
@Reseau_CRPV · X
RT @CRPV_Limoges: Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | Dementia and Cognitive Impairment |…
Jun 26, 2019 · 5 shares · 6,764 followersView post →
CL
CRPV_Limoges
@CRPV_Limoges · X
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | Dementia and Cognitive Impairment | JAMA Internal Medicine | JAMA Network https://t.co/3Q6Cz2i0mE
Jun 26, 2019 · 4 likes · 5 shares · 1,193 followersView post →
GD
Gaurav Goswami, MD, MS, DABRM
@GoswamiClinic · X
Coupland CAC, Hill T, Dening T, Morriss R, Moore M, Hippisley-Cox J. Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study. JAMA Intern Med. Published online June 24, 2019. https://t.co/W2GdDNpEKE
But the new libido drug causing mild nausea is too dangerous?
Jun 25, 2019 · 18 likes · 2 shares · 23,931 followersView post →
JM
Jocelyn J. Fitzgerald MD
@jjfitzgeraldMD · X
RT @dramypark: Maybe we can get better insurance coverage for mirabegron!
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested…
Jun 25, 2019 · 2 shares · 41,824 followersView post →
AM
Amy Park, MD
@dramypark · X
Maybe we can get better insurance coverage for mirabegron!
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | Dementia and Cognitive Impairment | JAMA Internal Medicine | JAMA Network https://t.co/RZSSGbQ8Bn
Jun 25, 2019 · 12 likes · 2 shares · 5,642 followersView post →
SD
Samuel Badalian, M.D, Ph.D
@DrBadalian · X
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | Dementia and Cognitive Impairment | JAMA Internal Medicine | JAMA Network https://t.co/KxQQ8MGkGz
“These findings highlight the importance of reducing exposure to anticholinergic drugs in middle-aged and older people.” Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | JAMA Internal Medicine | https://t.co/0ubNuO7BGD
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | Dementia and Cognitive Impairment | JAMA Internal Medicine | JAMA Network https://t.co/8pvaX27A07
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | JAMA Internal Medicine |
Evidence gets more and more solid, but the OR was 1.06 +/- .03. Not huge.... https://t.co/AtNCazd8Me
Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study | Dementia and Cognitive Impairment | JAMA Internal Medicine | JAMA Network https://t.co/eBqETCsS6F
RT @GrahamStretch: ‘Anticholinergic Drug Exposure and the Risk of Dementia, A Nested Case-Control Study’ Coupland et al. Further evidence o…
Jun 24, 2019 · 2 shares · 1,447 followersView post →
KM
Kaly Mo
@kaly_mohammad · X
RT @GrahamStretch: ‘Anticholinergic Drug Exposure and the Risk of Dementia, A Nested Case-Control Study’ Coupland et al. Further evidence o…
Jun 24, 2019 · 2 shares · 315 followersView post →
GS
Graham Stretch
@GrahamStretch · X
‘Anticholinergic Drug Exposure and the Risk of Dementia, A Nested Case-Control Study’ Coupland et al. Further evidence of anti-cholinergics risks and dementia https://t.co/8V2gxGeOZf https://t.co/DwpMtusDXo
Jun 24, 2019 · 11 likes · 2 shares · 9,234 followersView post →
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