PubHawk
Sci Rep July 2019 PMID 31278280

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults.

Dietrich Conze, Charles Brenner, Claire L Kruger

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Mentions

70
Peak: 2 in Jul 2019
across 6 sources since Jul 2019

Extended reach

210,458
potential audience

Total likes

36

Video views

560

Mentions per month

Jul 2019 – Sep 2024

Where it's discussed

  • News53 articles
  • X / Twitter9 posts
  • YouTube2 videos
  • Facebook2 posts
  • Reddit2 posts
  • Blogs2 articles

AI synopsis

What people are saying

The discussion includes posts that highlight the safety profile (e.g., 'safety data were excellent') and dose-dependent increases in NAD, demonstrating moderate engagement and interest. However, some comments, such as the mention of 'little to no effect on clinical outcomes,' reflect limited impact or enthusiasm, influenced by their neutral tone and focus on safety rather than broader implications.

AgreementModerate agreement

Most discussions acknowledge the study's findings, with some emphasizing its safety and dosage effects, although a few highlight limited clinical outcome impact.

InterestNeutral interest

The overall interest is neutral to moderate, as some posts focus on safety and dosage details, while others show indifference or lack of depth.

EngagementModerate engagement

Posts reference specific aspects like dosage comparisons and safety data, indicating some level of engagement, but others merely mention the study without deeper commentary.

ImpactModerate impact

The discussions suggest the study is viewed as somewhat impactful, particularly regarding safety affirmation, but less so for clinical outcomes.

Abstract in brief

  • Nicotinamide riboside (NR) is a newly identified vitamin that acts as a precursor to NAD and is considered safe for food and dietary supplements.
  • An 8-week clinical trial showed that taking varying doses of NR (100, 300, and 1000 mg) significantly boosted NAD levels in healthy, overweight adults without causing side effects.
  • The results suggest that NR is safe at different doses and supports the idea of establishing an upper intake limit for its consumption.
Read the full abstract

Top posts

Most liked on X and Bluesky
Charles Brenner, PhD
@CharlesMBrenner · X

@ElenaBartocci https://t.co/Ihs3gCNNdI

Mar 18, 2022 · 3 likes · 57,023 followers View post →
osamah
@xxxOsamahxxx · X

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) Study >> https://t.co/BZPUdO7ngM

Jan 10, 2024 · 3 likes · 136 followers View post →
Charles Brenner, PhD
@CharlesMBrenner · X

@devansADR by RCT, we showed that increase is greater at 1000 mg than 300 mg than 100 mg. safety data were excellent. specifically looked for methyl donor depletion and didn’t see any problem https://t.co/Ihs3gCNNdI

Mar 20, 2022 · 2 likes · 57,023 followers View post →
Charles Brenner, PhD
@CharlesMBrenner · X

@CurwenChris the former was a nice safety study https://t.co/JIGyckV1W4 i don't have any info on the latter

Jan 11, 2022 · 1 like · 57,023 followers View post →
Joel "Heart Prevention" Kahn MD, FACC
@drjkahn · X

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults | Scientific Reports ⁦@truniagen⁩ https://t.co/BmnqkIZv83

Jul 8, 2019 · 1 like · 32,288 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults #yup #this https://t.co/jumhmK6rMd

Jul 5, 2019 · 1 like · 2,241 followers View post →

All mentions

osamah
@xxxOsamahxxx · X

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) Study >> https://t.co/BZPUdO7ngM

Jan 10, 2024 · 3 likes · 136 followers View post →
Alex Leaf
@AlexJLeaf · X

@CharlesMBrenner Can you share? Here's a list of interventions showing it has little to no effect on clinical outcomes. https://t.co/IkTJUGcoTG https://t.co/gzFz1pNl4q https://t.co/ppApaZv2bA https://t.co/KD1y3lEM8h https://t.co/SRgr0bbZpK https://t.co/0ypM5uozRV https://t.co/HQo8SNxJN7

Jun 7, 2023 · 3,939 followers View post →
Charles Brenner, PhD
@CharlesMBrenner · X

@devansADR by RCT, we showed that increase is greater at 1000 mg than 300 mg than 100 mg. safety data were excellent. specifically looked for methyl donor depletion and didn’t see any problem https://t.co/Ihs3gCNNdI

Mar 20, 2022 · 2 likes · 57,023 followers View post →
Charles Brenner, PhD
@CharlesMBrenner · X

@ElenaBartocci https://t.co/Ihs3gCNNdI

Mar 18, 2022 · 3 likes · 57,023 followers View post →
Charles Brenner, PhD
@CharlesMBrenner · X

@CurwenChris the former was a nice safety study https://t.co/JIGyckV1W4 i don't have any info on the latter

Jan 11, 2022 · 1 like · 57,023 followers View post →
Gianfranco Sacco
@Gianfra95754820 · X

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized… https://t.co/gm7vbkN7wL

Oct 27, 2020 · 2 followers View post →
ConnieMaxwell
@ConstantMaxwell · X

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults | Scientific Reports https://t.co/7k273veyBq

Aug 6, 2019 · 224 followers View post →
Joel "Heart Prevention" Kahn MD, FACC
@drjkahn · X

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults | Scientific Reports ⁦@truniagen⁩ https://t.co/BmnqkIZv83

Jul 8, 2019 · 1 like · 32,288 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults #yup #this https://t.co/jumhmK6rMd

Jul 5, 2019 · 1 like · 2,241 followers View post →