Acta Crystallogr D Struct Biol July 2019 PMID 31282475

LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM.

George N Chiduza, Rachel M Johnson, Gareth S A Wright, Svetlana V Antonyuk, Stephen P Muench, S Samar Hasnain

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Peak: 8 in Jun 2019

across 2 sources since Jun 2019

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26,747

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Jun 2019 – May 2021

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AI synopsis

What people are saying

The discussions use positive and curious language, with mentions of the study revealing the flexibility of the LAT1 complex and implications for drug transport, demonstrating moderate enthusiasm and recognition of its significance while mostly focusing on the structural and functional insights provided by cryo-EM methods.

AgreementModerate agreement

Most discussions acknowledge the significance of the structural insights provided by the cryo-EM study, with some expressing excitement about its potential applications.

InterestModerate interest

The posts demonstrate moderate interest, as they highlight the relevance of the research for understanding transporter dynamics and drug delivery, but lack deep technical engagement.

EngagementModerate engagement

Participants show active involvement by retweeting and commenting, indicating an appreciation for how the findings could influence future studies or therapeutic strategies.

ImpactModerate impact

The discussions reflect the perceived importance of these findings, especially in relation to biomedical applications like cancer treatment and crossing the blood-brain barrier, suggesting a recognition of its high potential impact.

Abstract in brief

The study focuses on understanding the structure and dynamic behavior of the LAT1 SLC7A5 and CD98hc SLC3A2 complex, which is crucial for transporting amino acids and drugs across cell barriers like the blood-brain barrier and in cancer cells.
Using cryo-EM techniques, researchers analyzed the complex in different conformations, revealing that the CD98hc ectodomain does not strongly interact with LAT1's extracellular surface, allowing it to move freely.
These findings highlight the importance of the complex's structural flexibility for its function, providing insights that could impact therapeutic targeting of this transporter system.

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Structural Dynamics of LAT1 and CD98hc Complex in Transport Function

This study explores the conformational behavior of the LAT1 SLC7A5 and CD98hc SLC3A2 complex, crucial for amino acid and drug transport across cell barriers such as the blood-brain barrier and in cancer cells. Using…

International Union of Crystallography · Oct 18, 2019 203 views

Structural Dynamics of LAT1 SLC7A5 and CD98hc SLC3A2 Complex

This video presents the conformational dynamics of the LAT1 SLC7A5 and CD98hc SLC3A2 complex, crucial for amino acid and drug transport across barriers like the blood-brain barrier and in cancer. cryo-EM analysis…

International Union of Crystallography · Oct 18, 2019 87 views

Tim Witney

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@DavidYLewis @ThatKidSampson https://t.co/LhbKkLSaz9

May 9, 2021 · 2,349 followers View post →

African Synchrotron

@AfSynchrotron · X

LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM https://t.co/FtpLJ1vZjA via @ActaCrystD https://t.co/CADxXX2WVn

Aug 2, 2019 · 2,923 followers View post →

Structural Biology

@ActaCrystD · X

RT @cryoEM_Papers: LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM https://t.co/1hvo7Y9phz

Jul 1, 2019 · 3 shares · 3,020 followers View post →

Yongchan Lee

@YongChan_zzz · X

RT @ActaCrystD: Chiduza et al.: LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM #IUCr https://t.co/j…

Jun 30, 2019 · 4 shares · 994 followers View post →

Daniel Roche

@Daniel_B_Roche · X

RT @ActaCrystD: Chiduza et al.: LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM #IUCr https://t.co/j…

Jun 29, 2019 · 4 shares · 428 followers View post →

Chai Gopalasingam

@Chai_Gopal · X

RT @cryoEM_Papers: LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM https://t.co/1hvo7Y9phz

Jun 29, 2019 · 3 shares · 153 followers View post →

Killua

@ahtnamasala · X

RT @cryoEM_Papers: LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM https://t.co/1hvo7Y9phz

Jun 29, 2019 · 3 shares · 509 followers View post →

やし

@AlHSJCKtEfpFXtm · X

RT @ActaCrystD: Chiduza et al.: LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM #IUCr https://t.co/j…

Jun 28, 2019 · 4 shares · 356 followers View post →

2438@ROM

@t2438 · X

RT @ActaCrystD: Chiduza et al.: LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM #IUCr https://t.co/j…

Jun 28, 2019 · 4 shares · 817 followers View post →

Structural Biology

@ActaCrystD · X

Chiduza et al.: LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM #IUCr https://t.co/j3IYrl7uAt

Jun 28, 2019 · 7 likes · 4 shares · 3,020 followers View post →

cryoEM Papers

@cryoEM_Papers · X

LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM https://t.co/1hvo7Y9phz

Jun 28, 2019 · 6 likes · 3 shares · 11,825 followers View post →

LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Structural Dynamics of LAT1 and CD98hc Complex in Transport Function

Structural Dynamics of LAT1 SLC7A5 and CD98hc SLC3A2 Complex