September 2019 PMID 31303095

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research.

Kim Pc Kuypers, Livia Ng, David Erritzoe, Gitte M Knudsen, Charles D Nichols, David E Nichols, Luca Pani, Anaïs Soula, David Nutt

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Mentions

156
Peak: 47 in Jul 2019
across 6 sources since Jul 2019

Extended reach

490,212
potential audience

Total likes

4,602

Video views

105,573

Mentions per month

Jul 2019 – Aug 2024

Where it's discussed

  • X / Twitter74 posts
  • News57 articles
  • Blogs15 articles
  • Reddit4 posts
  • YouTube3 videos
  • Facebook3 posts

AI synopsis

What people are saying

These discussions reflect a strong interest in advancing scientific understanding, with posts citing receptor occupancy thresholds, potential safety issues, and therapeutic possibilities, emphasizing the article’s role as a key resource and catalyst for ongoing research in this emerging field.

AgreementModerate agreement

Most discussions acknowledge the article as a valuable, comprehensive overview, with some emphasizing the importance of further scientific investigation, indicating a general agreement on its significance.

InterestHigh interest

The posts signal high interest, referencing detailed research, calling it 'the most comprehensive review,' and highlighting ongoing scientific debates.

EngagementModerate engagement

Discussions involve referencing specific studies, mentioning receptor occupancy, and debating safety concerns, showing active and thoughtful engagement.

ImpactModerate impact

The widespread sharing, detailed citations, and calls for future research suggest the article has a modest but meaningful influence on scientific and public conversations about microdosing.

Abstract in brief

  • The article discusses the growing public interest in microdosing psychedelics, particularly psilocybin, but highlights that scientific research on its effects, both positive and negative, is limited and lacking consensus.
  • It emphasizes the need for future studies to address critical questions, such as defining what microdosing genuinely means and investigating potential risks associated with repeated low doses, especially since most current reports focus on benefits.
  • The authors suggest that future research should include preclinical studies on biological effects and cognitive impacts to better understand the safety and potential adverse effects of microdosing psychedelics.]

Top posts

Most liked on X and Bluesky
David Nutt
@ProfDavidNutt · X

the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology https://t.co/9b7ZAfEbxG @Drug_Science @BAPsych

Jul 15, 2019 · 87 likes · 35 shares · 64,527 followers View post →
amirmxt
@amirmxt · X

@NTFabiano Highly recommend this read. Psychedelics have been linked to individuals and their inventions I think even Engelbart used LSD to invent the keyboard and mouse https://t.co/488OrF03oE

Jul 7, 2024 · 22 likes · 8,001 followers View post →
Psychedelics Today
@PsydelicsToday · X

Your gateway to world-class research journals https://t.co/QL2XwtJUpa

Jul 19, 2019 · 8 likes · 4 shares · 41,555 followers View post →
Psychiatry_AUBMC
@AubmcPsychiatry · X

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research - Kim PC Kuypers, Livia Ng, David Erritzoe, Gitte M Knudsen, Charles D Nichols, David E Nichols, Luca Pani, Anaïs Soula, David Nutt #psychiatry https://t.co/k27EalxBys

Jul 26, 2019 · 5 likes · 1 share · 2,126 followers View post →
Amsterdam Psychedelic Research Association (APRA)
@APRAresearch · X

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research. https://t.co/oxHUyIWcHg

Aug 13, 2020 · 4 likes · 2 shares · 4,002 followers View post →
Vince Polito
@vincepsy · X

A great review of what we don't yet know about microdosing https://t.co/T8mrSwoJU8

Jul 15, 2019 · 4 likes · 1,217 followers View post →

All mentions

Optimizing Set and Setting for Magic Mushroom Use

This video explores the concept of 'set and setting' in relation to psychedelic substances, specifically focusing on psilocybin mushrooms. It aims to inform viewers through various sources, discussing the importance of…

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lugarzen
@lugarzen · X

@lakshay_creates It's a curious prompt: "Microdosing psychedelics: more questions than answers? An overview and suggestions for future research, dramatic dutch light"

Aug 27, 2024 · 1 like · 7,972 followers View post →
amirmxt
@amirmxt · X

@NTFabiano Highly recommend this read. Psychedelics have been linked to individuals and their inventions I think even Engelbart used LSD to invent the keyboard and mouse https://t.co/488OrF03oE

Jul 7, 2024 · 22 likes · 8,001 followers View post →
Psicodélicos News
@psiquedelicos · X

Excelente artigo publicado em 2019 sobre estudos e efeitos de microdose de psilocobina. Definição de microdose, pesquisas com usuários, estudos em animais e humanos, efeitos e comparações com outras doses são elencados em perguntas e respostas. https://t.co/OxYqlYe4ah

Dec 30, 2022 · 1 like · 72 followers View post →
Franziska Schwarz
@franzite · X

@spreeblick LSD administration was discontinued (…). These changes included increased aggression, scruffy appearance, anhedonia and hyper-reactivity.“ https://t.co/SgCUOBiWUc (2/2)

Dec 17, 2022 · 1 like · 98 followers View post →
Psychedelic Brain Science
@PsychedBrainSci · X

And some good considerations: Microdosing psychedelics: More questions than answers? An overview and suggestions for future research by Kim PC Kuypers 2019 https://t.co/S3cZJ210MQ

Dec 12, 2022 · 1,145 followers View post →
Awaken The “I AM” | r/microdosing | Mush Love
@LiveInMushLove · X

@psybalazs @ferenstein @thirdwaveishere @QuantCitizen @BeckleyPsytech @PIMaastricht @vincepsy @PLiknaitzky @PsydelicsToday "...doses producing less than 20% occupancy were not detectable either by psychological or physiological measurements, suggesting that this concentration might represent the threshold for microdosing, based on brain 5-HT2A receptor occupancy.": https://t.co/imu8GOlsdf

Oct 20, 2022 · 743 followers View post →
z i f
@zifferson · X

@squidgrow @ChimeraGenetics Homeopathy, but with enough active compound to have reasonable people concerned about side effects unique to chronic dosing (see, e.g., doi: 10.1177/0269881119857204).

Aug 4, 2022 · 137 followers View post →
Awaken The “I AM” | r/microdosing | Mush Love
@LiveInMushLove · X

@jasonluoma @ResearchGate I'm still waiting to see the first study that follows the @Jfadiman Protocol, i.e. microdose every few days for a month. And a (cost-prohibitive?) MEG/PET/fMRI scan to makes sure there is an estimated 20% 5-HT2AR occupancy and pharmacological effect: https://t.co/imu8GOkUnH

Jul 22, 2022 · 743 followers View post →
Awaken The “I AM” | r/microdosing | Mush Love
@LiveInMushLove · X

@alieninsect @JHPsychedelics @NatGeoScience @Drug_Researcher @ProfDavidNutt "In respect to...cardiovascular valvulopathy by chronic 2-HT2R activation, it is worth mentioning that the studies of Bender and Sankar (1968) in the 1960s involved doses of 100 μg LSD for up to 35 months on a daily basis without any observable damage.": https://t.co/Alj3J0gmKo

Feb 18, 2022 · 2 likes · 743 followers View post →
Awaken The “I AM” | r/microdosing | Mush Love
@LiveInMushLove · X

@alieninsect @GeorgeFejer @shashkes And: "... doses producing less than 20% occupancy were not detectable either by psychological or physiological measurements, suggesting that this concentration might represent the threshold for microdosing, based on brain 5-HT2A receptor occupancy": https://t.co/imu8GOkUnH

Feb 10, 2022 · 1 like · 743 followers View post →
Blossom
@blossomact · X

@zach_haigney Not really, maybe best is from this article (p1043) https://t.co/C5m0EEceUe The question (I have) is, will chronic mini-exposure be damaging/cummulative or not? I.e. eating a banana for 1000 days ≠ same radiation in 1 go

Feb 1, 2022 · 3,347 followers View post →
Awaken The “I AM” | r/microdosing | Mush Love
@LiveInMushLove · X

@ee_schenberg @MichielElk "...less than 20% occupancy were not detectable either by psychological or physiological measurements, suggesting that this concentration might represent the threshold for microdosing, based on brain 5-HT2A receptor occupancy.": https://t.co/imu8GOkUnH

Dec 18, 2021 · 743 followers View post →
Awaken The “I AM” | r/microdosing | Mush Love
@LiveInMushLove · X

@ferenstein @PaulStamets @whalebonemag @Drug_Researcher ....that this concentration might represent the threshold for microdosing, based on brain 5-HT2A receptor occupancy.": https://t.co/imu8GOkUnH

Oct 29, 2021 · 743 followers View post →
Views on Drugs
@ViewsOnDrugsBot · X

RT @ViewsOnDrugsBot: #Microdosing #psychedelics: More questions than answers? An overview and suggestions for future research 1/5 https://…

Oct 5, 2021 · 1 share · 2,049 followers View post →
Views on Drugs
@ViewsOnDrugsBot · X

#Microdosing #psychedelics: More questions than answers? An overview and suggestions for future research 1/5 https://t.co/Ocl7MaxNFg

Jul 16, 2021 · 1 share · 2,049 followers View post →
Arnþór
@arnthorjon · X

@marijuanacomau @thomasg_grizzle "the efficacy of microdosing may derive from its non-psychedelic dose range, which provides treatment without affecting cognition. Individuals also reported relief of pain with a long-term psychedelic microdosing regimen" https://t.co/jhwxpl8WwM

Aug 26, 2020 · 1,400 followers View post →
Plastic Shaman
@Entheogenist · X

RT @APRA_bot: Microdosing psychedelics: More questions than answers? An overview and suggestions for future research. https://t.co/oxHUyIWc…

Aug 13, 2020 · 2 shares · 396 followers View post →
Harsh Taneja
@harshtan · X

RT @APRA_bot: Microdosing psychedelics: More questions than answers? An overview and suggestions for future research. https://t.co/oxHUyIWc…

Aug 13, 2020 · 2 shares · 325 followers View post →
Amsterdam Psychedelic Research Association (APRA)
@APRAresearch · X

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research. https://t.co/oxHUyIWcHg

Aug 13, 2020 · 4 likes · 2 shares · 4,002 followers View post →
Enpsychedelia
@Enpsychedelia · X

RT @Neurons2Nirvana: Microdosing psychedelics: More questions than answers? An overview and suggestions for future research. Journal of Psy…

Jan 19, 2020 · 2 shares · 3,269 followers View post →
PsychedeliConnect
@PsychedelicJobs · X

RT @Neurons2Nirvana: Microdosing psychedelics: More questions than answers? An overview and suggestions for future research. Journal of Psy…

Jan 19, 2020 · 2 shares · 2,296 followers View post →
Awaken The “I AM” | r/microdosing | Mush Love
@LiveInMushLove · X

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research. Journal of Psychopharmacology, 33(9), 1039–1057. https://t.co/Alj3J0gmKo

Jan 19, 2020 · 3 likes · 2 shares · 743 followers View post →
Arnþór
@arnthorjon · X

@mmjinvesting "the efficacy of microdosing may derive from its non-psychedelic dose range, which provides treatment without affecting cognition. Individuals also reported relief of pain with a long-term psychedelic microdosing regimen"  https://t.co/jhwxpl8WwM

Sep 22, 2019 · 2 likes · 1,400 followers View post →
Jeff Robinson, CEO and Chairman of $MRES and $RLAB
@contrariansmind · X

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research - Kim PC Kuypers, Livia Ng, David Erritzoe, Gitte M Knudsen, Charles D Nichols, David E Nichols, Luca Pani, Anaïs Soula, David Nutt, 2019 https://t.co/sbZYd46Vu0

Sep 15, 2019 · 55,786 followers View post →
RecoveryTrek
@RecoveryTrek · X

#Microdosing #psychedelics: More questions than answers? An overview and suggestions for future research l #SubstanceAbuse - https://t.co/8HWQ5K358k https://t.co/V8OWR3VlEp

Aug 6, 2019 · 1 like · 860 followers View post →
Appalachian Wellness
@AppWellness · X

New post (Microdosing psychedelics: More questions than answers? An overview and suggestions for future research) has been published on Appalachian Wellness - https://t.co/w4MEkqBmBk

Aug 6, 2019 · 22 followers View post →
Korthlab
@Korthlab_HHU · X

Very important appeal to investigate this possible therapeutic option scientifically and with sobriety Microdosing psychedelics: More questions than answers? An overview and suggestions for future research - Kim PC Kuypers, ..., David Nutt, https://t.co/aoJiURQJvS

Aug 6, 2019 · 2,115 followers View post →
James Hawkins
@DrJamesHawkins · X

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research. https://t.co/dmmHEE2uRq

Jul 31, 2019 · 1,189 followers View post →
James Hawkins
@DrJamesHawkins · X

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research. https://t.co/mCPljkrYrc

Jul 29, 2019 · 1,189 followers View post →
Farid Talih
@faridtalih · X

RT @AubmcPsychiatry: Microdosing psychedelics: More questions than answers? An overview and suggestions for future research - Kim PC Kuyper…

Jul 26, 2019 · 1 share · 3,941 followers View post →
Psychiatry_AUBMC
@AubmcPsychiatry · X

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research - Kim PC Kuypers, Livia Ng, David Erritzoe, Gitte M Knudsen, Charles D Nichols, David E Nichols, Luca Pani, Anaïs Soula, David Nutt #psychiatry https://t.co/k27EalxBys

Jul 26, 2019 · 5 likes · 1 share · 2,126 followers View post →
CoffeeAficionado⛧
@TJMormor04 · X

RT @PsydelicsToday: Your gateway to world-class research journals https://t.co/QL2XwtJUpa

Jul 24, 2019 · 4 shares · 56 followers View post →
Psychedelic Newsfeed
@PsychedlicNews · X

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research https://t.co/H86QCE0SOG #psychedelics #microdosing #LSD #psilocybin

Jul 22, 2019 · 802 followers View post →
doedensguddom
@doedensguddom · X

RT @PsydelicsToday: Your gateway to world-class research journals https://t.co/QL2XwtJUpa

Jul 22, 2019 · 4 shares · 670 followers View post →
Gerlinde Schrön
@gerlindeschroen · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 22, 2019 · 35 shares · 3,998 followers View post →
SmokingJoe MonsterBud
@SmokingJoeBud · X

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research - Kim PC Kuypers, Livia Ng, David Erritzoe, Gitte M Knudsen, Charles D Nichols, David E Nichols, Anaïs Soula, David Nutt, 2019 https://t.co/LV93hK3KTJ

Jul 20, 2019 · 167 followers View post →
AMP
@thug_nasty_thug · X

RT @PsydelicsToday: Your gateway to world-class research journals https://t.co/QL2XwtJUpa

Jul 19, 2019 · 4 shares · 719 followers View post →
Psychedelics Today
@PsydelicsToday · X

Your gateway to world-class research journals https://t.co/QL2XwtJUpa

Jul 19, 2019 · 8 likes · 4 shares · 41,555 followers View post →
Stephen Snelders
@StephenSnelders · X

State of the art of microdosing research by Kim Kuypers et al #microdosing #lsd #psilocybin #drugs https://t.co/YIrn3L3IVG

Jul 19, 2019 · 171 followers View post →
Dave C
@dec200269 · X

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research - Kim PC Kuypers, Livia Ng, David Erritzoe, Gitte M Knudsen, Charles D Nichols, David E Nichols, Anaïs Soula, David Nutt, 2019 https://t.co/XppUwusJL1

Jul 18, 2019 · 1,651 followers View post →
N8URNURD
@Caelixian · X

RT @mappingthemind: Hot off the press! Microdosing Psychedelics: An overview and suggestions for future research. Probably the most compr…

Jul 18, 2019 · 1 share · 245 followers View post →
Mapping the Mind: Toronto Psychedelic Conference
@mappingthemind · X

Hot off the press! Microdosing Psychedelics: An overview and suggestions for future research. Probably the most comprehensive review on microdosing to date. https://t.co/2TID5VYh3E

Jul 18, 2019 · 3 likes · 1 share · 3,221 followers View post →
Greenthumb_one
@Greenthumb_one · X

RT @APRA_bot: New post: "Microdosing psychedelics: More questions than answers? An overview and suggestions for future research." https://t…

Jul 16, 2019 · 1 share · 4,510 followers View post →
CINP
@theCINP · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 16, 2019 · 35 shares · 1,449 followers View post →
Amsterdam Psychedelic Research Association (APRA)
@APRAresearch · X

New post: "Microdosing psychedelics: More questions than answers? An overview and suggestions for future research." https://t.co/IYDvIYEI9B

Jul 16, 2019 · 1 like · 1 share · 4,002 followers View post →
Jade Proudman
@JadeProudman · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 16, 2019 · 35 shares · 307 followers View post →
Vince Polito
@vincepsy · X

A great review of what we don't yet know about microdosing https://t.co/T8mrSwoJU8

Jul 15, 2019 · 4 likes · 1,217 followers View post →
Streetworks
@StreetworksAB · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 2,001 followers View post →
Ally
@fuzzysemi · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 3,746 followers View post →
Stephen Pimentel
@StephenPiment · X

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research https://t.co/MS5WYRYGmN

Jul 15, 2019 · 12,802 followers View post →
Jo Neill
@b_neuro · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 1,360 followers View post →
GCD
@GreenCourtDis · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 545 followers View post →
HEDN
@EnhancementDrug · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 1,159 followers View post →
Ross Heaney
@RossHeaney2 · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 8 followers View post →
Imperial Medicine
@ImperialMed · X

Jul 15, 2019 · 23,345 followers View post →
Evander
@Hereditarian98 · X

https://t.co/V16nrhO7ab

Jul 15, 2019 · 2,266 followers View post →
karen
@sunnyAlmeria123 · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 111 followers View post →
Michael Anthony Brito, PhD
@MBritoNeuro · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 1,538 followers View post →
Beckley Foundation | Psychedelic Research
@BeckleyResearch · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 60,196 followers View post →
ECNP
@ecnptweets · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 5,183 followers View post →
Ancyborov Andrei
@ancyborov · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 28 followers View post →
MIND Foundation
@mind_europe · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 5,446 followers View post →
Arnþór
@arnthorjon · X

#Microdosing #psychedelics: More questions than answers? An overview and suggestions for future research https://t.co/jhwxpl8WwM

Jul 15, 2019 · 3 likes · 1,400 followers View post →
ElectroPig™
@ElectroPig · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 1,781 followers View post →
Tim Nicholson
@Tim_R_Nicholson · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 3,764 followers View post →
Hope Humphreys bsky.social
@HumphreysHope · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 2,210 followers View post →
Niente e lasciato al caso.
@leevladf · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 1,207 followers View post →
Catherine de Jong
@Cath77777 · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 2,773 followers View post →
CannaLytica
@CannaLytica · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 1,086 followers View post →
Saoirse E.O'Sullivan
@ScienceSaoirse · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 2,254 followers View post →
David Lusseau
@lusseau · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 2,459 followers View post →
Ines Kurschat
@Inku_Lux · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 3,372 followers View post →
Prof Andrew Scholey PhD
@Scholey · X

RT @ProfDavidNutt: the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology h…

Jul 15, 2019 · 35 shares · 1,053 followers View post →
David Nutt
@ProfDavidNutt · X

the definitive #psychedelics #microdosing position paper and commentaries is just published in J of Psychopharmacology https://t.co/9b7ZAfEbxG @Drug_Science @BAPsych

Jul 15, 2019 · 87 likes · 35 shares · 64,527 followers View post →