Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants.

Abstract in brief

• This text explains how the nematode Caenorhabditis elegans is used to study the long-term and multi-generational effects of chemical toxicants on health and the environment, focusing on transgenerational (TG) and multigenerational (MGE and MGR) effects.
• The transgenerational effect study assesses whether chemical exposure to parent nematodes causes residual impacts on their offspring, often by killing the parents afterward and evaluating the offspring for any changes.
• Multi-generational studies investigate whether continuous exposure across multiple generations leads to adaptive responses, with experiments analyzing behaviors, reproduction, lifespan, biochemistry, and gene expression to understand long-term effects.]