J Neurosci September 2019 PMID 31405928

Negative Memory Engrams in the Hippocampus Enhance the Susceptibility to Chronic Social Defeat Stress.

Tian Rui Zhang, Amanda Larosa, Marie-Eve Di Raddo, Vanessa Wong, Alice S Wong, Tak Pan Wong

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Mentions

71
Peak: 24 in Aug 2019
across 5 sources since Aug 2019

Extended reach

157,769
potential audience

Total likes

3,292

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Mentions per month

Aug 2019 – Aug 2025

Where it's discussed

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AI synopsis

What people are saying

Several discussions highlight the importance of hippocampal engrams in stress susceptibility, with phrasing like 'interesting article' and 'nice study' showing genuine curiosity and appreciation. The tone is generally positive and interested, emphasizing the scientific novelty and potential relevance to depression research, but without strong claims about immediate impact, indicating a moderate perception of the publication's influence.

AgreementModerate agreement

Most posts acknowledge the significance of the research, with some expressions of appreciation for the study's contributions, such as 'Very nice study' and references to its relevance in understanding depression.

InterestHigh interest

Discussions show high curiosity about hippocampal engrams, with multiple mentions of 'interesting' and detailed references to scientific concepts like 'negative memory engrams' and 'susceptibility to stress,' indicating strong engagement.

EngagementModerate engagement

Posts occasionally reference figures, methods, and potential clinical relevance, but generally remain at a moderate level, suggesting interest but limited deep discussion.

ImpactModerate impact

While some comments hint at potential implications for understanding and possibly treating depression, most discussions do not assert groundbreaking impact, reflecting a perception of ongoing research rather than immediate scientific revolution.

Abstract in brief

  • The study suggests that negative memory engrams in the hippocampus, particularly in the CA1 region, play a key role in increasing vulnerability to depression-like symptoms following chronic social defeat stress in mice.
  • Mice susceptible to stress showed a higher reactivation of social defeat-related hippocampal engram cells, and manipulating these cells could respectively increase or decrease social avoidance behaviors.
  • The findings highlight that chronic stress, rather than short-term stress, boosts the density of negative memory engrams in the hippocampus, which may contribute to cognitive and emotional symptoms in depression.]

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SfN Journals
@SfNJournals · X

Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according to #animalresearch from @IPNMcGill published in #JNeurosci. More on engrams and how they could be involved in treating #depression: https://t.co/VclPGWqirR https://t.co/kzOmpaZjcv

Aug 14, 2019 · 25 likes · 9 shares · 22,701 followers View post →
Dr. Angélica Torres-Berrío
@angelica_atb · X

Very nice study by Dr. Wong's Lab at @IPNMcGill and @FdnDouglas in @SfNJournals!!! "Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress" https://t.co/bjLW6mlzM2

Aug 14, 2019 · 13 likes · 6 shares · 2,110 followers View post →
Mathias Schmidt
@MathiasVSchmidt · X

Interesting article on hippocampal #engrams on #susceptibility to chronic #stress in the latest issue of @JNeuroscience https://t.co/aM1VmpIC90

Sep 19, 2019 · 11 likes · 2 shares · 2,102 followers View post →
SfN Journals
@SfNJournals · X

Negative Memory Engrams in the Hippocampus Enhance the Susceptibility to Chronic Social Defeat Stress https://t.co/IndHdP70sF

Sep 24, 2019 · 10 likes · 3 shares · 22,701 followers View post →
NINET Lab
@NinetLab · X

Congratulations Brittany on your first publication! Very interesting work, check it out tweeps Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress https://t.co/SCGkUUOChn

Aug 13, 2019 · 2 likes · 1,269 followers View post →
VanessaVilasRiotorto
@Vilas_Riotorto · X

New research in ⁦@SfNJournals⁩ Negative #memory engrams in the #hippocampus enhance the susceptibility to chronic #socialdefeat stress An engram is an assembly of neurons associated with specific memories formed after encountering a stimulus/stressor https://t.co/f9UjLO28HG

Aug 18, 2019 · 1 like · 1,716 followers View post →

All mentions

RRID Robot
@RobotRrid · X

The authors of "Negative Memory Engrams in the Hippocampus Enhance…" (https://t.co/0yo47dhtCj) included RRIDs in their paper! Thank you for making your #methodsmatter. #RRID

Feb 25, 2021 · 161 followers View post →
Jim Bloom
@jimmyroybloom · X

https://t.co/6VvaqL46Bj

Nov 16, 2020 · 2,413 followers View post →
Jim Bloom
@jimmyroybloom · X

https://t.co/LhNyjSsjSy

Nov 16, 2020 · 2,413 followers View post →
Jim Bloom
@jimmyroybloom · X

https://t.co/RQgjqx4vdi

Jul 28, 2020 · 2,413 followers View post →
Sakshi Bhava
@memeristor · X

@PhilCorlett1 Perhaps of relevance https://t.co/41Ts67z17O

Oct 30, 2019 · 252 followers View post →
IVÁN
@ixcadena · X

RT @SfNJournals: Negative Memory Engrams in the Hippocampus Enhance the Susceptibility to Chronic Social Defeat Stress https://t.co/IndHdP7…

Sep 25, 2019 · 3 shares · 101 followers View post →
Marina Picciotto
@MarinaP63 · X

RT @SfNJournals: Negative Memory Engrams in the Hippocampus Enhance the Susceptibility to Chronic Social Defeat Stress https://t.co/IndHdP7…

Sep 25, 2019 · 3 shares · 15,025 followers View post →
SfN Journals
@SfNJournals · X

Negative Memory Engrams in the Hippocampus Enhance the Susceptibility to Chronic Social Defeat Stress https://t.co/IndHdP70sF

Sep 24, 2019 · 10 likes · 3 shares · 22,701 followers View post →
BunchOfChunk
@BunchOfChunk · X

Negative Memory Engrams in the Hippocampus Enhance the Susceptibility to Chronic Social Defeat Stress: The hippocampus has been highly implicated in depression symptoms. Recent findings suggest that the expression and susceptibility of depression… https://t.co/AbgqOfskjo https://t.co/WE69vYKTAw

Sep 22, 2019 · 59 followers View post →
Serena Dudek
@Serenadudette · X

RT @MathiasVSchmidt: Interesting article on hippocampal #engrams on #susceptibility to chronic #stress in the latest issue of @JNeuroscienc…

Sep 19, 2019 · 2 shares · 1,218 followers View post →
Dr. Angélica Torres-Berrío
@angelica_atb · X

RT @MathiasVSchmidt: Interesting article on hippocampal #engrams on #susceptibility to chronic #stress in the latest issue of @JNeuroscienc…

Sep 19, 2019 · 2 shares · 2,110 followers View post →
Mathias Schmidt
@MathiasVSchmidt · X

Interesting article on hippocampal #engrams on #susceptibility to chronic #stress in the latest issue of @JNeuroscience https://t.co/aM1VmpIC90

Sep 19, 2019 · 11 likes · 2 shares · 2,102 followers View post →
Jamie Hanson (@jamielarsh.bsky.social)
@JamieLarsH · X

Negative Memory Engrams in the Hippocampus Enhance the Susceptibility to Chronic Social Defeat Stress https://t.co/OX0KC7Eea7 https://t.co/Nti4ZhOz0Z

Sep 18, 2019 · 9,661 followers View post →
BrainSights iOS App
@BrainSightsApp · X

Negative Memory Engrams in the Hippocampus Enhance the Susceptibility to Chronic Social Defeat Stress - JNeurosci via BrainSights for iOS https://t.co/Qu2ndQpgCG

Sep 18, 2019 · 313 followers View post →
Jim Bloom
@jimmyroybloom · X

RT @angelica_atb: Very nice study by Dr. Wong's Lab at @IPNMcGill and @FdnDouglas in @SfNJournals!!! "Negative memory engrams in the hippoc…

Sep 13, 2019 · 6 shares · 2,413 followers View post →
MetaCell
@MetaCell · X

RT @SfNJournals: Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according…

Aug 27, 2019 · 9 shares · 1,930 followers View post →
Giovanni Idili
@John_Idol · X

RT @SfNJournals: Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according…

Aug 20, 2019 · 9 shares · 655 followers View post →
CAN ACN
@CAN_ACN · X

RT @SfNJournals: Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according…

Aug 19, 2019 · 9 shares · 6,834 followers View post →
laelle
@1ae11e · X

Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress https://t.co/kZXDNnAXJs

Aug 19, 2019 · 13 followers View post →
Shuo_wh
@Shuo_wh · X

RT @SfNJournals: Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according…

Aug 19, 2019 · 9 shares · 2,701 followers View post →
Jim Bloom
@jimmyroybloom · X

RT @CallinLilian: Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress https://t.co/4A8dPG…

Aug 19, 2019 · 1 share · 2,413 followers View post →
Guicherd-Callin Lilian
@CallinLilian · X

Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress https://t.co/4A8dPG1h4R

Aug 19, 2019 · 1 share · 60 followers View post →
VanessaVilasRiotorto
@Vilas_Riotorto · X

New research in ⁦@SfNJournals⁩ Negative #memory engrams in the #hippocampus enhance the susceptibility to chronic #socialdefeat stress An engram is an assembly of neurons associated with specific memories formed after encountering a stimulus/stressor https://t.co/f9UjLO28HG

Aug 18, 2019 · 1 like · 1,716 followers View post →
iBraiN Inserm Lab
@iBrain_Inserm · X

RT @SfNJournals: Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according…

Aug 15, 2019 · 9 shares · 1,725 followers View post →
Berenice Márquez
@Berenice_MV · X

RT @SfNJournals: Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according…

Aug 14, 2019 · 9 shares · 702 followers View post →
Julia Garcia-Fuster
@GarciaFusterLab · X

RT @SfNJournals: Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according…

Aug 14, 2019 · 9 shares · 544 followers View post →
Matthew Cooke
@MattCooke14 · X

Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress https://t.co/gFnKKD0cER

Aug 14, 2019 · 32 followers View post →
Integrated Prgrm. in Neuroscience
@IPNMcGill · X

RT @SfNJournals: Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according…

Aug 14, 2019 · 9 shares · 1,333 followers View post →
Integrated Prgrm. in Neuroscience
@IPNMcGill · X

RT @angelica_atb: Very nice study by Dr. Wong's Lab at @IPNMcGill and @FdnDouglas in @SfNJournals!!! "Negative memory engrams in the hippoc…

Aug 14, 2019 · 6 shares · 1,333 followers View post →
Molecular and Cellular Microscopy Platform
@MCMPcore · X

RT @angelica_atb: Very nice study by Dr. Wong's Lab at @IPNMcGill and @FdnDouglas in @SfNJournals!!! "Negative memory engrams in the hippoc…

Aug 14, 2019 · 6 shares · 489 followers View post →
SfN Journals
@SfNJournals · X

Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according to #animalresearch from @IPNMcGill published in #JNeurosci. More on engrams and how they could be involved in treating #depression: https://t.co/VclPGWqirR https://t.co/kzOmpaZjcv

Aug 14, 2019 · 25 likes · 9 shares · 22,701 followers View post →
Ian Mahar
@ianmahar · X

RT @angelica_atb: Very nice study by Dr. Wong's Lab at @IPNMcGill and @FdnDouglas in @SfNJournals!!! "Negative memory engrams in the hippoc…

Aug 14, 2019 · 6 shares · 330 followers View post →
Jim Bloom
@jimmyroybloom · X

RT @angelica_atb: Very nice study by Dr. Wong's Lab at @IPNMcGill and @FdnDouglas in @SfNJournals!!! "Negative memory engrams in the hippoc…

Aug 14, 2019 · 6 shares · 2,413 followers View post →
Friedman Brain Institute
@SinaiBrain · X

RT @angelica_atb: Very nice study by Dr. Wong's Lab at @IPNMcGill and @FdnDouglas in @SfNJournals!!! "Negative memory engrams in the hippoc…

Aug 14, 2019 · 6 shares · 12,264 followers View post →
Dr. Angélica Torres-Berrío
@angelica_atb · X

Very nice study by Dr. Wong's Lab at @IPNMcGill and @FdnDouglas in @SfNJournals!!! "Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress" https://t.co/bjLW6mlzM2

Aug 14, 2019 · 13 likes · 6 shares · 2,110 followers View post →
S. Arotce Quintas.
@SArotceQuintas · X

Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress https://t.co/1ZOR7KjyyT

Aug 13, 2019 · 107 followers View post →
NINET Lab
@NinetLab · X

Congratulations Brittany on your first publication! Very interesting work, check it out tweeps Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress https://t.co/SCGkUUOChn

Aug 13, 2019 · 2 likes · 1,269 followers View post →
Anton Pashkov
@anton_pashkov03 · X

Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress https://t.co/JmrfsoQWp7

Aug 13, 2019 · 1,677 followers View post →
Wong's lab
@tpwonglab · X

Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress https://t.co/zSQMaaXyAv

Aug 12, 2019 · 1 like · 42 followers View post →