Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according to #animalresearch from @IPNMcGill published in #JNeurosci. More on engrams and how they could be involved in treating #depression: https://t.co/VclPGWqirR https://t.co/kzOmpaZjcv
Negative Memory Engrams in the Hippocampus Enhance the Susceptibility to Chronic Social Defeat Stress.
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Aug 2019 – Aug 2025Where it's discussed
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What people are saying
Several discussions highlight the importance of hippocampal engrams in stress susceptibility, with phrasing like 'interesting article' and 'nice study' showing genuine curiosity and appreciation. The tone is generally positive and interested, emphasizing the scientific novelty and potential relevance to depression research, but without strong claims about immediate impact, indicating a moderate perception of the publication's influence.
Most posts acknowledge the significance of the research, with some expressions of appreciation for the study's contributions, such as 'Very nice study' and references to its relevance in understanding depression.
Discussions show high curiosity about hippocampal engrams, with multiple mentions of 'interesting' and detailed references to scientific concepts like 'negative memory engrams' and 'susceptibility to stress,' indicating strong engagement.
Posts occasionally reference figures, methods, and potential clinical relevance, but generally remain at a moderate level, suggesting interest but limited deep discussion.
While some comments hint at potential implications for understanding and possibly treating depression, most discussions do not assert groundbreaking impact, reflecting a perception of ongoing research rather than immediate scientific revolution.
Abstract in brief
- The study suggests that negative memory engrams in the hippocampus, particularly in the CA1 region, play a key role in increasing vulnerability to depression-like symptoms following chronic social defeat stress in mice.
- Mice susceptible to stress showed a higher reactivation of social defeat-related hippocampal engram cells, and manipulating these cells could respectively increase or decrease social avoidance behaviors.
- The findings highlight that chronic stress, rather than short-term stress, boosts the density of negative memory engrams in the hippocampus, which may contribute to cognitive and emotional symptoms in depression.]
Top posts
Most liked on X and BlueskyVery nice study by Dr. Wong's Lab at @IPNMcGill and @FdnDouglas in @SfNJournals!!! "Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress" https://t.co/bjLW6mlzM2
Interesting article on hippocampal #engrams on #susceptibility to chronic #stress in the latest issue of @JNeuroscience https://t.co/aM1VmpIC90
Negative Memory Engrams in the Hippocampus Enhance the Susceptibility to Chronic Social Defeat Stress https://t.co/IndHdP70sF
Congratulations Brittany on your first publication! Very interesting work, check it out tweeps Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress https://t.co/SCGkUUOChn
New research in @SfNJournals Negative #memory engrams in the #hippocampus enhance the susceptibility to chronic #socialdefeat stress An engram is an assembly of neurons associated with specific memories formed after encountering a stimulus/stressor https://t.co/f9UjLO28HG
All mentions
Hippocampal Negative Memory Engrams and Stress Susceptibility
Negative memory engrams in the hippocampus, especially in the CA1 region, increase vulnerability to depression-like symptoms following chronic social defeat stress. Manipulating these engrams can alter social avoidance…
The authors of "Negative Memory Engrams in the Hippocampus Enhance…" (https://t.co/0yo47dhtCj) included RRIDs in their paper! Thank you for making your #methodsmatter. #RRID
https://t.co/6VvaqL46Bj
https://t.co/LhNyjSsjSy
https://t.co/RQgjqx4vdi
@PhilCorlett1 Perhaps of relevance https://t.co/41Ts67z17O
RT @SfNJournals: Negative Memory Engrams in the Hippocampus Enhance the Susceptibility to Chronic Social Defeat Stress https://t.co/IndHdP7…
RT @SfNJournals: Negative Memory Engrams in the Hippocampus Enhance the Susceptibility to Chronic Social Defeat Stress https://t.co/IndHdP7…
Negative Memory Engrams in the Hippocampus Enhance the Susceptibility to Chronic Social Defeat Stress https://t.co/IndHdP70sF
Negative Memory Engrams in the Hippocampus Enhance the Susceptibility to Chronic Social Defeat Stress: The hippocampus has been highly implicated in depression symptoms. Recent findings suggest that the expression and susceptibility of depression… https://t.co/AbgqOfskjo https://t.co/WE69vYKTAw
RT @MathiasVSchmidt: Interesting article on hippocampal #engrams on #susceptibility to chronic #stress in the latest issue of @JNeuroscienc…
RT @MathiasVSchmidt: Interesting article on hippocampal #engrams on #susceptibility to chronic #stress in the latest issue of @JNeuroscienc…
Interesting article on hippocampal #engrams on #susceptibility to chronic #stress in the latest issue of @JNeuroscience https://t.co/aM1VmpIC90
Negative Memory Engrams in the Hippocampus Enhance the Susceptibility to Chronic Social Defeat Stress https://t.co/OX0KC7Eea7 https://t.co/Nti4ZhOz0Z
Negative Memory Engrams in the Hippocampus Enhance the Susceptibility to Chronic Social Defeat Stress - JNeurosci via BrainSights for iOS https://t.co/Qu2ndQpgCG
RT @angelica_atb: Very nice study by Dr. Wong's Lab at @IPNMcGill and @FdnDouglas in @SfNJournals!!! "Negative memory engrams in the hippoc…
RT @SfNJournals: Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according…
RT @SfNJournals: Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according…
RT @SfNJournals: Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according…
Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress https://t.co/kZXDNnAXJs
RT @SfNJournals: Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according…
RT @CallinLilian: Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress https://t.co/4A8dPG…
Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress https://t.co/4A8dPG1h4R
New research in @SfNJournals Negative #memory engrams in the #hippocampus enhance the susceptibility to chronic #socialdefeat stress An engram is an assembly of neurons associated with specific memories formed after encountering a stimulus/stressor https://t.co/f9UjLO28HG
RT @SfNJournals: Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according…
RT @SfNJournals: Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according…
RT @SfNJournals: Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according…
Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress https://t.co/gFnKKD0cER
RT @SfNJournals: Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according…
RT @angelica_atb: Very nice study by Dr. Wong's Lab at @IPNMcGill and @FdnDouglas in @SfNJournals!!! "Negative memory engrams in the hippoc…
RT @angelica_atb: Very nice study by Dr. Wong's Lab at @IPNMcGill and @FdnDouglas in @SfNJournals!!! "Negative memory engrams in the hippoc…
Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according to #animalresearch from @IPNMcGill published in #JNeurosci. More on engrams and how they could be involved in treating #depression: https://t.co/VclPGWqirR https://t.co/kzOmpaZjcv
RT @angelica_atb: Very nice study by Dr. Wong's Lab at @IPNMcGill and @FdnDouglas in @SfNJournals!!! "Negative memory engrams in the hippoc…
RT @angelica_atb: Very nice study by Dr. Wong's Lab at @IPNMcGill and @FdnDouglas in @SfNJournals!!! "Negative memory engrams in the hippoc…
RT @angelica_atb: Very nice study by Dr. Wong's Lab at @IPNMcGill and @FdnDouglas in @SfNJournals!!! "Negative memory engrams in the hippoc…
Very nice study by Dr. Wong's Lab at @IPNMcGill and @FdnDouglas in @SfNJournals!!! "Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress" https://t.co/bjLW6mlzM2
Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress https://t.co/1ZOR7KjyyT
Congratulations Brittany on your first publication! Very interesting work, check it out tweeps Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress https://t.co/SCGkUUOChn
Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress https://t.co/JmrfsoQWp7
Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress https://t.co/zSQMaaXyAv