@BradStanfieldMD you've just cited a study in which it was shown that mice and humans didn't behave the same way why not cite the known anti-inflammatory effects of NR in people? https://t.co/pgzrbgL709
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.
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Aug 2019 – Sep 2025Where it's discussed
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AI synopsis
What people are saying
The discussions reflect a generally positive reception, with users citing multiple studies showing anti-inflammatory effects of NR, and expressing curiosity about its mechanisms and benefits—highlighted by wording like 'fantastic work' and questions about its clinical relevance—indicating a keen engagement with both scientific details and broader implications.
Most discussions acknowledge the study’s findings on NR’s potential anti-inflammatory effects and its influence on skeletal muscle NAD+ levels, indicating general support for the results.
The topic generates high interest among users, many referencing specific details like inflammatory cytokines, muscle health, and related studies, showing active engagement.
Participants discuss methodological aspects, related research, and implications, indicating a moderate depth of engagement with scientific nuances.
While some posts question the overall significance and clinical relevance, many emphasize the potential therapeutic impact of NR, reflecting a recognition of its importance.
Abstract in brief
- Nicotinamide riboside (NR) supplementation in aged men increased key components of the NAD metabolome in skeletal muscle and decreased circulating inflammatory cytokines, suggesting potential anti-inflammatory benefits.
- Despite boosting NAD-related metabolites, NR did not affect mitochondrial energy processes, indicating it may influence muscle health through metabolic and anti-inflammatory pathways rather than mitochondrial function.
- The study provides evidence that oral NR is effective in aging humans for modulating muscle NAD levels and inflammatory markers, supporting its potential as a supplement to combat age-related metabolic and inflammatory decline.]
Top posts
Most liked on X and BlueskyNicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures: Cell Reports; fantastic work, @Yasir_SElhassan @Lavery_Lab
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures | New from @Lavery_Lab group https://t.co/EL2kowguaP
fyi, we've been seeing anti-inflammatory effects of NR in RCTs since 2019 https://t.co/pgzrbgL709 https://t.co/qmBQXuEFAW
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. - PubMed - NCBI https://t.co/up9yE61l9V
NAD+ Boosters 3/ Elhassan et al., 2019 Claimed citation: Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures PMID: 31412240
All mentions
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Longevity Science explores the impact of supplements and drug repurposing on health and aging. This video discusses how circadian alignment and caloric restriction can influence lifespan in mice, highlighting metabolic…
Understanding NAD and Its Significance in Cell Function
This video explores NAD Nicotinamide Adenine Dinucleotide, a natural coenzyme vital for cellular processes, factors affecting its production, and supplement options. It also covers synergistic nutrient combinations and…
NAD+ Boosters 3/ Elhassan et al., 2019 Claimed citation: Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures PMID: 31412240
@AnanondogDog there are 7 human clinical studies showing anti-inflammatory effects of NR this is the first https://t.co/pgzrbgL709
@BradStanfieldMD you've just cited a study in which it was shown that mice and humans didn't behave the same way why not cite the known anti-inflammatory effects of NR in people? https://t.co/pgzrbgL709
@CharlesMBrenner Can you share? Here's a list of interventions showing it has little to no effect on clinical outcomes. https://t.co/IkTJUGcoTG https://t.co/gzFz1pNl4q https://t.co/ppApaZv2bA https://t.co/KD1y3lEM8h https://t.co/SRgr0bbZpK https://t.co/0ypM5uozRV https://t.co/HQo8SNxJN7
@RaisingNad @zac_bow @LfcSingh82 NIH studies NMN and cardiovascular https://t.co/tQZsU7ka5G NR and skeletal muscle: https://t.co/VnXaGX5qxd
RT @CharlesMBrenner: fyi, we've been seeing anti-inflammatory effects of NR in RCTs since 2019 https://t.co/pgzrbgL709
fyi, we've been seeing anti-inflammatory effects of NR in RCTs since 2019 https://t.co/pgzrbgL709 https://t.co/qmBQXuEFAW
@DrMorganLevine @CharlesMBrenner https://t.co/IyW81YVnp2 https://t.co/QwiiY0EKui https://t.co/qXEIW3ZL16 https://t.co/d1GQcl5CXW https://t.co/LU9dxcBHEW https://t.co/xLV4H6TGPn However: https://t.co/wRkeil7o61 https://t.co/WdGN1nGkzd
The authors of "Nicotinamide Riboside Augments the Aged Human Skel…" (https://t.co/hINbfQbiCE) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #ReproducibleResearch #reproducibility
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures https://t.co/xEkFfyaxWz #Energy #Mitochondira #Nutrition #Science
@Jediphone @davidasinclair @PeterAttiaMD Small RCT shows that 1 g NR depresses TNFalpha circulation within 3 weeks in healthy older men https://t.co/DapydpStyf
@Warren68191011 we showed that 3 wks of NR decreases IL6 and other inflammatory cytokines in older men. i suspect this mechanism could relieve your symptoms. needs a larger study to confirm https://t.co/pgzrbgKzaB
@wyadvd @upyrbike Oh there’s a lot more to this story - both positive and clearly unsupportive of the idea. Some of the earlier Cell Metabolism articles are “confusing”. Little belief this is a magic bullet https://t.co/TFOM8AaRdv https://t.co/6hzLdcb6vx @andyphilp_lab
#RNAseq Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces ... https://t.co/rvx0HSaBdB
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. - PubMed - NCBI https://t.co/I2AXo0T0VQ
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. - PubMed - NCBI https://t.co/I2AXo0T0VQ
RT @Neuroscience_Dr: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-infl…
RT @Neuroscience_Dr: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-infl…
RT @Neuroscience_Dr: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-infl…
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures: Cell Reports; fantastic work, @Yasir_SElhassan @Lavery_Lab
RT @AntiAgify: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammato…
RT @AntiAgify: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammato…
RT @AntiAgify: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammato…
RT @HughesDC_Muscle: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-infl…
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures https://t.co/5gbmZeVo2R
#mitochondria Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. https://t.co/Bkq5CIXYRP via @MitochondriaNe1
RT @HughesDC_Muscle: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-infl…
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. https://t.co/zPu0Fml7fY
RT @Brunorm84: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammato…
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. https://t.co/VJWiwCjAYZ
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures @CellReports https://t.co/SAasGVOkss
RT @MitoMedicine: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflamm…
RT @MitoMedicine: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflamm…
RT @MitoMedicine: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflamm…
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures | New from @Lavery_Lab group https://t.co/EL2kowguaP
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. - PubMed - NCBI https://t.co/up9yE61l9V
RT @bioblastgeek: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflamm…
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures https://t.co/6tMf8VZGHD
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures: Cell Reports https://t.co/AzJRv9Pwzz
"Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures" https://t.co/FLZpJKePna
Does Oral NAD do much??? Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures https://t.co/iS14pYdYdN
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