August 2019 PMID 31412242

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.

Yasir S Elhassan, Katarina Kluckova, Rachel S Fletcher, Mark S Schmidt, Antje Garten, Craig L Doig, David M Cartwright, Lucy Oakey, Claire V Burley, Ned Jenkinson, Martin Wilson, Samuel J E Lucas, Ildem Akerman, Alex Seabright, Yu-Chiang Lai

Mentions

76
Peak: 28 in Aug 2019
across 5 sources since Aug 2019

Extended reach

370,458
potential audience

Total likes

120

Video views

2,163

Mentions per month

Aug 2019 – Sep 2025

Where it's discussed

  • X / Twitter43 posts
  • News20 articles
  • Facebook8 posts
  • Blogs3 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reflect a generally positive reception, with users citing multiple studies showing anti-inflammatory effects of NR, and expressing curiosity about its mechanisms and benefits—highlighted by wording like 'fantastic work' and questions about its clinical relevance—indicating a keen engagement with both scientific details and broader implications.

AgreementModerate agreement

Most discussions acknowledge the study’s findings on NR’s potential anti-inflammatory effects and its influence on skeletal muscle NAD+ levels, indicating general support for the results.

InterestHigh interest

The topic generates high interest among users, many referencing specific details like inflammatory cytokines, muscle health, and related studies, showing active engagement.

EngagementModerate engagement

Participants discuss methodological aspects, related research, and implications, indicating a moderate depth of engagement with scientific nuances.

ImpactModerate impact

While some posts question the overall significance and clinical relevance, many emphasize the potential therapeutic impact of NR, reflecting a recognition of its importance.

Abstract in brief

  • Nicotinamide riboside (NR) supplementation in aged men increased key components of the NAD metabolome in skeletal muscle and decreased circulating inflammatory cytokines, suggesting potential anti-inflammatory benefits.
  • Despite boosting NAD-related metabolites, NR did not affect mitochondrial energy processes, indicating it may influence muscle health through metabolic and anti-inflammatory pathways rather than mitochondrial function.
  • The study provides evidence that oral NR is effective in aging humans for modulating muscle NAD levels and inflammatory markers, supporting its potential as a supplement to combat age-related metabolic and inflammatory decline.]

Top posts

Most liked on X and Bluesky
Charles Brenner, PhD
@CharlesMBrenner · X

@BradStanfieldMD you've just cited a study in which it was shown that mice and humans didn't behave the same way why not cite the known anti-inflammatory effects of NR in people? https://t.co/pgzrbgL709

Feb 21, 2024 · 16 likes · 57,081 followers View post →
Lisa Hill
@Neuroscience_Dr · X

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures: Cell Reports; fantastic work, ⁦@Yasir_SElhassan⁩ ⁦@Lavery_Lab⁩

Aug 22, 2019 · 13 likes · 4 shares · 2,136 followers View post →
Dave Hughes
@HughesDC_Muscle · X

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures | New from @Lavery_Lab group https://t.co/EL2kowguaP

Aug 15, 2019 · 12 likes · 2 shares · 11,022 followers View post →
Charles Brenner, PhD
@CharlesMBrenner · X

fyi, we've been seeing anti-inflammatory effects of NR in RCTs since 2019 https://t.co/pgzrbgL709 https://t.co/qmBQXuEFAW

Oct 4, 2022 · 11 likes · 2 shares · 57,081 followers View post →
MitoMedicine
@MitoMedicine · X

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. - PubMed - NCBI https://t.co/up9yE61l9V

Aug 15, 2019 · 10 likes · 3 shares · 2,985 followers View post →
IntegralAnswers
@IntegralAnswers · X

NAD+ Boosters 3/ Elhassan et al., 2019 Claimed citation: Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures PMID: 31412240

Jul 18, 2025 · 7 likes · 8,333 followers View post →

All mentions

IntegralAnswers
@IntegralAnswers · X

NAD+ Boosters 3/ Elhassan et al., 2019 Claimed citation: Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures PMID: 31412240

Jul 18, 2025 · 7 likes · 8,333 followers View post →
Charles Brenner, PhD
@CharlesMBrenner · X

@AnanondogDog there are 7 human clinical studies showing anti-inflammatory effects of NR this is the first https://t.co/pgzrbgL709

Jun 12, 2024 · 57,081 followers View post →
Charles Brenner, PhD
@CharlesMBrenner · X

@BradStanfieldMD you've just cited a study in which it was shown that mice and humans didn't behave the same way why not cite the known anti-inflammatory effects of NR in people? https://t.co/pgzrbgL709

Feb 21, 2024 · 16 likes · 57,081 followers View post →
Alex Leaf
@AlexJLeaf · X

@CharlesMBrenner Can you share? Here's a list of interventions showing it has little to no effect on clinical outcomes. https://t.co/IkTJUGcoTG https://t.co/gzFz1pNl4q https://t.co/ppApaZv2bA https://t.co/KD1y3lEM8h https://t.co/SRgr0bbZpK https://t.co/0ypM5uozRV https://t.co/HQo8SNxJN7

Jun 7, 2023 · 4,190 followers View post →
Oceanman
@Kaidansei · X

@RaisingNad @zac_bow @LfcSingh82 NIH studies NMN and cardiovascular https://t.co/tQZsU7ka5G NR and skeletal muscle: https://t.co/VnXaGX5qxd

Jun 5, 2023 · 173 followers View post →
RaisingNAD.com
@RaisingNad · X

RT @CharlesMBrenner: fyi, we've been seeing anti-inflammatory effects of NR in RCTs since 2019 https://t.co/pgzrbgL709

Oct 4, 2022 · 2 shares · 1,067 followers View post →
Charles Brenner, PhD
@CharlesMBrenner · X

fyi, we've been seeing anti-inflammatory effects of NR in RCTs since 2019 https://t.co/pgzrbgL709 https://t.co/qmBQXuEFAW

Oct 4, 2022 · 11 likes · 2 shares · 57,081 followers View post →
BCNT
@BCNThomson · X

@DrMorganLevine @CharlesMBrenner https://t.co/IyW81YVnp2 https://t.co/QwiiY0EKui https://t.co/qXEIW3ZL16 https://t.co/d1GQcl5CXW https://t.co/LU9dxcBHEW https://t.co/xLV4H6TGPn However: https://t.co/wRkeil7o61 https://t.co/WdGN1nGkzd

Mar 19, 2022 · 458 followers View post →
RRID Robot
@RobotRrid · X

The authors of "Nicotinamide Riboside Augments the Aged Human Skel…" (https://t.co/hINbfQbiCE) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #ReproducibleResearch #reproducibility

Feb 25, 2021 · 161 followers View post →
The Natural Health Blogger
@naturalhealthbl · X

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures https://t.co/xEkFfyaxWz #Energy #Mitochondira #Nutrition #Science

Sep 1, 2020 · 2,287 followers View post →
Charles Brenner, PhD
@CharlesMBrenner · X

@Jediphone @davidasinclair @PeterAttiaMD Small RCT shows that 1 g NR depresses TNFalpha circulation within 3 weeks in healthy older men https://t.co/DapydpStyf

Jul 19, 2020 · 1 like · 57,081 followers View post →
Charles Brenner, PhD
@CharlesMBrenner · X

@Warren68191011 we showed that 3 wks of NR decreases IL6 and other inflammatory cytokines in older men. i suspect this mechanism could relieve your symptoms. needs a larger study to confirm https://t.co/pgzrbgKzaB

Jun 4, 2020 · 57,081 followers View post →
Jamie Timmons
@metapredict · X

@wyadvd @upyrbike Oh there’s a lot more to this story - both positive and clearly unsupportive of the idea. Some of the earlier Cell Metabolism articles are “confusing”. Little belief this is a magic bullet https://t.co/TFOM8AaRdv https://t.co/6hzLdcb6vx @andyphilp_lab

Nov 18, 2019 · 1 like · 2,060 followers View post →
SeqComplete
@SeqComplete · X

#RNAseq Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces ... https://t.co/rvx0HSaBdB

Nov 13, 2019 · 4,403 followers View post →
John T Weatherly
@jtwheat27 · X

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. - PubMed - NCBI https://t.co/I2AXo0T0VQ

Sep 22, 2019 · 1 like · 5,009 followers View post →
John T Weatherly
@jtwheat27 · X

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. - PubMed - NCBI https://t.co/I2AXo0T0VQ

Aug 23, 2019 · 5,009 followers View post →
Frank Jaksch
@JakschFrank · X

RT @Neuroscience_Dr: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-infl…

Aug 22, 2019 · 4 shares · 264 followers View post →
Craig Doig
@cld536 · X

RT @Neuroscience_Dr: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-infl…

Aug 22, 2019 · 4 shares · 301 followers View post →
UoB Department of Biomedical Sciences
@unibham_SoBMS · X

RT @Neuroscience_Dr: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-infl…

Aug 22, 2019 · 4 shares · 857 followers View post →
Lisa Hill
@Neuroscience_Dr · X

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures: Cell Reports; fantastic work, ⁦@Yasir_SElhassan⁩ ⁦@Lavery_Lab⁩

Aug 22, 2019 · 13 likes · 4 shares · 2,136 followers View post →
Dr. Aviseka
@aviseka · X

RT @AntiAgify: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammato…

Aug 19, 2019 · 3 shares · 2,457 followers View post →
Craig Doig
@cld536 · X

RT @AntiAgify: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammato…

Aug 19, 2019 · 3 shares · 301 followers View post →
AlfredoPietracatella
@alfredopietraca · X

RT @AntiAgify: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammato…

Aug 19, 2019 · 3 shares · 244 followers View post →
Professor Adam Sharples
@DrAdamPSharples · X

RT @HughesDC_Muscle: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-infl…

Aug 18, 2019 · 2 shares · 7,330 followers View post →
AntiAgify - Science will set you free
@AntiAgify · X

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures https://t.co/5gbmZeVo2R

Aug 17, 2019 · 5 likes · 3 shares · 1,353 followers View post →
Researchphilia
@researchphilia · X

Aug 16, 2019 · 480 followers View post →
Researchphilia
@researchphilia · X

Aug 16, 2019 · 1 like · 480 followers View post →
Mitochondrial News
@MitochondriaNe1 · X

#mitochondria Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. https://t.co/Bkq5CIXYRP via @MitochondriaNe1

Aug 15, 2019 · 2,255 followers View post →
Matías Monsalves-Álvarez
@profemonsalves · X

RT @HughesDC_Muscle: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-infl…

Aug 15, 2019 · 2 shares · 1,504 followers View post →
mitopapers
@mito_papers · X

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. https://t.co/zPu0Fml7fY

Aug 15, 2019 · 145 followers View post →
Federico Bernuzzi, PhD
@FedericoBernuzz · X

RT @Brunorm84: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammato…

Aug 15, 2019 · 1 share · 625 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. https://t.co/VJWiwCjAYZ

Aug 15, 2019 · 2,240 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures @CellReports https://t.co/SAasGVOkss

Aug 15, 2019 · 2 likes · 1 share · 6,454 followers View post →
Mayke Briggs
@MaykeBriggs · X

RT @MitoMedicine: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflamm…

Aug 15, 2019 · 3 shares · 611 followers View post →
Fernando Peña
@Fjpvega · X

RT @MitoMedicine: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflamm…

Aug 15, 2019 · 3 shares · 387 followers View post →
lewis
@COXNegative · X

RT @MitoMedicine: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflamm…

Aug 15, 2019 · 3 shares · 200 followers View post →
Dave Hughes
@HughesDC_Muscle · X

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures | New from @Lavery_Lab group https://t.co/EL2kowguaP

Aug 15, 2019 · 12 likes · 2 shares · 11,022 followers View post →
MitoMedicine
@MitoMedicine · X

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. - PubMed - NCBI https://t.co/up9yE61l9V

Aug 15, 2019 · 10 likes · 3 shares · 2,985 followers View post →
Barry Brady
@brady6517 · X

RT @bioblastgeek: Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflamm…

Aug 14, 2019 · 1 share · 140 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures https://t.co/6tMf8VZGHD

Aug 14, 2019 · 2,240 followers View post →
Craig Porter
@bioblastgeek · X

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures: Cell Reports https://t.co/AzJRv9Pwzz

Aug 14, 2019 · 7 likes · 1 share · 1,254 followers View post →
uc o;lj
@WeCanBeHeuros · X

"Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures" https://t.co/FLZpJKePna

Aug 13, 2019 · 1,039 followers View post →
Angie van Bemden
@DrvanBemden · X

Does Oral NAD do much??? Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures https://t.co/iS14pYdYdN

Aug 13, 2019 · 328 followers View post →