Cell Rep August 2019 PMID 31412252

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas.

Meng-Hsiung Hsieh, Joshua H Choe, Jashkaran Gadhvi, Yoon Jung Kim, Marcus A Arguez, Madison Palmer, Haleigh Gerold, Chance Nowak, Hung Do, Simbarashe Mazambani, Jordan K Knighton, Matthew Cha, Justin Goodwin, Min Kyu Kang, Ji Yun Jeong

Download social card

Mentions

78
Peak: 50 in Aug 2019
across 4 sources since Aug 2019

Extended reach

540,396
potential audience

Total likes

427

Video views

18,203

Mentions per month

Aug 2019 – Apr 2022

Where it's discussed

  • X / Twitter53 posts
  • News18 articles
  • Facebook5 posts
  • YouTube2 videos

AI synopsis

What people are saying

Many participants expressed enthusiasm about the findings, particularly regarding the ketogenic diet's role in potentially slowing down tumor growth, using phrases like 'anti-cancer effect' and 'game changer.' Discussions highlighted the correlations between glucose levels and patient outcomes, with one participant noting, 'a robust correlation between blood glucose concentration and worse survival rates.' This demonstrates the serious tone and urgency in addressing therapeutic strategies stemming from the research.

AgreementModerate agreement

A majority of the discussions show positive sentiments towards the findings, particularly in relation to the therapeutic implications of the research.

InterestHigh interest

The level of curiosity about the methods and applications mentioned in the publication is notably high, highlighted by multiple users engaging with the topic.

EngagementModerate engagement

While many participants share content, a few delve into specifics like the ketogenic diet and its relation to tumor growth inhibition, indicating moderate engagement.

ImpactHigh impact

Many contributors perceive the research as significant, discussing its potential to influence treatment strategies for squamous cell carcinomas.

Abstract in brief

  • Squamous cell carcinoma (SCC) is a type of cancer that shows a high dependency on glucose for survival and growth, largely due to hyperactive GLUT1 transporters.
  • Transcription factors p63 and SOX2 enhance glucose uptake by activating specific genes, leading to increased production of protective molecules like NADPH and GSH in SCC tumors.
  • Reducing glucose intake through methods like a ketogenic diet or using SGLT2 inhibitors can stress SCC tumors and inhibit their growth, suggesting potential therapeutic strategies to improve survival rates in SCC patients.

Top posts

Most liked on X and Bluesky
David Diamond
@LDLSkeptic · X

"Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting redox homeostasis and insulin/AKT pathways in vivo" https://t.co/ePmxj3tkrr @DominicDAgosti2

Aug 14, 2019 · 33 likes · 9 shares · 44,719 followers View post →
Cell Reports
@CellReports · X

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/3hy3P1ZORk

Aug 20, 2019 · 24 likes · 7 shares · 141,471 followers View post →
Ahmad B Mahmoud, PhD
@Ahmad_B_Mahmoud · X

Systemic glucose restriction by (keto diet) and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate intratumoral oxidative stress and tumor growth inhibition حمية الكيتو وتثبيط اعادة امتصاص الجلكوز في الكلى (قد) تساعد في تثبيط نمو الورم https://t.co/SvVsgxspag

Aug 15, 2019 · 19 likes · 8 shares · 4,553 followers View post →
Atanas G. Atanasov
@_atanas_ · X

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/MtzFUwKMNu

Aug 25, 2019 · 13 likes · 2 shares · 123,672 followers View post →
Tae Hoon Kim
@taehoonkim · X

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas: Cell Reports https://t.co/0kBOL64vel

Aug 15, 2019 · 7 likes · 2 shares · 782 followers View post →
Reiner 
@erlesen · X

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/6zN1p74zoI Preclinical research suggests anti-cancer effect of keto diet https://t.co/OxC98DoHgg restricting blood glucose levels might keep certain cancers at bay

Aug 16, 2019 · 5 likes · 3 shares · 7,857 followers View post →

All mentions

RRID Robot
@RobotRrid · X

RRIDs were included in the Cell Reports paper "p63 and SOX2 Dictate Glucose Reliance and Metaboli…" (https://t.co/180PDyIihs). Thank you for making your #methodsmatter. #OpenScience

Aug 19, 2021 · 161 followers View post →
Khalid
@Khalid_tch · X

@DrAhmedAlShehri https://t.co/bbjZLKou22 https://t.co/SThLbULwOv

Jun 21, 2021 View post →
Reiner 
@erlesen · X

RT @erlesen: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/6zN1p74zoI Precli…

Jan 21, 2020 · 3 shares · 7,857 followers View post →
Stephen Pimentel
@StephenPiment · X

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/MbKRAGPkoZ

Aug 29, 2019 · 1 like · 12,706 followers View post →
مقاومة الانسولين insulin resistance
@insulin_resista · X

RT @Ahmad_B_Mahmoud: Systemic glucose restriction by (keto diet) and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate…

Aug 27, 2019 · 8 shares · 30,524 followers View post →
OurWarOnCancer
@OurWarOnCancer · X

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas: Cell Reports https://t.co/0iuRc2tGLE

Aug 26, 2019 · 1 like · 1 share · 2,254 followers View post →
Lunapy
@pikarasukaru · X

RT @_atanas_: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/MtzFUwKMNu

Aug 25, 2019 · 2 shares · 1,038 followers View post →
Sadeeq Sheshe
@ShesheSadeeq · X

RT @_atanas_: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/MtzFUwKMNu

Aug 25, 2019 · 2 shares · 884 followers View post →
Miguel
@maperezmachado · X

RT @_atanas_: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/MtzFUwKMNu

Aug 25, 2019 · 2 shares · 627 followers View post →
Atanas G. Atanasov
@_atanas_ · X

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/MtzFUwKMNu

Aug 25, 2019 · 13 likes · 2 shares · 123,672 followers View post →
TheNutritionNetwork
@NutritionNetwor · X

RT @CNELM1: https://t.co/c9RTm3VTbA New research indicates that controlling blood sugar levels could increase the efficacy of chemotherapy…

Aug 23, 2019 · 2 shares · 2,802 followers View post →
Master Lectures On Stem Cells' Molecular Biology
@MastetB · X

RT @CellReports: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/3hy3P1ZORk

Aug 22, 2019 · 7 shares · 56 followers View post →
Coriander Stone Kitchen Coach
@CorianderStone · X

RT @CNELM1: https://t.co/c9RTm3VTbA New research indicates that controlling blood sugar levels could increase the efficacy of chemotherapy…

Aug 22, 2019 · 2 shares · 107 followers View post →
CNELM
@CNELM1 · X

https://t.co/c9RTm3VTbA New research indicates that controlling blood sugar levels could increase the efficacy of chemotherapy and help treat some forms of cancer.

Aug 22, 2019 · 2 likes · 2 shares · 923 followers View post →
epigenetist
@epigenetist · X

RT @CellReports: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/3hy3P1ZORk

Aug 21, 2019 · 7 shares · 239 followers View post →
Sadeeq Sheshe
@ShesheSadeeq · X

RT @CellReports: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/3hy3P1ZORk

Aug 21, 2019 · 7 shares · 884 followers View post →
Ming "Tommy" Tang
@tangming2005 · X

RT @CellReports: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/3hy3P1ZORk

Aug 21, 2019 · 7 shares · 41,041 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

RT @CellReports: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/3hy3P1ZORk

Aug 20, 2019 · 7 shares · 18,423 followers View post →
Jashkaran Gadhvi, PhD
@jashkaran · X

RT @CellReports: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/3hy3P1ZORk

Aug 20, 2019 · 7 shares · 243 followers View post →
Brandon Bustos
@genonauta · X

RT @CellReports: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/3hy3P1ZORk

Aug 20, 2019 · 7 shares · 143 followers View post →
Cell Reports
@CellReports · X

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/3hy3P1ZORk

Aug 20, 2019 · 24 likes · 7 shares · 141,471 followers View post →
Jashkaran Gadhvi, PhD
@jashkaran · X

RT @taehoonkim: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas: Cell Reports https://t.co/…

Aug 18, 2019 · 2 shares · 243 followers View post →
Reiner 
@erlesen · X

RT @erlesen: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/6zN1p74zoI Precli…

Aug 17, 2019 · 3 shares · 7,857 followers View post →
ilona kasza
@babilon1271 · X

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas: Cell Reports #cancer #glucose #keto #ketodiet #ketogenic #nutrition https://t.co/7oTKzFi0SP

Aug 17, 2019 · 204 followers View post →
Ori
@oriettamusic · X

RT @erlesen: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/6zN1p74zoI Precli…

Aug 17, 2019 · 3 shares · 22,817 followers View post →
Reiner 
@erlesen · X

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/6zN1p74zoI Preclinical research suggests anti-cancer effect of keto diet https://t.co/OxC98DoHgg restricting blood glucose levels might keep certain cancers at bay

Aug 16, 2019 · 5 likes · 3 shares · 7,857 followers View post →
Steven Seagull
@thirstytrapped · X

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. https://t.co/SVHQqOJ1l5

Aug 16, 2019 · 3,341 followers View post →
حسين
@Sci70021 · X

RT @Ahmad_B_Mahmoud: Systemic glucose restriction by (keto diet) and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate…

Aug 16, 2019 · 8 shares · 27 followers View post →
Rana Ahmed
@ranamadani09 · X

RT @Ahmad_B_Mahmoud: Systemic glucose restriction by (keto diet) and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate…

Aug 16, 2019 · 8 shares · 519 followers View post →
Naif Almontashiri
@naifalmontashir · X

RT @Ahmad_B_Mahmoud: Systemic glucose restriction by (keto diet) and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate…

Aug 16, 2019 · 8 shares · 24,953 followers View post →
Maurício Lima
@dj_surfista · X

Demonstraram uma correlação robusta entre a concentração de glicose no sangue e pior sobrevida entre os pacientes com Carcinoma de células escamosas da pele. https://t.co/OQDQvmDsMF #cancer #oncologia #oncology #ketogenicdiet #keto #ketosis #cetose #zerocarb https://t.co/7xtClxyYeC

Aug 16, 2019 · 743 followers View post →
Mark Borris Aldonza (@precursorcell.bsky.social
@PrecursorCell · X

RT @taehoonkim: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas: Cell Reports https://t.co/…

Aug 16, 2019 · 2 shares · 1,385 followers View post →
Khaled Alharbi
@kfh87 · X

RT @Ahmad_B_Mahmoud: Systemic glucose restriction by (keto diet) and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate…

Aug 16, 2019 · 8 shares · 864 followers View post →
محمد بن عبدالرحمن القاسم
@maq_05 · X

RT @Ahmad_B_Mahmoud: Systemic glucose restriction by (keto diet) and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate…

Aug 16, 2019 · 8 shares · 500 followers View post →
Dr Mazen Ghaith
@mm_ghaith · X

RT @Ahmad_B_Mahmoud: Systemic glucose restriction by (keto diet) and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate…

Aug 15, 2019 · 8 shares · 2,827 followers View post →
Ahmad B Mahmoud, PhD
@Ahmad_B_Mahmoud · X

Systemic glucose restriction by (keto diet) and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate intratumoral oxidative stress and tumor growth inhibition حمية الكيتو وتثبيط اعادة امتصاص الجلكوز في الكلى (قد) تساعد في تثبيط نمو الورم https://t.co/SvVsgxspag

Aug 15, 2019 · 19 likes · 8 shares · 4,553 followers View post →
Tae Hoon Kim
@taehoonkim · X

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas: Cell Reports https://t.co/0kBOL64vel

Aug 15, 2019 · 7 likes · 2 shares · 782 followers View post →
UT Dallas Biology
@UTD_Biology · X

New publication from UTD_Biology. https://t.co/HM4oy26lZn. p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas.

Aug 15, 2019 · 2 likes · 1,239 followers View post →
くずお
@tanpakugakatsu · X

RT @LDLSkeptic: "Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting red…

Aug 15, 2019 · 9 shares · 133 followers View post →
ケトジェニックボディメイカー
@ketobodymaker · X

RT @kojija: 扁平上皮癌細胞はGLUT1発現が上昇していた。強化されたGLUT1を介したブドウ糖流入は、抗酸化物質の生産を促進して生存を促進する。ブドウ糖制限は、代謝経路および発癌経路を同時に標的にする。ランダムな高い血糖値は予後不良と相関していた。 #扁平上皮癌…

Aug 14, 2019 · 2 shares · 1,631 followers View post →
きいちゃん
@ykha5451 · X

RT @kojija: 扁平上皮癌細胞はGLUT1発現が上昇していた。強化されたGLUT1を介したブドウ糖流入は、抗酸化物質の生産を促進して生存を促進する。ブドウ糖制限は、代謝経路および発癌経路を同時に標的にする。ランダムな高い血糖値は予後不良と相関していた。 #扁平上皮癌…

Aug 14, 2019 · 2 shares · 1,233 followers View post →
Michael_J_Koss
@Michael_J_Koss · X

RT @LDLSkeptic: "Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting red…

Aug 14, 2019 · 9 shares · 628 followers View post →
Fernpick
@Fernpick · X

RT @LDLSkeptic: "Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting red…

Aug 14, 2019 · 9 shares · 440 followers View post →
KOJI@プライマルコーチ
@kojija · X

扁平上皮癌細胞はGLUT1発現が上昇していた。強化されたGLUT1を介したブドウ糖流入は、抗酸化物質の生産を促進して生存を促進する。ブドウ糖制限は、代謝経路および発癌経路を同時に標的にする。ランダムな高い血糖値は予後不良と相関していた。 #扁平上皮癌 https://t.co/Eogj1WD3OV https://t.co/4k0dG4EDvO

Aug 14, 2019 · 5 likes · 2 shares · 2,309 followers View post →
laili
@laili_lai · X

RT @LDLSkeptic: "Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting red…

Aug 14, 2019 · 9 shares · 68 followers View post →
Lorraine Lanning
@Common_SenseCO · X

RT @LDLSkeptic: "Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting red…

Aug 14, 2019 · 9 shares · 1,640 followers View post →
Mette Varegg
@MVaregg · X

RT @LDLSkeptic: "Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting red…

Aug 14, 2019 · 9 shares · 231 followers View post →
Brian Lawenda, MD
@IOEssentials · X

Ketogenic diet slows squamous cell carcinoma (skin cancer but not adenocarcinoma) growth in head and neck cancers in mice. The researchers also noted anticancer synergy between a ketogenic diet and cisplatin chemotherapy. https://t.co/T7LAwwkH9c #skincancer #CancerResearch

Aug 14, 2019 · 632 followers View post →
Ana Cláudia
@Anawsantos · X

RT @LDLSkeptic: "Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting red…

Aug 14, 2019 · 9 shares · 354 followers View post →
Alberto García
@AGG7 · X

RT @LDLSkeptic: "Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting red…

Aug 14, 2019 · 9 shares · 549 followers View post →
David Diamond
@LDLSkeptic · X

"Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting redox homeostasis and insulin/AKT pathways in vivo" https://t.co/ePmxj3tkrr @DominicDAgosti2

Aug 14, 2019 · 33 likes · 9 shares · 44,719 followers View post →
Jorge Melendez-Zajgla
@Melendez_Zajgla · X

A saber si esto se replica para otros tumores escamosos. #ketogenic diet. p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/p9D8NtC3In

Aug 13, 2019 · 80 followers View post →
SV Mathan
@MathanSivapar · X

#p63 and #SOX2 Dictate #Glucose Reliance and Metabolic Vulnerabilities in #SquamousCellCarcinomas https://t.co/It3cg6ghWi @CellReports @UT_Dallas #GLUT1 #glucoserestriction #ketogenic diet #SGLT2

Aug 13, 2019 · 301 followers View post →