"Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting redox homeostasis and insulin/AKT pathways in vivo" https://t.co/ePmxj3tkrr @DominicDAgosti2
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas.
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Aug 2019 – Apr 2022Where it's discussed
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Many participants expressed enthusiasm about the findings, particularly regarding the ketogenic diet's role in potentially slowing down tumor growth, using phrases like 'anti-cancer effect' and 'game changer.' Discussions highlighted the correlations between glucose levels and patient outcomes, with one participant noting, 'a robust correlation between blood glucose concentration and worse survival rates.' This demonstrates the serious tone and urgency in addressing therapeutic strategies stemming from the research.
A majority of the discussions show positive sentiments towards the findings, particularly in relation to the therapeutic implications of the research.
The level of curiosity about the methods and applications mentioned in the publication is notably high, highlighted by multiple users engaging with the topic.
While many participants share content, a few delve into specifics like the ketogenic diet and its relation to tumor growth inhibition, indicating moderate engagement.
Many contributors perceive the research as significant, discussing its potential to influence treatment strategies for squamous cell carcinomas.
Abstract in brief
- Squamous cell carcinoma (SCC) is a type of cancer that shows a high dependency on glucose for survival and growth, largely due to hyperactive GLUT1 transporters.
- Transcription factors p63 and SOX2 enhance glucose uptake by activating specific genes, leading to increased production of protective molecules like NADPH and GSH in SCC tumors.
- Reducing glucose intake through methods like a ketogenic diet or using SGLT2 inhibitors can stress SCC tumors and inhibit their growth, suggesting potential therapeutic strategies to improve survival rates in SCC patients.
Top posts
Most liked on X and Blueskyp63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/3hy3P1ZORk
Systemic glucose restriction by (keto diet) and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate intratumoral oxidative stress and tumor growth inhibition حمية الكيتو وتثبيط اعادة امتصاص الجلكوز في الكلى (قد) تساعد في تثبيط نمو الورم https://t.co/SvVsgxspag
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/MtzFUwKMNu
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas: Cell Reports https://t.co/0kBOL64vel
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/6zN1p74zoI Preclinical research suggests anti-cancer effect of keto diet https://t.co/OxC98DoHgg restricting blood glucose levels might keep certain cancers at bay
All mentions
Metabolic Vulnerabilities in Squamous Cell Carcinomas
This video discusses how squamous cell carcinoma (SCC) is highly dependent on glucose for survival, driven by hyperactive GLUT1 transporters. We explore how transcription factors p63 and SOX2 enhance glucose uptake…
Exploring the Ketogenic Diet's Role in Cancer Treatment
Have you ever wondered if diet can play a role in disease progression? Emerging research indicates that the ketogenic diet may stress squamous cell carcinoma (SCC) tumors by reducing glucose intake, potentially…
RRIDs were included in the Cell Reports paper "p63 and SOX2 Dictate Glucose Reliance and Metaboli…" (https://t.co/180PDyIihs). Thank you for making your #methodsmatter. #OpenScience
@DrAhmedAlShehri https://t.co/bbjZLKou22 https://t.co/SThLbULwOv
RT @erlesen: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/6zN1p74zoI Precli…
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/MbKRAGPkoZ
RT @Ahmad_B_Mahmoud: Systemic glucose restriction by (keto diet) and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate…
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas: Cell Reports https://t.co/0iuRc2tGLE
RT @_atanas_: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/MtzFUwKMNu
RT @_atanas_: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/MtzFUwKMNu
RT @_atanas_: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/MtzFUwKMNu
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/MtzFUwKMNu
RT @CNELM1: https://t.co/c9RTm3VTbA New research indicates that controlling blood sugar levels could increase the efficacy of chemotherapy…
RT @CellReports: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/3hy3P1ZORk
RT @CNELM1: https://t.co/c9RTm3VTbA New research indicates that controlling blood sugar levels could increase the efficacy of chemotherapy…
https://t.co/c9RTm3VTbA New research indicates that controlling blood sugar levels could increase the efficacy of chemotherapy and help treat some forms of cancer.
RT @CellReports: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/3hy3P1ZORk
RT @CellReports: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/3hy3P1ZORk
RT @CellReports: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/3hy3P1ZORk
RT @CellReports: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/3hy3P1ZORk
RT @CellReports: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/3hy3P1ZORk
RT @CellReports: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/3hy3P1ZORk
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/3hy3P1ZORk
RT @taehoonkim: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas: Cell Reports https://t.co/…
RT @erlesen: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/6zN1p74zoI Precli…
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas: Cell Reports #cancer #glucose #keto #ketodiet #ketogenic #nutrition https://t.co/7oTKzFi0SP
RT @erlesen: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/6zN1p74zoI Precli…
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/6zN1p74zoI Preclinical research suggests anti-cancer effect of keto diet https://t.co/OxC98DoHgg restricting blood glucose levels might keep certain cancers at bay
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. https://t.co/SVHQqOJ1l5
RT @Ahmad_B_Mahmoud: Systemic glucose restriction by (keto diet) and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate…
RT @Ahmad_B_Mahmoud: Systemic glucose restriction by (keto diet) and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate…
RT @Ahmad_B_Mahmoud: Systemic glucose restriction by (keto diet) and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate…
Demonstraram uma correlação robusta entre a concentração de glicose no sangue e pior sobrevida entre os pacientes com Carcinoma de células escamosas da pele. https://t.co/OQDQvmDsMF #cancer #oncologia #oncology #ketogenicdiet #keto #ketosis #cetose #zerocarb https://t.co/7xtClxyYeC
RT @taehoonkim: p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas: Cell Reports https://t.co/…
RT @Ahmad_B_Mahmoud: Systemic glucose restriction by (keto diet) and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate…
RT @Ahmad_B_Mahmoud: Systemic glucose restriction by (keto diet) and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate…
RT @Ahmad_B_Mahmoud: Systemic glucose restriction by (keto diet) and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate…
Systemic glucose restriction by (keto diet) and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate intratumoral oxidative stress and tumor growth inhibition حمية الكيتو وتثبيط اعادة امتصاص الجلكوز في الكلى (قد) تساعد في تثبيط نمو الورم https://t.co/SvVsgxspag
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas: Cell Reports https://t.co/0kBOL64vel
New publication from UTD_Biology. https://t.co/HM4oy26lZn. p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas.
RT @LDLSkeptic: "Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting red…
RT @kojija: 扁平上皮癌細胞はGLUT1発現が上昇していた。強化されたGLUT1を介したブドウ糖流入は、抗酸化物質の生産を促進して生存を促進する。ブドウ糖制限は、代謝経路および発癌経路を同時に標的にする。ランダムな高い血糖値は予後不良と相関していた。 #扁平上皮癌…
RT @kojija: 扁平上皮癌細胞はGLUT1発現が上昇していた。強化されたGLUT1を介したブドウ糖流入は、抗酸化物質の生産を促進して生存を促進する。ブドウ糖制限は、代謝経路および発癌経路を同時に標的にする。ランダムな高い血糖値は予後不良と相関していた。 #扁平上皮癌…
RT @LDLSkeptic: "Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting red…
RT @LDLSkeptic: "Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting red…
扁平上皮癌細胞はGLUT1発現が上昇していた。強化されたGLUT1を介したブドウ糖流入は、抗酸化物質の生産を促進して生存を促進する。ブドウ糖制限は、代謝経路および発癌経路を同時に標的にする。ランダムな高い血糖値は予後不良と相関していた。 #扁平上皮癌 https://t.co/Eogj1WD3OV https://t.co/4k0dG4EDvO
RT @LDLSkeptic: "Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting red…
RT @LDLSkeptic: "Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting red…
RT @LDLSkeptic: "Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting red…
Ketogenic diet slows squamous cell carcinoma (skin cancer but not adenocarcinoma) growth in head and neck cancers in mice. The researchers also noted anticancer synergy between a ketogenic diet and cisplatin chemotherapy. https://t.co/T7LAwwkH9c #skincancer #CancerResearch
RT @LDLSkeptic: "Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting red…
RT @LDLSkeptic: "Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting red…
"Systemic glucose restriction by ketogenic diet or SGLT2 inhibition attenuates squamous tumor progression by disrupting redox homeostasis and insulin/AKT pathways in vivo" https://t.co/ePmxj3tkrr @DominicDAgosti2
A saber si esto se replica para otros tumores escamosos. #ketogenic diet. p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas https://t.co/p9D8NtC3In
#p63 and #SOX2 Dictate #Glucose Reliance and Metabolic Vulnerabilities in #SquamousCellCarcinomas https://t.co/It3cg6ghWi @CellReports @UT_Dallas #GLUT1 #glucoserestriction #ketogenic diet #SGLT2