Genome Med August 2019 PMID 31443728

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing.

Qian Zhang, Costanza L Vallerga, Rosie M Walker, Tian Lin, Anjali K Henders, Grant W Montgomery, Ji He, Dongsheng Fan, Javed Fowdar, Martin Kennedy, Toni Pitcher, John Pearson, Glenda Halliday, John B Kwok, Ian Hickie

Mentions

46
Peak: 20 in Aug 2019
across 5 sources since Aug 2019

Extended reach

396,407
potential audience

Total likes

4,752

Video views

189,771

Mentions per month

Aug 2019 – May 2022

Where it's discussed

  • X / Twitter37 posts
  • News3 articles
  • YouTube2 videos
  • Facebook2 posts
  • Blogs2 articles

AI synopsis

What people are saying

The discussions emphasize the scientific importance of the article, with posts mentioning how the research 'attains age prediction within ~2 years' and 'diminishes the association between methylation age and mortality.' Words like 'new,' 'important,' and references to implications for mortality and biological aging indicate a respectful acknowledgment of its significance. The tone varies from curiosity to cautious optimism, demonstrating engagement with the implications of the research without overhyping its immediate impact.

AgreementModerate agreement

Most discussions acknowledge the significance of the improved epigenetic clock, with some expressing support for its findings and relevance, although reactions are generally moderate rather than enthusiastic.

InterestHigh interest

Posts demonstrate a high level of curiosity, with several exploring implications for aging and health, reflecting a keen interest in the scientific advancements.

EngagementHigh engagement

Multiple comments delve into methodological details and potential applications, indicating deeper analytical engagement among the posters.

ImpactModerate impact

The perceived impact appears moderate, as some discussions highlight how the improved estimates challenge previous assumptions about aging markers but do not suggest revolutionary changes yet.

Abstract in brief

  • The study develops improved epigenetic age predictors based on DNA methylation data, showing that larger training sample sizes lead to more accurate age predictions and reduce the apparent link between predicted age acceleration and mortality.
  • As prediction accuracy increases with larger samples, the association between age acceleration residuals (AAR) and death weakens or disappears, suggesting that better chronological age estimates diminish confounding effects in mortality studies.
  • The research also finds that advanced predictors perform well across different tissue types, and that correcting for cellular composition in samples is more crucial for smaller datasets, highlighting the importance of large, diverse samples in epigenetic aging research.]

Top posts

Most liked on X and Bluesky
Shai Carmi
@ShaiCarmi · X

Important results: 1. Age can be predicted from methylation to within ~2 years. 2. The difference between "methylation age" and chronological age does not predict mortality. Previously detected association is mostly explained by cell type composition. https://t.co/Q8oeCp1kG3 https://t.co/I9pG6j2HBH

Aug 25, 2019 · 19 likes · 6 shares · 3,817 followers View post →
Nature Genetics
@NatureGenet · X

Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing https://t.co/60OUBcc5Mt https://t.co/RgIDZwHyH1

Sep 10, 2019 · 10 likes · 11 shares · 128,310 followers View post →
The Lothian Birth Cohorts
@EdinUniLBC · X

A new paper ‘Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing’ based on #LBC1921 and #LBC1936 data is now out in Genome Medicine. https://t.co/7n2YoGUOcQ @age_uk @SchoolofPPLS @EdinburghUni @UoE_Psychology @MarioniGroup https://t.co/Fjo2JRyPIm

Aug 30, 2019 · 5 likes · 3 shares · 2,151 followers View post →
Qian Zhang
@qianzhang314 · X

We found that improved epigenetic clock attenuates it’s association with mortality. https://t.co/3ShFJjog4B

Aug 24, 2019 · 5 likes · 1 share · 119 followers View post →
Ricardo Lebrón, Ph.D.
@rlebron_bioinfo · X

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing https://t.co/t3kMYAZYiU

Aug 25, 2019 · 3 likes · 1 share · 1,562 followers View post →
Richard Harper
@harpersnotes · X

Age biomarkers: Epigenetic clocks. Big Data. Current state of field. Excellent overview. (Zhang et al August 23, 2019 in Genome Medicine.) https://t.co/0KX9YbNEgX .. https://t.co/JRsyIYBKpD

Sep 12, 2019 · 1 like · 2,236 followers View post →

All mentions

Cheo (Chāy Ō)
@CheoWalker · X

Thomas DeLauer 9 Signs of UNHEALTHY Aging (how to fix) https://t.co/SmNqSi4lJq #keto

May 24, 2022 · 350 followers View post →
Cheo (Chāy Ō)
@CheoWalker · X

Thomas DeLauer How OLD are You | What is Your REAL Biological Age? https://t.co/sUmJ3n9vjx #keto

Apr 30, 2022 · 350 followers View post →
QBIpapers
@QBI_papers · X

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing. https://t.co/lMJ1XbjBb1

Jan 30, 2020 · 301 followers View post →
Epigenética
@Epigenetica · X

New in Pubmed: "Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing." https://t.co/2cwcgo17u6

Jan 30, 2020 · 622 followers View post →
Moreaux Jérôme
@moreauxjerome · X

RT @NatureGenet: Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for bio…

Sep 13, 2019 · 11 shares · 362 followers View post →
Juan C. Gutiérrez
@gutijuancg · X

RT @LeonidG77901288: New discussion and citation of our reliability theory of aging and longevity (see reference 2): 2. Gavrilov LA, Gavri…

Sep 12, 2019 · 1 share · 713 followers View post →
Richard Harper
@harpersnotes · X

Age biomarkers: Epigenetic clocks. Big Data. Current state of field. Excellent overview. (Zhang et al August 23, 2019 in Genome Medicine.) https://t.co/0KX9YbNEgX .. https://t.co/JRsyIYBKpD

Sep 12, 2019 · 1 like · 2,236 followers View post →
Leonid Gavrilov
@LeonidG77901288 · X

New discussion and citation of our reliability theory of aging and longevity (see reference 2): 2. Gavrilov LA, Gavrilova NS. The reliability theory of aging and longevity. J Theor Biol. 2001;213:527–45. Discussed and cited in: https://t.co/uIWGPJUQRe .

Sep 12, 2019 · 1 like · 1 share · 402 followers View post →
Dr.med. Bernd Kynast
@DrKynast · X

RT @NatureGenet: Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for bio…

Sep 11, 2019 · 11 shares · 3,018 followers View post →
VijayaBaskar
@msvbiol · X

RT @NatureGenet: Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for bio…

Sep 11, 2019 · 11 shares · 30 followers View post →
Jakob M Goldmann
@JakobMGoldmann · X

RT @NatureGenet: Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for bio…

Sep 10, 2019 · 11 shares · 156 followers View post →
Robert West, PhD ✝️
@westr · X

RT @NatureGenet: Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for bio…

Sep 10, 2019 · 11 shares · 19,325 followers View post →
Genome Medicine
@GenomeMedicine · X

RT @NatureGenet: Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for bio…

Sep 10, 2019 · 11 shares · 24,739 followers View post →
Zhikai Liang
@shanwai1234 · X

RT @NatureGenet: Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for bio…

Sep 10, 2019 · 11 shares · 928 followers View post →
Marrah Lachowicz-Scroggins
@LachowiczMarrah · X

RT @NatureGenet: Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for bio…

Sep 10, 2019 · 11 shares · 1,273 followers View post →
Nature Genetics
@NatureGenet · X

Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing https://t.co/60OUBcc5Mt https://t.co/RgIDZwHyH1

Sep 10, 2019 · 10 likes · 11 shares · 128,310 followers View post →
Naomi Attar
@naomiattar · X

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing @GenomeMedicine https://t.co/sd2YtnfRG0

Sep 2, 2019 · 1 like · 1,240 followers View post →
Heather Whalley
@heathersibley99 · X

RT @EdinUniLBC: A new paper ‘Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing’ bas…

Aug 30, 2019 · 3 shares · 464 followers View post →
Matina Liosi
@MatinaLiosi · X

between my political investigations, I read such interesting pieces that I have started to understand! #DNAmethylation https://t.co/nWjgKESR1p

Aug 30, 2019 · 1 like · 1,124 followers View post →
School of PPLS
@SchoolofPPLS · X

RT @EdinUniLBC: A new paper ‘Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing’ bas…

Aug 30, 2019 · 3 shares · 2,634 followers View post →
Anna Stevenson
@annajstevenson · X

RT @EdinUniLBC: A new paper ‘Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing’ bas…

Aug 30, 2019 · 3 shares · 293 followers View post →
The Lothian Birth Cohorts
@EdinUniLBC · X

A new paper ‘Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing’ based on #LBC1921 and #LBC1936 data is now out in Genome Medicine. https://t.co/7n2YoGUOcQ @age_uk @SchoolofPPLS @EdinburghUni @UoE_Psychology @MarioniGroup https://t.co/Fjo2JRyPIm

Aug 30, 2019 · 5 likes · 3 shares · 2,151 followers View post →
Europe PMC articles
@EuropePMC · X

New from #The_MRC https://t.co/Gaw7vZAIds Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Aug 29, 2019 · 1,553 followers View post →
Europe PMC articles
@EuropePMC · X

New from #wellcometrust https://t.co/Gaw7vZAIds Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Aug 29, 2019 · 1,553 followers View post →
Claude Bhérer
@claudebherer · X

RT @ShaiCarmi: Important results: 1. Age can be predicted from methylation to within ~2 years. 2. The difference between "methylation age"…

Aug 29, 2019 · 6 shares · 354 followers View post →
Milan Malinsky
@millanek1 · X

RT @ShaiCarmi: Important results: 1. Age can be predicted from methylation to within ~2 years. 2. The difference between "methylation age"…

Aug 26, 2019 · 6 shares · 777 followers View post →
Carlos Sarabia
@CarlosS29116341 · X

RT @ShaiCarmi: Important results: 1. Age can be predicted from methylation to within ~2 years. 2. The difference between "methylation age"…

Aug 26, 2019 · 6 shares · 411 followers View post →
Michal Feldman
@feldman_mich · X

RT @ShaiCarmi: Important results: 1. Age can be predicted from methylation to within ~2 years. 2. The difference between "methylation age"…

Aug 26, 2019 · 6 shares · 221 followers View post →
Ralph Stadhouders
@R_Stadhouders · X

RT @ShaiCarmi: Important results: 1. Age can be predicted from methylation to within ~2 years. 2. The difference between "methylation age"…

Aug 26, 2019 · 6 shares · 935 followers View post →
QBIpapers
@QBI_papers · X

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing. https://t.co/fCe5xIO1Aj

Aug 25, 2019 · 301 followers View post →
Bettina Colos
@bettina_colos · X

RT @rlebron_bioinfo: Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing https://t.co…

Aug 25, 2019 · 1 share · 362 followers View post →
Epigenética
@Epigenetica · X

New in Pubmed: "Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing." https://t.co/2cwcgo17u6

Aug 25, 2019 · 622 followers View post →
Bjarni Vilhjalmsson
@bvilhjal · X

RT @ShaiCarmi: Important results: 1. Age can be predicted from methylation to within ~2 years. 2. The difference between "methylation age"…

Aug 25, 2019 · 6 shares · 2,245 followers View post →
Ricardo Lebrón, Ph.D.
@rlebron_bioinfo · X

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing https://t.co/t3kMYAZYiU

Aug 25, 2019 · 3 likes · 1 share · 1,562 followers View post →
Shai Carmi
@ShaiCarmi · X

Important results: 1. Age can be predicted from methylation to within ~2 years. 2. The difference between "methylation age" and chronological age does not predict mortality. Previously detected association is mostly explained by cell type composition. https://t.co/Q8oeCp1kG3 https://t.co/I9pG6j2HBH

Aug 25, 2019 · 19 likes · 6 shares · 3,817 followers View post →
Huanwei Wang
@huanwei_wang · X

RT @Qian_flyingaway: We found that improved epigenetic clock attenuates it’s association with mortality. https://t.co/3ShFJjog4B

Aug 25, 2019 · 1 share · 465 followers View post →
Qian Zhang
@qianzhang314 · X

We found that improved epigenetic clock attenuates it’s association with mortality. https://t.co/3ShFJjog4B

Aug 24, 2019 · 5 likes · 1 share · 119 followers View post →