Important results: 1. Age can be predicted from methylation to within ~2 years. 2. The difference between "methylation age" and chronological age does not predict mortality. Previously detected association is mostly explained by cell type composition. https://t.co/Q8oeCp1kG3 https://t.co/I9pG6j2HBH
Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing.
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Aug 2019 – May 2022Where it's discussed
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X / Twitter37 posts
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News3 articles
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YouTube2 videos
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AI synopsis
What people are saying
The discussions emphasize the scientific importance of the article, with posts mentioning how the research 'attains age prediction within ~2 years' and 'diminishes the association between methylation age and mortality.' Words like 'new,' 'important,' and references to implications for mortality and biological aging indicate a respectful acknowledgment of its significance. The tone varies from curiosity to cautious optimism, demonstrating engagement with the implications of the research without overhyping its immediate impact.
Most discussions acknowledge the significance of the improved epigenetic clock, with some expressing support for its findings and relevance, although reactions are generally moderate rather than enthusiastic.
Posts demonstrate a high level of curiosity, with several exploring implications for aging and health, reflecting a keen interest in the scientific advancements.
Multiple comments delve into methodological details and potential applications, indicating deeper analytical engagement among the posters.
The perceived impact appears moderate, as some discussions highlight how the improved estimates challenge previous assumptions about aging markers but do not suggest revolutionary changes yet.
Abstract in brief
- The study develops improved epigenetic age predictors based on DNA methylation data, showing that larger training sample sizes lead to more accurate age predictions and reduce the apparent link between predicted age acceleration and mortality.
- As prediction accuracy increases with larger samples, the association between age acceleration residuals (AAR) and death weakens or disappears, suggesting that better chronological age estimates diminish confounding effects in mortality studies.
- The research also finds that advanced predictors perform well across different tissue types, and that correcting for cellular composition in samples is more crucial for smaller datasets, highlighting the importance of large, diverse samples in epigenetic aging research.]
Top posts
Most liked on X and BlueskyPublished in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing https://t.co/60OUBcc5Mt https://t.co/RgIDZwHyH1
A new paper ‘Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing’ based on #LBC1921 and #LBC1936 data is now out in Genome Medicine. https://t.co/7n2YoGUOcQ @age_uk @SchoolofPPLS @EdinburghUni @UoE_Psychology @MarioniGroup https://t.co/Fjo2JRyPIm
We found that improved epigenetic clock attenuates it’s association with mortality. https://t.co/3ShFJjog4B
Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing https://t.co/t3kMYAZYiU
Age biomarkers: Epigenetic clocks. Big Data. Current state of field. Excellent overview. (Zhang et al August 23, 2019 in Genome Medicine.) https://t.co/0KX9YbNEgX .. https://t.co/JRsyIYBKpD
All mentions
Understanding Aging: 9 Factors and Their Solutions
This video explores the 9 hallmarks of aging, their significance, and how they impact your health. With insights into DNA methylation and its correlation with age, learn actionable solutions to mitigate rapid aging…
Assess Your Biological Age Using Advanced Epigenetic Testing Techniques
Discover how biological age, influenced by genetics and lifestyle, may differ from chronological age. This video explores new epigenetic age predictors based on DNA methylation data, emphasizing the importance of large…
Thomas DeLauer 9 Signs of UNHEALTHY Aging (how to fix) https://t.co/SmNqSi4lJq #keto
Thomas DeLauer How OLD are You | What is Your REAL Biological Age? https://t.co/sUmJ3n9vjx #keto
Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing. https://t.co/lMJ1XbjBb1
New in Pubmed: "Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing." https://t.co/2cwcgo17u6
RT @NatureGenet: Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for bio…
RT @LeonidG77901288: New discussion and citation of our reliability theory of aging and longevity (see reference 2): 2. Gavrilov LA, Gavri…
Age biomarkers: Epigenetic clocks. Big Data. Current state of field. Excellent overview. (Zhang et al August 23, 2019 in Genome Medicine.) https://t.co/0KX9YbNEgX .. https://t.co/JRsyIYBKpD
New discussion and citation of our reliability theory of aging and longevity (see reference 2): 2. Gavrilov LA, Gavrilova NS. The reliability theory of aging and longevity. J Theor Biol. 2001;213:527–45. Discussed and cited in: https://t.co/uIWGPJUQRe .
RT @NatureGenet: Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for bio…
RT @NatureGenet: Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for bio…
RT @NatureGenet: Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for bio…
RT @NatureGenet: Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for bio…
RT @NatureGenet: Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for bio…
RT @NatureGenet: Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for bio…
RT @NatureGenet: Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for bio…
Published in @GenomeMedicine : Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing https://t.co/60OUBcc5Mt https://t.co/RgIDZwHyH1
Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing @GenomeMedicine https://t.co/sd2YtnfRG0
RT @EdinUniLBC: A new paper ‘Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing’ bas…
between my political investigations, I read such interesting pieces that I have started to understand! #DNAmethylation https://t.co/nWjgKESR1p
RT @EdinUniLBC: A new paper ‘Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing’ bas…
RT @EdinUniLBC: A new paper ‘Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing’ bas…
A new paper ‘Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing’ based on #LBC1921 and #LBC1936 data is now out in Genome Medicine. https://t.co/7n2YoGUOcQ @age_uk @SchoolofPPLS @EdinburghUni @UoE_Psychology @MarioniGroup https://t.co/Fjo2JRyPIm
New from #The_MRC https://t.co/Gaw7vZAIds Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing
New from #wellcometrust https://t.co/Gaw7vZAIds Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing
RT @ShaiCarmi: Important results: 1. Age can be predicted from methylation to within ~2 years. 2. The difference between "methylation age"…
RT @ShaiCarmi: Important results: 1. Age can be predicted from methylation to within ~2 years. 2. The difference between "methylation age"…
RT @ShaiCarmi: Important results: 1. Age can be predicted from methylation to within ~2 years. 2. The difference between "methylation age"…
RT @ShaiCarmi: Important results: 1. Age can be predicted from methylation to within ~2 years. 2. The difference between "methylation age"…
RT @ShaiCarmi: Important results: 1. Age can be predicted from methylation to within ~2 years. 2. The difference between "methylation age"…
Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing. https://t.co/fCe5xIO1Aj
RT @rlebron_bioinfo: Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing https://t.co…
New in Pubmed: "Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing." https://t.co/2cwcgo17u6
RT @ShaiCarmi: Important results: 1. Age can be predicted from methylation to within ~2 years. 2. The difference between "methylation age"…
Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing https://t.co/t3kMYAZYiU
Important results: 1. Age can be predicted from methylation to within ~2 years. 2. The difference between "methylation age" and chronological age does not predict mortality. Previously detected association is mostly explained by cell type composition. https://t.co/Q8oeCp1kG3 https://t.co/I9pG6j2HBH
RT @Qian_flyingaway: We found that improved epigenetic clock attenuates it’s association with mortality. https://t.co/3ShFJjog4B
We found that improved epigenetic clock attenuates it’s association with mortality. https://t.co/3ShFJjog4B