Sci Adv August 2019 PMID 31457083

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands.

S S Kale, M Bergeron-Brlek, Y Wu, M G Kumar, M V Pham, J Bortoli, J Vesin, X-D Kong, J Franco Machado, K Deyle, P Gonschorek, G Turcatti, L Cendron, A Angelini, C Heinis

Mentions

10
Peak: 2 in Sep 2019
across 3 sources since Sep 2019

Extended reach

4,754
potential audience

Total likes

1

Video views

1,425

Mentions per month

Sep 2019 – Feb 2023

Where it's discussed

  • News6 articles
  • X / Twitter2 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions highlight the importance of the research, such as references to its ability to screen large compound libraries and generate ligands, using positive language like 'enables' and 'significant.' Words like 'sharing' and mentions of social tags demonstrate a neutral engagement level, emphasizing awareness rather than deep analysis.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, with some explicitly endorsing its potential advantages.

InterestModerate interest

Participants show moderate curiosity, mainly focusing on the technical aspects and applications rather than deep critique or enthusiasm.

EngagementModerate engagement

Comments include sharing the publication and briefly explaining the method, indicating a basic level of involvement.

ImpactModerate impact

The conversations suggest recognition of the study’s scientific relevance but stop short of exploring long-term implications in detail.

Top posts

Most liked on X and Bluesky
torusengoku
@torusengoku · X

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands https://t.co/ZYx1s3XNh7

Sep 30, 2019 · 1 like · 3,073 followers View post →
Providion
@Providion · X

Sharing this from @ScienceAdvances on how Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands. https://t.co/xutz9cltL7 #science #massspectrometry

Sep 13, 2019 · 257 followers View post →

All mentions

torusengoku
@torusengoku · X

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands https://t.co/ZYx1s3XNh7

Sep 30, 2019 · 1 like · 3,073 followers View post →
Providion
@Providion · X

Sharing this from @ScienceAdvances on how Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands. https://t.co/xutz9cltL7 #science #massspectrometry

Sep 13, 2019 · 257 followers View post →