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Nat Microbiol December 2019 PMID 31477894

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut.

Thomas C Fung, Helen E Vuong, Cristopher D G Luna, Geoffrey N Pronovost, Antoniya A Aleksandrova, Noah G Riley, Anastasia Vavilina, Julianne McGinn, Tomiko Rendon, Lucy R Forrest, Elaine Y Hsiao

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Mentions

85
Peak: 37 in Sep 2019
across 5 sources since Sep 2019

Extended reach

356,644
potential audience

Total likes

864

Video views

43,262

Mentions per month

Sep 2019 – Sep 2025

Where it's discussed

  • X / Twitter42 posts
  • News20 articles
  • Blogs11 articles
  • Facebook10 posts
  • YouTube2 videos

AI synopsis

What people are saying

Discussions reflect a balanced recognition of the article's importance, with key phrases like 'can mess with your gut microbiome' and 'evidence shows modulation' conveying both skepticism and appreciation. The tone varies from factual to personal, demonstrating engagement with the implications of gut-serotonin interactions on health.

AgreementModerate agreement

Most discussions agree on the significance of the study, emphasizing that SSRIs affect gut microbiota and health.

InterestModerate interest

Posts show a moderate level of curiosity, with mentions of potential health impacts and connections to other conditions like autism.

EngagementModerate engagement

Comments include references to methods, implications, and personal experiences, indicating an average depth of involvement.

ImpactModerate impact

Users perceive the research as influential, highlighting its relevance for understanding medication side effects and gut health.

Abstract in brief

  • The study finds that increasing intestinal serotonin (5HT) levels, either through supplementation or genetic changes, raises the abundance of spore-forming bacteria like Turicibacter sanguinis, which can influence host 5HT production.
  • T. sanguinis expresses a protein similar to the human serotonin transporter (SERT) that imports 5HT, and this process can be blocked by the drug fluoxetine, affecting bacterial growth and colonization.
  • Modulating levels of 5HT or fluoxetine impacts both the bacterial population in the gut and host metabolic pathways, such as lipid metabolism, indicating a bidirectional communication between gut bacteria and the host serotonergic system.]
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Top posts

Most liked on X and Bluesky
John F. Cryan
@jfcryan · X

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colleagues in @NatureMicrobiol https://t.co/pNaGdoFxoB

Sep 3, 2019 · 46 likes · 21 shares · 22,441 followers View post →
Elaine Hsiao
@pipethero · X

@thomascf4116 @helenvuongphd @LucyRForrest @NatureMicrobiol Free to read on SharedIt: https://t.co/PQljnd489q Supplementary figs: https://t.co/Jmw27mfoG3 & a casual blog article on the main points: https://t.co/x6mJMOxXvz

Sep 2, 2019 · 29 likes · 9 shares · 3,487 followers View post →
Nature Microbiology
@NatureMicrobiol · X

#OnlineThisWeek Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut @pipethero @thomascf4116 & cols show that intestinal serotonin enhances colonization of Turicibacter sanguinis & enriches for spore-forming bacteria https://t.co/sZ4jBxqAbn https://t.co/hWKilfdRbn

Sep 5, 2019 · 5 likes · 2 shares · 74,130 followers View post →
مركز الأبحاث
@KFSHRC_Research · X

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut https://t.co/JCKwn9rnOU https://t.co/d3xUUZ9mSW

Sep 10, 2019 · 3 likes · 1 share · 71,901 followers View post →
Inaedifico
@inaedifico · X

@LucileeTarr1922 @jamesohardy Um, actually... SSRIs CAN mess with your gut microbiome https://t.co/zNrbjTha2O Your statement that "gut health is invented" is patently false. Gut microbiota can have an extremely broad range of impacts on human health/wellbeing & cognition. You're clearly not a doctor either.

Oct 18, 2023 · 3 likes · 2 shares · 28 followers View post →
HungryMicrobe
@hungrymicrobe · X

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut https://t.co/IOzcmZ9Msx

Sep 3, 2019 · 1 like · 1,451 followers View post →

All mentions

Clit Yeastwood.
@iiCrookedRain · X

RT @inaedifico: @LucileeTarr1922 @jamesohardy Um, actually... SSRIs CAN mess with your gut microbiome https://t.co/zNrbjTha2O Your stateme…

Oct 19, 2023 · 2 shares · 117 followers View post →
Inaedifico
@inaedifico · X

@LucileeTarr1922 @jamesohardy Um, actually... SSRIs CAN mess with your gut microbiome https://t.co/zNrbjTha2O Your statement that "gut health is invented" is patently false. Gut microbiota can have an extremely broad range of impacts on human health/wellbeing & cognition. You're clearly not a doctor either.

Oct 18, 2023 · 3 likes · 2 shares · 28 followers View post →
Vanessa Dumeaux @vdumeaux@genomic.social
@VDumeaux · X

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut | Nature Microbiology https://t.co/s4Xg1jJwz4

Sep 3, 2020 · 1 like · 410 followers View post →
Genetic Variation
@gen_var_papes · X

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut. https://t.co/CX1Azm2WiS https://t.co/9aLLygDk0s

Jul 8, 2020 · 213 followers View post →
Fitore Raka
@scientiste_fr · X

RT @NatureMicrobiol: #OnlineThisWeek Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut @pipethero @…

Oct 9, 2019 · 2 shares · 91 followers View post →
Anelya Gandy
@AnelyaGandy · X

@hthsci4bb3 #4bb3neuroimmune EVIDENCE: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut https://t.co/cn7e1NcsZL

Oct 4, 2019 · 1 like · 1 followers View post →
Dr. Karthik Ramanan - Emotional Health Mentor
@DrKRamanan · X

Prozac Side Effects | What You Need to Know to Protect Your Gut Microbiome https://t.co/YYBdoj5NwW via @YouTube

Sep 25, 2019 · 32 followers View post →
Paweł Gardzielewski
@PGardzielewski · X

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut | Nature Microbiology https://t.co/R5tWk6vtRD

Sep 12, 2019 · 103 followers View post →
Steve Hajioff
@DrSteveHajioff · X

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut | Nature Microbiology https://t.co/ce6RcZtZ4x

Sep 12, 2019 · 667 followers View post →
أأ.مرام منصور النفجان
@seatle88 · X

RT @KFSHRC_Research: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut https://t.co/JCKwn9rnOU https:…

Sep 10, 2019 · 1 share · 559 followers View post →
مركز الأبحاث
@KFSHRC_Research · X

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut https://t.co/JCKwn9rnOU https://t.co/d3xUUZ9mSW

Sep 10, 2019 · 3 likes · 1 share · 71,901 followers View post →
Jason
@JasonPeckham · X

Happy bacteria in the gut and intestines leads to a happy human. Ref: https://t.co/GLkmkyZcW7

Sep 7, 2019 · 281 followers View post →
Elena
@ElenaLucarini90 · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 6, 2019 · 21 shares · 226 followers View post →
Transporters and Solute carriers
@solutecarriers · X

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut https://t.co/SVLzW50is7

Sep 5, 2019 · 1,512 followers View post →
Meera Unnikrishnan
@MeeraUnnikri · X

RT @NatureMicrobiol: #OnlineThisWeek Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut @pipethero @…

Sep 5, 2019 · 2 shares · 1,037 followers View post →
Nature Microbiology
@NatureMicrobiol · X

#OnlineThisWeek Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut @pipethero @thomascf4116 & cols show that intestinal serotonin enhances colonization of Turicibacter sanguinis & enriches for spore-forming bacteria https://t.co/sZ4jBxqAbn https://t.co/hWKilfdRbn

Sep 5, 2019 · 5 likes · 2 shares · 74,130 followers View post →
Symbiosis papers
@Symbiosispapers · X

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut. https://t.co/1kT8CuykNl

Sep 4, 2019 · 1 like · 1,113 followers View post →
Katie Guzzetta
@ktguzz · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 4, 2019 · 21 shares · 4,773 followers View post →
Gayatri Jape
@GayatriJape · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 3, 2019 · 21 shares · 272 followers View post →
HungryMicrobe
@hungrymicrobe · X

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut https://t.co/IOzcmZ9Msx

Sep 3, 2019 · 1 like · 1,451 followers View post →
Nicholas Bustos
@BalokNB · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 3, 2019 · 21 shares · 602 followers View post →
Mr Gut
@CanhuiLan · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 3, 2019 · 21 shares · 272 followers View post →
Dr. Kim E. Barrett
@DrKimEBarrett · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 3, 2019 · 21 shares · 6,501 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 3, 2019 · 21 shares · 10,774 followers View post →
Shahrdad Lotfipour, Ph.D.
@shlotfipour · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 3, 2019 · 21 shares · 2,069 followers View post →
AB Johnson
@Hijo_de_Juan · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 3, 2019 · 21 shares · 157 followers View post →
EAULAB®
@eaulab · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 3, 2019 · 21 shares · 184 followers View post →
Salesianos Argentina
@salesianoarg1 · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 3, 2019 · 21 shares · 605 followers View post →
RosierSecondName
@NameRosier · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 3, 2019 · 21 shares · 281 followers View post →
Emad El-Omar
@emadelomar · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 3, 2019 · 21 shares · 3,878 followers View post →
Dr. Aparna Shah
@Neuro_musings · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 3, 2019 · 21 shares · 1,600 followers View post →
Ann Gregory, PhD
@gregory_annc · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 3, 2019 · 21 shares · 1,593 followers View post →
Ruth Singh
@Ruth_astrobrain · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 3, 2019 · 21 shares · 454 followers View post →
Carl Kirkpatrick
@CarlkRx · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 3, 2019 · 21 shares · 1,898 followers View post →
UltimApe
@ultimape · X

In late 2017 I found a 1996 study on autism+serotonin https://t.co/1uKHEa8623 which lead to a double-blind placebo-controlled trial on fluoxetine+autsim https://t.co/WkIya0I7tJ Today, I wondered what it does to microbes... and bam: https://t.co/pZjOgDGVaL https://t.co/vDHIOezYsG

Sep 3, 2019 · 6,451 followers View post →
Vidita Vaidya
@ViditaVaidya · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 3, 2019 · 21 shares · 14,156 followers View post →
Sashaina Fanibunda
@SashainaEF · X

RT @jfcryan: Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colle…

Sep 3, 2019 · 21 shares · 664 followers View post →
John F. Cryan
@jfcryan · X

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut -from @pipethero @thomascf4116 & colleagues in @NatureMicrobiol https://t.co/pNaGdoFxoB

Sep 3, 2019 · 46 likes · 21 shares · 22,441 followers View post →
Potro UAEM & IPN UPIIG
@RudoMxMx · X

RT @pipethero: @thomascf4116 @helenvuongphd @LucyRForrest @NatureMicrobiol Free to read on SharedIt: https://t.co/PQljnd489q Supplementary…

Sep 2, 2019 · 9 shares · 1,020 followers View post →
Nature Microbiology
@NatureMicrobiol · X

RT @pipethero: @thomascf4116 @helenvuongphd @LucyRForrest @NatureMicrobiol Free to read on SharedIt: https://t.co/PQljnd489q Supplementary…

Sep 2, 2019 · 9 shares · 74,130 followers View post →
Elaine Hsiao
@pipethero · X

@thomascf4116 @helenvuongphd @LucyRForrest @NatureMicrobiol Free to read on SharedIt: https://t.co/PQljnd489q Supplementary figs: https://t.co/Jmw27mfoG3 & a casual blog article on the main points: https://t.co/x6mJMOxXvz

Sep 2, 2019 · 29 likes · 9 shares · 3,487 followers View post →
micropapers
@micro_papers · X

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut https://t.co/JV9TX3xvQJ

Sep 2, 2019 · 1 like · 332 followers View post →