September 2019 PMID 31495251

Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G-Protein Coupled Receptor Autoantibodies.

William T Gunning, Heather Kvale, Paula M Kramer, Beverly L Karabin, Blair P Grubb

Mentions

98
Peak: 12 in Sep 2019
across 7 sources since Sep 2019

Extended reach

437,330
potential audience

Total likes

1,731

Video views

41,879

Mentions per month

Sep 2019 – Aug 2025

Where it's discussed

  • X / Twitter65 posts
  • Facebook12 posts
  • News11 articles
  • Reddit4 posts
  • YouTube3 videos
  • Blogs2 articles
  • Bluesky1 posts

AI synopsis

What people are saying

Discussions highlight the strong connection between Postural Orthostatic Tachycardia Syndrome (POTS) and autoimmune responses, with contributors noting that 89% of POTS patients had elevated autoantibodies against adrenergic receptors. Phrases like 'must-read research' and comments about personal experiences, coupled with references to additional studies, demonstrate urgency and a communal push for wider recognition of POTS's potentially autoimmune nature, emphasizing the transformative implications for treatment and diagnosis.

AgreementModerate agreement

Many discussions reflect a supportive stance towards the findings of the research regarding the autoimmune nature of POTS.

InterestHigh interest

The discussions show high curiosity about the links between POTS and autoimmunity, indicating a strong relevance to ongoing health discussions.

EngagementModerate engagement

A moderate level of engagement is evident, as some users reference significant data and seek to understand the complexities behind the disorder.

ImpactHigh impact

The consensus is that the publication holds substantial importance for understanding POTS, especially in relation to its potential autoimmune origins.

Abstract in brief

  • Postural Orthostatic Tachycardia Syndrome (POTS) is often misdiagnosed as anxiety disorders, but emerging evidence suggests it may be autoimmune in nature.
  • A study of 55 POTS patients found significant elevations in autoantibodies targeting G-protein coupled receptors, especially adrenergic and muscarinic types, indicating an autoimmune connection.
  • Although many patients showed elevated autoantibody levels, there was only a weak correlation between these levels and the severity of clinical symptoms, highlighting the complexity of the syndrome.

Top posts

Most liked on X and Bluesky
Michael Stingl
@neurostingl · X

Beeindruckendes Video, das klar macht, dass postvirale massive gesundheitliche Probleme nicht erst eine "Erfindung" von #covid19 sind. Für #POTS als #Autoimmunreaktion gibt es Hinweise in der Literatur, z.B. hier https://t.co/3DRwit4jW1 oder hier https://t.co/AvLuHxp42Z. https://t.co/l058mVNnru

Jun 2, 2020 · 18 likes · 16,200 followers View post →
Emily Johnson (is on Mastadon and Bsky)
@emily_rj · X

@jmatwood @NML_dc @slooterman POTS as immunocompromising with at least one common and possibly more biomarkers The study: https://t.co/MaEQxmIhTk The Science Daily report: https://t.co/RBSY3ZyXum A great explainer by one of the researchers: https://t.co/z0laR74LlA

Mar 11, 2020 · 11 likes · 4 shares · 7,902 followers View post →
Merogenomics
@merogenomics · X

The Surprising Link Between Rapid Heart Rate, Body Position, and a Revolutionary Solution You've Never Heard Of! https://t.co/uMtOy1BhQX

Mar 9, 2024 · 10 likes · 7 shares · 3,130 followers View post →
Dāvids Zalāns
@DavidsZalans · X

@ahandvanish You add that research to a1 adrenergic receptor autoantibodies. Probably almost all post-viral POTS have it. But to test it, you will not test it in your north america, I tested myself in a lab in Germany. https://t.co/RV6NxtlgYP

Jun 17, 2021 · 10 likes · 1,355 followers View post →
Renuka Dhinakaran
@renudhinakaran · X

https://t.co/qgzcDaNEpw This paper from 2019 (pre-Covid) shows that POTS patients had at least 1 G- Protein Coupled Receptor autoantibody (elevated). It is not a coincidence that a good no. of #Covid long haulers who've been lucky to get tested for GPCR autoantibodies have POTS.

May 2, 2022 · 9 likes · 1 share · 6,129 followers View post →
Olenka Sayko
@coco_chatel · X

@hiimjakekthx @MeetJess There’s no consensus on that, but there is a growing body of evidence that it may be autoimmune. https://t.co/kFN0hOM7IE

Feb 24, 2023 · 9 likes · 3,535 followers View post →

All mentions

Samuel Baudinette
@sambaudinette.bsky.social · Bluesky

I read Suzanne O’Sullivan for a “developmental psychopathology” class at my psychoanalytic training institute & found her work to be troubling (I was also troubled by how many of my classmates found it compelling). This video from Sluggish is a nice critique of her work! youtu.be/DFSxeI4DtuY?...

Aug 31, 2025 · 4 likes · 2 shares View post →
Samuel Baudinette
@SamBaudinette · X

I read Suzanne O’Sullivan for a “developmental psychopathology class at my training institute & found her work to be troubling (I was also troubled by how many of my classmates found it compelling). This video from Sluggish is a nice critique of her work! https://t.co/bhIIpU3Yed

Aug 31, 2025 · 2 likes · 1,827 followers View post →
Jeffrey Lubell (EDS, ME/CFS, LongCOVID Research)
@JeffLubell_C19 · X

@theedifyingword And this (POTS is associated with auto immune disorders.) https://t.co/OAzRl9y7eu.

Sep 28, 2024 · 3 likes · 3,582 followers View post →
J Peace 3
@JPeaceJPeace · X

@sanilrege @ZacharyGrinDPT @dysclinic As far as related to LC (and IMO ME/CFS) there is a high likelyhood autoimmunity is somehow the cause, although exactly how still needs more research. Logic suggests a maladaptive immune response interfering with important autonomic regulatory systems. https://t.co/nmpyzqVK3E

Aug 17, 2024 · 573 followers View post →
P123
@P1231032850 · X

@Raoul__Lucas @merogenomics beschreibt auch in verschiedenen Videos Vagus nerve stimulation. https://t.co/S6Zj74SRPq https://t.co/qFxfDG9FEr https://t.co/KmX2WXpoJd

Jul 23, 2024 · 3,218 followers View post →
TBennett
@be46990499 · X

@clif_high https://t.co/5gPkFS92ga

Apr 14, 2024 · 255 followers View post →
Marie McDonald
@mariez1 · X

RT @merogenomics: The Surprising Link Between Rapid Heart Rate, Body Position, and a Revolutionary Solution You've Never Heard Of! https:/…

Mar 25, 2024 · 7 shares · 517 followers View post →
Lizay916
@Lizay916 · X

This man does reporting on Covid & Vax studies as they come out. LOTS of great information from around the world. Breakthrough Relief Through Vagus Nerve Neuromodulation (POTS) (#130) || Merogenomics https://t.co/rqQejdKKF0 via @YouTube

Mar 20, 2024 · 2,326 followers View post →
G.
@ElAlam_Vnz · X

RT @merogenomics: The Surprising Link Between Rapid Heart Rate, Body Position, and a Revolutionary Solution You've Never Heard Of! https:/…

Mar 13, 2024 · 7 shares · 4,332 followers View post →
Tim Noakes
@ProfTimNoakes · X

RT @merogenomics: The Surprising Link Between Rapid Heart Rate, Body Position, and a Revolutionary Solution You've Never Heard Of! https:/…

Mar 10, 2024 · 7 shares · 158,502 followers View post →
Trash-e
@T_Dashe · X

RT @merogenomics: The Surprising Link Between Rapid Heart Rate, Body Position, and a Revolutionary Solution You've Never Heard Of! https:/…

Mar 10, 2024 · 7 shares · 85 followers View post →
Bonita Carmel
@44ad5c37594a420 · X

RT @merogenomics: The Surprising Link Between Rapid Heart Rate, Body Position, and a Revolutionary Solution You've Never Heard Of! https:/…

Mar 9, 2024 · 7 shares · 2,334 followers View post →
Fish Tank
@FishTanksSuck · X

video https://t.co/pXHqDgjeFL

Mar 9, 2024 · 686 followers View post →
Fish Tank
@FishTanksSuck · X

RT @merogenomics: The Surprising Link Between Rapid Heart Rate, Body Position, and a Revolutionary Solution You've Never Heard Of! https:/…

Mar 9, 2024 · 7 shares · 686 followers View post →
MelillianFlyer
@FlyerMelillian · X

RT @merogenomics: The Surprising Link Between Rapid Heart Rate, Body Position, and a Revolutionary Solution You've Never Heard Of! https:/…

Mar 9, 2024 · 7 shares · 1,335 followers View post →
Merogenomics
@merogenomics · X

The Surprising Link Between Rapid Heart Rate, Body Position, and a Revolutionary Solution You've Never Heard Of! https://t.co/uMtOy1BhQX

Mar 9, 2024 · 10 likes · 7 shares · 3,130 followers View post →
Governmentsandallbanksliekillandstealworldwide6969
@Politicarilazu1 · X

https://t.co/dBYjBbN067

Mar 6, 2024 · 381 followers View post →
Jamie POTS Strong
@Jamiepead · X

RT @P1231032850: Vagus nerve stimulation might help for

Feb 29, 2024 · 1 share · 1,271 followers View post →
P123
@P1231032850 · X

Vagus nerve stimulation might help for

Feb 29, 2024 · 2 likes · 1 share · 3,218 followers View post →
Erik Laken ✨️
@ErikLaken · X

https://t.co/ayI1HFkdSH

Feb 29, 2024 · 1,106 followers View post →
Luis
@lulopson · X

RT @Arobb52: Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G-Protein Coupled Receptor Autoantibodies - PubMed https…

Nov 3, 2023 · 1 share · 463 followers View post →
Arobb
@Arobb52 · X

Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G-Protein Coupled Receptor Autoantibodies - PubMed https://t.co/FbDYX2bMlR

Nov 3, 2023 · 2 likes · 1 share · 330 followers View post →
Kai
@_Kai_Pan_ · X

@kimgl1993 Es gibt auch Veröffentlichung, die genau das Gegenteil zeigen. Ich bin davon überzeugt, dass Dysautonomie durch AAKs verursacht wird. Der fast geheilte BC007-Studienteilnehmer hatte doch auch POTS, oder? Hier eine andere Publikation: https://t.co/t0dnhaYuDp

Sep 4, 2023 · 2 likes · 172 followers View post →
Olenka Sayko
@coco_chatel · X

@LongCovidComms @dysclinic https://t.co/kFN0hOMFyc

Apr 13, 2023 · 2 likes · 3,535 followers View post →
Olenka Sayko
@coco_chatel · X

@hiimjakekthx @MeetJess There’s no consensus on that, but there is a growing body of evidence that it may be autoimmune. https://t.co/kFN0hOM7IE

Feb 24, 2023 · 9 likes · 3,535 followers View post →
Cisco
@Francisco28000 · X

Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G-Protein Coupled Receptor Autoantibodies - PubMed #Covidlong #EM/SFC #MCAS https://t.co/Mf4ALJP5SR

Jan 19, 2023 · 1 like · 163 followers View post →
Naomi Harvey PhD #WearAMask
@Naomi_D_Harvey · X

@renudhinakaran @exceedhergrasp1 Additionally, the evidence for autoimmunity in POTS shows 89% of patients had elevated levels of autoantibodies against adrenergic alpha 1 receptor’s and 75% had them against beta adrenergic receptors https://t.co/J7FNoFlIX3

Jan 2, 2023 · 2 likes · 16,569 followers View post →
Brad
@AutonomicBrad · X

@ShaneyWright @sarahesteinberg Good question. Read this. https://t.co/bduD8IY4Bp

Jun 11, 2022 · 2 likes · 4,136 followers View post →
Fanatic Hermitude (orthostatic.bsky.social)
@hobbyhorrible · X

RT @renudhinakaran: https://t.co/qgzcDaNEpw This paper from 2019 (pre-Covid) shows that POTS patients had at least 1 G- Protein Coupled Re…

May 2, 2022 · 1 share · 938 followers View post →
Renuka Dhinakaran
@renudhinakaran · X

https://t.co/qgzcDaNEpw This paper from 2019 (pre-Covid) shows that POTS patients had at least 1 G- Protein Coupled Receptor autoantibody (elevated). It is not a coincidence that a good no. of #Covid long haulers who've been lucky to get tested for GPCR autoantibodies have POTS.

May 2, 2022 · 9 likes · 1 share · 6,129 followers View post →
Vociferous Eleanor Give me #Liothyronine on NHS
@ThyroidAction · X

RT @dr_kevinlee: #POTS Is Associated With Elevated G‐Protein Coupled Receptor Autoantibodies https://t.co/sXCU8VAi6k

Jan 20, 2022 · 1 share · 810 followers View post →
Dr Kevin Lee
@dr_kevinlee · X

#POTS Is Associated With Elevated G‐Protein Coupled Receptor Autoantibodies https://t.co/sXCU8VAi6k

Jan 20, 2022 · 2 likes · 1 share · 5,445 followers View post →
K2020
@K11235589 · X

@MandaravaN @AnitaSusmoka @ahandvanish There are other autoantibodies linked to POTS https://t.co/uV03lyExSq Follow @Dysautonomia

Nov 17, 2021 · 1 like · 224 followers View post →
Dr. Suzana Mantovani
@Tweet_Nutrition · X

RT @Cure_ME_CFS: @exceedhergrasp1 @GemzME @Tweet_Nutrition Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G‐Protei…

Oct 1, 2021 · 1 share · 4,574 followers View post →
CureME~CFS
@Cure_ME_CFS · X

@exceedhergrasp1 @GemzME @Tweet_Nutrition Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G‐Protein Coupled Receptor Autoantibodies https://t.co/FbXV2GK4IS

Oct 1, 2021 · 2 likes · 1 share · 476 followers View post →
Lorraine Moss
@MossLorraine · X

@WakeUpLookUp @WizardRheon @AXECOP https://t.co/gW7TpEQxQl

Aug 19, 2021 · 2 likes · 1,021 followers View post →
Riley
@theinvisible81 · X

@millie_hillie Most POTS cases are Autoimmune. Only autoantibody test available is through CellTrend in Germany( I had mine tested). But IVIG usually only approved if diagnosed w/ another Autoimmune condition like Sjorgens or Small Fibre Neuropathy. https://t.co/0l0oZ47PDO

Jul 8, 2021 · 1 like · 735 followers View post →
Dāvids Zalāns
@DavidsZalans · X

@ahandvanish You add that research to a1 adrenergic receptor autoantibodies. Probably almost all post-viral POTS have it. But to test it, you will not test it in your north america, I tested myself in a lab in Germany. https://t.co/RV6NxtlgYP

Jun 17, 2021 · 10 likes · 1,355 followers View post →
Anneka Sillitoe
@annekasillitoe · X

This study is very interesting for anyone with #POTS https://t.co/KLvfzL3IrC It talks of adrenergic receptors and I know many of us have adrenaline surges and weirdness with "fight or flight". I hope further research is done into this area.

Mar 11, 2021 · 629 followers View post →
Bea is Chronically Persisting✨
@Be_Kinderr · X

@abledoc @NG20194 Thanks, yes, more research is needed. There are several studies showing these elevated autoantibodies in ppl w POTS & MECFS. This is one showing 89% of POTS patients studied have elevated levels of autoantibodies against the adrenergic alpha 1 receptor. https://t.co/8ehhbCIpWA

Mar 5, 2021 · 9,814 followers View post →
threeofkites
@OfKites · X

@rebootfromstart Glad to hear.

Feb 15, 2021 · 1 like · 19 followers View post →
David Lee, MD
@DaveLeeERMD · X

@lauramholson @drfyzziks Definitely possible, see this reference and also follow @dysclinic who has some wonderful insights. Appreciate you sharing your experience. Medicine can often ignore what we don’t understand. Science is slow but hopefully we can figure this out. https://t.co/Q1pVKhCReI

Jan 22, 2021 · 2 likes · 8,821 followers View post →
心療内科夜想曲
@cKvWsvTnZAoU8Yr · X

以前よりPOTSを診ることもある医師ですが、AAGという診断はつけたことはなかったです。自律神経系の自己抗体を測定できる施設は非常に限られていると思うのですが、他施設に依頼するようなこともあるのでしょうか。2019のJAHAに論文が出て気になっています。https://t.co/dt3EyNuKbZ https://t.co/CPN5CvxHfh

Jan 7, 2021 · 5 likes · 394 followers View post →
心療内科夜想曲
@cKvWsvTnZAoU8Yr · X

https://t.co/dt3EyNuKbZ基本的には心療内科医は、基準が当てはまればODと診断し、問題をある程度外在化し、薬なども試しながら通院を継続させ、実際は心理社会的背景をしっかり扱っていくと思う。

Dec 28, 2020 · 2 likes · 394 followers View post →
ice9
@__ice9 · X

@KO_Sulli Glad to hear situation is better. COVID-19 sometimes produces POTS-like symptoms, and it isn't entirely clear why, though some theories fit better than others. It may be autoimmune. Not always permanent, but persistent cases often are. https://t.co/4FvPZikLrt

Dec 12, 2020 · 7,851 followers View post →
心療内科夜想曲
@cKvWsvTnZAoU8Yr · X

55人のPOTS患者の89%でα1アドレナリン受容体抗体上昇。患者の多くはPOTS発症前にEBウイルスや感染性胃腸炎ありと記載(data not shown?)。 JAHA 2019 https://t.co/2ZxSPU4P3S

Oct 16, 2020 · 394 followers View post →
Michael Stingl
@neurostingl · X

Beeindruckendes Video, das klar macht, dass postvirale massive gesundheitliche Probleme nicht erst eine "Erfindung" von #covid19 sind. Für #POTS als #Autoimmunreaktion gibt es Hinweise in der Literatur, z.B. hier https://t.co/3DRwit4jW1 oder hier https://t.co/AvLuHxp42Z. https://t.co/l058mVNnru

Jun 2, 2020 · 18 likes · 16,200 followers View post →
Hollis
@viaholiday · X

RT @emily_rj: @jmatwood @NML_dc @slooterman POTS as immunocompromising with at least one common and possibly more biomarkers The study: ht…

Mar 11, 2020 · 4 shares · 473 followers View post →
Julie is A REAL BIRD
@jmatwood · X

RT @emily_rj: @jmatwood @NML_dc @slooterman POTS as immunocompromising with at least one common and possibly more biomarkers The study: ht…

Mar 11, 2020 · 4 shares · 3,327 followers View post →
Emily Johnson (is on Mastadon and Bsky)
@emily_rj · X

@jmatwood @NML_dc @slooterman POTS as immunocompromising with at least one common and possibly more biomarkers The study: https://t.co/MaEQxmIhTk The Science Daily report: https://t.co/RBSY3ZyXum A great explainer by one of the researchers: https://t.co/z0laR74LlA

Mar 11, 2020 · 11 likes · 4 shares · 7,902 followers View post →
Collagen Thief
@CollagenThief · X

"A growing body of evidence suggests that POTS may be an autoimmune disorder." Must-read #POTS research. https://t.co/RrwnpDvG6z

Mar 8, 2020 · 1 like · 2,463 followers View post →
Its ME Matina
@justask · X

RT @ChronicallyTina: #Pwme If you also deal with POTS/Dysautonomia, this paper was written by Dr. Blair Grubb Dr. Beverly Karabin from Uni…

Nov 5, 2019 · 1 share · 2,389 followers View post →
Kristina Osobka
@ChronicallyTina · X

#Pwme If you also deal with POTS/Dysautonomia, this paper was written by Dr. Blair Grubb Dr. Beverly Karabin from Univ. Of Toledo. Definitely worth a read or to take to your Dr. #POTS #MyalgicE #Dysautonomia https://t.co/LGTRcx7MKf https://t.co/IJW57J00uJ

Nov 5, 2019 · 2 likes · 1 share · 1,274 followers View post →
sally
@sejwatson · X

@t7_linda @DrEReinhold @PKhakpour @Cheryl_Quist @jenbrea @adriofair also this very recent paper where the authors were looking for a marker which is simple to detect with a standard blood test: https://t.co/dXp6ap4CZ0

Nov 3, 2019 · 4 likes · 1,101 followers View post →
Circulation 日本版
@Circulation_nih · X

RT @JAHA_AHA: Potential autoimmune pathogenesis in postural orthostatic tachycardia syndrome https://t.co/meQzVjjYbW #AHAJournals https://t…

Sep 19, 2019 · 2 shares · 346 followers View post →
Reza Ghanavati, MD.
@Ghanavati_r · X

RT @JAHA_AHA: Potential autoimmune pathogenesis in postural orthostatic tachycardia syndrome https://t.co/meQzVjjYbW #AHAJournals https://t…

Sep 17, 2019 · 2 shares · 326 followers View post →
JAHA
@JAHA_AHA · X

Potential autoimmune pathogenesis in postural orthostatic tachycardia syndrome https://t.co/meQzVjjYbW #AHAJournals https://t.co/xC1qjurYHe

Sep 17, 2019 · 7 likes · 2 shares · 31,332 followers View post →
CureME~CFS
@Cure_ME_CFS · X

@GemzME @exceedhergrasp1 @OpenMedF @JanetDafoe @sjmnotes @vishkanyaaaa @courtney_37 Everything is psychosomatic for lazy doctors until biomarker is detected. #pots #MECFS POTS is Associated With Elevated G‐Protein Coupled Receptor Autoantibodies https://t.co/FbXV2GK4IS

Sep 15, 2019 · 2 likes · 476 followers View post →
Chronic Wholeness
@ChronicWholenes · X

RT @ChronicWholenes: On autoantibodies in postural orthostatic tachycardia syndrome. #POTS #dysautonomia Postural Orthostatic Tachycardia…

Sep 12, 2019 · 3 shares · 1,010 followers View post →
Project POTS
@ProjectPOTS · X

RT @ChronicWholenes: On autoantibodies in postural orthostatic tachycardia syndrome. #POTS #dysautonomia Postural Orthostatic Tachycardia…

Sep 10, 2019 · 3 shares · 10 followers View post →
Taís Gollo
@GolloTais · X

Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G‐Protein Coupled Receptor Autoantibodies | Journal of the American Heart Association https://t.co/wVUFtoF6He

Sep 10, 2019 · 48 followers View post →
S Blitshteyn MD, FAAN, FANA, Dysautonomia Clinic
@dysclinic · X

In this study by Dr. Grubb and colleagues, autoimmune etiology of POTS is once again suggested by the findings of alpha 1 adrenergic and muscarinic M4 antibodies in the majority of 55 patients with POTS tested via CellTrend testing kit. https://t.co/fs9UaCDP7w

Sep 9, 2019 · 2 likes · 21,468 followers View post →
ME|FM Society of BC
@mefmbc · X

Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G‐Protein Coupled Receptor Autoantibodies | Journal of the American Heart Association #POTS is very prevalent in patients living with #MEcfs https://t.co/bUkJNKs9cU

Sep 9, 2019 · 6 likes · 600 followers View post →
Miriam Alcántara
@Miriam5ht · X

RT @JRB_Neuropsiq: Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G‐Protein Coupled Receptor Autoantibodies | Journa…

Sep 9, 2019 · 1 share · 413 followers View post →
PwME 4 bioMEdical research
@ValeBodi · X

Just published: Postural Orthostatic Tachycardia Syndrome is Associated With Elevated G-Protein Coupled Receptor Autoantibodies Blair Grubb et al. #POTS is a frequent co-morbidity with #EDS #MECFS #PwME #Dysautonomia #Autommunity https://t.co/bxZbkYwOfX

Sep 9, 2019 · 1 like · 4,538 followers View post →
Jesus Ramirez-Bermudez
@JRBneuropsiq · X

Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G‐Protein Coupled Receptor Autoantibodies | Journal of the American Heart Association https://t.co/mHIbKZNMyk

Sep 9, 2019 · 6 likes · 1 share · 31,274 followers View post →