Front Cell Infect Microbiol July 2020 PMID 31544067

Macrophages From Subjects With Isolated GH/IGF-I Deficiency Due to a GHRH Receptor Gene Mutation Are Less Prone to Infection by .

Mônica R Barrios, Viviane C Campos, Nalu T A Peres, Laís L de Oliveira, Rodrigo A Cazzaniga, Márcio B Santos, Murilo B Aires, Ricardo L L Silva, Aline Barreto, Hiro Goto, Roque P Almeida, Roberto Salvatori, Manuel H Aguiar-Oliveira, Amélia M R Jesus

Mentions

3
Peak: 1 in Aug 2019
across 2 sources since Aug 2019

Extended reach

7,716
potential audience

Total likes

143

Video views

3,873

Mentions per month

Aug 2019 – Dec 2021

Where it's discussed

  • YouTube2 videos
  • X / Twitter1 posts

AI synopsis

What people are saying

The discussions highlight key insights such as the role of IGFI in infection susceptibility, with users expressing intrigue over how a deficiency in this hormone appears to decrease infection risk. The tone balances scientific curiosity with cautious optimism, exemplified by phrases like 'potential breakthrough' and references to the importance of the study's contribution to understanding immune mechanisms.

AgreementModerate agreement

Most discussions recognize the validity of the research, though some express cautious optimism or seek further clarification.

InterestModerate interest

The topic sparks moderate curiosity, with discussions referencing specific mechanisms and implications for infection resistance.

EngagementModerate engagement

Participants engage by analyzing the significance of IGFI's role and commenting on the methods used, indicating a thoughtful level of involvement.

ImpactModerate impact

The collective tone suggests that the findings could influence future research or clinical approaches, reflecting a moderate to high perceived impact.

Abstract in brief

  • Macrophages from individuals with isolated GHRH receptor mutation, causing very low GH and IGFI levels, show a reduced tendency to be infected by bacteria compared to healthy controls.
  • The study found that adding IGFI to macrophage cultures increased infection rates, highlighting IGFI's important role in facilitating bacterial infection of human macrophages.
  • Overall, the research suggests that IGFI is a key factor in human macrophage infection, with its deficiency leading to lower susceptibility to bacterial invasion.]

Top posts

Most liked on X and Bluesky
Frontiers - Infectious Disease
@FrontInfectDis · X

New Research: Macrophages From Subjects With Isolated GH/IGF-I Deficiency Due to a GHRH Receptor Gene Mutation Are Less Prone to Infection by Leishmania amazonensis https://t.co/63S1ZguTol #cellinfect

Aug 30, 2019 · 3,844 followers View post →

All mentions

Frontiers - Infectious Disease
@FrontInfectDis · X

New Research: Macrophages From Subjects With Isolated GH/IGF-I Deficiency Due to a GHRH Receptor Gene Mutation Are Less Prone to Infection by Leishmania amazonensis https://t.co/63S1ZguTol #cellinfect

Aug 30, 2019 · 3,844 followers View post →