The effects of bioavailable gluconate chelated stannous fluoride dentifrice on gingival bleeding: Meta-analysis of eighteen randomized controlled trials.

Abstract in brief

• The meta-analysis of 18 randomized controlled trials found that bioavailable gluconate chelated stannous fluoride (SnF) toothpaste significantly reduces gingival bleeding compared to both positive controls (triclosan) and negative controls (NaF or MFP) after 3 months of use.
• Subjects using SnF toothpaste showed a notable decrease in bleeding sites (51% versus negative controls and 31% versus positive controls) and had much higher odds of shifting from gingivitis to generally healthy gums.
• The studies had a low risk of bias, and the results clearly demonstrate that SnF dentifrices provide meaningful gingivitis benefits within a 3-month period.]