Front Aging Neurosci September 2019 PMID 31572171

A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD.

Ross Grant, Jade Berg, Richard Mestayer, Nady Braidy, James Bennett, Susan Broom, James Watson

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Mentions

19
Peak: 5 in Sep 2019
across 4 sources since Sep 2019

Extended reach

178,967
potential audience

Total likes

2,500

Video views

84,602

Mentions per month

Sep 2019 – Jun 2025

Where it's discussed

  • X / Twitter10 posts
  • News5 articles
  • YouTube2 videos
  • Reddit2 posts

AI synopsis

What people are saying

The discussions reflect a curiosity about the implications of NAD+ metabolism for health and aging, with posts mentioning enzyme activity, urinary excretion, and the potential for NAD+ infusions to impact cellular function. The tone varies from scientific interest to speculative claims, such as the assertion that NAD+ delivered intravenously is 'effectively and immediately utilized,' emphasizing both engagement and debate about its practical impact.

AgreementModerate agreement

Most posts acknowledge the study's findings, particularly regarding NAD+ metabolism and its implications for health, showing general support.

InterestHigh interest

Discussions are highly engaged with questions and references to broader health topics, indicating strong interest.

EngagementModerate engagement

Participants reference specific details such as enzyme activity, urinary metabolites, and ongoing debates about NAD+ supplementation, reflecting moderate effort and depth.

ImpactModerate impact

Posts suggest that the study influences ongoing conversations about NAD+ therapy, aging, and neuroprotection, indicating some perceived significance.

Abstract in brief

  • The study explored how a 6-hour intravenous infusion of NAD affects levels of NAD and its related metabolites in human plasma and urine, finding no immediate change in plasma NAD or many metabolites until after 2 hours.
  • Urinary excretion of certain products like methylnicotinamide (meNAM) and NAD increased by 6 hours, indicating ongoing metabolic processes, but nicotinamide (NAM) itself did not significantly rise in urine.
  • The findings suggest that at the infusion rate used, NAD is quickly cleared from the plasma within the first 2 hours, with the breakdown profile reflecting activity of specific enzymes (NAD glycohydrolase and NAD pyrophosphatase), and that NAD infusion leads to the excretion of NAD and methylated metabolites, but not free NAM.

Top posts

Most liked on X and Bluesky
Frontiers - Neuroscience
@FrontNeurosci · X

New Research: A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+: Accumulating evidence suggests that active maintenance of optimal levels of the essential… https://t.co/cPzFUzkNzM #ageing #neuroscience

Sep 16, 2019 · 6 likes · 4 shares · 81,095 followers View post →
Online Pharmacy
@PharmacyOnline8 · X

A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+ https://t.co/pf96kFGvpI https://t.co/bLz6RWYGPv

Oct 13, 2019 · 6,244 followers View post →
Rene Sugar
@renesugar · X

A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+ https://t.co/vh5opwFX3G https://t.co/hYRMInnnh4

Apr 25, 2022 · 3,971 followers View post →
Adam Knight
@Adam8Knight · X

A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+ https://t.co/JWgDItPp4m

Apr 24, 2022 · 1,843 followers View post →
Nkumbulo
@jamessodabi · X

RT @FrontNeurosci: New Research: A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intraven…

Sep 16, 2019 · 4 shares · 522 followers View post →
Absurd
@qualityisarul3 · X

RT @FrontNeurosci: New Research: A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intraven…

Sep 18, 2019 · 4 shares · 278 followers View post →

All mentions

Ron Akram
@ronakram · X

A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infus… https://t.co/gBgDZrqESk

Nov 24, 2024 · 73 followers View post →
Rene Sugar
@renesugar · X

A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+ https://t.co/vh5opwFX3G https://t.co/hYRMInnnh4

Apr 25, 2022 · 3,971 followers View post →
Adam Knight
@Adam8Knight · X

A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+ https://t.co/JWgDItPp4m

Apr 24, 2022 · 1,843 followers View post →
Online Pharmacy
@PharmacyOnline8 · X

A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+ https://t.co/pf96kFGvpI https://t.co/bLz6RWYGPv

Oct 13, 2019 · 6,244 followers View post →
Yuki Uehara
@YukiUehara7 · X

【NAD+】ヒトにNAD+を6時間静注し続けた時の血中および尿中NAD+代謝物の変化 https://t.co/UvO6bexjuY

Oct 10, 2019 · 232 followers View post →
IV ELEMENTS
@ivelements_nj · X

A pilot study investigating changes in the human plasma and urine NAD+ metabolome during a 6-hour intravenous infusion of NAD+ https://t.co/8mz3g8udPv

Sep 22, 2019 · 42 followers View post →
Ed Coleman ⬆
@edjcoleman · X

Given @PeterAttiaMD on @Kingsbu podcast wanted evidence NAD+ IV’s make it into your cells, hoping he’ll discuss this. An IV seller is claiming this is validation “NAD+ delivered directly to the bloodstream is effectively and immediately utilized.” https://t.co/YBZRomQDl3

Sep 21, 2019 · 42 followers View post →
Absurd
@qualityisarul3 · X

RT @FrontNeurosci: New Research: A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intraven…

Sep 18, 2019 · 4 shares · 278 followers View post →
Nkumbulo
@jamessodabi · X

RT @FrontNeurosci: New Research: A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intraven…

Sep 16, 2019 · 4 shares · 522 followers View post →
Frontiers - Neuroscience
@FrontNeurosci · X

New Research: A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+: Accumulating evidence suggests that active maintenance of optimal levels of the essential… https://t.co/cPzFUzkNzM #ageing #neuroscience

Sep 16, 2019 · 6 likes · 4 shares · 81,095 followers View post →