PubHawk
Science September 2019 PMID 31604241

REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories.

Shuntaro Izawa, Srikanta Chowdhury, Toh Miyazaki, Yasutaka Mukai, Daisuke Ono, Ryo Inoue, Yu Ohmura, Hiroyuki Mizoguchi, Kazuhiro Kimura, Mitsuhiro Yoshioka, Akira Terao, Thomas S Kilduff, Akihiro Yamanaka

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Mentions

182
Peak: 43 in Sep 2019
across 6 sources since Sep 2019

Extended reach

281,702
potential audience

Total likes

402

Video views

18,113

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Sep 2019 – Feb 2025

Where it's discussed

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AI synopsis

What people are saying

Many discussions explicitly reference the article's findings, focusing on the role of MCH neurons in the process of forgetting memories during REM sleep. Phrases like 'fascinating' and 'I must be forgetting a lot' reflect both excitement and personal connection to the topic. The tone is often casual but conveys a deeper intrigue about the science behind memory retention and the significance of REM sleep, enhancing the overall sentiment of curiosity and relevance.

AgreementModerate agreement

Most discussions reflect a favorable reception toward the findings, suggesting an overall support of the publication's conclusions.

InterestHigh interest

Participants exhibit a high level of curiosity regarding the implications of memory processing and the role of REM sleep.

EngagementModerate engagement

While many posts simply restate the article's title, some delve deeper with references to specific neurons and their functions, indicating a moderate level of engagement.

ImpactHigh impact

There is a widespread perception that the findings could significantly influence understanding of memory processes, especially in relation to sleep.

Abstract in brief

  • Researchers discovered that melanin concentrating hormone (MCH) neurons in the hypothalamus play an active role in forgetting hippocampus-dependent memories during REM sleep.
  • Activation of these MCH neurons affected memory retention, with stimulation leading to impaired memory and inhibition resulting in improved memory function.
  • Notably, the inhibition of MCH neurons during REM sleep specifically hindered forgetting without disrupting overall sleep quality or structure.
Read the full abstract

Top posts

Most liked on X and Bluesky
Kevin Mitchell
@WiringTheBrain · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/dn3a6EBLn8 - forgetting (unimportant) things while you sleep is an active process driven partly by specific neurons https://t.co/EINK5OhRex

Sep 20, 2019 · 24 likes · 10 shares · 40,321 followers View post →
CLaE
@leafs_s · X

Science (2019) REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/4AmfL41txw

Mar 26, 2021 · 18 likes · 10 shares · 28,256 followers View post →
Inscopix
@Inscopix · X

Many congratulations to the Yamanaka lab at @NagoyaUniv on their @sciencemagazine publication!

Oct 4, 2019 · 12 likes · 3 shares · 3,255 followers View post →
Vlad Vyazovskiy
@VVyazovskiy · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/oFLpG9vUxY

Sep 21, 2019 · 12 likes · 6 shares · 2,315 followers View post →
Yuval Nir
@LabNir · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/iW6Xvewb9I

Sep 19, 2019 · 11 likes · 8 shares · 1,759 followers View post →
Nori Saiki
@ns_ore_ns · X

レム睡眠時に活性化するmelanin-concentrating hormone (MCH)–producing neuronsによる海馬での能動的記憶消去 ツラいことは忘れてくれる機能をちゃんと備えている。 https://t.co/43AD8dj5lv

Oct 2, 2021 · 5 likes · 313 followers View post →

All mentions

こうた
@UkoutaTa75129 · X

この前のSRで「なんで夢ってすぐ忘れちゃうんだろうね、論文にしたい」って言ったのを思い出した https://t.co/kQuGQ8usLf

Aug 22, 2024 · 2 likes · 88 followers View post →
matiere*
@matiere · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/zy3SvesmOL

May 25, 2022 · 2,851 followers View post →
Nori Saiki
@ns_ore_ns · X

レム睡眠時に活性化するmelanin-concentrating hormone (MCH)–producing neuronsによる海馬での能動的記憶消去 ツラいことは忘れてくれる機能をちゃんと備えている。 https://t.co/43AD8dj5lv

Oct 2, 2021 · 5 likes · 313 followers View post →
Sara Jafakesh
@JafakeshSara · X

RT @leafs_s: Science (2019) REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/4AmfL41txw

Mar 29, 2021 · 10 shares · 205 followers View post →
Octavio Henao-Orrego (OCHO)
@OctavioHenao · X

RT @leafs_s: Science (2019) REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/4AmfL41txw

Mar 29, 2021 · 10 shares · 468 followers View post →
Edward Harding
@EdwardCHarding · X

RT @leafs_s: Science (2019) REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/4AmfL41txw

Mar 27, 2021 · 10 shares · 743 followers View post →
Dixie Flatline
@_dix_flatline_ · X

RT @leafs_s: Science (2019) REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/4AmfL41txw

Mar 27, 2021 · 10 shares · 63 followers View post →
CLaE
@leafs_s · X

RT @leafs_s: Science (2019) REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/4AmfL41txw

Mar 27, 2021 · 10 shares · 28,256 followers View post →
Eino-Mikael Talvitie
@EinoMikael · X

RT @leafs_s: Science (2019) REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/4AmfL41txw

Mar 27, 2021 · 10 shares · 18 followers View post →
Lorenzo Pia
@lorenzopia · X

RT @leafs_s: Science (2019) REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/4AmfL41txw

Mar 26, 2021 · 10 shares · 1,170 followers View post →
Julien Burcher
@Dowellenough · X

RT @leafs_s: Science (2019) REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/4AmfL41txw

Mar 26, 2021 · 10 shares · 1,852 followers View post →
De myth ology
@kevinmcld · X

RT @leafs_s: Science (2019) REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/4AmfL41txw

Mar 26, 2021 · 10 shares · 743 followers View post →
Gemma Serradell Asensi
@gemma_serradell · X

RT @leafs_s: Science (2019) REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/4AmfL41txw

Mar 26, 2021 · 10 shares · 274 followers View post →
CLaE
@leafs_s · X

Science (2019) REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/4AmfL41txw

Mar 26, 2021 · 18 likes · 10 shares · 28,256 followers View post →
Truthhurts but lies kill
@Truthova · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/ENP4Fs6SYF

Aug 22, 2020 · 118 followers View post →
青柳
@FBWM8888 · X

RT @uranus_2: 覚醒時に活発なMCHニューロンとREM睡眠時に活発なMCHニューロンは別の細胞群で担われており、視床下部での分布はランダム。この内、能動的忘却に関わるのはREM睡眠時に活発なMCHニューロン。REM sleep–active MCH neurons…

Jun 29, 2020 · 734 followers View post →
マーキュリー２世
@uranus_2 · X

覚醒時に活発なMCHニューロンとREM睡眠時に活発なMCHニューロンは別の細胞群で担われており、視床下部での分布はランダム。この内、能動的忘却に関わるのはREM睡眠時に活発なMCHニューロン。REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent… https://t.co/cYWEPitGjy

Jun 29, 2020 · 5,526 followers View post →
Carlos D. Castillo
@neurologo · X

La importancia de olvidar para mantener la memoria. Y el papel del sueño en la consolidación de la misma. (¿Por estas neuronas no recordamos los sueños?) REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories | Science https://t.co/2LFp1M0V7z

Jan 16, 2020 · 1,439 followers View post →
biodomtomi
@biodomtomi · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/nvTXR1aNx3

Jan 13, 2020 · 170 followers View post →
Jack Lin
@linjj4 · X

RT @aaron_wilber: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/A8RYI5uAGN

Nov 18, 2019 · 1 share · 351 followers View post →
Aaron Wilber
@aaron_wilber · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/A8RYI5uAGN

Nov 18, 2019 · 3 likes · 1 share · 938 followers View post →
David Ulysse
@DavidUlysse1 · X

RT @claytonsbingham: REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/O5jx7Qom00 https:/…

Nov 5, 2019 · 5 shares · 2,147 followers View post →
Trevor Dixon
@allknowing67 · X

RT @claytonsbingham: REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/O5jx7Qom00 https:/…

Nov 1, 2019 · 5 shares · 34,404 followers View post →
Der_Namenlose
@Sven_de_Vries · X

RT @claytonsbingham: REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/O5jx7Qom00 https:/…

Oct 31, 2019 · 5 shares · 53 followers View post →
Ene
@ene3112 · X

RT @claytonsbingham: REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/O5jx7Qom00 https:/…

Oct 31, 2019 · 5 shares · 2,116 followers View post →
Mary Cotey
@cotey_mary · X

RT @claytonsbingham: REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/O5jx7Qom00 https:/…

Oct 31, 2019 · 5 shares · 3,161 followers View post →
Yu Ohmura
@OhmuraYu · X

My collaborators published an article in Science! Congratulations! DOI: 10.1126/science.aax9238

Oct 18, 2019 · 7 followers View post →
Alicia Costa
@AliciaC21900377 · X

Science. 2019 Sep 20;365(6459):1308-1313. doi: 10.1126/science.aax9238. REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories.

Oct 15, 2019 · 51 followers View post →
Researching the Brain
@Brain_Database · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/H4xMWuTvnk

Oct 5, 2019 · 1,038 followers View post →
Daniel Lam
@dna_lam · X

RT @Inscopix: Many congratulations to the Yamanaka lab at @NagoyaUniv on their @sciencemagazine publication!

Oct 5, 2019 · 3 shares · 196 followers View post →
Rhiannan Williams
@NAPSsci · X

RT @Inscopix: Many congratulations to the Yamanaka lab at @NagoyaUniv on their @sciencemagazine publication!

Oct 5, 2019 · 3 shares · 146 followers View post →
Inscopix
@Inscopix · X

Many congratulations to the Yamanaka lab at @NagoyaUniv on their @sciencemagazine publication!

Oct 4, 2019 · 12 likes · 3 shares · 3,255 followers View post →
NonLocalityGuy
@NonLocalityGuy · X

RT @LabNir: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/iW6Xvewb9I

Oct 3, 2019 · 8 shares · 1,745 followers View post →
Ye Ella Tian
@yetianmed · X

Why can't I remember my dream? REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/gKLMtQFHQW

Sep 28, 2019 · 2 likes · 2,184 followers View post →
Dr. Anna Radke
@aradprof · X

Fascinating: "REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories" https://t.co/xGx16QDcI9

Sep 28, 2019 · 1 like · 2,226 followers View post →
Adri
@atri2adrian · X

I must be forgetting a lot: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/DhTP6YpHDL

Sep 24, 2019 · 69 followers View post →
Sergii Tukaiev
@byzant69 · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/JOP3cktdhU

Sep 24, 2019 · 168 followers View post →
Amuza Inc
@AmuzaInc · X

Yamanaka Lab uses Teleopto Wireless Optogenetics in @sciencemagazine publication: REM sleep–active MCH neurons are involved in forgetting hippocampus dependent memories https://t.co/EfcqMB4Dej #Teleopto #Optogenetic #AmuzaInc

Sep 23, 2019 · 2 likes · 53 followers View post →
Victor Rush
@RushVicrush · X

RT @VVyazovskiy: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/oFLpG9vUxY

Sep 23, 2019 · 6 shares · 222 followers View post →
たと
@tatojii · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/UXqeL3bFcW これか(今更)

Sep 23, 2019 · 669 followers View post →
Karen Morris
@KarenMo06514375 · X

RT @WiringTheBrain: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/dn3a6EBLn8 - forget…

Sep 22, 2019 · 10 shares · 569 followers View post →
Prof. Cleiton Lopes Aguiar
@NeuroCleiton · X

RT @VVyazovskiy: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/oFLpG9vUxY

Sep 22, 2019 · 6 shares · 815 followers View post →
The Chronicles of Chris Young PSA scrub-your-hands
@YoungChris27040 · X

RT @WiringTheBrain: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/dn3a6EBLn8 - forget…

Sep 22, 2019 · 10 shares · 5,837 followers View post →
Tomoko Yamagata
@Tomoko_Yamagata · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/ANivgLhw65

Sep 22, 2019 · 15 followers View post →
Dr. Erika Calvo-Ochoa (she/ella)
@erikacalvophd · X

Sep 21, 2019 · 1,074 followers View post →
Neuroscience News
@TT_Neuroscience · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories | Science https://t.co/GScqUKKKMF, see more https://t.co/P6itrQPnIb

Sep 21, 2019 · 244 followers View post →
Raquel Adaia
@adaiasand · X

RT @VVyazovskiy: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/oFLpG9vUxY

Sep 21, 2019 · 6 shares · 238 followers View post →
Paul Anastasiades
@P_Anastasiades · X

RT @VVyazovskiy: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/oFLpG9vUxY

Sep 21, 2019 · 6 shares · 1,567 followers View post →
Anaclet Lab
@anaclet_lab · X

RT @VVyazovskiy: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/oFLpG9vUxY

Sep 21, 2019 · 6 shares · 275 followers View post →
Vlad Vyazovskiy
@VVyazovskiy · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/oFLpG9vUxY

Sep 21, 2019 · 12 likes · 6 shares · 2,315 followers View post →
Daniel Krawczyk PhD
@DanKrawczykPhD · X

RT @WiringTheBrain: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/dn3a6EBLn8 - forget…

Sep 21, 2019 · 10 shares · 318 followers View post →
SergeAhmed
@SergeAhmed · X

RT @WiringTheBrain: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/dn3a6EBLn8 - forget…

Sep 21, 2019 · 10 shares · 3,955 followers View post →
Health and Fitness Teacher
@HealthFitness_6 · X

REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/s2Qrvnccna https://t.co/i7qHWxPFP8

Sep 21, 2019 · 192 followers View post →
Laura Andreae
@L_andreae · X

RT @WiringTheBrain: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/dn3a6EBLn8 - forget…

Sep 21, 2019 · 10 shares · 1,863 followers View post →
rd pascual-marqui
@Pascual_Marqui · X

RT @LabNir: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/iW6Xvewb9I

Sep 21, 2019 · 8 shares · 914 followers View post →
Kevin Mitchell
@WiringTheBrain · X

RT @WiringTheBrain: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/dn3a6EBLn8 - forget…

Sep 20, 2019 · 10 shares · 40,321 followers View post →
Niklas Schneider
@schn_niklas · X

RT @LabNir: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/iW6Xvewb9I

Sep 20, 2019 · 8 shares · 53 followers View post →
Reto Huber
@hubereto · X

RT @LabNir: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/iW6Xvewb9I

Sep 20, 2019 · 8 shares · 296 followers View post →
Beatriz Rico
@Rico_lab · X

RT @WiringTheBrain: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/dn3a6EBLn8 - forget…

Sep 20, 2019 · 10 shares · 1,895 followers View post →
Steven Gussman
@schwinn3 · X

RT @WiringTheBrain: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/dn3a6EBLn8 - forget…

Sep 20, 2019 · 10 shares · 495 followers View post →
Edgar Bermudez, PhD
@viajesubmarino · X

RT @WiringTheBrain: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/dn3a6EBLn8 - forget…

Sep 20, 2019 · 10 shares · 674 followers View post →
stefania conti
@stefaniaconti · X

RT @luigidegennar: Un ruolo del sonno REM per l'oblio delle memorie indesiderate? REM sleep–active MCH neurons are involved in forgetting…

Sep 20, 2019 · 1 share · 3,621 followers View post →
David
@Foreman1David · X

RT @WiringTheBrain: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/dn3a6EBLn8 - forget…

Sep 20, 2019 · 10 shares · 2,115 followers View post →
Dr. Michael Rothman
@DrRothman · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/46LbSrRnFu genetic ablation of MCH neurons increased memory performance in mice. Conversely, pharmacogenetic activation of MCH neurons impaired memory.

Sep 20, 2019 · 42 followers View post →
Kevin Mitchell
@WiringTheBrain · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/dn3a6EBLn8 - forgetting (unimportant) things while you sleep is an active process driven partly by specific neurons https://t.co/EINK5OhRex

Sep 20, 2019 · 24 likes · 10 shares · 40,321 followers View post →
Luigi De Gennaro
@luigidegennar · X

Un ruolo del sonno REM per l'oblio delle memorie indesiderate? REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/0WC1uMK8vS

Sep 20, 2019 · 1 like · 1 share · 14,105 followers View post →
Giacomo Maddaloni
@giac_madd · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/R9ruDjR4vF

Sep 20, 2019 · 623 followers View post →
Faith McGown
@faithmcgown · X

Why we forget our dreams: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/S10viA9bC0

Sep 20, 2019 · 743 followers View post →
Eric Landsness
@EricLandsness · X

RT @LabNir: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/iW6Xvewb9I

Sep 20, 2019 · 8 shares · 644 followers View post →
Dr Anthony Martin
@AMAinsight · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/eOBvpJFqRX

Sep 20, 2019 · 914 followers View post →
Kå-Låï Wðñg 黃嘉麗
@KaLaiWong · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/n2xkOjv3Bq

Sep 20, 2019 · 269 followers View post →
S. Arotce Quintas.
@SArotceQuintas · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/B1OdlkfT2J

Sep 20, 2019 · 109 followers View post →
Hans-Peter Landolt
@Hypnos8320 · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/C3UmqKLunh

Sep 20, 2019 · 264 followers View post →
Ana Paula Crestani
@apcrest · X

RT @LabNir: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/iW6Xvewb9I

Sep 20, 2019 · 8 shares · 239 followers View post →
Nanthia Suthana
@SuthanaLab · X

RT @LabNir: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/iW6Xvewb9I

Sep 19, 2019 · 8 shares · 4,695 followers View post →
Yuval Nir
@LabNir · X

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories https://t.co/iW6Xvewb9I

Sep 19, 2019 · 11 likes · 8 shares · 1,759 followers View post →