March 2020 PMID 31621967

Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts.

R J Johnson, P Stenvinkel, P Andrews, L G Sánchez-Lozada, T Nakagawa, E Gaucher, A Andres-Hernando, B Rodriguez-Iturbe, C R Jimenez, G Garcia, D-H Kang, D R Tolan, M A Lanaspa

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Mentions

152
Peak: 24 in Apr 2023
across 6 sources since Oct 2019

Extended reach

1,377,254
potential audience

Total likes

21,739

Video views

716,895

Mentions per month

Oct 2019 – Mar 2024

Where it's discussed

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AI synopsis

What people are saying

Several discussions reflect on the evolutionary benefits of fructose, with users mentioning phrases like 'transform fat into energy' and referencing ancestral diets that included natural sugars. The tone varies from enthusiastic appreciation, like 'I'm blown away by this review,' to critical remarks about modern fructose consumption contributing to obesity, illustrating a spectrum of responses that underscore the complexity of dietary impacts.

AgreementModerate agreement

Most discussions show moderate support for the concepts presented in the publication, with several users acknowledging its potential relevance to dietary and evolutionary health.

InterestHigh interest

The majority of users express a strong interest in the evolutionary implications of fructose metabolism, highlighting its connection to survival strategies in times of adversity.

EngagementModerate engagement

While some users delve into specific aspects of the research, there are also dismissive tones towards the negative health implications of fructose, suggesting a mixed level of engagement.

ImpactHigh impact

Many contributors believe that the insights from the publication could have significant implications for understanding metabolic health and dietary choices.

Abstract in brief

  • Evolutionary adaptations in fructose metabolism helped species survive past climate challenges, such as food shortages and droughts.
  • Fructose aids in energy and water storage by shifting fuel storage to fat and glycogen, while also reducing oxygen demands during low-oxygen conditions.
  • Mutations that enhanced fructose metabolism occurred during two major extinction events, but today's high intake of fructose from refined sugars has led to modern health issues like obesity and diabetes.

Top posts

Most liked on X and Bluesky
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co/wdY0s1li9f

Apr 12, 2023 · 150 likes · 26 shares · 291,677 followers View post →
Aureliano Stingi PhD
@AurelianoStingi · X

I nostri antenati successivamente si sono spostati nella fredda Europa. Dove la priorità era accumulare grasso per l'inverno. Qui alcuni nostri antenati hanno ereditato una mutazione che gli permetteva di trasformare il fruttosio in.........grasso! 9/n https://t.co/hEkwLDBPmH

Jul 4, 2023 · 90 likes · 4 shares · 38,647 followers View post →
ライブラン
@LiveRunApp · X

加工された砂糖を取りすぎると、カロリー問題とは別に、メタボスイッチがONになる仕組みを #ライブラン の #Forever23 セッションで説明しました。 食料が少なくなった長い冬を乗り越えることができたのもこのメカニズムのおかげ。 https://t.co/cV3rgdaBs7 https://t.co/C9udg5TqRm

Feb 20, 2022 · 38 likes · 1 share · 27,352 followers View post →
FrezzaLab
@FrezzaLab · X

This is an interesting evolutionary perspective on fructose: Fructose Metabolism as a Common Evolutionary Pathway of Survival associated with climate change, food shortage and droughts https://t.co/pTN9twHs2Z

Oct 20, 2019 · 15 likes · 6 shares · 26,989 followers View post →
Agingdoc
@agingdoc1 · X

Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts (2019 - hypothesis) https://t.co/JAVhGAySvZ https://t.co/jpEK5bH5L1

Aug 23, 2022 · 8 likes · 3 shares · 41,414 followers View post →
Marcus Goncalves
@MarcusDGon · X

I'm blown away by this review. Fructose Metabolism as a Common Evolutionary Pathway of Survival associated with climate change, food shortage and droughts. #strongwork #HFCS https://t.co/7vMUUcMj5h

Oct 22, 2019 · 7 likes · 2,545 followers View post →

All mentions

Juan I Enghelmayer 2022
@Juani1000 · X

RT @leticiakawano: @Juani1000 @IPFdoc @jskim8223 @KaminskiMed @DrPujaMehta1 @RichardPAConway @jeffsparks @drdayjee @PilarRiveraOrt1 @tkulka…

Mar 2, 2024 · 1 share · 1,127 followers View post →
Leticia Kawano-Dourado (I'm on BlueSky/LinkedIn)
@leticiakawano · X

@Juani1000 @IPFdoc @jskim8223 @KaminskiMed @DrPujaMehta1 @RichardPAConway @jeffsparks @drdayjee @PilarRiveraOrt1 @tkulkarn1 Coool Juani! And there's so much more to unfold beyond caloric deficit but what nutrients (or toxins, like fructose) we are eating There is no recommendation to patients going through an inflammatory, on how to choose foods for example For us to think https://t.co/xZli6poXNO https://t.co/CiembjSKOo

Mar 1, 2024 · 3 likes · 1 share · 14,629 followers View post →
Melissa Sandfort
@MelissaSandfort · X

Fructose is starvation-food garbage. Keep it as low as possible! https://t.co/b2tlA4SSfE

Feb 25, 2024 · 163 followers View post →
keto3000
@keto3000 · X

@nicknorwitz @BenBikmanPhD TY for this. I found this paper on fructose met as poss evolutionary pathway for survival interesting! — https://t.co/0yCIX1a408. @fire_bottle @Outdoctrination

Jan 2, 2024 · 577 followers View post →
Omid
@Omid34525285 · X

@scottisaacsmd https://t.co/tTninXvr0Y

Dec 18, 2023 · 150 followers View post →
H Nairobian
@HNairobian · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Dec 14, 2023 · 26 shares · 32 followers View post →
SDK
@ScottDavidKeefe · X

@CarnivoreTeach You need to understand the fructokinase mutation in humans. Other primates do not have this mutation. Fruit and honey (not vegetation) is a normal part of the ancestral diet along with meat in tropical zones. See hunter gatherers like the Hadza. https://t.co/pzu4TS9ybc

Nov 11, 2023 · 3 likes · 617 followers View post →
Travis Smith, D.O. FAAEM
@RosenelliEM · X

@theliverdr It all depends on what you are taking things for. Vit C plays a roll in preventing fat storage from fructose metabolism. https://t.co/5jS6CjJQ4z

Oct 30, 2023 · 5,113 followers View post →
umbeumbi
@umbeumbi · X

RT @AurelianoStingi: I nostri antenati successivamente si sono spostati nella fredda Europa. Dove la priorità era accumulare grasso per l'…

Jul 4, 2023 · 4 shares · 314 followers View post →
Capitan Harlok
@CapitanHarlok6 · X

RT @AurelianoStingi: I nostri antenati successivamente si sono spostati nella fredda Europa. Dove la priorità era accumulare grasso per l'…

Jul 4, 2023 · 4 shares · 1,313 followers View post →
beverari_M
@Beverari_M · X

RT @AurelianoStingi: I nostri antenati successivamente si sono spostati nella fredda Europa. Dove la priorità era accumulare grasso per l'…

Jul 4, 2023 · 4 shares · 796 followers View post →
Ben Tranellio ᏍᏏᏉᏯ
@tranellio · X

RT @AurelianoStingi: I nostri antenati successivamente si sono spostati nella fredda Europa. Dove la priorità era accumulare grasso per l'…

Jul 4, 2023 · 4 shares · 6,323 followers View post →
Aureliano Stingi PhD
@AurelianoStingi · X

I nostri antenati successivamente si sono spostati nella fredda Europa. Dove la priorità era accumulare grasso per l'inverno. Qui alcuni nostri antenati hanno ereditato una mutazione che gli permetteva di trasformare il fruttosio in.........grasso! 9/n https://t.co/hEkwLDBPmH

Jul 4, 2023 · 90 likes · 4 shares · 38,647 followers View post →
Rich Collins
@richcollins · X

RT @alephh: Fructose metabolism as an evolutionary pathway of survival – Twice in history, mutations occurred during periods of mass extinc…

May 7, 2023 · 1 share · 2,065 followers View post →
alephh
@alephh · X

Fructose metabolism as an evolutionary pathway of survival – Twice in history, mutations occurred during periods of mass extinction that enhanced activity of fructose to generate fat: first being a mutation in vit-C 65MY ago & second in uricase 12–14MY ago https://t.co/ZB6ROwPElu

May 7, 2023 · 1 like · 1 share · 388 followers View post →
Nick Papageorge
@NickPapageorge1 · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 22, 2023 · 26 shares · 2,044 followers View post →
•Mairead•
@RayMairead · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 15, 2023 · 26 shares · 37,834 followers View post →
toto
@toto21448375 · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 14, 2023 · 26 shares · 21 followers View post →
Sérgio F. Cardoso
@sfcardoso1965 · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 13, 2023 · 26 shares · 858 followers View post →
Kenneth W Pratt
@KennethWPratt · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 13, 2023 · 26 shares · 5,786 followers View post →
Milan Strongman
@milan_strongman · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 13, 2023 · 26 shares · 27,100 followers View post →
AmericanEgoist
@AmericanEgoist · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 12, 2023 · 26 shares · 162 followers View post →
Truth Cooperators
@SkrivenaIstina · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 12, 2023 · 26 shares · 88 followers View post →
Dupont Daniel
@DupontDaniel2 · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 12, 2023 · 26 shares · 25 followers View post →
PC ⛓
@PC65049955 · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 12, 2023 · 26 shares · 1,472 followers View post →
Emad
@healOMF · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 12, 2023 · 26 shares · 192 followers View post →
John Barratt
@jwbarratt2_john · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 12, 2023 · 26 shares · 190 followers View post →
POURUZ
@flywithpouruz · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 12, 2023 · 26 shares · 293 followers View post →
KanLi NDn - Holistic Approach, Learn & Teach
@CalinNadasan · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 12, 2023 · 26 shares · 132 followers View post →
Craig Huntington
@b2hcraig · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 12, 2023 · 26 shares · 3,701 followers View post →
Attila - M.T.C.H⚡
@AttilaTheJoyous · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 12, 2023 · 26 shares · 114 followers View post →
OneFlewOver_USA
@OneFlewOver_USA · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 12, 2023 · 26 shares · 2,089 followers View post →
Susan Amdroit
@maglady3525 · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 12, 2023 · 26 shares · 195 followers View post →
Sagittarius
@guani_vic · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 12, 2023 · 26 shares · 678 followers View post →
Nish
@TraderNish · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 12, 2023 · 26 shares · 5,041 followers View post →
Pelón JJ
@drjjza · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 12, 2023 · 26 shares · 491 followers View post →
Saturnsky, MBA, BigTech Exec Corporate Demon
@mba_big · X

RT @Mangan150: Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co…

Apr 12, 2023 · 26 shares · 234 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Dietary sugar is basically telling your brain that it's going to be a lean winter, so you better gain weight. https://t.co/wdY0s1li9f

Apr 12, 2023 · 150 likes · 26 shares · 291,677 followers View post →
Tim Rees
@NutritionalThe3 · X

The brain converts glucose ➡️ fructose when blood sugar remains high. No doubt this is protective. "Fructose causes sodium retention and raises blood pressure and likely helped survival in the setting of dehydration or salt deprivation." https://t.co/HB275Iy68n

Feb 27, 2023 · 6 likes · 4,924 followers View post →
ShayGaetz
@MajorPriapus · X

@lean_minded @TheBush84 @robertlufkinmd @PeterAttiaMD @RichardJJohns11 @drjasonfung I already gave you a link how human fruit consumption drives obesity https://t.co/rKnTdx4uio It’s hard wired into our biochemistry as a result of evolution

Feb 14, 2023 · 120 followers View post →
ShayGaetz
@MajorPriapus · X

@lean_minded @TheBush84 @robertlufkinmd Follow expert opinion such as @PeterAttiaMD & @RichardJJohns11 @drjasonfung Our ancestors were lean mean fighting machines all year but packed on weight just before winter by eating ripe fruit Fructose (found in fruit) is very fattening! https://t.co/rKnTdx4uio

Feb 14, 2023 · 120 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts…

Aug 23, 2022 · 3 shares · 133 followers View post →
paengineer
@paengineer · X

RT @agingdoc1: Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts…

Aug 23, 2022 · 3 shares · 2,564 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @agingdoc1: Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts…

Aug 23, 2022 · 3 shares · 32,522 followers View post →
Agingdoc
@agingdoc1 · X

Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts (2019 - hypothesis) https://t.co/JAVhGAySvZ https://t.co/jpEK5bH5L1

Aug 23, 2022 · 8 likes · 3 shares · 41,414 followers View post →
didaclopez
@didaclopez · X

@enriccanela @CosmoCaixa @CPanchon @CrecimUab @CreaNoParisMai @crhistis @crismunozp @UniversitatsANC @david_vallespin @debatub @delgoveu @DignaCouso @elnacionalcat @elsa_artadi @emontoliod @EnricJuliana La trampa evolutiva del metabolisme de la fructosa. https://t.co/CccqjRLA5W

Aug 10, 2022 · 1 like · 3,430 followers View post →
Tomo Takada
@toroeater · X

RT @LiveRunApp: 加工された砂糖を取りすぎると、カロリー問題とは別に、メタボスイッチがONになる仕組みを #ライブラン の #Forever23 セッションで説明しました。 食料が少なくなった長い冬を乗り越えることができたのもこのメカニズムのおかげ。 htt…

Feb 21, 2022 · 1 share · 17,975 followers View post →
ライブラン
@LiveRunApp · X

加工された砂糖を取りすぎると、カロリー問題とは別に、メタボスイッチがONになる仕組みを #ライブラン の #Forever23 セッションで説明しました。 食料が少なくなった長い冬を乗り越えることができたのもこのメカニズムのおかげ。 https://t.co/cV3rgdaBs7 https://t.co/C9udg5TqRm

Feb 20, 2022 · 38 likes · 1 share · 27,352 followers View post →
David Wyant
@wyadvd · X

@MattCKeto And certain birds develop a fatty liver seasonally as a natural response to preparing for migration. https://t.co/PDtGlSNBzT

May 27, 2021 · 5 likes · 2,693 followers View post →
Agnes Ayton
@AgnesAyton · X

@JohnSpeakman4 Here you go. https://t.co/kpocq2gXbS

Apr 9, 2021 · 1 like · 7,380 followers View post →
Jerry Gabriel-MD
@JerryGa18988557 · X

Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts... by R. Johnson. Interesting physiological effects... including Uric Acid- know your levels?

Mar 29, 2021 · 2 likes · 193 followers View post →
Shaun Scott
@upyrbike · X

“fructose shifts the energy provided in nutrients towards fuel storage”

Mar 28, 2021 · 1 like · 1,439 followers View post →
D Laws
@d_magpie · X

The excessive intake of fructose due to the availability of refined sugar and high‐fructose corn syrup is driving ‘burden of life style’ diseases, including obesity, diabetes and high blood pressure. https://t.co/ExKl1GrlM3 https://t.co/zVLGYsH7ox

Mar 6, 2021 · 2 likes · 774 followers View post →
Maurício Lima
@dj_surfista · X

Metabolismo da #frutose como uma via evolutiva comum de sobrevivência associada às mudanças climáticas, escassez de alimentos e secas. #Fructose https://t.co/bECjC6OwEA

Mar 3, 2021 · 3 likes · 743 followers View post →
PF Anderson @pfanderson@disabled.social
@pfanderson · X

Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts https://t.co/Epi0JL2j4u

Sep 30, 2020 · 10,793 followers View post →
Marcus Goncalves
@MarcusDGon · X

I'm blown away by this review. Fructose Metabolism as a Common Evolutionary Pathway of Survival associated with climate change, food shortage and droughts. #strongwork #HFCS https://t.co/7vMUUcMj5h

Oct 22, 2019 · 7 likes · 2,545 followers View post →
TheNutritionNetwork
@NutritionNetwor · X

RT @BANTonline: Fructose Metabolism as a Common Evolutionary Pathway of Survival associated with climate change, food shortage and droughts…

Oct 21, 2019 · 1 share · 2,802 followers View post →
Natalie Niemi
@nieminm · X

RT @FrezzaLab: This is an interesting evolutionary perspective on fructose: Fructose Metabolism as a Common Evolutionary Pathway of Survi…

Oct 20, 2019 · 6 shares · 4,229 followers View post →
Lum Lab
@lum_lab · X

RT @FrezzaLab: This is an interesting evolutionary perspective on fructose: Fructose Metabolism as a Common Evolutionary Pathway of Survi…

Oct 20, 2019 · 6 shares · 1,208 followers View post →
Mimi_ Cardio
@mimi_cardio · X

RT @FrezzaLab: This is an interesting evolutionary perspective on fructose: Fructose Metabolism as a Common Evolutionary Pathway of Survi…

Oct 20, 2019 · 6 shares · 188 followers View post →
Santos Thiago
@SantosF_DNA · X

Balanced diet is the secret! More vegetables with low glycemic index ;) Fructose Metabolism as a Common Evolutionary Pathway of Survival associated with climate change, food shortage and droughts https://t.co/vjnPX8Lw1b

Oct 20, 2019 · 132 followers View post →
Leprivier Lab "Stress responses and cancer"
@AGLeprivier · X

Fructose diet and evolution: a way to survive dehydration, salt deprivation or low oxygen? Fructose Metabolism as a Common Evolutionary Pathway of Survival associated with climate change, food shortage and droughts https://t.co/RtpubFrbi1

Oct 20, 2019 · 1 like · 236 followers View post →
Ben-Sahra Lab
@bensahralab · X

RT @FrezzaLab: This is an interesting evolutionary perspective on fructose: Fructose Metabolism as a Common Evolutionary Pathway of Survi…

Oct 20, 2019 · 6 shares · 2,570 followers View post →
Federico Bernuzzi, PhD
@FedericoBernuzz · X

RT @FrezzaLab: This is an interesting evolutionary perspective on fructose: Fructose Metabolism as a Common Evolutionary Pathway of Survi…

Oct 20, 2019 · 6 shares · 624 followers View post →
FrezzaLab
@FrezzaLab · X

This is an interesting evolutionary perspective on fructose: Fructose Metabolism as a Common Evolutionary Pathway of Survival associated with climate change, food shortage and droughts https://t.co/pTN9twHs2Z

Oct 20, 2019 · 15 likes · 6 shares · 26,989 followers View post →
Sara Di Rienzi
@SaraDiRienzi · X

Mass extinctions, climate change, and fructose all in one really enjoyable review paper. Argument is that humans have adaptations to make the most of fructose during starvation periods. https://t.co/WVXBekZb8Z

Oct 19, 2019 · 4 likes · 1 share · 446 followers View post →
BANT
@BANTonline · X

Fructose Metabolism as a Common Evolutionary Pathway of Survival associated with climate change, food shortage and droughts https://t.co/0IjJJTsBtM

Oct 18, 2019 · 2 likes · 1 share · 7,663 followers View post →
DesignedByNature
@DesignedNature · X

I just posted "Fructose Metabolism as a Common Evolutionary Pathway of Survival associated with climate change, food shortage and droughts. - October 2019" on Reddit https://t.co/k5NEoCyR1G

Oct 18, 2019 · 441 followers View post →
JIM - Journal of Internal Medicine
@JInternMed · X

Expanding biomedical investigation beyond its decades old conventional practices to new approaches based on a broad awareness of the diversity of animal life and comparative physiology can accelerate innovations in healthcare under motto Nature Knows Best https://t.co/ZpUSPxzXYO https://t.co/3ctiMkHUmt

Oct 18, 2019 · 2 likes · 2 shares · 1,641 followers View post →