Hypertension December 2019 PMID 31656099

Gender-Affirming Hormone Therapy, Vascular Health and Cardiovascular Disease in Transgender Adults.

Paul J Connelly, E Marie Freel, Colin Perry, John Ewan, Rhian M Touyz, Gemma Currie, Christian Delles

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Mentions

62
Peak: 7 in Nov 2019
across 4 sources since Oct 2019

Extended reach

73,991
potential audience

Total likes

168

Video views

6,246

Mentions per month

Oct 2019 – Jun 2025

Where it's discussed

  • X / Twitter50 posts
  • News8 articles
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

The overall tone demonstrates active engagement with both supporting and questioning the findings, such as posts mentioning increased risks of cardiovascular disease like strokes and heart attacks, along with calls for more research. The use of terms like 'conflicting results' and references to ongoing debates show a nuanced and critical attitude towards the publication's conclusions.

AgreementModerate agreement

Most discussions recognize that gender-affirming hormone therapy has associated cardiovascular risks, but many also acknowledge conflicting evidence or the need for further research.

InterestHigh interest

Posts show high engagement with the subject, referencing specific studies and debates, indicating strong curiosity and concern about the health effects.

EngagementModerate engagement

Several discussions delve into details of studies, citing specific risks such as strokes and heart attacks, and critique of existing research methodologies.

ImpactModerate impact

The conversations highlight the importance of understanding the article's implications for treatment and health policy, although some express skepticism about conclusive outcomes.

Top posts

Most liked on X and Bluesky
Matilda Gosling
@matildagosling · X

[Infertility: https://t.co/BToOHqErnh. Loss of sexual function: https://t.co/rCt9bNT1FO / https://t.co/VZhAzG2vbf. Health: https://t.co/DfSwcyDyNl]

Jul 16, 2023 · 36 likes · 4 shares · 3,443 followers View post →
Yohann Hoarau - Éthique et Psycho (Rdv sur Bsky)
@YohannHoarau · X

Avec @RaieFutee, on a fait une critique du discours anti-trans de Marguerite Stern et Dora Moutot qui sont passées dans plein de médias pour dire n'importe quoi sur ce sujet https://t.co/ai75PSf7yl https://t.co/0tPxHx0vkH

Jun 6, 2024 · 15 likes · 4 shares · 524 followers View post →
UofG SCMH
@UofGSCMH · X

A systematic review led @BHFCoREGlasgow Clinical Fellow Paul Connelly @ConnellyPJ with Prof Christian Delles & Prof Rhian Touyz @LabTouyz in @HyperAHA and NHS colleagues provides insight into the impact of gender-affirming hormone in cardiovascular health.https://t.co/YkWFKMj6Zq https://t.co/l6G4X0n6Ce

Nov 4, 2019 · 10 likes · 5 shares · 2,168 followers View post →
Greg
@Williams94Greg · X

I can find papers too "Conversely, transgender males receiving testosterone lack any consistent or convincing evidence of increased risk of cardiovascular or cerebrovascular disease." https://t.co/e8UdKkNHXf

Jul 5, 2020 · 2 likes · 485 followers View post →
Javi Ciborro
@papayaykware · X

(9) P. Connelly y otros. Gender-Affirming Hormone Therapy, Vascular Health and Cardiovascular Disease in Transgender Adults. Hypertension, 74(6): 1266-1274.

Feb 21, 2021 · 1 like · 8,035 followers View post →
Jenni Burton
@JenniKBurton · X

And a shout out for @ConnellyPJ inspiring new research https://t.co/T0AjbBXfJi in @HyperAHA #gateevenings

Nov 27, 2019 · 1 like · 3,956 followers View post →

All mentions

Straw Hat Finn
@straw_finn · X

@LabMonkey @FoxxDoesArtt @not12x oh looks like i was mistaken! i had been told that T increased my chances of heart problems, but it looks like that’s not the case. E does seem to increase risk of cardio issues but there’s no evidence that it leads to increased mortality (https://t.co/53akkg7iGb) https://t.co/5WJpjqMY0n

Jun 5, 2025 · 1 like · 484 followers View post →
Bobby Labamba
@Beezer2000 · X

@salsaccino @esjesjesj https://t.co/O5eocOQDfv

Mar 5, 2025 · 379 followers View post →
Bobby Labamba
@Beezer2000 · X

@Nocty16 Vascular damage - again strokes and heart attacks! https://t.co/cIM74NOk5F

Dec 6, 2024 · 379 followers View post →
Bobby Labamba
@Beezer2000 · X

@DerpyErika @finngalkn Heart attacks AND stroke https://t.co/cIM74NOk5F

Dec 6, 2024 · 379 followers View post →
Tea
@Tea94852859 · X

@g4137983139548 @Psychgirl211 Lots of unknown risks, ie not studied long enough. 'Gender-Affirming Hormone Therapy, Vascular Health and Cardiovascular Disease in Transgender Adults Paul J. Connelly et al. 2019 https://t.co/vEGGj49p8H

Nov 9, 2024 · 1 like · 2,484 followers View post →
Gigant Rejser
@GigantRejser · X

@RK3Korsar @PeruPavel @AdamKoscielak @PoProstu_Wiktor Strona 6 https://t.co/VJlu8fhuEY

Aug 10, 2024 · 200 followers View post →
Gigant Rejser
@GigantRejser · X

@RK3Korsar @PeruPavel @AdamKoscielak @PoProstu_Wiktor Wieloma https://t.co/mHHXBhKlay https://t.co/l3hkovgiHi https://t.co/6A1ZvCltgj https://t.co/heAJtqii9T https://t.co/rwjBjWh3qb

Aug 10, 2024 · 200 followers View post →
Eva Martes
@EvMartes · X

RT @YohannHoarau: Avec @RaieFutee, on a fait une critique du discours anti-trans de Marguerite Stern et Dora Moutot qui sont passées dans p…

Jun 14, 2024 · 4 shares · 132 followers View post →
Tony
@Tony24488 · X

RT @YohannHoarau: Avec @RaieFutee, on a fait une critique du discours anti-trans de Marguerite Stern et Dora Moutot qui sont passées dans p…

Jun 7, 2024 · 4 shares · 265 followers View post →
Behague Jimmy
@BehagueJimmy · X

RT @YohannHoarau: Avec @RaieFutee, on a fait une critique du discours anti-trans de Marguerite Stern et Dora Moutot qui sont passées dans p…

Jun 6, 2024 · 4 shares · 1,379 followers View post →
Yohann Hoarau - Éthique et Psycho (Rdv sur Bsky)
@YohannHoarau · X

Avec @RaieFutee, on a fait une critique du discours anti-trans de Marguerite Stern et Dora Moutot qui sont passées dans plein de médias pour dire n'importe quoi sur ce sujet https://t.co/ai75PSf7yl https://t.co/0tPxHx0vkH

Jun 6, 2024 · 15 likes · 4 shares · 524 followers View post →
Louise...#ledbycommunists
@Peitho70 · X

@TransmanVers @BasedRockEnjoy @redheadranting "Existing epidemiological data suggest that the use of estrogens in transgender females confers an increased risk of myocardial infarction and ischemic stroke." https://t.co/O4GMojtVEM

Feb 21, 2024 · 4,506 followers View post →
Все кто воюют долбоёбы
@RedFatCat8205 · X

@mirumir420 @vesna_democrat https://t.co/XX2TiBi6hX вот ещё ссылка, никак не влияет на здоровье сосудов

Feb 9, 2024 · 390 followers View post →
Jeanette Dietrich
@Dr_JDietrich · X

@ErinInTheMorn This review shows it's a bit of dog's breakfast with conflicting results from a number of small studies with different comparison groups. https://t.co/wkBvJ5pNPm

Oct 9, 2023 · 1 like · 76 followers View post →
David Pasko
@DavidPasko_ · X

RT @matildagosling: [Infertility: https://t.co/BToOHqErnh. Loss of sexual function: https://t.co/rCt9bNT1FO / https://t.co/VZhAzG2vbf. Heal…

Jul 17, 2023 · 4 shares · 2,621 followers View post →
JorgiPorgi
@JPorgi · X

RT @matildagosling: [Infertility: https://t.co/BToOHqErnh. Loss of sexual function: https://t.co/rCt9bNT1FO / https://t.co/VZhAzG2vbf. Heal…

Jul 16, 2023 · 4 shares · 456 followers View post →
Drivebylawyer
@drivebylawyer5 · X

RT @matildagosling: [Infertility: https://t.co/BToOHqErnh. Loss of sexual function: https://t.co/rCt9bNT1FO / https://t.co/VZhAzG2vbf. Heal…

Jul 16, 2023 · 4 shares · 1,587 followers View post →
Louise
@_loobyloo · X

RT @matildagosling: [Infertility: https://t.co/BToOHqErnh. Loss of sexual function: https://t.co/rCt9bNT1FO / https://t.co/VZhAzG2vbf. Heal…

Jul 16, 2023 · 4 shares · 1,621 followers View post →
Matilda Gosling
@matildagosling · X

[Infertility: https://t.co/BToOHqErnh. Loss of sexual function: https://t.co/rCt9bNT1FO / https://t.co/VZhAzG2vbf. Health: https://t.co/DfSwcyDyNl]

Jul 16, 2023 · 36 likes · 4 shares · 3,443 followers View post →
Stanisław Gąska
@Warcholkrzycza · X

@Paimonde_Mon @slwstr pediatrics. Connelly P.J. i in., Gender-Affirming Hormone Therapy, Vascular Health and Cardiovascular Disease in Transgender Adults, „Hypertension” 2019, v. 74, iss. 6.

May 25, 2023 · 157 followers View post →
Pani Lambda
@Pani_Lambda · X

@Bookerranana @___lzcat https://t.co/gHqrFxgOba https://t.co/d2zmbO8pYC https://t.co/E7vIgaTGDV https://t.co/x2i1IsG49i https://t.co/SkvnUb9qKs Amerykańska Agencja Żywności i Leków czy Akademia Oxfordu to wg ciebie instytuty z dupy? xD

May 15, 2023 · 1 like · 13 followers View post →
M. Investigator Fox
@MercurialMulder · X

@greghavenner @DANNlWANTSFOOD @Juggerbear95 @TheRealMillerz Fuck, sorry, wrong article. This one shows that MtF HRT causes a noticable increase in certain forms of cardiovascular disease. In general, from my understanding, sexual dimorphism doesn’t change the effect of estrogen on the cardiovascular system: https://t.co/Q5RatemniY

May 15, 2023 · 1,445 followers View post →
Pani Lambda
@Pani_Lambda · X

@pyxyly6 @___lzcat https://t.co/CZbbNMCDPL https://t.co/d2zmbO8pYC https://t.co/3z5Swbt3Vf https://t.co/9h3gadUWt8 https://t.co/o4JwRb3bK2 "Only 2.5% to 20% of all cases of GID in childhood and adolescence are the initial manifestation of irreversible transsexualism."

May 15, 2023 · 13 followers View post →
Javi Ciborro
@papayaykware · X

(9) P. Connelly y otros. Gender-Affirming Hormone Therapy, Vascular Health and Cardiovascular Disease in Transgender Adults. Hypertension, 74(6): 1266-1274. https://t.co/rc19GHsyyc

Feb 20, 2023 · 8,035 followers View post →
ThePeoplesBacon
@BaconOTPeople · X

@Kelly_K_77 @NicoIsAModerate @robmorris123 @SaltyFlGrl @theavboys @DrLoupis @SteviesQuotes You can start here if you prefer: https://t.co/CVk2YjSI1C

Feb 1, 2023 · 634 followers View post →
Mickey
@MickeyLain · X

@isnotasitwas @oliver74614039 @alantrollazo @fraga42491680 @re_basado https://t.co/RJ7CukVQeJ

Dec 20, 2022 · 1 like · 247 followers View post →
Nate Weymouth
@NateWeymouth · X

@GatherDust @dsdtzero @FetsKatze @lmcgaughy @hachx0 Increase cancer and cardiovascular risk of GAC especially among adolescents: https://t.co/pbhYtbtCoo https://t.co/3HMVNsHHYD Ethical Issues: https://t.co/I1fV0ruoBL

Dec 7, 2022 · 2,403 followers View post →
ABertheim
@ABertheim · X

@cmind_g @segm_ebm @daringtospeak No, transition does not have "measurable results". Available studies don't use validated measures of well-being, lack appropriate controls, etc. And the long term health effects are a black box. https://t.co/NdydTfMxga https://t.co/8Vq7WGc3W5

Dec 2, 2022 · 333 followers View post →
Anja
@AntiAnja · X

@JensWildman @AakreMoberg @torunnwg @BritiskV @StianAmadeus Vel, altså... https://t.co/6Ipm4opsOB

Aug 7, 2022 · 1,391 followers View post →
Alexandra Shaw
@transadventurer · X

@lascapigliata8 @millihill @FondOfBeetles @sexnotgenderNM @hoovlet @nmcnews https://t.co/Cmws5bYLFB

May 20, 2022 · 9 followers View post →
Grown_UpWoman
@Grown_UpWoman · X

@wurwur13 @real_mrsjonsnow https://t.co/Qbm2UK0q2E

May 8, 2022 · 2,406 followers View post →
Edmom
@Edmom10 · X

@ewarren Gender-Affirming Hormone Therapy, Vascular Health and Cardiovascular Disease in Transgender Adults | Hypertension https://t.co/OVni6lKry2

Apr 27, 2021 · 178 followers View post →
Aureliano Buendia
@Fredridiculous · X

@Pierce1215 @schmidtsam7 @ConceptualJames Heart attack and stroke are elevated in TGF and CGM, controlled for age. Data for health implications of exogenous gender steroid applications is severely limited and exclusively epidemiologically based. But sure, give them to give year olds. https://t.co/pjLYmvjoRW

Apr 6, 2021 · 1 like · 106 followers View post →
Aureliano Buendia
@Fredridiculous · X

@bringmepizza81 @schmidtsam7 @ConceptualJames Significant difference between CGM and TGFs rate of ischemic stroke and myocardial infarction. I showed you mine, you show me yours https://t.co/pjLYmvjoRW

Apr 6, 2021 · 106 followers View post →
Javi Ciborro
@papayaykware · X

(9) P. Connelly y otros. Gender-Affirming Hormone Therapy, Vascular Health and Cardiovascular Disease in Transgender Adults. Hypertension, 74(6): 1266-1274.

Feb 21, 2021 · 1 like · 8,035 followers View post →
Robin McStay, Esquirrel
@robinmcstay · X

@notsooimpressed @ElPolloDiabloX @AbigailShrier @chadfelixg It appears testosterone suppression has a negative cardiovascular effect, particularly when started in younger persons, but there are only limited studies so far. https://t.co/L1hhmiS499

Jan 21, 2021 · 566 followers View post →
Salora the 'I'm on Tumblr'
@salorarainriver · X

@aLilacAngel @themetrobolist @youngjoanna1 @BluskyeAllison one last study, this one on testosterone in trans men. note however, that it expresses a desire for further research to confirm results. https://t.co/VxwqSpKatG

Sep 4, 2020 · 226 followers View post →
Greg
@Williams94Greg · X

I can find papers too "Conversely, transgender males receiving testosterone lack any consistent or convincing evidence of increased risk of cardiovascular or cerebrovascular disease." https://t.co/e8UdKkNHXf

Jul 5, 2020 · 2 likes · 485 followers View post →
Danielle Anne Baum MLS
@danielleabaum · X

this article only cites part of the study read the full one here: https://t.co/384CVNJFC1 it doesn't cover adolscents nor does it take into accout other factors, which the authors admit to. do you research before you keep spreading bullshit. https://t.co/widJB5TR95

Jul 5, 2020 · 1,029 followers View post →
✝️ Hello, world. ✝️
@RoyalDraco1 · X

@TeenyTinyDraws https://t.co/WUQDnrWg6R This is the best I could find in the time given. And even then I am unsure. As I have said, Google hides the things they don't want you to see. Sadly that leaves most of the population in the dark in key issues such as this.

Apr 24, 2020 · 147 followers View post →
#Transgender
@Transgender_Sci · X

Correction to: Gender-Affirming Hormone Therapy, Vascular Health and Cardiovascular Disease in Transgender Adults. https://t.co/SFo6WzjzIT #PubMed #Transgender

Mar 12, 2020 · 192 followers View post →
Sicco Bessem
@newsicco · X

@honkhonkbeep @andrewdoyle_com Maybe also try this one https://t.co/QXVZGdd9vj Have a good day/nigth.

Dec 20, 2019 · 76 followers View post →
Jenni Burton
@JenniKBurton · X

And a shout out for @ConnellyPJ inspiring new research https://t.co/T0AjbBXfJi in @HyperAHA #gateevenings

Nov 27, 2019 · 1 like · 3,956 followers View post →
Ramzy Ross
@DrRamzyRoss · X

RT @UofGICAMS: A systematic review led @BHFCoREGlasgow Clinical Fellow Paul Connelly @ConnellyPJ with Prof Christian Delles & Prof Rhian To…

Nov 8, 2019 · 5 shares · 1,275 followers View post →
George Baillie
@gbma25 · X

RT @UofGICAMS: A systematic review led @BHFCoREGlasgow Clinical Fellow Paul Connelly @ConnellyPJ with Prof Christian Delles & Prof Rhian To…

Nov 5, 2019 · 5 shares · 1,223 followers View post →
Martin W McBride
@mmcbride66 · X

RT @UofGICAMS: A systematic review led @BHFCoREGlasgow Clinical Fellow Paul Connelly @ConnellyPJ with Prof Christian Delles & Prof Rhian To…

Nov 4, 2019 · 5 shares · 83 followers View post →
BHF CoRE Glasgow
@BHFCoREGlasgow · X

RT @UofGICAMS: A systematic review led @BHFCoREGlasgow Clinical Fellow Paul Connelly @ConnellyPJ with Prof Christian Delles & Prof Rhian To…

Nov 4, 2019 · 5 shares · 1,563 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @UofGICAMS: A systematic review led @BHFCoREGlasgow Clinical Fellow Paul Connelly @ConnellyPJ with Prof Christian Delles & Prof Rhian To…

Nov 4, 2019 · 5 shares · 6,712 followers View post →
UofG SCMH
@UofGSCMH · X

A systematic review led @BHFCoREGlasgow Clinical Fellow Paul Connelly @ConnellyPJ with Prof Christian Delles & Prof Rhian Touyz @LabTouyz in @HyperAHA and NHS colleagues provides insight into the impact of gender-affirming hormone in cardiovascular health.https://t.co/YkWFKMj6Zq https://t.co/l6G4X0n6Ce

Nov 4, 2019 · 10 likes · 5 shares · 2,168 followers View post →
Mike
@michaelscally · X

[OA] Gender-Affirming Hormone Therapy, Vascular Health and Cardiovascular Disease in Transgender Adults Gender-affirming or cross-sex hormone therapy is integral to the management of... https://t.co/7iMA0EUF20

Oct 28, 2019 · 1 like · 896 followers View post →