October 2019 PMID 31675500

Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow.

Cornelia Schwayer, Shayan Shamipour, Kornelija Pranjic-Ferscha, Alexandra Schauer, Maria Balda, Masazumi Tada, Karl Matter, Carl-Philipp Heisenberg

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Mentions

71
Peak: 43 in Nov 2019
across 5 sources since Oct 2019

Extended reach

421,817
potential audience

Total likes

192

Video views

1,811

Mentions per month

Oct 2019 – Oct 2024

Where it's discussed

  • X / Twitter63 posts
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AI synopsis

What people are saying

Many discussions highlight the implications of ZO-1 phase separation and its role in tight junction formation during zebrafish embryonic development, with users describing it as a pivotal study in epithelial mechanics. Phrases like 'a key role in cell movement' and references to related research demonstrate a tone of enthusiasm and curiosity, contributing to an overall perception of importance surrounding the publication.

AgreementModerate agreement

The majority of discussions reflect a supportive stance towards the article, appreciating its contributions to the field.

InterestHigh interest

Discussion participants exhibit high levels of curiosity, signaling a strong connection to the subject matter.

EngagementModerate engagement

The posts indicate moderate engagement, with some users referencing specific aspects of the research, though less detailed analysis was prevalent.

ImpactHigh impact

Many contributors express the belief that the findings hold significant implications for understanding mechanosensation in cell biology.

Abstract in brief

  • TJs (tight junctions) in zebrafish embryos respond to mechanical forces by changing their structure and function, influenced by the actomyosin network.
  • The protein ZO1 accumulates at TJs in response to actomyosin tension, which is enabled by retrograde flow transporting ZO1 clusters towards the junctions.
  • If the process of ZO1 cluster formation or their integration into TJs is disrupted, the mechanosensitivity of the junctions diminishes, affecting cellular movement.

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Heisenberg Lab
@HeisenbergCPLab · X

(1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #tightjunctions through ZO-1 #phaseseparation and #retrogradeflow mediates proper epithelial spreading during #zebrafish gastrulation. https://t.co/fHDhDhoCBo

Nov 1, 2019 · 55 likes · 17 shares · 3,788 followers View post →
LIB
@L_I_B · X

タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.co/v6L9mxpyti Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow: Cell https://t.co/D9n91KcCKB

Nov 1, 2019 · 40 likes · 22 shares · 2,155 followers View post →
Cell
@CellCellPress · X

Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://t.co/pMjZvVhuKi

Oct 31, 2019 · 31 likes · 11 shares · 263,116 followers View post →
ISTAustria
@ISTAustria · X

New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosensitive cell-cell junctions and phase separation play a key role in cell movement in early zebrafish embryo! DOI: 10.1016/j.cell.2019.10.006 ©Heisenberg group https://t.co/QYytKrfSva

Oct 31, 2019 · 31 likes · 8 shares · 11,193 followers View post →
epithelial mechanics fan club
@EpiMechFC · X

Schwayer, C., Shamipour, S., Pranjic-Ferscha, K., Schauer, A., Balda, M., Tada, M., Matter, K., & Heisenberg, C. P. (2019). Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow. Cell, 179(4), 937–952.e18. #EpithelialMechanics https://t.co/PFLJZXJ28Y https://t.co/FBFm4QshcQ

Oct 2, 2024 · 9 likes · 2,555 followers View post →
ShorterLab
@ShorterLab · X

Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow: https://t.co/yOkxF0wEr5

Oct 31, 2019 · 2 likes · 12,060 followers View post →

All mentions

epithelial mechanics fan club
@EpiMechFC · X

Schwayer, C., Shamipour, S., Pranjic-Ferscha, K., Schauer, A., Balda, M., Tada, M., Matter, K., & Heisenberg, C. P. (2019). Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow. Cell, 179(4), 937–952.e18. #EpithelialMechanics https://t.co/PFLJZXJ28Y https://t.co/FBFm4QshcQ

Oct 2, 2024 · 9 likes · 2,555 followers View post →
mrnn
@mrnn53697955 · X

RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…

Jul 22, 2021 · 22 shares · 13 followers View post →
UCL Discovery
@ucl_discovery · X

Open Access UCL Research: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow https://t.co/jDZNrZlnPB

Feb 2, 2021 · 2,524 followers View post →
akihito_k
@itaihito2 · X

RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…

Feb 6, 2020 · 22 shares · 502 followers View post →
Peter M.J. Quinn
@PeterMJQuinn · X

RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…

Nov 11, 2019 · 17 shares · 420 followers View post →
Xavier Trepat
@XavierTrepat · X

RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…

Nov 10, 2019 · 17 shares · 7,118 followers View post →
Trivedi Lab
@LabTrivedi · X

RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…

Nov 9, 2019 · 17 shares · 1,550 followers View post →
EMBL Barcelona
@EMBLBarcelona · X

RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…

Nov 9, 2019 · 17 shares · 4,621 followers View post →
Vikas Trivedi
@viktri08 · X

RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…

Nov 8, 2019 · 17 shares · 889 followers View post →
Alexis Haas
@AlexisHaas7 · X

RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…

Nov 7, 2019 · 17 shares · 332 followers View post →
Alexis Haas
@AlexisHaas7 · X

RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…

Nov 7, 2019 · 11 shares · 332 followers View post →
the paper link
@the_paper_link · X

Trend new: *Schwayer C* et al (Cell) __Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow.__ https://t.co/uTLV4mGY2p

Nov 5, 2019 · 136 followers View post →
Renno Justine
@JustineRenno · X

DOI: 10.1016/j.cell.2019.10.006

Nov 4, 2019 · 1 like · 136 followers View post →
Alexis Lomakin, Ph.D. (אל) אַלעקסיס לאָמאַקין
@Alexis_Lomakin · X

RT @JDHL18: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow https://t.co/c1wAfiif3h

Nov 2, 2019 · 2 shares · 3,643 followers View post →
MarionBaraban
@MarionBaraban · X

RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…

Nov 2, 2019 · 17 shares · 133 followers View post →
fabrice senger
@fabrice_senger · X

RT @JDHL18: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow https://t.co/c1wAfiif3h

Nov 2, 2019 · 2 shares · 840 followers View post →
Serini Lab
@adhynamic · X

RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…

Nov 1, 2019 · 17 shares · 1,600 followers View post →
Nikhil Mishra
@NMishra_bio · X

RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…

Nov 1, 2019 · 17 shares · 146 followers View post →
Kichi
@kichi_hrs · X

このビッグウェーブに乗るときが来たか。。。( ゚д゚ ) ガタッ #まだ論文読んでない | Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow: Cell https://t.co/t4mcjDaZtM

Nov 1, 2019 · 2 likes · 144 followers View post →
Mark Khoury
@khourmark · X

RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…

Nov 1, 2019 · 17 shares · 330 followers View post →
Alexis Lomakin, Ph.D. (אל) אַלעקסיס לאָמאַקין
@Alexis_Lomakin · X

RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…

Nov 1, 2019 · 17 shares · 3,643 followers View post →
_Pulzar
@_Pulzar · X

RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…

Nov 1, 2019 · 17 shares · 463 followers View post →
湯太郎
@rhktrmck · X

RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…

Nov 1, 2019 · 22 shares · 370 followers View post →
MPI-CBG Dresden
@mpicbg · X

RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…

Nov 1, 2019 · 17 shares · 14,239 followers View post →
吉田
@yosidaamonn · X

RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…

Nov 1, 2019 · 22 shares · 346 followers View post →
takanzai
@takanzai · X

RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…

Nov 1, 2019 · 22 shares · 4,407 followers View post →
Cerveza bibere
@YKShake0 · X

RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…

Nov 1, 2019 · 22 shares · 2,057 followers View post →
Heisenberg Lab
@HeisenbergCPLab · X

(1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #tightjunctions through ZO-1 #phaseseparation and #retrogradeflow mediates proper epithelial spreading during #zebrafish gastrulation. https://t.co/fHDhDhoCBo

Nov 1, 2019 · 55 likes · 17 shares · 3,788 followers View post →
S crypto NFT researcher
@ekizarube_san · X

RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…

Nov 1, 2019 · 22 shares · 421 followers View post →
TN_biostructchem☆
@BioStructChem · X

RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…

Nov 1, 2019 · 22 shares · 1,907 followers View post →
あーてぃちょーく@ラボ
@artichoke_lab · X

RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…

Nov 1, 2019 · 22 shares · 469 followers View post →
kwitschas
@kwitschas · X

RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…

Nov 1, 2019 · 11 shares · 1,792 followers View post →
Mark Peifer
@peiferlabunc · X

RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…

Nov 1, 2019 · 11 shares · 11,890 followers View post →
Valeria Marasco
@V_Marasco · X

RT @ISTAustria: New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosen…

Nov 1, 2019 · 8 shares · 504 followers View post →
たかとー
@takatoh1 · X

RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…

Nov 1, 2019 · 22 shares · 605 followers View post →
ぱんつ
@Fm7 · X

RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…

Nov 1, 2019 · 22 shares · 3,034 followers View post →
Chii Jou (Joe) Chan
@ChiiJChan1 · X

RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…

Nov 1, 2019 · 11 shares · 1,030 followers View post →
Drosophilosopher
@HammedBadmos · X

RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…

Nov 1, 2019 · 11 shares · 1,365 followers View post →
Pyon-kichi
@wanwanbooboodog · X

RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…

Nov 1, 2019 · 22 shares · 87 followers View post →
SNZK
@shinopp · X

RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…

Nov 1, 2019 · 22 shares · 720 followers View post →
トクロンティヌス
@tokurontinus · X

RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…

Nov 1, 2019 · 22 shares · 25,001 followers View post →
UO
@druoh · X

RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…

Nov 1, 2019 · 22 shares · 1,725 followers View post →
EK
@uchinadap · X

Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow: Cell https://t.co/tfaq8Ur1Cx

Nov 1, 2019 · 90 followers View post →
m
@m5196245258 · X

RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…

Nov 1, 2019 · 22 shares · 695 followers View post →
全合成たん
@chemiegg · X

RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…

Nov 1, 2019 · 22 shares · 2,474 followers View post →
SatoKazoo
@SatoKazoo · X

RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…

Nov 1, 2019 · 22 shares · 409 followers View post →
LIB
@L_I_B · X

タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.co/v6L9mxpyti Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow: Cell https://t.co/D9n91KcCKB

Nov 1, 2019 · 40 likes · 22 shares · 2,155 followers View post →
Alexis Lomakin, Ph.D. (אל) אַלעקסיס לאָמאַקין
@Alexis_Lomakin · X

RT @ISTAustria: New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosen…

Oct 31, 2019 · 8 shares · 3,643 followers View post →
Picard Marion
@MarionALPicard · X

RT @ISTAustria: New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosen…

Oct 31, 2019 · 8 shares · 203 followers View post →
Paulo Caldas
@pcaldas90 · X

RT @ISTAustria: New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosen…

Oct 31, 2019 · 8 shares · 105 followers View post →
Theory of Living Matter Group
@TLM_Cambridge · X

RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…

Oct 31, 2019 · 11 shares · 4,170 followers View post →
Trivedi Lab
@LabTrivedi · X

RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…

Oct 31, 2019 · 11 shares · 1,550 followers View post →
Deniz Senyilmaz Tiebe
@DenizSenyilmaz · X

Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow: Cell https://t.co/b7SScymgyM

Oct 31, 2019 · 202 followers View post →
Ozren Bogdanovic
@bogdanoviclab · X

RT @ISTAustria: New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosen…

Oct 31, 2019 · 8 shares · 2,544 followers View post →
karlahuljev
@karlahuljev · X

RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…

Oct 31, 2019 · 11 shares · 168 followers View post →
Yu-Shan Cherry Huang
@cherryhuang0120 · X

RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…

Oct 31, 2019 · 11 shares · 392 followers View post →
Ste Tavano
@SteTavano · X

RT @ISTAustria: New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosen…

Oct 31, 2019 · 8 shares · 316 followers View post →
Theory of Living Matter Group
@TLM_Cambridge · X

RT @ISTAustria: New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosen…

Oct 31, 2019 · 8 shares · 4,170 followers View post →
Suyash Naik
@SuyashNaik6 · X

RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…

Oct 31, 2019 · 11 shares · 211 followers View post →
Science Austria
@ScienceAustria · X

RT @ISTAustria: New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosen…

Oct 31, 2019 · 8 shares · 608 followers View post →
ShorterLab
@ShorterLab · X

Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow: https://t.co/yOkxF0wEr5

Oct 31, 2019 · 2 likes · 12,060 followers View post →
ISTAustria
@ISTAustria · X

New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosensitive cell-cell junctions and phase separation play a key role in cell movement in early zebrafish embryo! DOI: 10.1016/j.cell.2019.10.006 ©Heisenberg group https://t.co/QYytKrfSva

Oct 31, 2019 · 31 likes · 8 shares · 11,193 followers View post →
Cell
@CellCellPress · X

Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://t.co/pMjZvVhuKi

Oct 31, 2019 · 31 likes · 11 shares · 263,116 followers View post →