(1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #tightjunctions through ZO-1 #phaseseparation and #retrogradeflow mediates proper epithelial spreading during #zebrafish gastrulation. https://t.co/fHDhDhoCBo
Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow.
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Oct 2019 – Oct 2024Where it's discussed
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What people are saying
Many discussions highlight the implications of ZO-1 phase separation and its role in tight junction formation during zebrafish embryonic development, with users describing it as a pivotal study in epithelial mechanics. Phrases like 'a key role in cell movement' and references to related research demonstrate a tone of enthusiasm and curiosity, contributing to an overall perception of importance surrounding the publication.
The majority of discussions reflect a supportive stance towards the article, appreciating its contributions to the field.
Discussion participants exhibit high levels of curiosity, signaling a strong connection to the subject matter.
The posts indicate moderate engagement, with some users referencing specific aspects of the research, though less detailed analysis was prevalent.
Many contributors express the belief that the findings hold significant implications for understanding mechanosensation in cell biology.
Abstract in brief
- TJs (tight junctions) in zebrafish embryos respond to mechanical forces by changing their structure and function, influenced by the actomyosin network.
- The protein ZO1 accumulates at TJs in response to actomyosin tension, which is enabled by retrograde flow transporting ZO1 clusters towards the junctions.
- If the process of ZO1 cluster formation or their integration into TJs is disrupted, the mechanosensitivity of the junctions diminishes, affecting cellular movement.
Top posts
Most liked on X and Blueskyタイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.co/v6L9mxpyti Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow: Cell https://t.co/D9n91KcCKB
Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://t.co/pMjZvVhuKi
New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosensitive cell-cell junctions and phase separation play a key role in cell movement in early zebrafish embryo! DOI: 10.1016/j.cell.2019.10.006 ©Heisenberg group https://t.co/QYytKrfSva
Schwayer, C., Shamipour, S., Pranjic-Ferscha, K., Schauer, A., Balda, M., Tada, M., Matter, K., & Heisenberg, C. P. (2019). Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow. Cell, 179(4), 937–952.e18. #EpithelialMechanics https://t.co/PFLJZXJ28Y https://t.co/FBFm4QshcQ
Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow: https://t.co/yOkxF0wEr5
All mentions
Mechanosensation of Tight Junctions via ZO1 Cluster Flow
Phaseseparated ZO1 protein clusters flow towards the yolktissue boundary, where they get incorporated into tight junctions. This process is influenced by mechanical forces and the actomyosin network, ensuring proper…
Mechanosensation and Tissue Movement in Early Zebrafish Development
Imaging of tissue spreading during early zebrafish development highlights how tight junctions respond to mechanical forces. The study reveals that ZO-1 accumulation at tight junctions is crucial for the…
Schwayer, C., Shamipour, S., Pranjic-Ferscha, K., Schauer, A., Balda, M., Tada, M., Matter, K., & Heisenberg, C. P. (2019). Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow. Cell, 179(4), 937–952.e18. #EpithelialMechanics https://t.co/PFLJZXJ28Y https://t.co/FBFm4QshcQ
RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…
Open Access UCL Research: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow https://t.co/jDZNrZlnPB
RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…
RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…
RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…
RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…
RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…
RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…
RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…
RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…
Trend new: *Schwayer C* et al (Cell) __Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow.__ https://t.co/uTLV4mGY2p
DOI: 10.1016/j.cell.2019.10.006
RT @JDHL18: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow https://t.co/c1wAfiif3h
RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…
RT @JDHL18: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow https://t.co/c1wAfiif3h
RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…
RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…
このビッグウェーブに乗るときが来たか。。。( ゚д゚ ) ガタッ #まだ論文読んでない | Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow: Cell https://t.co/t4mcjDaZtM
RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…
RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…
RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…
RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…
RT @HeisenbergCPLab: (1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #t…
RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…
RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…
RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…
(1/7) Check out our latest paper @CellCellPress by @Cschwayer with our collaborators @UCL on how #mechanosensing of #tightjunctions through ZO-1 #phaseseparation and #retrogradeflow mediates proper epithelial spreading during #zebrafish gastrulation. https://t.co/fHDhDhoCBo
RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…
RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…
RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…
RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…
RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…
RT @ISTAustria: New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosen…
RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…
RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…
RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…
RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…
RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…
RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…
RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…
RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…
Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow: Cell https://t.co/tfaq8Ur1Cx
RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…
RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…
RT @L_I_B: タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.c…
タイトジャンクション形成と機械刺激応答も相分離なの…… Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions: Cell https://t.co/v6L9mxpyti Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow: Cell https://t.co/D9n91KcCKB
RT @ISTAustria: New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosen…
RT @ISTAustria: New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosen…
RT @ISTAustria: New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosen…
RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…
RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…
Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow: Cell https://t.co/b7SScymgyM
RT @ISTAustria: New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosen…
RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…
RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…
RT @ISTAustria: New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosen…
RT @ISTAustria: New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosen…
RT @CellCellPress: Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://…
RT @ISTAustria: New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosen…
Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow: https://t.co/yOkxF0wEr5
New study out in Cell by @cellpresspress by #PhDstudent Cornelia Schwayer from @HeisenbergCPlab discovering that mechanosensitive cell-cell junctions and phase separation play a key role in cell movement in early zebrafish embryo! DOI: 10.1016/j.cell.2019.10.006 ©Heisenberg group https://t.co/QYytKrfSva
Article in this issue of Cell: Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow - https://t.co/pMjZvVhuKi