PubHawk
February 2020 PMID 31685720

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men.

Junichiro Irie, Emi Inagaki, Masataka Fujita, Hideaki Nakaya, Masanori Mitsuishi, Shintaro Yamaguchi, Kazuya Yamashita, Shuhei Shigaki, Takashi Ono, Hideo Yukioka, Hideyuki Okano, Yo-Ichi Nabeshima, Shin-Ichiro Imai, Masato Yasui, Kazuo Tsubota

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Mentions

37
Peak: 4 in Feb 2021
across 6 sources since Nov 2019

Extended reach

462,101
potential audience

Total likes

6,097

Video views

300,876

Mentions per month

Nov 2019 – Aug 2024

Where it's discussed

  • News17 articles
  • X / Twitter11 posts
  • Facebook3 posts
  • YouTube2 videos
  • Reddit2 posts
  • Blogs2 articles

AI synopsis

What people are saying

The discussions mainly focus on the safety and potential therapeutic benefits of NMN as evidenced by references to Japanese clinical trials and mentions of metabolic effects, emphasizing a cautious optimism; words like 'feasible' and 'potential' reflect appreciation of the research's importance, while some posts acknowledge possible metabolic risks, indicating nuanced engagement.

AgreementModerate agreement

Most discussions recognize the study as positive, noting NMN safety and potential benefits, though some express caution about long-term effects.

InterestModerate interest

Participants show moderate interest, with many referencing the clinical trial and mentioning detailed results, indicating engagement with the research specifics.

EngagementModerate engagement

Posts include mentions of scientific implications and references to related papers, suggesting a deeper level of interaction.

ImpactModerate impact

The discussions imply that the research could influence future aging therapies, highlighting the significance of these findings.

Abstract in brief

  • The study found that a single oral dose of NMN (nicotinamide mononucleotide) is safe for healthy men and leads to dose-dependent increases in certain metabolites, without causing significant adverse effects on clinical parameters, sleep quality, or eye health.
  • Laboratory results showed minor changes within normal ranges, such as increased serum bilirubin and decreased serum creatinine, chloride, and glucose levels, regardless of the dose, suggesting NMN metabolism is well-tolerated.
  • Overall, the findings support the potential of NMN as a therapeutic option to combat aging-related disorders by boosting NAD levels, though further research is needed to confirm long-term safety and effectiveness.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Analyze & Optimize
@Outdoctrination · X

Nicotinamide mononucleotide seems to be safer and more beneficial overall, but still can lead to some of these methylated toxins https://t.co/sighF4iQPs

Aug 2, 2024 · 21 likes · 1 share · 118,479 followers View post →
Dr Brad Stanfield
@BradStanfieldMD · X

Here are the links to the NMN papers referenced in the video (1/2): 1. https://t.co/4dwkhSrASo 2. https://t.co/8cGAKsSCRV 3. https://t.co/80uigKlVoU 4. https://t.co/qdM4r2aPck 5. https://t.co/EzT2UplCZx 6. https://t.co/QKHFRP0wiZ

Aug 20, 2023 · 6 likes · 29,403 followers View post →
Kristoph
@ikristoph · X

@AshurTheCreator @BradStanfieldMD https://t.co/oAwLcIevu0 Thus, the oral administration of NMN was found to be feasible, implicating a potential therapeutic strategy to mitigate aging-related disorders in humans.

Feb 17, 2023 · 1 like · 2,570 followers View post →
Norbert Chojecki
@Norbert47868633 · X

@centruizm @deZeZed @NaukowyBelkot https://t.co/gBGcMJQDgb https://t.co/1u4JneKmEV https://t.co/99PmvVqvtd https://t.co/jirz3AItNl https://t.co/Z1JF4uRI66

Apr 29, 2024 · 1 like · 19 followers View post →
ChildofGod
@sjkroger · X

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite lev… https://t.co/8GeYLWYVSD

Sep 10, 2022 · 5,400 followers View post →
Roaring Brain
@BrainRoaring · X

RT @Veniceblair_13: Human Clinical Trial -Effect of oral administration of nicotinamide mononucleotide NMN-

Feb 12, 2021 · 1 share · 2,501 followers View post →

All mentions

Analyze & Optimize
@Outdoctrination · X

Nicotinamide mononucleotide seems to be safer and more beneficial overall, but still can lead to some of these methylated toxins https://t.co/sighF4iQPs

Aug 2, 2024 · 21 likes · 1 share · 118,479 followers View post →
Norbert Chojecki
@Norbert47868633 · X

@centruizm @deZeZed @NaukowyBelkot https://t.co/gBGcMJQDgb https://t.co/1u4JneKmEV https://t.co/99PmvVqvtd https://t.co/jirz3AItNl https://t.co/Z1JF4uRI66

Apr 29, 2024 · 1 like · 19 followers View post →
Dr Brad Stanfield
@BradStanfieldMD · X

Here are the links to the NMN papers referenced in the video (1/2): 1. https://t.co/4dwkhSrASo 2. https://t.co/8cGAKsSCRV 3. https://t.co/80uigKlVoU 4. https://t.co/qdM4r2aPck 5. https://t.co/EzT2UplCZx 6. https://t.co/QKHFRP0wiZ

Aug 20, 2023 · 6 likes · 29,403 followers View post →
Kristoph
@ikristoph · X

@AshurTheCreator @BradStanfieldMD https://t.co/oAwLcIevu0 Thus, the oral administration of NMN was found to be feasible, implicating a potential therapeutic strategy to mitigate aging-related disorders in humans.

Feb 17, 2023 · 1 like · 2,570 followers View post →
ChildofGod
@sjkroger · X

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite lev… https://t.co/8GeYLWYVSD

Sep 10, 2022 · 5,400 followers View post →
Roaring Brain
@BrainRoaring · X

RT @Veniceblair_13: Human Clinical Trial -Effect of oral administration of nicotinamide mononucleotide NMN-

Feb 12, 2021 · 1 share · 2,501 followers View post →
Xenomorph13x
@Xenomorph13x · X

Human Clinical Trial -Effect of oral administration of nicotinamide mononucleotide NMN-

Feb 12, 2021 · 1 share · 18 followers View post →
Xenomorph13x
@Xenomorph13x · X

First Human trial - Effect of oral NMN -nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men https://t.co/kQaajJD9nN

Feb 12, 2021 · 18 followers View post →
pochi
@unattened_bag · X

J-STAGE Articles - Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men https://t.co/xsefcDz4k0

Feb 11, 2021 · 262 followers View post →
tiktak
@taisukun · X

健康な日本人男性の臨床パラメーターとニコチンアミド代謝物レベルに対するニコチンアミドモノヌクレオチドの経口投与の効果 https://t.co/Wz1BQtuMej

Oct 22, 2020 · 310 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. https://t.co/IYU8Tj0iYY

Nov 8, 2019 · 2,240 followers View post →