Nat Cell Biol November 2019 PMID 31685986

A chromosome folding intermediate at the condensin-to-cohesin transition during telophase.

Kristin Abramo, Anne-Laure Valton, Sergey V Venev, Hakan Ozadam, A Nicole Fox, Job Dekker

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Peak: 7 in Nov 2019

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Discussions highlight the significance of the study by noting its focus on the transition between condensin and cohesin during telophase, with some posts emphasizing the methods and potential implications. The tone varies from curiosity to cautious optimism, underscored by phrases like 'key transition phase' and 'transient folding state,' suggesting moderate engagement and interest among participants.

AgreementNeither agree nor disagree

Most discussions recognize the importance of the study, but few show strong support or disagreement, reflecting neutral consensus.

InterestModerate interest

Participants show an above-average interest, often mentioning the novel insights into chromosome organization during telophase.

EngagementModerate engagement

Comments include references to previous research, clarification of concepts, and some speculation, indicating moderate engagement.

ImpactNeutral impact

While some posts hint at significance for future research, overall impact perception is cautious, with many viewing it as a step forward rather than a breakthrough.

Abstract in brief

During mitosis, chromosomes are folded into helical loops by condensins, while in interphase, cohesin complexes create loops and TADs, and a separate compartmentalization process segregates active and inactive chromatin.
The study shows that at telophase, condensin-mediated loops disappear, creating a transient folding state before cohesin and CTCF establish the loops and TADs characteristic of interphase, with compartment boundaries forming early but long-range organization taking hours.
These findings detail the timing and sequence of molecular events that transform chromosomes from mitotic to interphase conformation, highlighting telophase as a key transition phase between condensin-driven and cohesin-driven chromosome organization.]

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All mentions

Chromosome Folding Transition During Telophase Explained

Dynamic view of chromosome structure during telophase, showing the transition from condensin-mediated loops to cohesin-driven architecture, highlighting key steps in chromosome reorganization after mitosis.

WashU Epigenome Browser · Apr 22, 2020 284 views

Chromosome Folding Transition During Telophase Revealed by Epigenome Browser

Dynamic view of chromosome reorganization during telophase shows transient folding states as condensins disassemble and cohesin complexes establish interphase structures, crucial for understanding chromosome…

WashU Epigenome Browser · Oct 7, 2021 122 views

Francesca Cole

@ColeFrancesca · X

RT @meiosis_papers: A chromosome folding intermediate at the condensin-to-cohesin transition during telop…|Nat Cell Biol•Dekker J https://t…

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cohesin_papers

@cohesin_papers · X

A chromosome folding intermediate at the condensin-to-cohesin transition during telophase. https://t.co/f8FEQyPHUk

Nov 8, 2019 · 2 likes · 1,758 followers View post →

epigenetist

@epigenetist · X

RT @CTCF_Papers: A chromosome folding intermediate at the condensin-to-cohesin transition during telophase. https://t.co/iYAMKmp3k6

Nov 8, 2019 · 2 shares · 239 followers View post →

Cheng Tan

@OiniL · X

RT @CTCF_Papers: A chromosome folding intermediate at the condensin-to-cohesin transition during telophase. https://t.co/iYAMKmp3k6

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CTCF Papers

@CTCF_Papers · X

A chromosome folding intermediate at the condensin-to-cohesin transition during telophase. https://t.co/iYAMKmp3k6

Nov 7, 2019 · 3 likes · 2 shares · 2,966 followers View post →

Gaurav Jain

@gauravjain49 · X

RT @rlebron_bioinfo: A chromosome folding intermediate at the condensin-to-cohesin transition during telophase https://t.co/u2Lhy5Xxy6

Nov 7, 2019 · 3 shares · 652 followers View post →

Ming "Tommy" Tang

@tangming2005 · X

RT @rlebron_bioinfo: A chromosome folding intermediate at the condensin-to-cohesin transition during telophase https://t.co/u2Lhy5Xxy6

Nov 7, 2019 · 3 shares · 41,044 followers View post →

Ricardo Lebrón, Ph.D.

@rlebron_bioinfo · X

A chromosome folding intermediate at the condensin-to-cohesin transition during telophase https://t.co/u2Lhy5Xxy6

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BioRxivCurator

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A chromosome folding intermediate at the condensin-to-cohesin transition during telophase https://t.co/TI5VP7AJcs

Jun 22, 2019 · 254 followers View post →

bioRxiv Genomics

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A chromosome folding intermediate at the condensin-to-cohesin transition during telophase https://t.co/mw8dgqaU3Z #biorxiv_genomic

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bioRxiv

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A chromosome folding intermediate at the condensin-to-cohesin transition during telophase https://t.co/xvoY1hyJqL #bioRxiv

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