Am J Physiol Endocrinol Metab December 2019 PMID 31689143

The gut microbiota is a major regulator of androgen metabolism in intestinal contents.

Hannah Colldén, Andreas Landin, Ville Wallenius, Erik Elebring, Lars Fändriks, Maria E Nilsson, Henrik Ryberg, Matti Poutanen, Klara Sjögren, Liesbeth Vandenput, Claes Ohlsson

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Mentions

44
Peak: 5 in Jun 2022
across 6 sources since Nov 2019

Extended reach

493,472
potential audience

Total likes

3,519

Video views

119,522

Mentions per month

Nov 2019 – Jun 2025

Where it's discussed

  • X / Twitter32 posts
  • Facebook3 posts
  • Reddit3 posts
  • YouTube2 videos
  • News2 articles
  • Blogs2 articles

AI synopsis

What people are saying

The overall discussions strongly support the article's significance, with users highlighting its role in regulating androgens and connecting it to health conditions like hair loss and hormonal imbalances. The tone is notably optimistic, with words like 'major regulator' and 'impact' used to emphasize the importance, and the focus on mechanisms like bacterial activity and hormone metabolism indicates deep engagement.

AgreementStrong agreement

Most discussions strongly endorse the findings, emphasizing that the gut microbiota plays a key role in androgen metabolism, with multiple posts referencing the article as 'major regulator' and highlighting the significance of bacterial processes like deg

InterestHigh interest

The discussions demonstrate high curiosity, with several users exploring implications for health, hormone regulation, and potential therapies, indicating elevated engagement with the topic.

EngagementHigh engagement

Many discussions delve into specific mechanisms (e.g., bacterial impact on DHT and testosterone) and potential health impacts (e.g., baldness, hormone-related diseases), showing deep engagement rather than superficial mention.

ImpactModerate impact

While many posts convey enthusiasm about the research's importance, some express anticipation for clinical applications or further studies, reflecting an understanding of its high potential impact but not definitive immediate change.

Abstract in brief

  • The gut microbiota (GM) significantly influences how androgens like testosterone and DHT are metabolized in the intestines, with high levels of active DHT found in the distal parts of the gut in both mice and humans.
  • In mice with normal GM, there are high levels of free DHT in the intestines, whereas germ-free mice show mostly conjugated (inactive) forms, indicating that microbiota play a role in activating androgens through processes like deglucuronidation.
  • The study highlights that the GM's activity leads to extremely high free DHT levels in the colon, which could have important effects on androgen-related functions in tissues and the intestinal environment.]

Top posts

Most liked on X and Bluesky
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

The gut microbiota is a major regulator of androgen metabolism in intestinal contents https://t.co/9SAfmh8GkH Gut microbiota dysbiosis mediating androgenic alopecia and male pattern baldness? https://t.co/dhZgTp7YG7

Jun 4, 2022 · 87 likes · 10 shares · 133,653 followers View post →
American Physiological Society
@APSPhysiology · X

Gut #microbiota is a major regulator of androgen metabolism in the intestines. #Probiotic treatment & diet changes affecting gut microbiota may change intestinal androgen metabolism & affect risk of androgen-related diseases: https://t.co/m4K8w7YvIX via @AJPEndoMetab #APSselect https://t.co/h3Dm0grRwz

Jan 9, 2020 · 6 likes · 2 shares · 13,996 followers View post →
AJP-Endocrinology and Metabolism
@AJPEndoMetab · X

The #gut #microbiota is a major regulator of #androgen #metabolism in intestinal contents; new research from @goteborgsuni @UniTurku Click here for details: https://t.co/oB9wFZtJbj #dihydrotestosterone #glucuronidation #gutbacteria #intracrinology #testosterone https://t.co/rgd1WJLBqI

Dec 9, 2019 · 6 likes · 2 shares · 2,673 followers View post →
APS Publications
@APSPublications · X

The gut microbiota is a major regulator of androgen metabolism in intestinal contents - new research in @AJPEndoMetab https://t.co/RRrRLoo4uZ https://t.co/leWzWeQRvQ

Nov 6, 2019 · 3 likes · 1 share · 7,381 followers View post →
AJP-Endocrinology and Metabolism
@AJPEndoMetab · X

The gut microbiota is a major regulator of #androgen metabolism in intestinal contents; NEW #ArticlesinPresS by researchers @SahlgrenskaAcad @goteborgsuni For details, click here: https://t.co/XplTbXDe6f #gutbacteria #testosterone #dihydrotestosterone #intracrinology #microbiota https://t.co/fzuHYluIXS

Nov 6, 2019 · 3 likes · 1 share · 2,673 followers View post →
Sahlgrenska Academy
@SahlgrenskaAcad · X

Vi gratulerar våra forskare som uppmärksammas av den amerikanska fysiologiföreningens tidskrift @APSselect för artikeln om hur tarmbakterier är involverade i hormonomsättningen av androgener i tarmen. https://t.co/Vtsd2C3182 https://t.co/P36v8tz78a

Jan 14, 2020 · 2 likes · 2,835 followers View post →

All mentions

UltimApe
@ultimape · X

@BowTiedUM "The gut microbiota is a major regulator of androgen metabolism in intestinal contents" [2019] https://t.co/ilGaCEyUGT These are related.

Jun 8, 2025 · 6,707 followers View post →
UltimApe
@ultimape · X

@worlddestroyar You can see the signature of the problem by looking at aromatase and DHT availability that correlate with healthy guts, and secondary impacts of gut metabolites on liver function. https://t.co/O2yK0U7DfL

Mar 14, 2025 · 1 like · 6,707 followers View post →
Medicinal Endobiome
@EndoMedChem · X

https://t.co/DE7VZUaNAc

Feb 28, 2025 · 953 followers View post →
UltimApe
@ultimape · X

@eigenrobot @Duckue It's a little harder to extrapolate it because most of the studies on Leutinizing Hormone are in men, https://t.co/V3nvHKb27L but this also seems to change immune function in women as well.

Sep 23, 2024 · 6,707 followers View post →
Hi2u
@RETsetLife · X

And bacteria produce sulphate a that are precursors to androgens. The gut microbiota is a major regulator of androgen metabolism in intestinal contents ➡️https://t.co/qF6JCEqSD7

Sep 19, 2024 · 414 followers View post →
Buckeye089
@buckeye089 · X

RT @Grimhood: The gut microbiota is a major regulator of androgen metabolism in intestinal contents https://t.co/9SAfmh8GkH Gut microbiota…

May 15, 2023 · 10 shares · 1,729 followers View post →
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

RT @Grimhood: The gut microbiota is a major regulator of androgen metabolism in intestinal contents https://t.co/9SAfmh8GkH Gut microbiota…

May 15, 2023 · 10 shares · 133,653 followers View post →
Dominic Buanderie
@Domingo_Salut · X

@HansAmato Unrelated, but I curious to know what is your take on this research:https://t.co/FDIugLpMnP

Oct 2, 2022 View post →
W1LL14M
@W1LL14M723 · X

RT @Grimhood: The gut microbiota is a major regulator of androgen metabolism in intestinal contents https://t.co/9SAfmh8GkH Gut microbiota…

Jul 7, 2022 · 10 shares · 4 followers View post →
bloodybricks
@bloodybricks · X

RT @Grimhood: The gut microbiota is a major regulator of androgen metabolism in intestinal contents https://t.co/9SAfmh8GkH Gut microbiota…

Jun 9, 2022 · 10 shares · 339 followers View post →
J P Fanton
@HealthyFellow · X

RT @Grimhood: The gut microbiota is a major regulator of androgen metabolism in intestinal contents https://t.co/9SAfmh8GkH Gut microbiota…

Jun 4, 2022 · 10 shares · 26,015 followers View post →
zerO711
@711phoenixdemon · X

RT @Grimhood: The gut microbiota is a major regulator of androgen metabolism in intestinal contents https://t.co/9SAfmh8GkH Gut microbiota…

Jun 4, 2022 · 10 shares · 5 followers View post →
aribahabdullah
@aribahabdullah · X

RT @Grimhood: The gut microbiota is a major regulator of androgen metabolism in intestinal contents https://t.co/9SAfmh8GkH Gut microbiota…

Jun 4, 2022 · 10 shares · 1,260 followers View post →
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

The gut microbiota is a major regulator of androgen metabolism in intestinal contents https://t.co/9SAfmh8GkH Gut microbiota dysbiosis mediating androgenic alopecia and male pattern baldness? https://t.co/dhZgTp7YG7

Jun 4, 2022 · 87 likes · 10 shares · 133,653 followers View post →
UltimApe
@ultimape · X

@ekverstania I'd actually start at looking at gut inflammation factors, but the research on gut and TSH / dopamine / androgens are still like less than 3 years old. https://t.co/V3nvHKb27L

Nov 28, 2021 · 6,707 followers View post →
Diana Dee Jarvis
@DianaDeeJarvis · X

Eating FIBER Positively Affects Testosterone (Artichokes, Asparagus) https://t.co/KqwODqbMBw via @YouTube

Jul 13, 2021 · 398 followers View post →
David Thomas
@davidthomasweb · X

https://t.co/ErSWaNT5m0 https://t.co/AAMpPFtmLb We've Got The Acid Reflux Answers You Need If you notice that spicy foods cause you problems, do not eat anything with peppers or chilies i

Jul 13, 2021 · 3 followers View post →
David Thomas
@davidthomasweb · X

https://t.co/qHTInb5Hu5 https://t.co/mzRjHVA8B1 How Much Do You Know About Green Coffee Bean Extract For Weight Loss? Green coffee bean extract has created a buzz in the health and fitness market, and i

Jun 22, 2021 · 3 followers View post →
Jared Polowick
@jaredpolowick · X

@cashbomber @Mangan150 https://t.co/F1nXiSEWeu https://t.co/yPKpJwColM

Mar 22, 2021 · 2,668 followers View post →
Carolyn Alexander
@DrCAlexanderFer · X

RT @AgeFreezeMD: The gut #microbiota is a major regulator of #androgen metabolism in intestinal contents @DrCAlexanderFer https://t.co/I2PV…

Apr 15, 2020 · 1 share · 1,553 followers View post →
Carolyn Alexander MD
@AgeFreezeMD · X

The gut #microbiota is a major regulator of #androgen metabolism in intestinal contents @DrCAlexanderFer https://t.co/I2PVl7KoGS

Apr 15, 2020 · 2 likes · 1 share View post →
AJP-Endocrinology and Metabolism
@AJPEndoMetab · X

ICYMI: 1 of 2 January #APSselect articles, FREE to read through this month at https://t.co/dSXEEXlL0L #dihydrotestosterone #glucuronidation #gutbacteria #intracrinology #testosterone https://t.co/mnPe7nM2E4

Feb 6, 2020 · 2,673 followers View post →
Sahlgrenska Academy
@SahlgrenskaAcad · X

Vi gratulerar våra forskare som uppmärksammas av den amerikanska fysiologiföreningens tidskrift @APSselect för artikeln om hur tarmbakterier är involverade i hormonomsättningen av androgener i tarmen. https://t.co/Vtsd2C3182 https://t.co/P36v8tz78a

Jan 14, 2020 · 2 likes · 2,835 followers View post →
American Physiological Society
@APSPhysiology · X

Gut #microbiota is a major regulator of androgen metabolism in the intestines. #Probiotic treatment & diet changes affecting gut microbiota may change intestinal androgen metabolism & affect risk of androgen-related diseases: https://t.co/m4K8w7YvIX via @AJPEndoMetab #APSselect https://t.co/h3Dm0grRwz

Jan 9, 2020 · 6 likes · 2 shares · 13,996 followers View post →
APS Publications
@APSPublications · X

RT @AJPEndoMetab: The #gut #microbiota is a major regulator of #androgen #metabolism in intestinal contents; new research from @goteborgsun…

Dec 9, 2019 · 2 shares · 7,381 followers View post →
Nutriepigen
@nutriepigen · X

RT @Brunorm84: The gut microbiota is a major regulator of androgen metabolism in intestinal contents @AJPEndoMetab https://t.co/bcV64EXyRA

Dec 9, 2019 · 3 shares · 341 followers View post →
AJP-Endocrinology and Metabolism
@AJPEndoMetab · X

The #gut #microbiota is a major regulator of #androgen #metabolism in intestinal contents; new research from @goteborgsuni @UniTurku Click here for details: https://t.co/oB9wFZtJbj #dihydrotestosterone #glucuronidation #gutbacteria #intracrinology #testosterone https://t.co/rgd1WJLBqI

Dec 9, 2019 · 6 likes · 2 shares · 2,673 followers View post →
Jonathan Schertzer (SchertzerLab)
@SchertzerLab · X

The gut microbiota is a major regulator of androgen metabolism in intestinal contents https://t.co/leuWR64eTH

Dec 1, 2019 · 2 likes · 1,482 followers View post →
AJP-Endocrinology and Metabolism
@AJPEndoMetab · X

RT @APSPublications: The gut microbiota is a major regulator of androgen metabolism in intestinal contents - new research in @AJPEndoMetab…

Nov 6, 2019 · 1 share · 2,673 followers View post →
APS Publications
@APSPublications · X

The gut microbiota is a major regulator of androgen metabolism in intestinal contents - new research in @AJPEndoMetab https://t.co/RRrRLoo4uZ https://t.co/leWzWeQRvQ

Nov 6, 2019 · 3 likes · 1 share · 7,381 followers View post →
Thiago Gagliano-Jucá
@Thiago_Gagliano · X

RT @AJPEndoMetab: The gut microbiota is a major regulator of #androgen metabolism in intestinal contents; NEW #ArticlesinPresS by researche…

Nov 6, 2019 · 1 share · 175 followers View post →
AJP-Endocrinology and Metabolism
@AJPEndoMetab · X

The gut microbiota is a major regulator of #androgen metabolism in intestinal contents; NEW #ArticlesinPresS by researchers @SahlgrenskaAcad @goteborgsuni For details, click here: https://t.co/XplTbXDe6f #gutbacteria #testosterone #dihydrotestosterone #intracrinology #microbiota https://t.co/fzuHYluIXS

Nov 6, 2019 · 3 likes · 1 share · 2,673 followers View post →