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Bioessays December 2019 PMID 31701567

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the "Non-Coding DNA" Mystery.

Giorgio Bernardi

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Mentions

22
Peak: 7 in Nov 2019
across 3 sources since Nov 2019

Extended reach

294,326
potential audience

Total likes

143

Video views

4,364

Mentions per month

Nov 2019 – Aug 2023

Where it's discussed

  • X / Twitter19 posts
  • YouTube2 videos
  • Facebook1 posts

AI synopsis

What people are saying

The discussions reflect a high level of agreement and interest, with users frequently mentioning the breakthrough in explaining how non-coding DNA influences chromatin structures, supported by phrases like 'crucial role' and 'solves the mystery.' The tone combines enthusiasm with technical appreciation, indicating a recognition of the article's significant impact on the field.

AgreementStrong agreement

Most discussions express strong agreement, emphasizing the significance of the research in solving longstanding mysteries about non-coding DNA and chromatin organization.

InterestHigh interest

The posts show high interest, often highlighting the groundbreaking implications of the findings and their relevance to genome biology.

EngagementModerate engagement

Many discussions delve into detailed interpretations and implications, though some are more brief or supportive rather than exploratory.

ImpactHigh impact

Users generally believe the publication could have a transformative effect on understanding genetics, with phrases like 'game changer' and references to resolving fundamental questions.

Abstract in brief

  • Recent research shows that human genome isochores are grouped into two superfamilies with distinct 3D structures, which influence chromatin organization and nucleosome binding.
  • GC-poor isochores tend to form lamina-associated domains (LADs), while GC-rich isochores are involved in creating topologically associating domains (TADs) through sequence distribution and extrusion mechanisms.
  • This understanding of the genomic code explains how noncoding, often called "junk" or "selfish" DNA, actually plays a crucial role in shaping chromatin structure and resolving longstanding questions about genome organization.
Read the full abstract

Top posts

Most liked on X and Bluesky
Ricardo Lebrón, Ph.D.
@rlebron_bioinfo · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the "Non‐Coding DNA" Mystery https://t.co/iXXt3hhxmw https://t.co/e6k8pTgZcF

Nov 12, 2019 · 7 likes · 2 shares · 1,558 followers View post →
ünal kurtçimeni
@kurtimeni · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the “Non‐Coding DNA” Mystery https://t.co/mrvafybLN4

Sep 7, 2021 · 4 likes · 1 share · 27,341 followers View post →
ünal kurtçimeni
@kurtimeni · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the “Non‐Coding DNA” Mystery https://t.co/2PHSk3jP5o

Jul 22, 2020 · 4 likes · 1 share · 27,341 followers View post →
ünal kurtçimeni
@kurtimeni · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the “Non‐Coding DNA” Mystery https://t.co/Z4YN9aAHdq

Oct 1, 2020 · 2 likes · 27,341 followers View post →
Victor V. Lobanenkov
@boris_ctcf · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the “Non‐Coding DNA” Mystery https://t.co/Xsz3HdtpdV

Nov 13, 2019 · 2 likes · 2,056 followers View post →
ünal kurtçimeni
@kurtimeni · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the “Non‐Coding DNA” Mystery https://t.co/5Eb6SBeG5k

Jun 3, 2020 · 1 like · 27,341 followers View post →

All mentions

ünal kurtçimeni
@kurtimeni · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the “Non‐Coding DNA” Mystery https://t.co/mrvafybLN4

Sep 7, 2021 · 4 likes · 1 share · 27,341 followers View post →
Isatou Sarr
@IsatouSarr4 · X

https://t.co/uOGEeu2CO8

Jul 8, 2021 · 1 like · 46 followers View post →
ünal kurtçimeni
@kurtimeni · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the “Non‐Coding DNA” Mystery https://t.co/Z4YN9aAHdq

Oct 1, 2020 · 2 likes · 27,341 followers View post →
ünal kurtçimeni
@kurtimeni · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the “Non‐Coding DNA” Mystery https://t.co/4gye6IC3IB

Aug 13, 2020 · 27,341 followers View post →
haber
@ilimlevebilimle · X

RT @kurtimeni: The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the “Non‐Coding DNA” Mystery https:…

Jul 22, 2020 · 1 share · 2,098 followers View post →
ünal kurtçimeni
@kurtimeni · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the “Non‐Coding DNA” Mystery https://t.co/2PHSk3jP5o

Jul 22, 2020 · 4 likes · 1 share · 27,341 followers View post →
ünal kurtçimeni
@kurtimeni · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the “Non‐Coding DNA” Mystery https://t.co/c8eTB8HCW7

Jul 6, 2020 · 1 like · 27,341 followers View post →
ünal kurtçimeni
@kurtimeni · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the “Non‐Coding DNA” Mystery https://t.co/9ijmsjkNxr

Jun 24, 2020 · 1 like · 27,341 followers View post →
ünal kurtçimeni
@kurtimeni · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the “Non‐Coding DNA” Mystery https://t.co/LnYLFD2hug

Jun 9, 2020 · 1 like · 1 share · 27,341 followers View post →
ünal kurtçimeni
@kurtimeni · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the “Non‐Coding DNA” Mystery https://t.co/HlzXRkZYFI

Jun 7, 2020 · 1 like · 27,341 followers View post →
ünal kurtçimeni
@kurtimeni · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the “Non‐Coding DNA” Mystery https://t.co/35PRTgLw2f

Jun 3, 2020 · 1 like · 27,341 followers View post →
ünal kurtçimeni
@kurtimeni · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the “Non‐Coding DNA” Mystery https://t.co/5Eb6SBeG5k

Jun 3, 2020 · 1 like · 27,341 followers View post →
Victor V. Lobanenkov
@boris_ctcf · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the “Non‐Coding DNA” Mystery https://t.co/Xsz3HdtpdV

Nov 13, 2019 · 2 likes · 2,056 followers View post →
Ron Finn
@Finnsense · X

RT @rlebron_bioinfo: The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the "Non‐Coding DNA" Mystery…

Nov 12, 2019 · 2 shares · 1,121 followers View post →
Ricardo Lebrón, Ph.D.
@rlebron_bioinfo · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the "Non‐Coding DNA" Mystery https://t.co/iXXt3hhxmw https://t.co/e6k8pTgZcF

Nov 12, 2019 · 7 likes · 2 shares · 1,558 followers View post →
Cheng Tan
@OiniL · X

RT @Nucleosome_Bot: The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the "Non-Coding DNA" Mystery.…

Nov 9, 2019 · 1 share · 221 followers View post →
cohesin_papers
@cohesin_papers · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the "Non-Coding DNA" Mystery. https://t.co/qdzGGEPztg

Nov 9, 2019 · 1,757 followers View post →
CTCF Papers
@CTCF_Papers · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the "Non-Coding DNA" Mystery. https://t.co/jwOO7dvuBK

Nov 9, 2019 · 2,964 followers View post →
Nucleosome papers
@Nucleosome_Bot · X

The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the "Non-Coding DNA" Mystery. https://t.co/BwBdqrnV6e

Nov 9, 2019 · 1 like · 1 share · 4,702 followers View post →
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