PubHawk
January 2020 PMID 31704740

Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: the Valkyrie Study.

An S De Vriese, Rogier Caluwé, Lotte Pyfferoen, Dirk De Bacquer, Koen De Boeck, Joost Delanote, Didier De Surgeloose, Piet Van Hoenacker, Bruno Van Vlem, Francis Verbeke

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Mentions

52
Peak: 17 in Nov 2019
across 4 sources since Nov 2019

Extended reach

142,063
potential audience

Total likes

117

Video views

6,029

Mentions per month

Nov 2019 – Jul 2024

Where it's discussed

  • X / Twitter46 posts
  • YouTube2 videos
  • Facebook2 posts
  • Blogs2 articles

AI synopsis

What people are saying

Discussions highlight the study's investigation of rivaroxaban versus warfarin and the role of vitamin K2, with comments reflecting both curiosity and critique, such as noting the 'failed' outcomes and questioning the transformative potential of these strategies. The tone suggests a thoughtful engagement with the research's nuances and implications for clinical practice.

AgreementModerate agreement

Most discussions recognize the study's findings, especially the limited impact of vitamin K2 on vascular calcification, showing general agreement.

InterestHigh interest

The complex topic of anticoagulation in dialysis patients generates high curiosity, with many referencing detailed trial results.

EngagementHigh engagement

Comments include references to methodology, past studies, and implications for clinical practice, indicating deep involvement.

ImpactModerate impact

While some see the study as insightful, there is a shared view that its findings may modestly influence current treatment approaches in this patient group.

Abstract in brief

  • The study investigated how replacing Vitamin K antagonists (VKAs) with rivaroxaban, with or without vitamin K2, affects vascular calcification (VC) and health outcomes in hemodialysis patients with atrial fibrillation.
  • Results showed that while baseline vitamin K deficiency was common and VKAs worsened vitamin K deficiency (indicated by increased dpucMGP levels), there was no significant difference in VC progression or cardiovascular events across treatment groups, although rivaroxaban was associated with fewer severe bleeding episodes.
  • Supplementing with vitamin K2 alongside rivaroxaban improved vitamin K status but did not significantly slow VC progression, suggesting that while changing anticoagulation strategies may improve vitamin K levels and reduce bleeding risks, they do not markedly impact vascular calcification in this patient population.
Read the full abstract

Top posts

Most liked on X and Bluesky
Jonathan Chávez
@JonathanNefro · X

En pacientes en hemodiálisis y ANTICOAGULADOS con RIVAROXABAN o WARFARINA por fibrilación auricular, la administración de VITAMINA K no disminuyó los puntajes de CALCIFICACIÓN VASCULAR En el ensayo clínico VALKIRIE, otro más fallido

Jan 29, 2020 · 26 likes · 11 shares · 37,870 followers View post →
JASN_News
@JASN_News · X

Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: the Valkyrie Study @RogierCaluwe https://t.co/FXmt0qHjCX https://t.co/S5ty2uOHxw

Nov 9, 2019 · 19 likes · 14 shares · 22,527 followers View post →
Ahmad Masri
@MasriAhmadMD · X

@mbelshazly @Hragy @Bloodman Yes they were testing the vit K hypothesis See their earlier pub https://t.co/EaUN6jNvyY

Mar 22, 2021 · 3 likes · 9,019 followers View post →
Gunnar Henrik Heine
@gunnar_heine · X

#WorldStrokeDay 2023 - here comes our 2022 discussion on Anticoagulation & Atrial Fibrillation in CKD - VALKYRIE with An de Vriese with @StephanSchirme2 and @AntMarlies (Partner @oegnephro @dgfn_ev @com_SFNDT) https://t.co/pXY0kZxEre via @YouTube

Oct 29, 2023 · 2 likes · 2,408 followers View post →
Trip Primary Care
@TripPrimaryCare · X

New2Trip: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban w/ or without Vitamin K2 in Hemodialysis Patients w/ Atrial Fibrillation: Valkyrie Study https://t.co/y9bGEjEVRF

Mar 5, 2020 · 1 like · 2,470 followers View post →
Gunnar Henrik Heine
@gunnar_heine · X

@sarah_halmer @AKronbichler @Cihan_Ay_MD @m_windp @AntMarlies @oegnephro @fervenzafernan1 @PfallerBirgit @HerrmannMd @IngoEitel and in the meantime re-listen to Dr de Vriese's ideas at https://t.co/HvadGUQfZ0

May 10, 2024 · 1 like · 2,408 followers View post →

All mentions

Gunnar Henrik Heine
@gunnar_heine · X

@sarah_halmer @AKronbichler @Cihan_Ay_MD @m_windp @AntMarlies @oegnephro @fervenzafernan1 @PfallerBirgit @HerrmannMd @IngoEitel and in the meantime re-listen to Dr de Vriese's ideas at https://t.co/HvadGUQfZ0

May 10, 2024 · 1 like · 2,408 followers View post →
Gunnar Henrik Heine
@gunnar_heine · X

#WorldStrokeDay 2023 - here comes our 2022 discussion on Anticoagulation & Atrial Fibrillation in CKD - VALKYRIE with An de Vriese with @StephanSchirme2 and @AntMarlies (Partner @oegnephro @dgfn_ev @com_SFNDT) https://t.co/pXY0kZxEre via @YouTube

Oct 29, 2023 · 2 likes · 2,408 followers View post →
Ahmad Masri
@MasriAhmadMD · X

@mbelshazly @Hragy @Bloodman Yes they were testing the vit K hypothesis See their earlier pub https://t.co/EaUN6jNvyY

Mar 22, 2021 · 3 likes · 9,019 followers View post →
renalRCTs
@renalRCTs · X

Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: the Valkyrie Study. https://t.co/Em2DkBKPNY https://t.co/VTdjoG1P0L

Jul 17, 2020 · 39 followers View post →
Trip Primary Care
@TripPrimaryCare · X

New2Trip: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban w/ or without Vitamin K2 in Hemodialysis Patients w/ Atrial Fibrillation: Valkyrie Study https://t.co/y9bGEjnl07

Mar 12, 2020 · 2,470 followers View post →
Trip Primary Care
@TripPrimaryCare · X

New2Trip: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban w/ or without Vitamin K2 in Hemodialysis Patients w/ Atrial Fibrillation: Valkyrie Study https://t.co/y9bGEjnl07

Mar 9, 2020 · 2,470 followers View post →
Trip Primary Care
@TripPrimaryCare · X

New2Trip: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban w/ or without Vitamin K2 in Hemodialysis Patients w/ Atrial Fibrillation: Valkyrie Study https://t.co/y9bGEjnl07

Mar 7, 2020 · 2,470 followers View post →
Trip Database
@tripdatabase · X

New2Trip: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban w/ or without Vitamin K2 in Hemodialysis Patients w/ Atrial Fibrillation: Valkyrie Study https://t.co/jikLmgivR3

Mar 7, 2020 · 4,409 followers View post →
Trip Primary Care
@TripPrimaryCare · X

New2Trip: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban w/ or without Vitamin K2 in Hemodialysis Patients w/ Atrial Fibrillation: Valkyrie Study https://t.co/y9bGEjEVRF

Mar 5, 2020 · 1 like · 2,470 followers View post →
Trip Primary Care
@TripPrimaryCare · X

New2Trip: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban w/ or without Vitamin K2 in Hemodialysis Patients w/ Atrial Fibrillation: Valkyrie Study https://t.co/y9bGEjnl07

Mar 1, 2020 · 2,470 followers View post →
Trip Database
@tripdatabase · X

New2Trip: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban w/ or without Vitamin K2 in Hemodialysis Patients w/ Atrial Fibrillation: Valkyrie Study https://t.co/jikLmgivR3

Mar 1, 2020 · 4,409 followers View post →
Trip Primary Care
@TripPrimaryCare · X

New2Trip: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban w/ or without Vitamin K2 in Hemodialysis Patients w/ Atrial Fibrillation: Valkyrie Study https://t.co/y9bGEjnl07

Feb 28, 2020 · 2,470 followers View post →
Trip Primary Care
@TripPrimaryCare · X

New2Trip: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban w/ or without Vitamin K2 in Hemodialysis Patients w/ Atrial Fibrillation: Valkyrie Study https://t.co/y9bGEjnl07

Feb 26, 2020 · 2,470 followers View post →
Trip Primary Care
@TripPrimaryCare · X

New2Trip: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban w/ or without Vitamin K2 in Hemodialysis Patients w/ Atrial Fibrillation: Valkyrie Study https://t.co/y9bGEjnl07

Feb 23, 2020 · 2,470 followers View post →
Trip Primary Care
@TripPrimaryCare · X

New2Trip: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban w/ or without Vitamin K2 in Hemodialysis Patients w/ Atrial Fibrillation: Valkyrie Study https://t.co/y9bGEjnl07

Feb 21, 2020 · 2,470 followers View post →
Trip Database
@tripdatabase · X

New2Trip: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban w/ or without Vitamin K2 in Hemodialysis Patients w/ Atrial Fibrillation: Valkyrie Study https://t.co/jikLmgivR3

Feb 21, 2020 · 4,409 followers View post →
Trip Primary Care
@TripPrimaryCare · X

New2Trip: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban w/ or without Vitamin K2 in Hemodialysis Patients w/ Atrial Fibrillation: Valkyrie Study https://t.co/y9bGEjnl07

Feb 19, 2020 · 2,470 followers View post →
Fran Nuñez Valverde
@fmnv71 · X

RT @Manugrillo2: Clinical Research Restricted Access Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by #Riva…

Feb 3, 2020 · 1 share · 164 followers View post →
Manu Morales Sánchez
@Manugrillo2 · X

Clinical Research Restricted Access Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by #Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: the Valkyrie Study https://t.co/UWhJQ2wmQw

Feb 3, 2020 · 1 like · 1 share · 2,135 followers View post →
Luis Gómez
@lbgm1983 · X

RT @JonathanNefro: En pacientes en hemodiálisis y ANTICOAGULADOS con RIVAROXABAN o WARFARINA por fibrilación auricular, la administración d…

Feb 2, 2020 · 11 shares · 173 followers View post →
Mel Tapia
@7Melkin · X

RT @JonathanNefro: En pacientes en hemodiálisis y ANTICOAGULADOS con RIVAROXABAN o WARFARINA por fibrilación auricular, la administración d…

Feb 1, 2020 · 11 shares · 33 followers View post →
Dr. Ronald Caraballo NEFROLOGO
@ronald_nefro · X

RT @JonathanNefro: En pacientes en hemodiálisis y ANTICOAGULADOS con RIVAROXABAN o WARFARINA por fibrilación auricular, la administración d…

Jan 29, 2020 · 11 shares · 662 followers View post →
Alanepe
@Alanepe1 · X

RT @JonathanNefro: En pacientes en hemodiálisis y ANTICOAGULADOS con RIVAROXABAN o WARFARINA por fibrilación auricular, la administración d…

Jan 29, 2020 · 11 shares · 1,281 followers View post →
Anace Pastor ✨️ Renalis
@anace710 · X

RT @JonathanNefro: En pacientes en hemodiálisis y ANTICOAGULADOS con RIVAROXABAN o WARFARINA por fibrilación auricular, la administración d…

Jan 29, 2020 · 11 shares · 1,898 followers View post →
Gustavo A. Bautista
@metanefro · X

RT @JonathanNefro: En pacientes en hemodiálisis y ANTICOAGULADOS con RIVAROXABAN o WARFARINA por fibrilación auricular, la administración d…

Jan 29, 2020 · 11 shares · 53 followers View post →
fausto heredia z.
@drfherediaz · X

RT @JonathanNefro: En pacientes en hemodiálisis y ANTICOAGULADOS con RIVAROXABAN o WARFARINA por fibrilación auricular, la administración d…

Jan 29, 2020 · 11 shares · 4,376 followers View post →
Ricardo Orozco C.
@Dr_Orozco_Nefro · X

RT @JonathanNefro: En pacientes en hemodiálisis y ANTICOAGULADOS con RIVAROXABAN o WARFARINA por fibrilación auricular, la administración d…

Jan 29, 2020 · 11 shares · 1,384 followers View post →
javier rodriguez
@javier_rdgz · X

RT @JonathanNefro: En pacientes en hemodiálisis y ANTICOAGULADOS con RIVAROXABAN o WARFARINA por fibrilación auricular, la administración d…

Jan 29, 2020 · 11 shares · 286 followers View post →
Jonathan Chávez
@JonathanNefro · X

En pacientes en hemodiálisis y ANTICOAGULADOS con RIVAROXABAN o WARFARINA por fibrilación auricular, la administración de VITAMINA K no disminuyó los puntajes de CALCIFICACIÓN VASCULAR En el ensayo clínico VALKIRIE, otro más fallido

Jan 29, 2020 · 26 likes · 11 shares · 37,870 followers View post →
Mehdi Maanaoui
@MaanaouiMehdi · X

Ballsy haha rivaroxaban in dialysis patients, safe and efficient? Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: the Valkyrie Study https://t.co/MKytVBPN9R

Nov 15, 2019 · 1 like · 1,002 followers View post →
renalRCTs
@renalRCTs · X

Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: the Valkyrie Study. https://t.co/XlBTHFHTk6

Nov 11, 2019 · 39 followers View post →
Ana Maria Matias
@AMCMA6 · X

RT @JASN_News: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hem…

Nov 10, 2019 · 14 shares · 313 followers View post →
MousTapha Faye
@MF_NephroEpi · X

RT @JASN_News: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hem…

Nov 9, 2019 · 14 shares · 2,216 followers View post →
Miguel Guillen 140#
@AnayaGuillen · X

RT @JASN_News: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hem…

Nov 9, 2019 · 14 shares · 420 followers View post →
Ahmed Tall
@ahmedtall35 · X

RT @JASN_News: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hem…

Nov 9, 2019 · 14 shares · 835 followers View post →
BVNSBN
@BSNrenal · X

RT @JASN_News: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hem…

Nov 9, 2019 · 14 shares · 165 followers View post →
MyintZu Aung
@MyintZuAung1 · X

RT @JASN_News: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hem…

Nov 9, 2019 · 14 shares · 5 followers View post →
Tanganxoan
@Tangan_zuan · X

RT @JASN_News: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hem…

Nov 9, 2019 · 14 shares · 48 followers View post →
thomas robert
@nephrobug · X

RT @JASN_News: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hem…

Nov 9, 2019 · 14 shares · 1,941 followers View post →
bruno van vlem
@brunovanvlem · X

RT @JASN_News: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hem…

Nov 9, 2019 · 14 shares · 67 followers View post →
Paula Duran
@PaulaDu88412761 · X

RT @JASN_News: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hem…

Nov 9, 2019 · 14 shares · 183 followers View post →
AnitaN189
@AnitaFanse80 · X

RT @JASN_News: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hem…

Nov 9, 2019 · 14 shares · 300 followers View post →
Sinead Stoneman
@Stones__ · X

RT @JASN_News: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hem…

Nov 9, 2019 · 14 shares · 1,608 followers View post →
Zoran Paunic
@unicipa · X

RT @JASN_News: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hem…

Nov 9, 2019 · 14 shares · 1,523 followers View post →
Rogier Caluwé
@RogierCaluwe · X

RT @JASN_News: Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hem…

Nov 9, 2019 · 14 shares · 83 followers View post →
JASN_News
@JASN_News · X

Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: the Valkyrie Study @RogierCaluwe https://t.co/FXmt0qHjCX https://t.co/S5ty2uOHxw

Nov 9, 2019 · 19 likes · 14 shares · 22,527 followers View post →