Toxicol Lett February 2020 PMID 31707106

Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids.

Shyam H Kamble, Abhisheak Sharma, Tamara I King, Erin C Berthold, Francisco León, P Katharina L Meyer, Siva Rama Raju Kanumuri, Lance R McMahon, Christopher R McCurdy, Bonnie A Avery

Mentions

7
Peak: 1 in Nov 2019
across 4 sources since Nov 2019

Extended reach

2,059
potential audience

Total likes

25

Video views

719

Mentions per month

Nov 2019 – Sep 2021

Where it's discussed

  • YouTube2 videos
  • Reddit2 posts
  • News2 articles
  • X / Twitter1 posts

AI synopsis

What people are saying

Several discussions highlight the significance of the research by mentioning specific enzymes like CYP2D6 and the potential for adverse drug interactions, with phrases such as 'significant interactions' and 'may cause serious effects'. The tone varies from cautious to analytical, reflecting a shared interest in understanding kratom's health implications and the study's potential to impact medical approaches.

AgreementModerate agreement

Most discussions align with the importance of the research, emphasizing the potential risks associated with kratom alkaloids and drug interactions.

InterestHigh interest

Participants show high curiosity about the implications, mentioning specific enzymes and potential adverse effects.

EngagementModerate engagement

The posts include detailed references to enzyme mechanisms and implications, indicating moderate depth of engagement.

ImpactModerate impact

The discussions suggest the findings could influence future research or clinical considerations, although some posts remain cautiously optimistic.

Abstract in brief

  • Mitragynine (MTG) and corynantheidine (COR) were found to be strong inhibitors specifically of the CYP2D6 enzyme, which plays a major role in processing many drugs, and they block this enzyme through a competitive mechanism.
  • The study suggests that coadministration of kratom containing MTG and COR could cause significant interactions with other medications metabolized by CYP2D6, potentially leading to adverse effects, while effects on other CYP enzymes (like CYP3A4) were minimal or specific to certain substrates.]

Top posts

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Drug Delivery News
@DeliveryDrug · X

Exploration of Cytochrome P450 Inhibition Mediated DrugDrug Interaction Potential of Kratom Alkaloids.: In vitro cytochrome P450 inhibition of major kratom alkaloids mitragynine MTG speciogynine SPG speciocilliatine SPC corynantheidine COR… https://t.co/Y8Taa5ePIC

Nov 11, 2019 · 1 share · 1,339 followers View post →

All mentions

Drug Delivery News
@DeliveryDrug · X

Exploration of Cytochrome P450 Inhibition Mediated DrugDrug Interaction Potential of Kratom Alkaloids.: In vitro cytochrome P450 inhibition of major kratom alkaloids mitragynine MTG speciogynine SPG speciocilliatine SPC corynantheidine COR… https://t.co/Y8Taa5ePIC

Nov 11, 2019 · 1 share · 1,339 followers View post →