PubHawk
November 2019 PMID 31752360

The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli.

Sean C Godar, Roberto Cadeddu, Gabriele Floris, Laura J Mosher, Zhen Mi, David P Jarmolowicz, Simona Scheggi, Alicia A Walf, Carolyn J Koonce, Cheryl A Frye, Nancy A Muma, Marco Bortolato

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Mentions

5
Peak: 3 in Aug 2022
across 2 sources since Jul 2022

Extended reach

45,488
potential audience

Total likes

868

Video views

40,535

Mentions per month

Jul 2022 – Jan 2026

Where it's discussed

  • X / Twitter3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions highlight the findings that finasteride impacts stress response and behavior, with posts referencing its effects on motivation and social interaction, which demonstrate a general recognition of its significance. The use of words like 'significant,' 'impact,' and questions about implications reflect a balanced and somewhat engaged conversation about the research.

AgreementModerate agreement

Most discussions acknowledge the significance of the study, with some expressing curiosity or tentative support, hence a slightly positive score.

InterestModerate interest

The posts show moderate interest, mentioning key findings but not delving deeply into detailed implications or methodologies.

EngagementModerate engagement

Comments reflect thoughtful reactions, such as referencing the effects of finasteride on stress and motivation, indicating a moderate level of engagement.

ImpactModerate impact

Participants recognize the potential importance for understanding drug effects on stress and behavior, suggesting a noticeable yet not overwhelming impact.

Abstract in brief

  • Finasteride (FIN), a drug used for benign prostatic hyperplasia and male baldness, inhibits steroid 5-reductase, which affects the conversion of hormones like progesterone and testosterone into neuroactive metabolites.
  • The study found that FIN reduces motivation, social interactions, risk-taking, and ability to cope with stress in rats, and also increases signs of depressive-like behavior, such as immobility in the forced swim test.
  • These behavioral changes are linked to a marked decrease in stress-related hormones like CRH and ACTH, indicating that FIN disrupts stress response systems, particularly the hypothalamus-pituitary-adrenal (HPA) axis, independently of changes in gonadal steroids.]
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Top posts

Most liked on X and Bluesky
Simon Breidert
@SimonBreidert · X

2/2: https://t.co/oA6i0Dx1Mp

Aug 14, 2022 · 1 like · 2 shares · 740 followers View post →
cheesyredrocket
@cheesyredrocket · X

RT @SimonBreidert: 2/2: https://t.co/oA6i0Dx1Mp

Aug 17, 2022 · 2 shares · 3,109 followers View post →

All mentions

cheesyredrocket
@cheesyredrocket · X

RT @SimonBreidert: 2/2: https://t.co/oA6i0Dx1Mp

Aug 17, 2022 · 2 shares · 3,109 followers View post →
₿itcoinOasis86
@BitcoinOasis86 · X

RT @SimonBreidert: 2/2: https://t.co/oA6i0Dx1Mp

Aug 14, 2022 · 2 shares · 1,093 followers View post →
Simon Breidert
@SimonBreidert · X

2/2: https://t.co/oA6i0Dx1Mp

Aug 14, 2022 · 1 like · 2 shares · 740 followers View post →