Psychopharmacology (Berl) March 2020 PMID 31832720

Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats.

Norsyifa Harun, Illa Syafiqah Johari, Sharif Mahsufi Mansor, Mohammed Shoaib

Download social card

Mentions

Peak: 11 in Mar 2020

across 3 sources since Mar 2020

Extended reach

77,120

potential audience

Total likes

Video views

224

Mentions per month

Mar 2020 – Jul 2022

Where it's discussed

X / Twitter31 posts
Bluesky1 posts
YouTube1 videos

AI synopsis

What people are saying

Participants express high agreement with the findings, citing phrases like 'confirms that kratom doesn’t cause dependence' and 'suggests it could help manage opioid withdrawal,' demonstrating alignment with the study’s conclusions. The tone varies from cautious optimism to detailed scientific interest, with some posts discussing the potential shift in treatment approaches, which underscores the study's significance and the engaged nature of the discussions.

AgreementStrong agreement

Most discussions interpret the study as providing solid evidence that mitragynine does not cause dependence and may be useful for treating opioid withdrawal, indicating strong agreement with its findings.

InterestModerate interest

Participants show moderate curiosity about the therapeutic potential of mitragynine, with some focusing on its role as an alternative to opioids, but overall curiosity remains balanced.

EngagementHigh engagement

Many posts reference the study's methods and implications, with detailed mentions of schedule-controlled testing and its significance, reflecting deep engagement.

ImpactHigh impact

Multiple comments highlight the importance of the research in advancing pharmacotherapy for opioid use disorder, emphasizing its potential to influence treatment strategies, thus indicating high impact.

Abstract in brief

This study investigates the dependence and withdrawal potential of mitragynine (MG), the main psychoactive compound in kratom, by testing its effects on rats' scheduled behavior, and compares its therapeutic effects to buprenorphine in morphine-dependent rats.
The results show that acute MG does not cause dose-related decreases in rats' responding and does not lead to physiological dependence after stopping treatment, although withdrawal symptoms can be precipitated with antagonists like naloxone.
Higher doses of MG can reduce withdrawal symptoms in morphine-dependent rats, suggesting MG might help alleviate opioid withdrawal symptoms without causing dependence itself, highlighting its potential as a treatment option for opioid use disorder.

Read the full abstract

All mentions

Evaluating Mitragynine's Dependence Potential and Pain Relief Effects in Rats

This study examines mitragynine's effects on rat behavior and its potential to reduce opioid withdrawal symptoms, suggesting its promise as a non-dependent pain management option. We discuss extraction methods, receptor…

Kratom Science · Sep 17, 2020 224 views

ThaTeaBishhh♥️

@misteaz79 · X

@cravingtheyum @TeamKratom https://t.co/IXkUrKV9xE

Jul 15, 2022 · 2 likes · 1,558 followers View post →

ThaTeaBishhh♥️

@misteaz79 · X

Journal Club w/ Dr. Jonathan Cachat #5: Mitragynine Study in Rats Leads ... https://t.co/CUNmt2czsZ via @YouTube

Feb 12, 2022 · 1,560 followers View post →

Keith Kratom Legal

@Kpascuch · X

RT @GraceHo71957450: @Alfred_Brock @RecoveryCOA @RecoveryNOLA @iowademocrats @seattletimes @CBS6Albany @NewHampJournal @TalkRadioNews @talk…

Nov 22, 2021 · 1 share · 4,979 followers View post →

Grace Lorraine Howell

@GraceHo71957450 · X

Nov 21, 2021 · 2 likes · 1 share · 7 followers View post →

Rion Motley

@RionMotley · X

RT @HaddowMac: https://t.co/AGKLCHbrj1

Jun 10, 2021 · 12 shares · 578 followers View post →

@ForensicMHSA · X

Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats - PubMed https://t.co/UtAf1in6I1

Apr 3, 2021 · 2,386 followers View post →

Victor M. Cartwright

@VictorMCartwri1 · X

RT https://t.co/DB93zClXUy this wks @kratomscience podcast breaks down Assessing physiological #dependence and withdrawal potential of #mitragynine (PDF @ https://t.co/MKO0pqF7gB) adds to growing… https://t.co/cJ9hn5aBq3

Sep 18, 2020 · 544 followers View post →

ThaTeaBishhh♥️

@misteaz79 · X

RT @jcachat: this wks @kratomscience podcast breaks down Assessing physiological #dependence and withdrawal potential of #mitragynine (PDF…

Sep 17, 2020 · 2 shares · 1,560 followers View post →

Kratom Science

@kratomscience · X

RT @jcachat: this wks @kratomscience podcast breaks down Assessing physiological #dependence and withdrawal potential of #mitragynine (PDF…

Sep 17, 2020 · 2 shares · 4,342 followers View post →

Jonathan Cachat, PhD

@jcachat · X

Sep 17, 2020 · 9 likes · 2 shares · 1,206 followers View post →

Jonathan Cachat

@jcachat.bsky.social · Bluesky

this wks @kratomscience podcast breaks down Assessing physiological #dependence and withdrawal potential of #mitragynine (PDF @ adds to growing evidence for use of #kratom as #opiate substitute & hints differences from #opioids https://www.youtube.com/watch?v=5eP8huTeH3M

Sep 17, 2020 View post →

Kratom Science

@kratomscience · X

Youtube version https://t.co/kSVvB5IJzY

Sep 17, 2020 · 4,342 followers View post →

Wiwid

@Wiwidpoerwito · X

RT @kratomscience: Study concludes #kratom "does not induce physiological dependence but can alleviate the physical symptoms associated wit…

Aug 19, 2020 · 2 shares · 833 followers View post →

Only Dogs Hear Dog Whistles

@prettywise78 · X

RT @kratomscience: Study concludes #kratom "does not induce physiological dependence but can alleviate the physical symptoms associated wit…

Aug 19, 2020 · 2 shares · 457 followers View post →

Kratom Science

@kratomscience · X

Aug 19, 2020 · 9 likes · 2 shares · 4,340 followers View post →

The Kratom Company

@TheKratomCom · X

https://t.co/F96ktDnfr4 https://t.co/3qLXBcMrwQ

May 23, 2020 · 1 like · 1,554 followers View post →

Vapura.cl

@VapuraC · X

RT @HaddowMac: https://t.co/AGKLCHbrj1

May 23, 2020 · 12 shares · 21 followers View post →

Melody

@MelodyHope5 · X

@HaddowMac Assessing Physiological Dependence and Withdrawal Potential of Mitragynine Using Schedule-Controlled Behaviour in Rats. https://t.co/Q2CX10ByBW

May 22, 2020 · 1,381 followers View post →

Science Alerts

@Science_Alerts · X

RT @EurekaMag: Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats https…

Apr 25, 2020 · 2 shares · 1,214 followers View post →

POPLINE

@POPLINE_org · X

RT @EurekaMag: Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats https…

Apr 25, 2020 · 2 shares · 5,184 followers View post →

EurekaMag

@EurekaMag · X

Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats https://t.co/4z0hu01Cxu

Apr 25, 2020 · 2 shares · 6,529 followers View post →

Kratomex

@kratomex · X

Como lo saben millones de usuarios de kratom, el kratom no es adictivo. Un estudio reciente confirmó que el kratom "no induce dependencia fisiológica" https://t.co/cKqtmzkMgf

Mar 31, 2020 · 1 like · 106 followers View post →

she3po

@Boggytown · X

RT @HaddowMac: https://t.co/AGKLCHbrj1

Mar 29, 2020 · 12 shares · 2,648 followers View post →

Britt

@IAMKRATOM0424 · X

RT @HaddowMac: https://t.co/AGKLCHbrj1

Mar 28, 2020 · 12 shares · 991 followers View post →

The Kratom Company

@TheKratomCom · X

represent the desired characteristics of novel pharmacotherapeutic interventions for managing opioid use disorder (OUD). https://t.co/F96ktDnfr4

Mar 28, 2020 · 5 likes · 1,554 followers View post →

Erika M.

@ErikaM1377 · X

RT @HaddowMac: https://t.co/AGKLCHbrj1

Mar 28, 2020 · 12 shares · 1,225 followers View post →

DEA or KGB

@DEAorKGB · X

RT @HaddowMac: https://t.co/AGKLCHbrj1

Mar 28, 2020 · 12 shares · 134 followers View post →

Kratom Theory

@Botanist_Beauty · X

RT @HaddowMac: https://t.co/AGKLCHbrj1

Mar 28, 2020 · 12 shares · 2,130 followers View post →

American Kratom Association

@TheKratomAssn · X

RT @HaddowMac: https://t.co/AGKLCHbrj1

Mar 28, 2020 · 12 shares · 15,476 followers View post →

D. Evans

@HopAlongLefty · X

RT @HaddowMac: https://t.co/AGKLCHbrj1

Mar 28, 2020 · 12 shares · 1,105 followers View post →

Justin F

@DJMF420 · X

RT @HaddowMac: https://t.co/AGKLCHbrj1

Mar 28, 2020 · 12 shares · 1,182 followers View post →

Mac Haddow

@HaddowMac · X

https://t.co/AGKLCHbrj1

Mar 28, 2020 · 61 likes · 12 shares · 5,467 followers View post →

Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Evaluating Mitragynine's Dependence Potential and Pain Relief Effects in Rats