Front Immunol October 2020 PMID 31866999

Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination.

Zebing Rao, Xin Chen, Junxian Wu, Mengjun Xiao, Jing Zhang, Binghao Wang, Lei Fang, Hongjie Zhang, Xiaoming Wang, Shuo Yang, Yunzi Chen

Mentions

28
Peak: 5 in Jan 2022
across 3 sources since Jul 2020

Extended reach

629,871
potential audience

Total likes

12,948

Video views

497,208

Mentions per month

Jul 2020 – Oct 2023

Where it's discussed

  • X / Twitter23 posts
  • YouTube3 videos
  • Facebook2 posts

AI synopsis

What people are saying

The discussions reflect appreciation for the research's potential health implications, such as controlling inflammation through vitamin D, with phrases like 'Vitamin D helps prevent it' and mentions of its relevance to COVID and aging, demonstrating both recognition of scientific significance and influence on health narratives.

AgreementModerate agreement

Most discussions acknowledge the inhibitory role of vitamin D receptor (VDR) on NLRP3 activation, with some posts explicitly referencing the research findings.

InterestNeutral interest

Participants show moderate interest, connecting the research to broader health topics like COVID, aging, and nutrition, but some posts divert to unrelated topics or skepticism.

EngagementModerate engagement

Posts cite mechanisms, implications, or related compounds like caffeine and vitamins, indicating active engagement with the scientific content while some are brief or general.

ImpactModerate impact

Several comments suggest that understanding VDR's role could influence health strategies or treatments, though the overall perceived impact varies among users.

Abstract in brief

  • The NLRP3 inflammasome is essential for triggering inflammation by activating cytokines like IL-1β and IL-18, and its dysregulation is linked to autoimmune diseases.
  • Researchers have discovered that the vitamin D receptor (VDR) acts as a negative regulator for NLRP3, preventing its activation and reducing inflammation.
  • This indicates that VDR signaling could be a promising target for treating diseases related to NLRP3 inflammasome activation.

Top posts

Most liked on X and Bluesky
Joe B
@JBianco215 · X

https://t.co/Qg3U8U4RJw Potential caffeine downside Vitamin D receptor activation is needed to inhibit the NLRP3 inflammasome & caspase-1, a central inflammatory enzyme that activates interleukin cytokines Caffeine decreases vitamin D receptor expression https://t.co/fPE5R1y6l3

May 7, 2022 · 9 likes · 1 share · 4,593 followers View post →
Robert Rand
@robertwrand · X

@richardursomd Ianamd but noticed <<vitamin D negatively regulates the NLRP3 inflammasome via VDR signaling to effectively inhibit IL-1β secretion.>> https://t.co/Gubuc461Ib

Mar 22, 2021 · 7 likes · 2 shares · 2,028 followers View post →
Martin Juhl
@MartinJuhl2 · X

Link between vitamin D and NLRP3 inflammasome VitD Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination, Vitamin D is shown to enhance the vitamin D receptor (VDR)-Mediated Inhibition of NLRP3 Inflammasome Activation https://t.co/Qhx4dZNvbu 18/x

Jan 17, 2022 · 2 likes · 1,862 followers View post →
Woody Nist
@Woodynist · X

2/2 (thanks again, @fredeyragues) Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination https://t.co/AVWYemrf7J

Jun 3, 2022 · 1 like · 1,311 followers View post →
skyblue101
@skyblue101 · X

Wild Effect of Vitamin D on Aging & Longevity https://t.co/ZSsomfm1x9 via @YouTube

Jun 11, 2021 · 1 like · 1,122 followers View post →
FRANCIS - BULLBITCOIN.COM
@francispouliot_ · X

RT @Andiesimplelife: @francispouliot_ Vitamin D helps prevent it. https://t.co/RnwSUfrHAM

Oct 3, 2020 · 2 shares · 107,725 followers View post →

All mentions

Frank Paul Mora
@InTime_49 · X

@heniek_htw Published Dec 2019 Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination https://t.co/CiZ5ri6Sxv

Oct 21, 2023 · 384 followers View post →
Sagittarius
@guani_vic · X

The vitamin D receptor inhibits NLRP3 activation. (2) Covid also Drives NLRP3 activation as does Fructose associated uric acid production in the liver once the serum becomes saturated. https://t.co/28I3YIe7cu https://t.co/bt9ZS6FRgJ

Sep 17, 2023 · 678 followers View post →
Sagittarius
@guani_vic · X

https://t.co/SHDKyD8O7B

Jun 13, 2023 · 678 followers View post →
babibel sur GETTR: @babibelle33
@babibelle33 · X

RT @Woodynist: 2/2 (thanks again, @fredeyragues) Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitina…

Jun 3, 2022 · 4,128 followers View post →
Woody Nist
@Woodynist · X

2/2 (thanks again, @fredeyragues) Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination https://t.co/AVWYemrf7J

Jun 3, 2022 · 1 like · 1,311 followers View post →
Amazing Human
@MyAmazingHuman · X

RT @jojiswims: https://t.co/Qg3U8U4RJw Potential caffeine downside Vitamin D receptor activation is needed to inhibit the NLRP3 inflammaso…

May 7, 2022 · 1 share · 80 followers View post →
Joe B
@JBianco215 · X

https://t.co/Qg3U8U4RJw Potential caffeine downside Vitamin D receptor activation is needed to inhibit the NLRP3 inflammasome & caspase-1, a central inflammatory enzyme that activates interleukin cytokines Caffeine decreases vitamin D receptor expression https://t.co/fPE5R1y6l3

May 7, 2022 · 9 likes · 1 share · 4,593 followers View post →
Ines White
@inmari1 · X

You're using the WRONG Vitamin D https://t.co/mFjAIy0W7R via @YouTube

Apr 14, 2022 · 34 followers View post →
Libertarian Boxcar2
@TrixieNovel2 · X

Health medical Nutrition https://t.co/8daxakOcB4

Jan 27, 2022 · 733 followers View post →
David Thomas
@davidthomasweb · X

https://t.co/7WevNxFb9s https://t.co/Ydv7nkL8YR

Jan 21, 2022 · 3 followers View post →
Cheo (Chāy Ō)
@CheoWalker · X

Thomas DeLauer You're using the WRONG Vitamin D https://t.co/9VEIlpGqOy #keto

Jan 21, 2022 · 348 followers View post →
Martin Juhl
@MartinJuhl2 · X

Link between vitamin D and NLRP3 inflammasome VitD Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination, Vitamin D is shown to enhance the vitamin D receptor (VDR)-Mediated Inhibition of NLRP3 Inflammasome Activation https://t.co/Qhx4dZNvbu 18/x

Jan 17, 2022 · 2 likes · 1,862 followers View post →
skyblue101
@skyblue101 · X

Wild Effect of Vitamin D on Aging & Longevity https://t.co/ZSsomfm1x9 via @YouTube

Jun 11, 2021 · 1 like · 1,122 followers View post →
Diana Dee Jarvis
@DianaDeeJarvis · X

Wild Effect of Vitamin D on Aging & Longevity https://t.co/THPpJc9f8x via @YouTube

May 19, 2021 · 392 followers View post →
Blahnikgurl
@TippiTheVegan · X

Vitamin D3 & K2 is one of the most important supplements that you could take. Vitamin C, D3, K2, Quercetin & Zinc, a healthy diet & exercise. Why isn’t the government promoting this? No profits for corrupt politicians & pharmaceutical companies. https://t.co/qDslShmF3C

May 19, 2021 · 3,657 followers View post →
David Thomas
@davidthomasweb · X

https://t.co/l8UJCKRmIm https://t.co/Ib7XsotRCn The Best and Worst of Your Week One of the main reasons why losing weight is so hard to accomplish is that each 24 hour period presents a new set of challenges.

May 19, 2021 · 3 followers View post →
David Thomas
@davidthomasweb · X

https://t.co/bBTsPQ32SF https://t.co/K27at3ONjC The Daunting Risks of Laparoscopic Obesity Surgery Laparoscopic obesity surgery has a list of daunting risks that occur in the post-surgery period. The complicat

Apr 30, 2021 · 3 followers View post →
Janet Masleid
@LuVD3 · X

RT @robertwrand: @richardursomd Ianamd but noticed <<vitamin D negatively regulates the NLRP3 inflammasome via VDR signaling to effectively…

Mar 22, 2021 · 2 shares · 161 followers View post →
Seamus
@Seamus01952928 · X

RT @robertwrand: @richardursomd Ianamd but noticed <<vitamin D negatively regulates the NLRP3 inflammasome via VDR signaling to effectively…

Mar 22, 2021 · 2 shares · 1,524 followers View post →
Robert Rand
@robertwrand · X

@richardursomd Ianamd but noticed <<vitamin D negatively regulates the NLRP3 inflammasome via VDR signaling to effectively inhibit IL-1β secretion.>> https://t.co/Gubuc461Ib

Mar 22, 2021 · 7 likes · 2 shares · 2,028 followers View post →
Zedd
@TrdisOprtr · X

RT @Andiesimplelife: @francispouliot_ Vitamin D helps prevent it. https://t.co/RnwSUfrHAM

Oct 3, 2020 · 2 shares · 352 followers View post →
FRANCIS - BULLBITCOIN.COM
@francispouliot_ · X

RT @Andiesimplelife: @francispouliot_ Vitamin D helps prevent it. https://t.co/RnwSUfrHAM

Oct 3, 2020 · 2 shares · 107,725 followers View post →
María Elena González
@nenagoin · X

https://t.co/LrwIH9NfRk

Jul 20, 2020 · 841 followers View post →