J Assist Reprod Genet March 2020 PMID 31872386

Impact of BRCA1 and BRCA2 mutations on ovarian reserve and fertility preservation outcomes in young women with breast cancer.

Eleonora Porcu, Giulia Maria Cillo, Linda Cipriani, Federica Sacilotto, Leonardo Notarangelo, Giuseppe Damiano, Maria Dirodi, Ilaria Roncarati

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Mentions

Peak: 1 in Jan 2020

across 3 sources since Jan 2020

Extended reach

233,829

potential audience

Total likes

2,673

Video views

233,304

Mentions per month

Jan 2020 – May 2023

Where it's discussed

YouTube2 videos
News2 articles
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AI synopsis

What people are saying

Discussions highlight the significance of the study by mentioning that women with BRCA1 mutations experience lower ovarian reserves, with phrases like 'game-changing' and 'important for treatment decisions' indicating recognition of its clinical relevance. Others express neutral or questioning tones, reflecting mixed engagement and interest levels.

AgreementModerate agreement

Most discussions acknowledge the findings, with some expressing support for the importance of understanding genetic effects on fertility.

InterestNeutral interest

Interest levels vary, with some comments showing curiosity about fertility implications, while others are more neutral or dismissive.

EngagementModerate engagement

Several users delve into methodological details or comment on clinical relevance, indicating moderate engagement.

ImpactModerate impact

The overall tone suggests the research is recognized as valuable, though not universally transformative yet.

Abstract in brief

The study investigated how BRCA1 and BRCA2 gene mutations affect ovarian reserve and fertility preservation in young women with breast cancer, focusing on outcomes like hormone levels and oocyte quality.
Results showed that women with BRCA1 mutations had significantly lower Anti-Müllerian Hormone (AMH) levels and fewer mature oocytes compared to women without these mutations and healthy controls, indicating reduced ovarian reserve.
Additionally, breast cancer patients, especially those with BRCA mutations, required higher doses of gonadotropins for ovarian stimulation, but there were no significant differences in other fertility indicators such as basal FSH or stimulation duration across the groups.

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All mentions

Understanding AMH and Ovarian Reserve in Fertility Testing

Learn about fertility testing, ovarian reserve, and factors affecting fertility, including endometriosis and surgical impacts. Discover how AMH levels serve as reliable indicators of egg quantity for women planning…

Natalie Crawford, MD · Jun 7, 2021 147,095 views

Understanding How Low AMH Affects Fertility and Ovarian Reserve

Dr. Natalie Crawford discusses AMH, its testing, how it impacts fertility, and factors affecting ovarian reserve, highlighting the importance of timely assessment and fertility preservation options for women.

Natalie Crawford, MD · May 10, 2023 86,210 views

Margalida Torres

@Marga_torres · X

Impact of BRCA1 and BRCA2 mutations on ovarian reserve and fertility preservation outcomes in young women with breast cancer. - PubMed - NCBI https://t.co/luKSIWUJP3

Jan 3, 2020 · 506 followers View post →

Fertility preservation in patients with BRCA mutation - ecancer

News

... 10.1007/s10815-019-01658-9 PMCID: 7125060. 13. Turan V and Oktay K (2020) BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging Hum ...

Jan 11, 2026 View →

Fertility preservation in endocrine responsive breast cancer: data ...