J Nanobiotechnology Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer: 5-Fluorouracil (5-FU) has been commonly prescribed for patients with… https://t.co/nwtxgslBm9 #Research via @BioMedCentral
Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer.
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Jan 2020 – May 2024Where it's discussed
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What people are saying
The discussions express enthusiasm about the article's innovative use of exosomes, with phrases such as 'game-changing' and 'promising approach,' reflecting high interest and recognition of its potential impact; analytical comments on molecular mechanisms also show engagement and understanding of its significance.
Many discussions highlight positive views on the potential of engineered exosomes in overcoming drug resistance, indicating general agreement with the study's significance.
The high interest score reflects strong curiosity about innovative approaches to cancer treatment, as seen in comments mentioning 'exciting potential' and 'promising strategy.'
Posts often discuss mechanisms like miR-21 inhibition and tumor suppression, indicating moderate engagement with specific scientific details.
Participants recognize the method's potential to improve therapy outcomes, but some aspects remain speculative, resulting in a moderate impact score.
Abstract in brief
- Engineered exosomes were used to deliver both the chemotherapy drug 5FU and a miR21 inhibitor to resistant colon cancer cells, effectively overcoming drug resistance and reducing tumor growth.
- The study found that this co-delivery system increased cellular uptake, downregulated miR21 levels, induced cell cycle arrest, promoted cell death, and restored the expression of tumor-suppressor genes, leading to significant tumor suppression in mice.
- This approach demonstrates a promising strategy for combining genetic and chemotherapeutic treatments via exosomes to overcome drug resistance in colon cancer therapy.
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Engineered Exosomes for Targeted Delivery to Overcome Colon Cancer Drug Resistance
Engineered exosomes deliver chemotherapy and miR-21 inhibitors to resistant colon cancer cells, reducing tumor growth and overcoming drug resistance by enhancing cellular uptake and restoring tumor suppressor gene…
Engineered Exosomes for Targeted Delivery to Overcome Colon Cancer Drug Resistance
Engineered exosomes deliver both 5FU and miR-21 inhibitor to resistant colon cancer cells, reducing tumor growth. This method enhances cellular uptake, downregulates miR21, induces cell cycle arrest, and restores tumor…
Engineered Exosomes for Targeted Delivery to Overcome Colon Cancer Drug Resistance
Engineered exosomes deliver 5FU and miR-21 inhibitor to resistant colon cancer cells, reducing tumor growth and restoring tumor suppressor gene expression, offering a promising approach for overcoming drug resistance.
Engineered Exosomes for Targeted Co-Delivery in Colon Cancer Therapy
Engineered exosomes deliver miR-21 inhibitors and chemotherapeutics to resistant colon cancer cells, overcoming drug resistance by enhancing cellular uptake, inducing tumor suppressor gene expression, and reducing tumor…
Engineered Exosomes for Targeted Co-Delivery in Colon Cancer Therapy
Engineered exosomes deliver chemotherapeutic 5FU and miR-21 inhibitor to resistant colon cancer cells, overcoming drug resistance and reducing tumor growth.
J Nanobiotechnology Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer: 5-Fluorouracil (5-FU) has been commonly prescribed for patients with… https://t.co/nwtxgslBm9 #Research via @BioMedCentral