Rapid Commun Mass Spectrom May 2020 PMID 31922636

Cytokines in the grass, a lesson learnt: Measuring cytokines in plasma using multiple reaction monitoring mass spectrometry.

Omar Mendoza-Porras, Pedro R L Pires, Hareshwar Goswami, Flavio V Meirelles, Michelle L Colgrave, Gene Wijffels

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Mentions

3
Peak: 1 in Jan 2020
across 2 sources since Jan 2020

Extended reach

6,066
potential audience

Total likes

2

Video views

75

Mentions per month

Jan 2020 – Jul 2025

Where it's discussed

  • YouTube2 videos
  • X / Twitter1 posts

AI synopsis

What people are saying

The discussions demonstrate a balanced view with many focusing on the novel LC-MRMMS technique and its promise for cytokine detection, illustrated by phrases like 'more accurate detection' and 'new possibilities.' Words like 'challenges' and 'matrix effects' reveal critical engagement with the technical details, highlighting a genuine interest in the method's potential and limitations.

AgreementModerate agreement

Most discussions acknowledge the significance of the new measurement technique and its potential benefits, though some express cautious optimism or highlight ongoing challenges.

InterestModerate interest

Participants show moderate interest, noting both the technical advancements and limitations, indicating a curiosity about the method's applications.

EngagementModerate engagement

Comments reflect thoughtful reflections on the methodology and its implications, such as mentions of measurement accuracy, matrix effects, and potential future uses.

ImpactModerate impact

The discussions suggest the research could influence biomarker detection practices, especially in less complex biological fluids, which may impact future research and diagnostic approaches.

Abstract in brief

  • This text discusses the development of a new method using liquid chromatography-multiple reaction monitoring mass spectrometry (LCMRMMS) to measure cytokines like IL1, IL6, IFN, and TNF in plasma, offering potentially more accurate and sensitive detection compared to traditional antibody-based methods.
  • The study shows that while the method achieved very low detection and quantification limits in pure standards, detecting cytokines in complex sera samples is challenging due to matrix effects, which significantly reduce measurement accuracy.
  • Despite these challenges, the LCMRMMS approach could be useful for studying cytokines in less complex biological fluids, such as synovial fluid or cerebrospinal fluid, providing new possibilities for biomarker research beyond conventional techniques.

Top posts

Most liked on X and Bluesky
BioMassSpec
@realBioMassSpec · X

Cytokines in the grass, a lesson learnt: Measuring cytokines in plasma using multiple reaction monitoring mass spectrometry #RCM https://t.co/QawG3b2j33

Jan 11, 2020 · 1 like · 5,992 followers View post →

All mentions

BioMassSpec
@realBioMassSpec · X

Cytokines in the grass, a lesson learnt: Measuring cytokines in plasma using multiple reaction monitoring mass spectrometry #RCM https://t.co/QawG3b2j33

Jan 11, 2020 · 1 like · 5,992 followers View post →