PubHawk
Proc Natl Acad Sci U S A January 2020 PMID 31953264

Structure of a rabies virus polymerase complex from electron cryo-microscopy.

Joshua A Horwitz, Simon Jenni, Stephen C Harrison, Sean P J Whelan

Full text PDF Download social card

Mentions

24
Peak: 8 in Jan 2020
across 2 sources since Oct 2019

Extended reach

291,108
potential audience

Total likes

119

Video views

839

Mentions per month

Oct 2019 – Dec 2025

Where it's discussed

  • X / Twitter22 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone indicates a neutral to slightly positive interest in the structural findings, with some discussions highlighting the relevance of electron cryo-microscopy and comparisons to other viruses. Occasional dismissive comments advise audiences to verify information through reputable sources like Google Scholar, showing a cautious but engaged attitude towards scientific credibility.

AgreementNeither agree nor disagree

Many discussions simply acknowledge the publication without expressing strong support or disagreement, indicating neutral stance.

InterestModerate interest

Several posts show moderate interest, especially those sharing links or emphasizing the significance of the structure, but some dismissive comments suggest limited engagement with the scientific details.

EngagementModerate engagement

Posts include sharing of the article, mentions of electron cryo-microscopy, and references to related viral structures, reflecting a moderate level of involvement.

ImpactModerate impact

The publication appears to influence microbiology and virology discussions, as reflected in multiple shares and mentions in scientific contexts, though not universally perceived as transformative.

Abstract in brief

  • The study presents the complete structure of the rabies virus (RABV) polymerase complex, determined by electron cryomicroscopy at 3.3 Å resolution, revealing its similarities and differences with the vesicular stomatitis virus (VSV) polymerase.
  • The RABV polymerase L protein, a large enzyme, performs multiple functions such as mRNA transcription, replication, capping, and cap methylation, with this structure representing a preinitiation (early) state.
  • Comparisons with other virus polymerase structures suggest variations between the initiation and elongation phases of transcription, and internal cavity analysis indicates specific pathways for template and product entry/exit during the viral RNA synthesis process.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Nature Reviews Microbiology
@NatureRevMicro · X

Structure of a rabies virus polymerase complex from electron cryo-microscopy @PNASNews @vsv512 https://t.co/j2oSWO1E4c https://t.co/XJl1gCKGI5

Feb 4, 2020 · 17 likes · 5 shares · 81,001 followers View post →
Joost Snijder
@joostsnijder · X

Structure of a rabies virus polymerase complex from electron cryo-microscopy https://t.co/LlTlVCsyhs

Jan 18, 2020 · 8 likes · 2 shares · 1,361 followers View post →
Abdullah Tozluyurt
@drabdmge · X

@gulltemel Maalesef yazdiklari doğru değil ve insanlari yanlış yonlendirmektedir. Buyrun elektron mikroskobisi ile yapilan ve saygin bir dergideki ilgili virüsün yapisini detaylica aciklayan yayin asagidadir. https://t.co/661g4HQQhB Bunun gibilere itibar etmeyin. Google scholara bakin.

Dec 12, 2024 · 8 likes · 17 followers View post →
bioRxiv
@biorxivpreprint · X

Structure of a rabies virus polymerase complex from electron cryo-microscopy https://t.co/hq59KRvC3Y #bioRxiv

Oct 6, 2019 · 6 likes · 2 shares · 138,417 followers View post →
cryoEM Papers
@cryoEM_Papers · X

Structure of a rabies virus polymerase complex from electron cryo-microscopy [Microbiology] https://t.co/BOSRRIPx1V

Jan 28, 2020 · 5 likes · 1 share · 11,797 followers View post →
cryoEM Papers
@cryoEM_Papers · X

Structure of a rabies virus polymerase complex from electron cryo-microscopy [Microbiology] https://t.co/mrGyYCK7Dg

Jan 19, 2020 · 4 likes · 2 shares · 11,797 followers View post →

All mentions

Dr. Brian Poe
@PoeBrianL · X

@momootjem3 @KateShemirani @zegtSjaan https://t.co/BU2RV9eWnI

Dec 10, 2025 · 5,873 followers View post →
Abdullah Tozluyurt
@drabdmge · X

@gulltemel Maalesef yazdiklari doğru değil ve insanlari yanlış yonlendirmektedir. Buyrun elektron mikroskobisi ile yapilan ve saygin bir dergideki ilgili virüsün yapisini detaylica aciklayan yayin asagidadir. https://t.co/661g4HQQhB Bunun gibilere itibar etmeyin. Google scholara bakin.

Dec 12, 2024 · 8 likes · 17 followers View post →
PublicKnows.com
@KnowsPublic · X

Structure of a rabies virus polymerase complex from electron cryo-microscopy [Microbiology] https://t.co/dyOV1EdBPh

May 26, 2020 · 17 followers View post →
Patricia
@Deacgator · X

RT @NatureRevMicro: Structure of a rabies virus polymerase complex from electron cryo-microscopy @PNASNews @vsv512 https://t.co/j2oSWO1E4…

Feb 5, 2020 · 5 shares · 98 followers View post →
Decroly Etienne
@DecrolyE · X

RT @NatureRevMicro: Structure of a rabies virus polymerase complex from electron cryo-microscopy @PNASNews @vsv512 https://t.co/j2oSWO1E4…

Feb 5, 2020 · 5 shares · 2,137 followers View post →
clara rehmann
@ramencult · X

RT @NatureRevMicro: Structure of a rabies virus polymerase complex from electron cryo-microscopy @PNASNews @vsv512 https://t.co/j2oSWO1E4…

Feb 4, 2020 · 5 shares · 16,066 followers View post →
Nature Reviews Microbiology
@NatureRevMicro · X

Structure of a rabies virus polymerase complex from electron cryo-microscopy @PNASNews @vsv512 https://t.co/j2oSWO1E4c https://t.co/XJl1gCKGI5

Feb 4, 2020 · 17 likes · 5 shares · 81,001 followers View post →
Center for host-pathogen interaction
@mosconaporotto · X

RT @cryoEM_Papers: Structure of a rabies virus polymerase complex from electron cryo-microscopy [Microbiology] https://t.co/BOSRRIPx1V

Jan 28, 2020 · 1 share · 395 followers View post →
cryoEM Papers
@cryoEM_Papers · X

Structure of a rabies virus polymerase complex from electron cryo-microscopy [Microbiology] https://t.co/BOSRRIPx1V

Jan 28, 2020 · 5 likes · 1 share · 11,797 followers View post →
puey
@PueyLab · X

RT @cryoEM_Papers: Structure of a rabies virus polymerase complex from electron cryo-microscopy [Microbiology] https://t.co/mrGyYCK7Dg

Jan 25, 2020 · 2 shares · 490 followers View post →
Max Maletta
@MalettaMax · X

RT @cryoEM_Papers: Structure of a rabies virus polymerase complex from electron cryo-microscopy [Microbiology] https://t.co/mrGyYCK7Dg

Jan 20, 2020 · 2 shares · 519 followers View post →
Grdzelishvili Lab at UNC Charlotte
@Virology_Lab · X

"Structure of a rabies virus polymerase complex from electron cryo-microscopy" https://t.co/hMS8eTqoO8

Jan 19, 2020 · 2 likes · 482 followers View post →
cryoEM Papers
@cryoEM_Papers · X

Structure of a rabies virus polymerase complex from electron cryo-microscopy [Microbiology] https://t.co/mrGyYCK7Dg

Jan 19, 2020 · 4 likes · 2 shares · 11,797 followers View post →
Dr Naresh Hanchate, PhD
@Naresh_hanchate · X

RT @joostsnijder: Structure of a rabies virus polymerase complex from electron cryo-microscopy https://t.co/LlTlVCsyhs

Jan 18, 2020 · 2 shares · 1,194 followers View post →
Joost Snijder
@joostsnijder · X

Structure of a rabies virus polymerase complex from electron cryo-microscopy https://t.co/LlTlVCsyhs

Jan 18, 2020 · 8 likes · 2 shares · 1,361 followers View post →
Joost Snijder
@joostsnijder · X

Structure of a rabies virus polymerase complex from electron cryo-microscopy https://t.co/ofnrfa93ck

Oct 11, 2019 · 1,361 followers View post →
cryoEM Papers
@cryoEM_Papers · X

Structure of a rabies virus polymerase complex from electron cryo-microscopy https://t.co/fpy1t0YEPl

Oct 7, 2019 · 1 like · 11,797 followers View post →
aDNA_papers
@aDNA_papers · X

Structure of a rabies virus polymerase complex from electron cryo-microscopy https://t.co/lsvVNJl82y

Oct 7, 2019 · 1,702 followers View post →
io
@io_1337 · X

RT @biorxivpreprint: Structure of a rabies virus polymerase complex from electron cryo-microscopy https://t.co/hq59KRvC3Y #bioRxiv

Oct 7, 2019 · 2 shares · 2,744 followers View post →
bxv_molbiol
@bxv_molbiol · X

Structure of a rabies virus polymerase complex from electron cryo-microscopy https://t.co/mQGTrgJTA4

Oct 6, 2019 · 112 followers View post →
2438@ROM
@t2438 · X

RT @biorxivpreprint: Structure of a rabies virus polymerase complex from electron cryo-microscopy https://t.co/hq59KRvC3Y #bioRxiv

Oct 6, 2019 · 2 shares · 817 followers View post →
bioRxiv
@biorxivpreprint · X

Structure of a rabies virus polymerase complex from electron cryo-microscopy https://t.co/hq59KRvC3Y #bioRxiv

Oct 6, 2019 · 6 likes · 2 shares · 138,417 followers View post →