PubHawk
May 2020 PMID 31961826

Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity.

Alana E O'Mara, James W Johnson, Joyce D Linderman, Robert J Brychta, Suzanne McGehee, Laura A Fletcher, Yael A Fink, Devika Kapuria, Thomas M Cassimatis, Nathan Kelsey, Cheryl Cero, Zahraa Abdul Sater, Francesca Piccinini, Alison S Baskin, Brooks P Leitner

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Mentions

60
Peak: 30 in Jan 2020
across 5 sources since Jan 2020

Extended reach

419,265
potential audience

Total likes

218

Video views

3,267

Mentions per month

Jan 2020 – Apr 2025

Where it's discussed

  • X / Twitter44 posts
  • News6 articles
  • Facebook4 posts
  • Blogs4 articles
  • YouTube2 videos

AI synopsis

What people are saying

Many discussions emphasize the significance of the findings, with posts highlighting phrases like 'important breakthrough' and 'promising strategy for metabolic diseases.' The tone suggests excitement and recognition of the potential impact, particularly in comments referencing the activation of brown fat and improved insulin sensitivity. The use of supportive language and mentions of future applications underscore the perceived high impact of this research.

AgreementStrong agreement

The majority of discussions express strong support or positive acknowledgment of the study's findings, highlighting the potential benefits and significance of the research.

InterestHigh interest

Posts demonstrate high engagement by sharing detailed summaries, praising the methodology, or pondering future implications, indicating genuine curiosity and relevance.

EngagementModerate engagement

While many discussions are detailed and reference specific data or potential applications, some are more brief or supportive without deep elaboration, reflecting moderate levels of engagement.

ImpactHigh impact

Several posts emphasize the importance of the findings for future treatments of metabolic disorders, indicating that the discussions view this research as a potentially game-changing development.

Abstract in brief

  • Chronic treatment with mirabegron, a drug approved for overactive bladder, can enhance brown fat activity, increase HDL cholesterol, improve insulin sensitivity, and elevate energy expenditure in humans.
  • The study involved 14 healthy women who took 100 mg of mirabegron daily for 4 weeks, resulting in higher brown fat metabolic activity, increased beneficial lipoproteins, and improved glucose and insulin metabolism without changes in body weight.
  • These findings suggest that stimulating brown fat using drugs like mirabegron could be a promising strategy for treating metabolic diseases such as obesity and diabetes.
Read the full abstract

Top posts

Most liked on X and Bluesky
Alexander Bartelt
@BarteltLab · X

Two important human studies out now in @jclinicalinvest - #brownfat activation with mirabegron

Jan 22, 2020 · 37 likes · 6 shares · 9,062 followers View post →
Yu-Hua Tseng
@tsengyuhua · X

Chronic mirabegron treatment increases human #brown fat, HDL cholesterol, and #insulin sensitivity @acypess https://t.co/SiWnyKIZu1

Jan 21, 2020 · 16 likes · 4 shares · 1,223 followers View post →
Aaron Cypess
@acypess · X

Very pleased with our team's work: JCI - Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity https://t.co/wVHUxNTuvd

Jan 30, 2020 · 10 likes · 667 followers View post →
Yaron Rotman
@NASH_and_coffee · X

Today in JCI - @NIDDKgov's Aaron Cypess showing that #mirabegron treatment can increase human #brown #fat. Glad that @KapuriaMd and I were able to be part of this breakthrough study! https://t.co/awNESgI6JF

Jan 21, 2020 · 9 likes · 4 shares · 1,544 followers View post →
Luiz Osório Leiria
@luiz_leiria · X

JCI - Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity https://t.co/xvw4RufFXe

Jan 22, 2020 · 7 likes · 710 followers View post →
Journal of Clinical Investigation
@jclinicalinvest · X

O’Mara, Johnson, et al. @NIDDKgov observed that chronic mirabegron treatment increased metabolically active brown adipose tissue, thereby enhancing resting energy expenditure and improving insulin sensitivity in 14 healthy women. https://t.co/WnnYTd6A8G

Mar 31, 2020 · 5 likes · 4 shares · 50,970 followers View post →

All mentions

Kaamuland
@kaamuland · X

これかぁ、はぇー

Feb 18, 2023 · 144 followers View post →
Ranganath Muniyappa
@dr_muniyappa · X

@metapredict @DanielJDrucker @CellRepMed Correlations

Sep 16, 2021 · 1,089 followers View post →
FDA Patient Info
@FDAPatientinfo · X

RT @NIHClinicalCntr: Research at the @NIHClinicalCntr: Chronic Mirabegron Treatment Increases Human Brown Fat, HDL Cholesterol, and Insulin…

Apr 23, 2020 · 1 share · 4,107 followers View post →
NIH Clinical Center
@NIHClinicalCntr · X

Research at the @NIHClinicalCntr: Chronic Mirabegron Treatment Increases Human Brown Fat, HDL Cholesterol, and Insulin Sensitivity https://t.co/0KgG7BNLwA https://t.co/mtpcV404K7

Apr 23, 2020 · 1 like · 1 share · 81,813 followers View post →
Joni Lance
@JoniLance1 · X

RT @jclinicalinvest: O’Mara, Johnson, et al. @NIDDKgov observed that chronic mirabegron treatment increased metabolically active brown adip…

Apr 8, 2020 · 4 shares · 201 followers View post →
Patrick M Sexton
@PatrickMSexton1 · X

RT @DanielJDrucker: @mradjenkinson1 "BAT is not relevant in adult humans" Today. Thats why folks do research. I have no skin in the BAT gam…

Apr 7, 2020 · 1 share · 1,035 followers View post →
Daniel J Drucker
@DanielJDrucker · X

@mradjenkinson1 "BAT is not relevant in adult humans" Today. Thats why folks do research. I have no skin in the BAT game, just watch with respect (mostly) as many smart colleagues dissect the biology, in mice and humans. Lots of things in science never work, until they do https://t.co/h8M3QqHzt0 https://t.co/h9Uybtq5Zm

Apr 7, 2020 · 2 likes · 1 share · 34,407 followers View post →
NIDDK
@NIDDKgov · X

RT @jclinicalinvest: O’Mara, Johnson, et al. @NIDDKgov observed that chronic mirabegron treatment increased metabolically active brown adip…

Apr 1, 2020 · 4 shares · 13,825 followers View post →
Rexford S. Ahima, MD, PhD
@rex_ahima · X

RT @jclinicalinvest: O’Mara, Johnson, et al. @NIDDKgov observed that chronic mirabegron treatment increased metabolically active brown adip…

Mar 31, 2020 · 4 shares · 637 followers View post →
john randall
@johnran28545123 · X

RT @jclinicalinvest: O’Mara, Johnson, et al. @NIDDKgov observed that chronic mirabegron treatment increased metabolically active brown adip…

Mar 31, 2020 · 4 shares · 136 followers View post →
Journal of Clinical Investigation
@jclinicalinvest · X

O’Mara, Johnson, et al. @NIDDKgov observed that chronic mirabegron treatment increased metabolically active brown adipose tissue, thereby enhancing resting energy expenditure and improving insulin sensitivity in 14 healthy women. https://t.co/WnnYTd6A8G

Mar 31, 2020 · 5 likes · 4 shares · 50,970 followers View post →
James Wheeler Johnson, MD
@jameswjohnsonmd · X

RT @BarteltLab: Two important human studies out now in @jclinicalinvest - #brownfat activation with mirabegron

Feb 10, 2020 · 6 shares · 514 followers View post →
Emmani Nascimento, PhD
@NascimentoE3 · X

1 month B3 agonist mirabegron in women activates #brownfat and improves parameters related to glucose homeostasis. Can the effects of B3 activation on the heart be even further bypassed in the future? Fascinating research by @acypess https://t.co/npy9APuGbV

Feb 4, 2020 · 2 likes · 1 share · 92 followers View post →
Guillermo D Scolari
@GuiyoScolari · X

JCI - Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity https://t.co/YxGmrLbOrk

Feb 3, 2020 · 101 followers View post →
Aaron Cypess
@acypess · X

Very pleased with our team's work: JCI - Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity https://t.co/wVHUxNTuvd

Jan 30, 2020 · 10 likes · 667 followers View post →
Mouse Phenotyping
@NationalMMPC · X

RT @NIDDKgov: The study brings researchers closer to finding effective ways to stimulate brown fat and possibly treat metabolic disorders.…

Jan 24, 2020 · 1 share · 643 followers View post →
Luiz Gustavo Brito, MD,MSc,PhD
@lgobrito · X

Mirabegron seems to have non-urinary benefits to be used as well - check out this paper published at @jclinicalinvest - https://t.co/vD01MPiNI1

Jan 24, 2020 · 1 like · 1,668 followers View post →
COPD News
@COPD_bio · X

RT @COPD_bio: Chronic mirabegron treatment increases human brown fat HDL cholesterol and insulin sensitivity.: Mirabegron is a 3adrenergic…

Jan 24, 2020 · 1 share · 1,292 followers View post →
Katja
@Krapivner1 · X

RT @BarteltLab: Two important human studies out now in @jclinicalinvest - #brownfat activation with mirabegron

Jan 23, 2020 · 6 shares · 6 followers View post →
George Ioannou
@gnioannou · X

RT @NASH_and_coffee: Today in JCI - @NIDDKgov's Aaron Cypess showing that #mirabegron treatment can increase human #brown #fat. Glad that @…

Jan 22, 2020 · 4 shares · 3,154 followers View post →
COPD News
@COPD_bio · X

Chronic mirabegron treatment increases human brown fat HDL cholesterol and insulin sensitivity.: Mirabegron is a 3adrenergic receptor 3AR agonist approved only for the treatment of overactive bladder. Encouraging preclinical results suggest that 3AR… https://t.co/k03fMlJ5Uo

Jan 22, 2020 · 1 share · 1,292 followers View post →
NIDDK
@NIDDKgov · X

The study brings researchers closer to finding effective ways to stimulate brown fat and possibly treat metabolic disorders. Read more in @jclinicalinvest: https://t.co/aDXGMKNtai

Jan 22, 2020 · 1 like · 1 share · 13,825 followers View post →
Gil Ben Yakov
@gilbenyakov · X

RT @NASH_and_coffee: Today in JCI - @NIDDKgov's Aaron Cypess showing that #mirabegron treatment can increase human #brown #fat. Glad that @…

Jan 22, 2020 · 4 shares · 431 followers View post →
Cidiav
@cidiavas · X

RT @BarteltLab: Two important human studies out now in @jclinicalinvest - #brownfat activation with mirabegron

Jan 22, 2020 · 6 shares · 2,507 followers View post →
Journal of Clinical Investigation
@jclinicalinvest · X

RT @BarteltLab: Two important human studies out now in @jclinicalinvest - #brownfat activation with mirabegron

Jan 22, 2020 · 6 shares · 50,970 followers View post →
Matías Monsalves-Álvarez
@profemonsalves · X

Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity on women! Cool PET images https://t.co/spQQyZTXFQ

Jan 22, 2020 · 1,505 followers View post →
Filipe Almeida
@ChessCarnival · X

RT @NASH_and_coffee: Today in JCI - @NIDDKgov's Aaron Cypess showing that #mirabegron treatment can increase human #brown #fat. Glad that @…

Jan 22, 2020 · 4 shares · 198 followers View post →
Daniel J Drucker
@DanielJDrucker · X

@acypess Elegant comprehensive human studies @jclinicalinvest congrats, even GIP is elevated

Jan 22, 2020 · 3 likes · 34,407 followers View post →
Craig Porter
@bioblastgeek · X

Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity. https://t.co/JLLjSSHcSx

Jan 22, 2020 · 3 likes · 1,254 followers View post →
Kevin Hall
@KevinH_PhD · X

RT @NASH_and_coffee: Today in JCI - @NIDDKgov's Aaron Cypess showing that #mirabegron treatment can increase human #brown #fat. Glad that @…

Jan 22, 2020 · 4 shares · 38,539 followers View post →
Alessandro Bartolomucci Lab
@BartolomucciLab · X

RT @BarteltLab: Two important human studies out now in @jclinicalinvest - #brownfat activation with mirabegron

Jan 22, 2020 · 6 shares · 1,519 followers View post →
Jorge I. Castillo-Quan, MD, PhD
@CastilloQuan_JI · X

RT @tsengyuhua: Chronic mirabegron treatment increases human #brown fat, HDL cholesterol, and #insulin sensitivity @acypess https://t.co/Si…

Jan 22, 2020 · 4 shares · 2,054 followers View post →
Luiz Osório Leiria
@luiz_leiria · X

JCI - Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity https://t.co/xvw4RufFXe

Jan 22, 2020 · 7 likes · 710 followers View post →
Adipose Papers
@adipose_papers · X

Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity. https://t.co/bJYLwdKulP

Jan 22, 2020 · 2,457 followers View post →
Alexander Bartelt
@BarteltLab · X

Two important human studies out now in @jclinicalinvest - #brownfat activation with mirabegron

Jan 22, 2020 · 37 likes · 6 shares · 9,062 followers View post →
名前
@akkiii0830 · X

RT @Office_j: 【過活動膀胱治療薬でBAT活性増加？：JCI】 健常女性14名 [平均27.5歳、BMI 25.4] 対象： 過活動膀胱治療薬ミラベグロン４週間で、褐色脂肪細胞活性が有意に増加。脂肪・糖代謝も改善。 https://t.co/DlUoApQsdX

Jan 21, 2020 · 1 share · 246 followers View post →
Yaron Rotman
@NASH_and_coffee · X

Today in JCI - @NIDDKgov's Aaron Cypess showing that #mirabegron treatment can increase human #brown #fat. Glad that @KapuriaMd and I were able to be part of this breakthrough study! https://t.co/awNESgI6JF

Jan 21, 2020 · 9 likes · 4 shares · 1,544 followers View post →
宇津 貴史 /Utsu, Takashi
@Office_j · X

【過活動膀胱治療薬でBAT活性増加？：JCI】 健常女性14名 [平均27.5歳、BMI 25.4] 対象： 過活動膀胱治療薬ミラベグロン４週間で、褐色脂肪細胞活性が有意に増加。脂肪・糖代謝も改善。 https://t.co/DlUoApQsdX

Jan 21, 2020 · 1 share · 4,914 followers View post →
Alessandro Bartolomucci Lab
@BartolomucciLab · X

RT @tsengyuhua: Chronic mirabegron treatment increases human #brown fat, HDL cholesterol, and #insulin sensitivity @acypess https://t.co/Si…

Jan 21, 2020 · 4 shares · 1,519 followers View post →
Maria Chondronikola
@maria_chond · X

RT @tsengyuhua: Chronic mirabegron treatment increases human #brown fat, HDL cholesterol, and #insulin sensitivity @acypess https://t.co/Si…

Jan 21, 2020 · 4 shares · 699 followers View post →
Andréa Rocha
@rochaandreal · X

RT @tsengyuhua: Chronic mirabegron treatment increases human #brown fat, HDL cholesterol, and #insulin sensitivity @acypess https://t.co/Si…

Jan 21, 2020 · 4 shares · 404 followers View post →
Yu-Hua Tseng
@tsengyuhua · X

Chronic mirabegron treatment increases human #brown fat, HDL cholesterol, and #insulin sensitivity @acypess https://t.co/SiWnyKIZu1

Jan 21, 2020 · 16 likes · 4 shares · 1,223 followers View post →
NIDDK
@NIDDKgov · X

Learn more about this @NIH research in @jclinicalinvest https://t.co/aDXGMKNtai

Jan 21, 2020 · 13,825 followers View post →
The Obesity Society
@ObesitySociety · X

A National Institutes of Health study found that chronic treatment with mirabegron, a drug approved to treat overactive bladder, activated brown fat in a small group of healthy women. The research was published on Jan. 21. https://t.co/mWLs4wMDup.

Jan 21, 2020 · 3 likes · 34,179 followers View post →